LOCUS       NM_002005               2737 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FES proto-oncogene, tyrosine kinase (FES), transcript
            variant 1, mRNA.
ACCESSION   NM_002005
VERSION     NM_002005.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Karamanavi,E., McVey,D.G., van der Laan,S.W., Stanczyk,P.J.,
            Morris,G.E., Wang,Y., Yang,W., Chan,K., Poston,R.N., Luo,J.,
            Zhou,X., Gong,P., Jones,P.D., Cao,J., Kostogrys,R.B., Webb,T.R.,
            Pasterkamp,G., Yu,H., Xiao,Q., Greer,P.A., Stringer,E.J.,
            Samani,N.J. and Ye,S.
  TITLE     The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits
            Atherosclerosis
  JOURNAL   Circ Res 131 (12), 1004-1017 (2022)
   PUBMED   36321446
  REMARK    GeneRIF: The FES Gene at the 15q26 Coronary-Artery-Disease Locus
            Inhibits Atherosclerosis.
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Debackere,K., van der Krogt,J.A., Tousseyn,T., Ferreiro,J.A.F., Van
            Roosbroeck,K., Marcelis,L., Graux,C., Dierickx,D., Ameye,G.,
            Vandenberghe,P., Michaux,L., Cools,J. and Wlodarska,I.
  TITLE     FER and FES tyrosine kinase fusions in follicular T-cell lymphoma
  JOURNAL   Blood 135 (8), 584-588 (2020)
   PUBMED   31746983
  REMARK    GeneRIF: This study supports the critical role of FER and FES
            tyrosine kinase fusions in the pathogenesis of follicular T-cell
            lymphoma and provides additional evidence that these can drive
            follicular T-cell lymphoma in the absence of RHOA mutations.
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Kim,B.H., Kim,Y.J., Kim,M.H., Na,Y.R., Jung,D., Seok,S.H., Kim,J.
            and Kim,H.J.
  TITLE     Identification of FES as a Novel Radiosensitizing Target in Human
            Cancers
  JOURNAL   Clin Cancer Res 26 (1), 265-273 (2020)
   PUBMED   31573955
  REMARK    GeneRIF: Identification of FES as a Novel Radiosensitizing Target
            in Human Cancers.
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   Hu,J., Zheng,L., Shen,X., Zhang,Y., Li,C. and Xi,T.
  TITLE     MicroRNA-125b inhibits AML cells differentiation by directly
            targeting Fes
  JOURNAL   Gene 620, 1-9 (2017)
   PUBMED   28389358
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Jucker,M., Roebroek,A.J., Mautner,J., Koch,K., Eick,D., Diehl,V.,
            Van de Ven,W.J. and Tesch,H.
  TITLE     Expression of truncated transcripts of the proto-oncogene c-fps/fes
            in human lymphoma and lymphoid leukemia cell lines
  JOURNAL   Oncogene 7 (5), 943-952 (1992)
   PUBMED   1373879
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Bowden,D.W., Akots,G. and Rothschild,C.B.
  TITLE     An insertion deletion polymorphism associated with C-FES
  JOURNAL   Nucleic Acids Res 19 (15), 4311 (1991)
   PUBMED   1870997
REFERENCE   8  (bases 1 to 2737)
  AUTHORS   Polymeropoulos,M.H., Rath,D.S., Xiao,H. and Merril,C.R.
  TITLE     Tetranucleotide repeat polymorphism at the human c-fes/fps
            proto-oncogene (FES)
  JOURNAL   Nucleic Acids Res 19 (14), 4018 (1991)
   PUBMED   1862005
REFERENCE   9  (bases 1 to 2737)
  AUTHORS   Alcalay,M., Antolini,F., Van de Ven,W.J., Lanfrancone,L.,
            Grignani,F. and Pelicci,P.G.
  TITLE     Characterization of human and mouse c-fes cDNA clones and
            identification of the 5' end of the gene
  JOURNAL   Oncogene 5 (3), 267-275 (1990)
   PUBMED   2179816
REFERENCE   10 (bases 1 to 2737)
  AUTHORS   MacDonald,I., Levy,J. and Pawson,T.
  TITLE     Expression of the mammalian c-fes protein in hematopoietic cells
            and identification of a distinct fes-related protein
  JOURNAL   Mol Cell Biol 5 (10), 2543-2551 (1985)
   PUBMED   2426571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X52192.1 and AC124248.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002005.3.
            
            Summary: This gene encodes the human cellular counterpart of a
            feline sarcoma retrovirus protein with transforming capabilities.
            The gene product has tyrosine-specific protein kinase activity and
            that activity is required for maintenance of cellular
            transformation. Its chromosomal location has linked it to a
            specific translocation event identified in patients with acute
            promyelocytic leukemia but it is also involved in normal
            hematopoiesis as well as growth factor and cytokine receptor
            signaling. Alternative splicing results in multiple variants
            encoding different isoforms.[provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035357.1, X52192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328850.8/ ENSP00000331504.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2204              X52192.1           26-2229
            2205-2253           AC124248.6         136243-136291
            2254-2376           AC124248.6         136416-136538
            2377-2737           AC124248.6         137896-138256
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2737
                     /gene="FES"
                     /gene_synonym="FPS"
                     /note="FES proto-oncogene, tyrosine kinase"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
     exon            1..41
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            42..263
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2519
                     /gene="FES"
                     /gene_synonym="FPS"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Oncogene FES, feline sarcoma virus; feline sarcoma
                     (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma
                     (PRCII) viral (v-fps) oncogene homolog; p93c-fes; feline
                     sarcoma oncogene; proto-oncogene tyrosine-protein kinase
                     Fes/Fps; proto-oncogene c-Fes; proto-oncogene c-Fps;
                     feline sarcoma/Fujinami avian sarcoma oncogene homolog"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fes/Fps isoform 1"
                     /protein_id="NP_001996.1"
                     /db_xref="CCDS:CCDS10365.1"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
                     /translation="MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREY
                     AGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKL
                     SLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEAS
                     KDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEE
                     MACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPP
                     CVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQL
                     QQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLG
                     PGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPE
                     VQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQS
                     LDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQ
                     IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG
                     VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHR
                     DLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSE
                     SDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWA
                     YEPGQRPSFSTIYQELQSIRKRHR"
     exon            264..437
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            438..534
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            535..718
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            719..856
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            857..976
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1099
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1286
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1370
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1580
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1703
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1757
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1876
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1971
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2095
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2253
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2376
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2737
                     /gene="FES"
                     /gene_synonym="FPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FES"
                     /gene_synonym="FPS"
                     /note="hexamer: AATAAA"
     polyA_site      2737
                     /gene="FES"
                     /gene_synonym="FPS"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggtcc gaggccgtcc caggagcagc tgcccgtgcg gaacagcact atgggcttct
       61 cttccgagct gtgcagcccc cagggccacg gggtcctgca gcaaatgcag gaggccgagc
      121 ttcgtctact ggagggcatg agaaagtgga tggcccagcg ggtcaagagt gacagggagt
      181 atgcaggact gcttcaccac atgtccctgc aggacagtgg gggccagagc cgggccatca
      241 gccctgacag ccccatcagt cagtcctggg ctgagatcac cagccaaact gagggcctga
      301 gccgcttgct gcggcagcac gcagaggatc tgaactcagg gcccctgagc aagctgagcc
      361 tgctcatccg ggaacggcag cagcttcgca agacctacag cgagcagtgg cagcagctgc
      421 agcaggagct caccaagacc cacagccagg acattgagaa gctgaagagc cagtaccgag
      481 ctctggcacg ggacagtgcc caagccaagc gcaagtacca ggaggccagc aaagacaagg
      541 accgtgacaa ggctaaggac aagtatgtgc gcagcctgtg gaagctcttt gctcaccaca
      601 accgctatgt gctgggcgtg cgggctgcgc agctacacca ccagcaccac caccagctcc
      661 tgctgcccgg cctgctgcgg tcactgcagg acctgcacga ggagatggct tgcatcctga
      721 aggagatcct gcaggaatac ctggagatta gcagcctggt gcaggatgag gtggtggcca
      781 ttcaccggga gatggctgca gctgctgccc gcatccagcc tgaggctgag taccaaggct
      841 tcctgcgaca gtatgggtcc gcacctgacg tcccaccctg tgtcacgttc gatgagtcac
      901 tgcttgagga gggtgaaccg ctggagcctg gggagctcca gctgaacgag ctgactgtgg
      961 agagcgtgca gcacacgctg acctcagtga cagatgagct ggctgtggcc accgagatgg
     1021 tgttcaggcg gcaggagatg gttacgcagc tgcaacagga gctccggaat gaagaggaga
     1081 acacccaccc ccgggagcgg gtgcagctgc tgggcaagag gcaagtgctg caagaagcac
     1141 tgcaggggct gcaggtagcg ctgtgcagcc aggccaagct gcaggcccag caggagttgc
     1201 tgcagaccaa gctggagcac ctgggccccg gcgagccccc gcctgtgctg ctcctgcagg
     1261 atgaccgcca ctccacgtcg tcctcggagc aggagcgaga ggggggaagg acacccacgc
     1321 tggagatcct taagagccac atctcaggaa tcttccgccc caagttctcg ctccctccac
     1381 cgctgcagct cattccggag gtgcagaagc ccctgcatga gcagctgtgg taccacgggg
     1441 ccatcccgag ggcagaggtg gctgagctgc tggtgcactc tggggacttc ctggtgcggg
     1501 agagccaggg caagcaggag tacgtgctgt cggtgctgtg ggatggtctg ccccggcact
     1561 tcatcatcca gtccttggat aacctgtacc gactggaagg ggaaggcttt cctagcattc
     1621 ctttgctcat cgaccaccta ctgagcaccc agcagcccct caccaagaag agtggtgttg
     1681 tcctgcacag ggctgtgccc aaggacaagt gggtgctgaa ccatgaggac ctggtgttgg
     1741 gtgagcagat tggacggggg aactttggcg aagtgttcag cggacgcctg cgagccgaca
     1801 acaccctggt ggcggtgaag tcttgtcgag agacgctccc acctgacctc aaggccaagt
     1861 ttctacagga agcgaggatc ctgaagcagt acagccaccc caacatcgtg cgtctcattg
     1921 gtgtctgcac ccagaagcag cccatctaca tcgtcatgga gcttgtgcag gggggcgact
     1981 tcctgacctt cctccgcacg gagggggccc gcctgcgggt gaagactctg ctgcagatgg
     2041 tgggggatgc agctgctggc atggagtacc tggagagcaa gtgctgcatc caccgggacc
     2101 tggctgctcg gaactgcctg gtgacagaga agaatgtcct gaagatcagt gactttggga
     2161 tgtcccgaga ggaagccgat ggggtctatg cagcctcagg gggcctcaga caagtccccg
     2221 tgaagtggac cgcacctgag gcccttaact acggccgcta ctcctccgaa agcgacgtgt
     2281 ggagctttgg catcttgctc tgggagacct tcagcctggg ggcctccccc tatcccaacc
     2341 tcagcaatca gcagacacgg gagtttgtgg agaagggggg ccgtctgccc tgcccagagc
     2401 tgtgtcctga tgccgtgttc aggctcatgg agcagtgctg ggcctatgag cctgggcagc
     2461 ggcccagctt cagcaccatc taccaggagc tgcagagcat ccgaaagcgg catcggtgag
     2521 gctgggaccc ccttctcaag ctggtggcct ctgcaggcct aggtgcagct cctcagcggc
     2581 tccagctcat atgctgacag ctcttcacag tcctggactc ctgccaccag catccacact
     2641 gccggcagga tgcagcgccg tgtcctctct gtgtccctgc tgctgccagg gcttcctctt
     2701 ccgggcagaa acaataaaac cacttgtgcc cactgaa
//
