LOCUS       NM_017521               1406 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens FEV transcription factor, ETS family member (FEV),
            mRNA.
ACCESSION   NM_017521
VERSION     NM_017521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Liang,Y.X., Liang,Y.K., Zou,Z.H., Zhuo,Y.J., Ye,J.H., Zhu,X.J.,
            Cai,Z.D., Lin,Z.Y., Mo,R.J., Wu,S.L., Zhang,Y.Q. and Zhong,W.D.
  TITLE     Tumor Suppressor Role and Clinical Significance of the FEV Gene in
            Prostate Cancer
  JOURNAL   Dis Markers 2022, 8724035 (2022)
   PUBMED   35548776
  REMARK    GeneRIF: Tumor Suppressor Role and Clinical Significance of the FEV
            Gene in Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Tsuda,Y., Dickson,B.C., Swanson,D., Sung,Y.S., Zhang,L., Meyers,P.,
            Healey,J.H. and Antonescu,C.R.
  TITLE     Ewing sarcoma with FEV gene rearrangements is a rare subset with
            predilection for extraskeletal locations and aggressive behavior
  JOURNAL   Genes Chromosomes Cancer 59 (5), 286-294 (2020)
   PUBMED   31756779
  REMARK    GeneRIF: Ewing sarcoma with FEV gene rearrangements is a rare
            subset with predilection for extraskeletal locations and aggressive
            behavior.
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Chang,H., Yan,Q., Tang,L., Huang,J., Ma,Y., Ye,X., Wu,C., Wu,L. and
            Yu,Y.
  TITLE     Association of genetic variations in the serotonin and dopamine
            systems with aggressive behavior in the Chinese adolescent
            population: Single- and multiple-risk genetic variants
  JOURNAL   J Affect Disord 225, 374-380 (2018)
   PUBMED   28846959
  REMARK    GeneRIF: This study adds to the growing evidence on the association
            of single- and multiple-risk variants in DRD3, DRD4, and FEV with
            aggressive behavior in Chinese adolescents.
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Liu,T.H., Tang,Y.J., Huang,Y., Wang,L., Guo,X.L., Mi,J.Q.,
            Liu,L.G., Zhu,H., Zhang,Y., Chen,L., Liu,X., Zhang,L.H., Ye,Q.J.,
            Li,B.S., Tang,J.Y., Ford,A., Enver,T., Liu,F., Chen,G.Q. and
            Hong,D.L.
  TITLE     Expression of the fetal hematopoiesis regulator FEV indicates
            leukemias of prenatal origin
  JOURNAL   Leukemia 31 (5), 1079-1086 (2017)
   PUBMED   27807368
  REMARK    GeneRIF: identified FEV is unique to fetal HSCs and stably
            expressed in leukemic cells of prenatal origin
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Scott,M.M., Krueger,K.C. and Deneris,E.S.
  TITLE     A differentially autoregulated Pet-1 enhancer region is a critical
            target of the transcriptional cascade that governs serotonin neuron
            development
  JOURNAL   J Neurosci 25 (10), 2628-2636 (2005)
   PUBMED   15758173
  REMARK    GeneRIF: Analysis of transgene expression in Pet-1 null mice
            indicates that Pet-1 is required to maintain the activity of the
            Pet-1 enhancer region in a subset of serotonin (5-HT) neurons.
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Maurer,P., Rorive,S., de Kerchove d'Exaerde,A., Schiffmann,S.N.,
            Salmon,I. and de Launoit,Y.
  TITLE     The Ets transcription factor Fev is specifically expressed in the
            human central serotonergic neurons
  JOURNAL   Neurosci Lett 357 (3), 215-218 (2004)
   PUBMED   15003288
  REMARK    GeneRIF: We showed that fev is exclusively expressed in the midline
            part of the human brainstem containing raphe nuclei, which also
            specifically expressed 5-HT transporter (sert) and tryptophan
            hydroxylase (tph), two markers of the 5-HT neurotransmitter system.
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Maurer,P., T'Sas,F., Coutte,L., Callens,N., Brenner,C., Van
            Lint,C., de Launoit,Y. and Baert,J.L.
  TITLE     FEV acts as a transcriptional repressor through its DNA-binding ETS
            domain and alanine-rich domain
  JOURNAL   Oncogene 22 (21), 3319-3329 (2003)
   PUBMED   12761502
  REMARK    GeneRIF: FEV acts as a transcriptional repressor through its
            DNA-binding ETS domain and alanine-rich domain.
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Mastrangelo,T., Modena,P., Tornielli,S., Bullrich,F., Testi,M.A.,
            Mezzelani,A., Radice,P., Azzarelli,A., Pilotti,S., Croce,C.M.,
            Pierotti,M.A. and Sozzi,G.
  TITLE     A novel zinc finger gene is fused to EWS in small round cell tumor
  JOURNAL   Oncogene 19 (33), 3799-3804 (2000)
   PUBMED   10949935
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Peter,M., Couturier,J., Pacquement,H., Michon,J., Thomas,G.,
            Magdelenat,H. and Delattre,O.
  TITLE     A new member of the ETS family fused to EWS in Ewing tumors
  JOURNAL   Oncogene 14 (10), 1159-1164 (1997)
   PUBMED   9121764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097468.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 23, 2019 this sequence version replaced NM_017521.2.
            
            Summary: This gene belongs to the ETS transcription factor family.
            ETS family members have a highly conserved 85-amino acid ETS domain
            that binds purine-rich DNA sequences. The alanine-rich C-terminus
            of this gene indicates that it may act as a transcription
            repressor. This gene is exclusively expressed in neurons of the
            central serotonin (5-HT) system, a system implicated in the
            pathogeny of such psychiatric diseases as depression, anxiety, and
            eating disorders. In some types of Ewing tumors, this gene is fused
            to the Ewing sarcoma (EWS) gene following chromosome
            translocations. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023511.2, Y08976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295727.2/ ENSP00000295727.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC097468.3         64662-64822         c
            162-236             AC097468.3         63869-63943         c
            237-1406            AC097468.3         60725-61894         c
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1406
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /note="FEV transcription factor, ETS family member"
                     /db_xref="GeneID:54738"
                     /db_xref="HGNC:HGNC:18562"
                     /db_xref="MIM:607150"
     exon            1..161
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..826
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /note="FEV, ETS transcription factor; fifth Ewing variant
                     protein; PC12 ETS domain-containing transcription factor
                     1; FEV (ETS oncogene family)"
                     /codon_start=1
                     /product="protein FEV"
                     /protein_id="NP_059991.1"
                     /db_xref="CCDS:CCDS2428.1"
                     /db_xref="GeneID:54738"
                     /db_xref="HGNC:HGNC:18562"
                     /db_xref="MIM:607150"
                     /translation="MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGS
                     GQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLS
                     RALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGAL
                     YKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQ
                     PPPGPFGAVAAASHLGGHYH"
     exon            162..236
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..1406
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1406
                     /gene="FEV"
                     /gene_synonym="HSRNAFEV; PET-1"
                     /note="major polyA site"
ORIGIN      
        1 cttgtcaccc gcggtcgctt cgggcgggga tcggtgccac cgagcgcaaa gcctgcctcg
       61 ccccccttcc ccgtcccccc catctcccac cgcccagtcc ccggcggcga tgagacagag
      121 cggcgcctcc cagcccctgc tgatcaacat gtacctgcca gatcccgtcg gagacggtct
      181 cttcaaggac gggaagaacc cgagctgggg gccgctgagc cccgcggttc agaaaggcag
      241 cggacagatc cagctgtggc agtttctgct ggagctgctg gctgaccgcg cgaacgccgg
      301 ctgcatcgcg tgggagggcg gtcacggcga gttcaagctc acggacccgg acgaggtggc
      361 gcggcggtgg ggcgagcgca agagcaagcc caacatgaac tacgacaagc tgagccgcgc
      421 cctgcgctac tactacgaca agaacatcat gagcaaggtg catggcaagc gctacgccta
      481 ccgcttcgac ttccagggcc tggcgcaggc ctgccagccg ccgcccgcgc acgctcatgc
      541 cgccgccgca gctgctgccg ccgccgcggc cgcccaggac ggcgcgctct acaagctgcc
      601 cgccggcctc gccccgctgc ccttccccgg cctctccaaa ctcaacctca tggccgcctc
      661 ggccggggtc gcgcccgccg gcttctccta ctggccgggc ccgggccccg ccgccaccgc
      721 tgccgccgcc accgccgcgc tctaccccag tcccagcttg cagcccccgc ccgggccctt
      781 cggggccgtg gccgcagcct cgcacttggg gggccattac cactagacgg ggcggtcggg
      841 tgcctgcggc ctcgcccgca cgcctagagt ctcgcccgat cccatcggca tcccggggag
      901 ggcccgggag cctccgtcaa ccgtcctcta atccagagtt tactccacct gccgcactta
      961 gcagggggac gggaccgaag ctccctcaat ccttgtctgg tactagattt gctcctgtcc
     1021 caccccgcag tcccctgagg agggcgatgt gcgccctctt tcactttttt tcttctaggt
     1081 ctccaggtcc cggaggggat ttgtggacct ctcttgtctc cccaccactc cagtgcattt
     1141 ccgcctggct cctagaagcc ccattcaata tcactactct ttaacgagtg ccaaatcttt
     1201 tcccactttt gctcttcccc aaggaactgc tcccacctca gcacgtggag gcctctcacg
     1261 gtcctccttc ctgggacctg agcaggtttg gtgaaagcca ccgtcctccg tgacacacgg
     1321 cccccttcct cctgtcccca cactcccagg agaaactccc ggtgtgtttc tgaccctttc
     1381 agccccatta aagctcctga gctctc
//
