LOCUS       NM_014375               1721 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens fetuin B (FETUB), transcript variant 1, mRNA.
ACCESSION   NM_014375
VERSION     NM_014375.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Zhang,W., Yao,J., Chen,C., Wang,J. and Zhou,A.
  TITLE     Fetuin-B Overexpression Promotes Inflammation in Diabetic
            Retinopathy Through Activating Microglia and the NF-kappaB
            Signaling Pathway
  JOURNAL   Curr Eye Res 49 (2), 168-179 (2024)
   PUBMED   37883127
  REMARK    GeneRIF: Fetuin-B Overexpression Promotes Inflammation in Diabetic
            Retinopathy Through Activating Microglia and the NF-kappaB
            Signaling Pathway.
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Wang,D., Wu,M., Zhang,X., Li,L., Lin,M., Shi,X., Zhao,Y., Huang,C.
            and Li,X.
  TITLE     Hepatokine Fetuin B expression is regulated by leptin-STAT3
            signalling and associated with leptin in obesity
  JOURNAL   Sci Rep 12 (1), 12869 (2022)
   PUBMED   35896788
  REMARK    GeneRIF: Hepatokine Fetuin B expression is regulated by
            leptin-STAT3 signalling and associated with leptin in obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Zhan,K., Liu,R., Tong,H., Gao,S., Yang,G., Hossain,A., Li,T. and
            He,W.
  TITLE     Fetuin B overexpression suppresses proliferation, migration, and
            invasion in prostate cancer by inhibiting the PI3K/AKT signaling
            pathway
  JOURNAL   Biomed Pharmacother 131, 110689 (2020)
   PUBMED   32892030
  REMARK    GeneRIF: Fetuin B overexpression suppresses proliferation,
            migration, and invasion in prostate cancer by inhibiting the
            PI3K/AKT signaling pathway.
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Jung,S.H., Lee,D., Jin,H., Lee,H.M., Ko,H.M., Lee,K.J., Kim,S.J.,
            Ryu,Y., Choi,W.S., Kim,B. and Won,K.J.
  TITLE     Fetuin-B regulates vascular plaque rupture via TGF-beta
            receptor-mediated Smad pathway in vascular smooth muscle cells
  JOURNAL   Pflugers Arch 472 (5), 571-581 (2020)
   PUBMED   32382986
  REMARK    GeneRIF: Fetuin-B regulates vascular plaque rupture via TGF-beta
            receptor-mediated Smad pathway in vascular smooth muscle cells.
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Wajih,N., Borras,T., Xue,W., Hutson,S.M. and Wallin,R.
  TITLE     Processing and transport of matrix gamma-carboxyglutamic acid
            protein and bone morphogenetic protein-2 in cultured human vascular
            smooth muscle cells: evidence for an uptake mechanism for serum
            fetuin
  JOURNAL   J Biol Chem 279 (41), 43052-43060 (2004)
   PUBMED   15280384
  REMARK    GeneRIF: serum fetuin has a role in processing and transport of
            matrix gamma-carboxyglutamic acid protein and bone morphogenetic
            protein-2 in cultured human vascular smooth muscle cells
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Hsu,S.J., Nagase,H. and Balmain,A.
  TITLE     Identification of Fetuin-B as a member of a cystatin-like gene
            family on mouse chromosome 16 with tumor suppressor activity
  JOURNAL   Genome 47 (5), 931-946 (2004)
   PUBMED   15499407
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Denecke,B., Graber,S., Schafer,C., Heiss,A., Woltje,M. and
            Jahnen-Dechent,W.
  TITLE     Tissue distribution and activity testing suggest a similar but not
            identical function of fetuin-B and fetuin-A
  JOURNAL   Biochem J 376 (Pt 1), 135-145 (2003)
   PUBMED   12943536
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Olivier,E., Soury,E., Ruminy,P., Husson,A., Parmentier,F.,
            Daveau,M. and Salier,J.P.
  TITLE     Fetuin-B, a second member of the fetuin family in mammals
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 589-597 (2000)
   PUBMED   10947975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069670.1, AJ242928.1,
            BX115543.1 and AC068631.16.
            
            On May 17, 2019 this sequence version replaced NM_014375.2.
            
            Summary: The protein encoded by this gene is a member of the fetuin
            family, part of the cystatin superfamily of cysteine protease
            inhibitors. Fetuins have been implicated in several diverse
            functions, including osteogenesis and bone resorption, regulation
            of the insulin and hepatocyte growth factor receptors, and response
            to systemic inflammation. This protein may be secreted by cells.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069820.1, AF534529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265029.8/ ENSP00000265029.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1503              BC069670.1         37-1539
            1504-1585           AJ242928.1         1542-1623
            1586-1588           BX115543.1         14-16               c
            1589-1721           AC068631.16        8431-8563           c
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..1721
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="fetuin B"
                     /db_xref="GeneID:26998"
                     /db_xref="HGNC:HGNC:3658"
                     /db_xref="MIM:605954"
     exon            1..287
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1211
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fetuin-like protein IRL685"
                     /codon_start=1
                     /product="fetuin-B isoform 1 precursor"
                     /protein_id="NP_055190.2"
                     /db_xref="CCDS:CCDS3279.1"
                     /db_xref="GeneID:26998"
                     /db_xref="HGNC:HGNC:3658"
                     /db_xref="MIM:605954"
                     /translation="MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAV
                     AGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQ
                     DCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPT
                     DSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTK
                     SQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPT
                     NLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNP
                     QGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNASPLVLPP"
     exon            288..398
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     exon            399..486
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     exon            487..656
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     exon            657..758
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     exon            759..842
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1721
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1468
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="major polyA site"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="hexamer: TATAAA"
     polyA_site      1529
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="major polyA site"
     polyA_site      1551
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
                     /note="hexamer: AGTAAA"
     polyA_site      1586
                     /gene="FETUB"
                     /gene_synonym="16G2; Gugu; IRL685"
ORIGIN      
        1 acaagccagc cagtccctgc agctccacaa actgacccat cctgggcctt gttctccaca
       61 gaatgggtct gctccttccc ctggcactct gcatcctagt cctgtgctgc ggagcaatgt
      121 ctccacccca gctggccctc aacccctcgg ctctgctctc ccggggctgc aatgactcag
      181 atgtgctggc agttgcaggc tttgccctgc gggatattaa caaagacaga aaggatggct
      241 atgtgctgag actcaaccga gtgaacgacg cccaggaata cagacggggt ggcctgggat
      301 ctctgttcta tcttacactg gatgtgctag agactgactg ccatgtgctc agaaagaagg
      361 catggcaaga ctgtggaatg aggatatttt ttgaatcagt ttatggtcaa tgcaaagcaa
      421 tattttatat gaacaaccca agtagagttc tctatttagc tgcttataac tgtactcttc
      481 gcccagtttc aaaaaaaaag atttacatga cgtgccctga ctgcccaagc tccataccca
      541 ctgactcttc caatcaccaa gtgctggagg ctgccaccga gtctcttgcg aaatacaaca
      601 atgagaacac atccaagcag tattctctct tcaaagtcac cagggcttct agccagtggg
      661 tggtcggccc ttcttacttt gtggaatact taattaaaga atcaccatgt actaaatccc
      721 aggccagcag ctgttcactt cagtcctccg actctgtgcc tgttggtctt tgcaaaggtt
      781 ctctgactcg aacacactgg gaaaagtttg tctctgtgac ttgtgacttc tttgaatcac
      841 aggctccagc cactggaagt gaaaactctg ctgttaacca gaaacctaca aaccttccca
      901 aggtggaaga atcccagcag aaaaacaccc ccccaacaga ctccccctcc aaagctgggc
      961 caagaggatc tgtccaatat cttcctgact tggatgataa aaattcccag gaaaagggcc
     1021 ctcaggaggc ctttcctgtg catctggacc taaccacgaa tccccaggga gaaaccctgg
     1081 atatttcctt cctcttcctg gagcctatgg aggagaagct ggtggtcctg cctttcccca
     1141 aagaaaaagc acgcactgct gagtgcccag ggccagccca gaatgccagc cctcttgtcc
     1201 ttccgccatg agaatcacac agagtcttct gtaggggtat ggtgcgccgc atgacatggg
     1261 aggcgatggg gacgatggac agagacagag cgtgcacacg tagagtggct agtgaaggac
     1321 gcctttttga ctcttcttgg tctcagcatg ttgactggga ttggaaataa tgagactgag
     1381 ccctcggctt gggctgcact ctaccctgta cactgccttg taccctgagc tgcatcacct
     1441 cctaaactga gcagtctcat accatggaga gatgcctctc ttatgtcttc agccactcac
     1501 ttataaagat acttatcttt tcagcagtat atatgtgctg aaatctcagc atgaaagcat
     1561 tgcatgagta aagatacttt ccctaacacc gggaggcgtg agcaactaat gcccagcaca
     1621 gtttcagtcc ctaaattccc tttaattcca ggacaggtat tagctgcgta gggcccatac
     1681 catttccaac cctctacctc ttttcatctg tctggaagtc t
//
