LOCUS       NM_005103               4583 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens fasciculation and elongation protein zeta 1 (FEZ1),
            transcript variant 1, mRNA.
ACCESSION   NM_005103
VERSION     NM_005103.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Malikov,V. and Naghavi,M.H.
  TITLE     FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently
            Regulating Capsid Transport and Host Interferon-Stimulated Gene
            Expression
  JOURNAL   J Virol 97 (6), e0049923 (2023)
   PUBMED   37219433
  REMARK    GeneRIF: FEZ1 Plays Dual Roles in Early HIV-1 Infection by
            Independently Regulating Capsid Transport and Host
            Interferon-Stimulated Gene Expression.
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Malikov,V., Meade,N., Simons,L.M., Hultquist,J.F. and Naghavi,M.H.
  TITLE     FEZ1 phosphorylation regulates HSPA8 localization and
            interferon-stimulated gene expression
  JOURNAL   Cell Rep 38 (7), 110396 (2022)
   PUBMED   35172151
  REMARK    GeneRIF: FEZ1 phosphorylation regulates HSPA8 localization and
            interferon-stimulated gene expression.
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Gunaseelan,S., Wang,Z., Tong,V.K.J., Ming,S.W.S., Razar,R.B.B.A.,
            Srimasorn,S., Ong,W.Y., Lim,K.L. and Chua,J.J.E.
  TITLE     Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes
            locomotion defects and early mortality by impairing motor neuron
            development
  JOURNAL   Hum Mol Genet 30 (1), 5-20 (2021)
   PUBMED   33395696
  REMARK    GeneRIF: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes
            locomotion defects and early mortality by impairing motor neuron
            development.
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Huang,Y., Liu,G., Ma,H., Tian,Y., Huang,C., Liu,F., Jia,Y. and
            Jiang,D.
  TITLE     Plasma lncRNA FEZF1-AS1 as a potential biomarker for diagnosis of
            non-small-cell lung carcinoma
  JOURNAL   Medicine (Baltimore) 99 (26), e21019 (2020)
   PUBMED   32590821
  REMARK    GeneRIF: Diagnosis of numerous cancers has been closely linked to
            the expression of certain long non-coding RNAs. This study aimed to
            evaluate levels of plasma FEZ family zinc finger 1 antisense RNA 1
            (FEZF1-AS1) relative to non-small-cell lung carcinoma (NSCLC)
            diagnosis.
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Surpili,M.J., Delben,T.M. and Kobarg,J.
  TITLE     Identification of proteins that interact with the central
            coiled-coil region of the human protein kinase NEK1
  JOURNAL   Biochemistry 42 (51), 15369-15376 (2003)
   PUBMED   14690447
REFERENCE   7  (bases 1 to 4583)
  AUTHORS   Miyoshi,K., Honda,A., Baba,K., Taniguchi,M., Oono,K., Fujita,T.,
            Kuroda,S., Katayama,T. and Tohyama,M.
  TITLE     Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia,
            participates in neurite outgrowth
  JOURNAL   Mol Psychiatry 8 (7), 685-694 (2003)
   PUBMED   12874605
  REMARK    GeneRIF: FEZ1 is an interacting partner of DISC1. The interaction
            of DISC1 and FEZ1 is associated with direct FEZ1 binding to
            F-actin.
REFERENCE   8  (bases 1 to 4583)
  AUTHORS   Whitehouse,C., Chambers,J., Howe,K., Cobourne,M., Sharpe,P. and
            Solomon,E.
  TITLE     NBR1 interacts with fasciculation and elongation protein zeta-1
            (FEZ1) and calcium and integrin binding protein (CIB) and shows
            developmentally restricted expression in the neural tube
  JOURNAL   Eur J Biochem 269 (2), 538-545 (2002)
   PUBMED   11856312
  REMARK    GeneRIF: interacts with NBR1 protein
REFERENCE   9  (bases 1 to 4583)
  AUTHORS   Kuroda,S., Nakagawa,N., Tokunaga,C., Tatematsu,K. and Tanizawa,K.
  TITLE     Mammalian homologue of the Caenorhabditis elegans UNC-76 protein
            involved in axonal outgrowth is a protein kinase C zeta-interacting
            protein
  JOURNAL   J Cell Biol 144 (3), 403-411 (1999)
   PUBMED   9971736
REFERENCE   10 (bases 1 to 4583)
  AUTHORS   Bloom,L. and Horvitz,H.R.
  TITLE     The Caenorhabditis elegans gene unc-76 and its human homologs
            define a new gene family involved in axonal outgrowth and
            fasciculation
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3414-3419 (1997)
   PUBMED   9096408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA697171.1, BC009545.1,
            BM663785.1 and AP000708.5.
            
            On May 17, 2019 this sequence version replaced NM_005103.4.
            
            Summary: This gene is an ortholog of the C. elegans unc-76 gene,
            which is necessary for normal axonal bundling and elongation within
            axon bundles. Expression of this gene in C. elegans unc-76 mutants
            can restore to the mutants partial locomotion and axonal
            fasciculation, suggesting that it also functions in axonal
            outgrowth. The N-terminal half of the gene product is highly
            acidic. Alternatively spliced transcript variants encoding
            different isoforms of this protein have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the full-length
            isoform (1), which has a longer C-terminal end compared to isoform
            2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.98314.1,
                                           SRR1803615.25693.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278919.8/ ENSP00000278919.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DA697171.1         53-90
            39-1712             BC009545.1         1-1674
            1713-1719           BM663785.1         18-24               c
            1720-4583           AP000708.5         24320-27183         c
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..4583
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /note="fasciculation and elongation protein zeta 1"
                     /db_xref="GeneID:9638"
                     /db_xref="HGNC:HGNC:3659"
                     /db_xref="MIM:604825"
     exon            1..145
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            146..501
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1369
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /note="isoform 1 is encoded by transcript variant 1; zygin
                     I; zygin-1"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-1
                     isoform 1"
                     /protein_id="NP_005094.1"
                     /db_xref="CCDS:CCDS31716.1"
                     /db_xref="GeneID:9638"
                     /db_xref="HGNC:HGNC:3659"
                     /db_xref="MIM:604825"
                     /translation="MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLS
                     ELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQD
                     EEVWDALTDNYIPSLSEDWRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEP
                     LLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNN
                     WSYEGLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIE
                     VQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGS
                     SGTDKQYLNTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
                     "
     exon            502..601
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            602..688
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            689..857
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1129
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1210
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1286
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1352
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..4583
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /note="major polyA site"
ORIGIN      
        1 ggagctgcgc ggggagcgct cgctggctgg ctggctggct ggctctccgc tgcgctgcgc
       61 tgcgctccgg ccgctcccgc ggcccgtgga tgggggtgtc cggctgagcc ccgggatccg
      121 cctccctccg ccaggacccg cacagataaa ctcatcctga aagtcgctgt tgttctcctg
      181 ctgagcaaga atggaggccc cactggtgag tctggatgaa gagtttgagg accttcgacc
      241 ctcctgctcg gaggacccgg aggagaagcc ccagtgtttc tatggttcat ctccccacca
      301 tctcgaggac ccctccctct ccgagcttga gaatttttct tccgaaataa tcagcttcaa
      361 gtccatggag gacctcgtaa atgaatttga tgagaagctc aatgtctgct ttcggaacta
      421 caacgccaag accgagaacc tagctcccgt gaagaaccag ttacagatcc aagaggagga
      481 ggagaccctt caggacgagg aggtttggga tgctctgaca gacaattaca tcccttcact
      541 ctcagaagac tggagggatc caaacatcga ggctctgaat ggcaactgct ctgacactga
      601 gatccatgag aaagaagagg aagagttcaa tgagaagagt gaaaatgatt ccggtatcaa
      661 cgaggagcct ctgctcacag cagatcaggt aattgaggag attgaggaaa tgatgcagaa
      721 ctccccagac cctgaggaag aagaggaggt tctggaagaa gaggatggag gagaaacttc
      781 ctcccaggca gactcggtcc tcctgcagga gatgcaggca ttgacacaga ccttcaacaa
      841 caactggtcc tatgaagggc tgaggcacat gtctgggtct gagctgaccg agctgctgga
      901 ccaggtggag ggtgccatcc gtgacttctc ggaggagctg gtgcagcagc tggcccgccg
      961 ggacgagctg gagtttgaga aggaagtgaa gaactccttt atcacggtgc ttattgaggt
     1021 tcagaacaag cagaaggagc agcgagaact gatgaaaaag aggcggaaag agaaagggct
     1081 gagcctgcag agcagccgga tagagaaggg aaaccagatg cctctcaagc gcttcagcat
     1141 ggaaggcatc tccaacattc tgcagagtgg catccgccag acctttggct cctcaggaac
     1201 tgacaaacag tatctgaaca cagtcattcc ttacgagaag aaagcctctc ctccctcagt
     1261 ggaagacctg cagatgctga caaacattct ctttgccatg aaggaggata atgagaaggt
     1321 gcctactttg ctaacggact acattttaaa agtgctctgc cctacctaac cttgcccttt
     1381 ggagcagcct cgctgcagga ggtcactgag caagagtcat tccatcacag ggactgcatg
     1441 agaccatgta acctccgaca tgtatttaaa cgtgtatagc ttaacctgga ttaaacacga
     1501 gcaagcgcgc ggggtccttt gccgttggct tctagtgcta gtaatcattg gatgcatgat
     1561 ggggcagggc cggtgatggt gcctccccct tgctggtgtc aggagagggg aaggcagccg
     1621 ctttcaccgc tcattatgta gtctggctac agccctcaaa aacagcttat actcttaaga
     1681 ctaattttga aataaaacct tcatttaatt aatattcttc atgtgctttg gagtgtgatg
     1741 tccattagcc ctctgctcca gactccagag acgggctgta tagcattctt tgcacgccgg
     1801 cctgtggcct gtggcagcca gtgctgtgtt tagggaccgg gcgcatgtcc tgttgtgggt
     1861 cgtggtggga tcatgggaca cagtggggct gcatacagca taggcagaag gagaccctct
     1921 gcaacctcag tttttgctgc tcagccacat gcaagggagc tgcaccaggg gctgcagaaa
     1981 ggagctggtc agagtgggtg agacgggggt gagagtgtgc aattagcaga tagaaagtgg
     2041 gcctcatgga ggagccacac agctgcagat ctcctggtgg gatggccagg ctggccctgg
     2101 agaccctccc caggctgtcc acggggacct ggaggctcag ggcctgcggg aagtcagctc
     2161 tgctgagctt tcccaacgta ggggactgca acttgtttcc tgtacttgac gaaaccacca
     2221 ctccctgttt gtccccaacg acccctggca acagtgtcct ttgactttgc agtgctgtcc
     2281 tggcccttcc cgcggccctc catgaacagc agctctgact cctcgcactg tctccagcat
     2341 tgatggcagg cagctgccag ccttgaccaa ccagcaggcg aaggtctcct cgtatcccgg
     2401 atgctggctc gatctcacca cagtctgaat tctgttggct tccgtcttct ggcttgaaag
     2461 acattgagcc tgccaattcc catatcctcc tctgaaagca aaaacttgta ctgggcactt
     2521 gctgtagcct gcactggctt catcgtgcat tagcacacat cacagcatca ccacgtgtaa
     2581 acaggtgcta gtatgatccc gattttgcag aggaggaaac caagcagcag agatgttcag
     2641 tagctcgccc aaggctgtgt aggaagtggt agagtcaggc tggcatttag gtttcttatc
     2701 cagtgagact tccattgatt cccaggagtt tagtgtctgc ttgaactaag catgccacag
     2761 agaaagccat actttatcac atcagcagct ccacagaagg ccacagaatc catctagggg
     2821 acacagaagg cactcccagt gccctgcctc ccttcctggg cctctgcttt ttttttttca
     2881 gacggagttt gactcttgtt gctcaggctg gagtacaatg gcgctatctc agctcgccgc
     2941 aaactccgcc tcccacgttc aagtgattct cctgcctcag cctcccgagt agctgggatt
     3001 acaggcatgc agcaccacac ccagctaatt ttatattttt agtagagacc aggtttctac
     3061 atgttggtca ggttggtctc gaactcccga cctcaggcga tctgccctcc taggcttccc
     3121 aaagtgctgg gattataggc gtgagtcacc gcgcctagct cggcttctgc ttttccagaa
     3181 gcagaacact agcaatctta gctaggggtg gcggagactt atccccccag gaaaactgct
     3241 gcaatgccta aagctctagt ccaggcatct gcccagagca gagcttctcc atagatagag
     3301 ccccggctgc cacaggagca tggaagtgac aactcgtcct gtgataaaag ggcatggatt
     3361 cagttcggca gttcactggt gctaaggctg aacatgccca gggtcattag tggtgtgagg
     3421 tcattagcat gtttagcact ctgccggcga cggggttttt caccagcctc agcaaagggg
     3481 aagcagtgaa ttcctgagag cttttcttcc tgccttggat ttgtcagatc tgggtcagcc
     3541 actcctttcc cccaatttat cctgccagca ggtgtctgaa gcggcagaga caagctaatc
     3601 aaagctgctg ggagttaaaa ataaatctcg agtgttgggg atacactctg gctaggagga
     3661 ggtgagcagg gcaggctgaa aacagtggct cctcctttct ctcttgtttg tccgtctatc
     3721 aggagtttaa ggggaatatg aaatcaattc ctcatggttt tgcattgccc ttccctgtgt
     3781 tcttcctatt caaagtgtgc tttccaggcc agcagcactg accgcactta gaagcttgtt
     3841 agaaatgcaa aatctcaggc cccacatcag gcctactaag tcagaatttg cattttaaca
     3901 aggtctccct ttaaaaggga ggcagctctt ctcttaaaag gagcctgggt tttgtgcctt
     3961 gagttcaaat gcagctctac tacgtattaa gctaaatctc cctgcaactt gtatttgcat
     4021 caaggattag agaaactctg ccctaggttt tcagagttgc tgaatccttg actcttcaat
     4081 gctgaaccta gggaatttgt ggctagtgtg attatcaggt gaacccaatt gtcttccctc
     4141 agcttttccc tcttctggtc tttctggatt gtagaaacct cacagaagag tcccaagaat
     4201 taactgattt tcaggcctga gtcaatcctg attgcaaaac tcaagtcctg tctaggatgt
     4261 ccgcactccg caaagtgtgc cagagagcca cggtctgcag ggagccctcc taggtaggtc
     4321 agaggtctgt ctggcaaata cagcctataa atgaggtatg tttccatcaa ttaaaggatt
     4381 ttgctaggcc tagtctggtc aagttctggt aagaaaactc caccacaggg ccgggcgtgg
     4441 tggctcatgc ctgtaatccc agaactttgg gaggccgagg tgggcagatc acctgaggtc
     4501 aggagtttga gaccagcctg gccaacatgg tgaaaccccc tctctactga aaatacaaaa
     4561 attagccagc tgtagtggtg cac
//
