LOCUS       NM_006832               3286 bp    mRNA    linear   PRI 02-MAR-2025
DEFINITION  Homo sapiens FERM domain containing kindlin 2 (FERMT2), transcript
            variant 1, mRNA.
ACCESSION   NM_006832
VERSION     NM_006832.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Ma,X., Zhao,D., Liu,S., Zuo,J., Wang,W., Wang,F., Li,Y., Ding,Z.,
            Wang,J. and Wang,X.
  TITLE     FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage
            polarization
  JOURNAL   Oral Dis 30 (3), 991-1003 (2024)
   PUBMED   37357349
  REMARK    GeneRIF: FERMT2 upregulation in CAFs enhances EMT of OSCC and M2
            macrophage polarization.
REFERENCE   2  (bases 1 to 3286)
  AUTHORS   Yadav,R.P. and Baranwal,S.
  TITLE     Kindlin-2 regulates colonic cancer stem-like cells survival and
            self-renewal via Wnt/beta-catenin mediated pathway
  JOURNAL   Cell Signal 113, 110953 (2024)
   PUBMED   38084837
  REMARK    GeneRIF: Kindlin-2 regulates colonic cancer stem-like cells
            survival and self-renewal via Wnt/beta-catenin mediated pathway.
REFERENCE   3  (bases 1 to 3286)
  AUTHORS   Dong,Y., Ma,G., Hou,X., Han,Y., Ding,Z., Tang,W., Chen,L., Chen,Y.,
            Zhou,B., Rao,F., Lv,K., Du,C. and Cao,H.
  TITLE     Kindlin-2 controls angiogenesis through modulating Notch1 signaling
  JOURNAL   Cell Mol Life Sci 80 (8), 223 (2023)
   PUBMED   37480504
  REMARK    GeneRIF: Kindlin-2 controls angiogenesis through modulating Notch1
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3286)
  AUTHORS   Yeon,M., Bertolini,I., Agarwal,E., Ghosh,J.C., Tang,H.Y.,
            Speicher,D.W., Keeney,F., Sossey-Alaoui,K., Pluskota,E.,
            Bialkowska,K., Plow,E.F., Languino,L.R., Skordalakes,E., Caino,M.C.
            and Altieri,D.C.
  TITLE     Parkin ubiquitination of Kindlin-2 enables mitochondria-associated
            metastasis suppression
  JOURNAL   J Biol Chem 299 (6), 104774 (2023)
   PUBMED   37142218
  REMARK    GeneRIF: Parkin ubiquitination of Kindlin-2 enables
            mitochondria-associated metastasis suppression.
REFERENCE   5  (bases 1 to 3286)
  AUTHORS   Xia,W., Gao,Z., Jiang,X., Jiang,L., Qin,Y., Zhang,D., Tian,P.,
            Wang,W., Zhang,Q., Zhang,R., Zhang,N. and Xu,S.
  TITLE     Alzheimer's risk factor FERMT2 promotes the progression of
            colorectal carcinoma via Wnt/beta-catenin signaling pathway and
            contributes to the negative correlation between Alzheimer and
            cancer
  JOURNAL   PLoS One 17 (12), e0278774 (2022)
   PUBMED   36480537
  REMARK    GeneRIF: Alzheimer's risk factor FERMT2 promotes the progression of
            colorectal carcinoma via Wnt/beta-catenin signaling pathway and
            contributes to the negative correlation between Alzheimer and
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3286)
  AUTHORS   Siegel,D.H., Ashton,G.H., Penagos,H.G., Lee,J.V., Feiler,H.S.,
            Wilhelmsen,K.C., South,A.P., Smith,F.J., Prescott,A.R.,
            Wessagowit,V., Oyama,N., Akiyama,M., Al Aboud,D., Al Aboud,K., Al
            Githami,A., Al Hawsawi,K., Al Ismaily,A., Al-Suwaid,R.,
            Atherton,D.J., Caputo,R., Fine,J.D., Frieden,I.J., Fuchs,E.,
            Haber,R.M., Harada,T., Kitajima,Y., Mallory,S.B., Ogawa,H.,
            Sahin,S., Shimizu,H., Suga,Y., Tadini,G., Tsuchiya,K., Wiebe,C.B.,
            Wojnarowska,F., Zaghloul,A.B., Hamada,T., Mallipeddi,R., Eady,R.A.,
            McLean,W.H., McGrath,J.A. and Epstein,E.H.
  TITLE     Loss of kindlin-1, a human homolog of the Caenorhabditis elegans
            actin-extracellular-matrix linker protein UNC-112, causes Kindler
            syndrome
  JOURNAL   Am J Hum Genet 73 (1), 174-187 (2003)
   PUBMED   12789646
REFERENCE   7  (bases 1 to 3286)
  AUTHORS   Weinstein,E.J., Bourner,M., Head,R., Zakeri,H., Bauer,C. and
            Mazzarella,R.
  TITLE     URP1: a member of a novel family of PH and FERM domain-containing
            membrane-associated proteins is significantly over-expressed in
            lung and colon carcinomas
  JOURNAL   Biochim Biophys Acta 1637 (3), 207-216 (2003)
   PUBMED   12697302
REFERENCE   8  (bases 1 to 3286)
  AUTHORS   Tu,Y., Wu,S., Shi,X., Chen,K. and Wu,C.
  TITLE     Migfilin and Mig-2 link focal adhesions to filamin and the actin
            cytoskeleton and function in cell shape modulation
  JOURNAL   Cell 113 (1), 37-47 (2003)
   PUBMED   12679033
REFERENCE   9  (bases 1 to 3286)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y. PMID: 37491470]
REFERENCE   10 (bases 1 to 3286)
  AUTHORS   Wick,M., Burger,C., Brusselbach,S., Lucibello,F.C. and Muller,R.
  TITLE     Identification of serum-inducible genes: different patterns of gene
            regulation during G0-->S and G1-->S progression
  JOURNAL   J Cell Sci 107 (Pt 1), 227-239 (1994)
   PUBMED   8175911
  REMARK    Erratum:[J Cell Sci. 1994 Mar;107 ( Pt 3):preceding table of
            contents. PMID: 8006057]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017327.2, BX161467.1, AL139317.5 and BC011125.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006832.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.163956.1,
                                           SRR1660805.118251.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341590.8/ ENSP00000340391.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1023              BC017327.2         48-1070
            1024-1741           BX161467.1         992-1709
            1742-1866           AL139317.5         118225-118349       c
            1867-2008           AL139317.5         117457-117598       c
            2009-3232           AL139317.5         115211-116434       c
            3233-3286           BC011125.1         1881-1934
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..3286
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /note="FERM domain containing kindlin 2"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
     exon            1..130
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            131..296
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2182
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology domain containing, family C (with FERM
                     domain) member 1; mitogen inducible gene 2 protein;
                     pleckstrin homology domain containing, family C member 1;
                     kindlin 2; PH domain-containing family C member 1;
                     fermitin family homolog 2; mitogen inducible gene-2;
                     fermitin family member 2"
                     /codon_start=1
                     /product="fermitin family homolog 2 isoform 1"
                     /protein_id="NP_006823.1"
                     /db_xref="CCDS:CCDS9713.1"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
                     /translation="MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGV
                     MLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQ
                     LPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSE
                     DEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNP
                     GILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKY
                     YSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSEN
                     HLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGY
                     KQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEG
                     MNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLI
                     PEQITTDITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLP
                     EFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMV
                     TVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV"
     exon            297..530
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            531..665
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            666..891
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..994
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1102
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1237
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1287
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1412
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1519
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1741
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1866
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2008
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..3286
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /note="hexamer: AATAAA"
     polyA_site      2279
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /note="hexamer: AATAAA"
     polyA_site      3286
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /note="major polyA site"
ORIGIN      
        1 attagccgct ccggccacag gcagcgcttc gccagccgag gaaccggacg cggacaccgc
       61 cgccccgcga gcctccagcc cctcgcctgt tgccgcgcga gtcccgggcc cggagcgcta
      121 ggagcgcgcg gaaggagcca tggctctgga cgggataagg atgccagatg gctgctacgc
      181 ggacgggacg tgggaactga gtgtccatgt gacggacctg aaccgcgatg tcaccctgag
      241 agtgaccggc gaggtgcaca ttggaggcgt gatgcttaag ctggtggaga aactcgatgt
      301 aaaaaaagat tggtctgacc atgctctctg gtgggaaaag aagagaactt ggcttctgaa
      361 gacacattgg accttagata agtatggtat tcaggcagat gctaagcttc agttcacccc
      421 tcagcacaaa ctgctccgcc tgcagcttcc caacatgaag tatgtgaagg tgaaagtgaa
      481 tttctctgat agagtcttca aagctgtttc tgacatctgt aagactttta atatcagaca
      541 ccccgaagaa ctttctctct taaagaaacc cagagatcca acaaagaaaa aaaagaagaa
      601 gctagatgac cagtctgaag atgaggcact tgaattagag gggcctctta tcactcctgg
      661 atcaggaagt atatattcaa gcccaggact gtatagtaaa acaatgaccc ccacttatga
      721 tgctcatgat ggaagcccct tgtcaccaac ttctgcttgg tttggtgaca gtgctttgtc
      781 agaaggcaat cctggtatac ttgctgtcag tcaaccaatc acgtcaccag aaatcttggc
      841 aaaaatgttc aagcctcaag ctcttcttga taaagcaaaa atcaaccaag gatggcttga
      901 ttcctcaaga tctctcatgg aacaagatgt gaaggaaaat gaggccttgc tgctccgatt
      961 caagtattac agcttttttg atttgaatcc aaagtatgat gcaatcagaa tcaatcagct
     1021 ttacgagcag gccaaatggg ccattctcct ggaagagatt gaatgcacag aagaagaaat
     1081 gatgatgttt gcagccctgc agtatcatat caataagctg tcaatcatga catcagagaa
     1141 tcatttgaac aacagtgaca aagaagttga tgaagttgat gctgcccttt cagacctgga
     1201 gattactctg gaagggggta aaacgtcaac aattttgggt gacattactt ccattcctga
     1261 acttgctgac tacattaaag ttttcaagcc aaaaaagctg actctgaaag gttacaaaca
     1321 atattggtgc accttcaaag acacatccat ttcttgttat aagagcaaag aagaatccag
     1381 tggcacacca gctcatcaga tgaacctcag gggatgtgaa gttaccccag atgtaaacat
     1441 ttcaggccaa aaatttaaca ttaaactcct gattccagtt gcagaaggca tgaatgaaat
     1501 ctggcttcgt tgtgacaatg aaaaacagta tgcacactgg atggcagcct gcagattagc
     1561 ctccaaaggc aagaccatgg cggacagttc ttacaactta gaagttcaga atattctttc
     1621 ctttctgaag atgcagcatt taaacccaga tcctcagtta ataccagagc agatcacgac
     1681 tgatataact cctgaatgtt tggtgtctcc ccgctatcta aaaaagtata agaacaagca
     1741 gataacagcg agaatcttgg aggcccatca gaatgtagct cagatgagtc taattgaagc
     1801 caagatgaga tttattcaag cttggcagtc actacctgaa tttggcatca ctcacttcat
     1861 tgcaaggttc caagggggca aaaaagaaga acttattgga attgcataca acagactgat
     1921 tcggatggat gccagcactg gagatgcaat taaaacatgg cgtttcagca acatgaaaca
     1981 gtggaatgtc aactgggaaa tcaaaatggt caccgtagag tttgcagatg aagtacgatt
     2041 gtccttcatt tgtactgaag tagattgcaa agtggttcat gaattcattg gtggctacat
     2101 atttctctca acacgtgcaa aagaccaaaa cgagagttta gatgaagaga tgttctacaa
     2161 acttaccagt ggttgggtgt gaataggaat actgtttaat gaaactccac ggccataaca
     2221 atatttaact ttaaaagctg tttgttatat gctgcttaat aaagtaagct tgaaatttat
     2281 cattttatca tgaaaacttc tttgccttac cagaccagtt aatatgtgca ctaaacaagc
     2341 acgactatta atctatcatg ttatgatata ataaacttga atttgtcaca cattccttag
     2401 ggccatgaat tgaaaactga aatagtgggc aaatcaggaa caaaccatca ctgatttact
     2461 gatttaagct agccaaactg taagaaacaa gccatctatt ttaaagctat ccagggctta
     2521 acctatatga actctattta tcatgtctaa tgcatgtgat ttaatgtatg tttaatttga
     2581 tatcatgttt taaaatatcc tacttctggt agccatttaa ttcctccccc tacccccaaa
     2641 taaatcaggc atgcaggagg cctgatattt agtaatgtca ttgtgtttga ccttgaagga
     2701 aaatgctatt agtccgtcgt gcttgatttg tttttgtcct tgaataagca tgttatgtat
     2761 attgtctcgt gtttttattt ttacaccata ttgtattaca cttttagtat tcaccagcat
     2821 aatcactgtc tgcctaaaat atgcaactct ttgcattaca atatgaagta aagttctatg
     2881 aagtatgcat tttgtgtaac taatgtaaaa acacaaattt tataaaattg tacagttttt
     2941 taaaaactac tcacaactag cagatggctt aaatgtagca atctctgcgt taattaaatg
     3001 cctttaagag atataattaa cgtgcagttt taatatctac taaattaaga atgacttcat
     3061 tatgatcatg atttgccaca atgtccttaa ctctaatgcc tggactggcc atgttctagt
     3121 ctgttgcgct gttacaatct gtattggtgc tagtcagaaa attcctagct cacatagccc
     3181 aaaagggtgc gagggagagg tggattacca gtattgttca ataatccatg gttcaaagac
     3241 tgtataaatg cattttattt taaataaaag caaaactttt atttaa
//
