LOCUS       NM_152898                640 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Fer3 like bHLH transcription factor (FERD3L), mRNA.
ACCESSION   NM_152898
VERSION     NM_152898.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 640)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 640)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 640)
  AUTHORS   Lansdell,T.A., Fisher,C., Simmonds,K., Reeves,M.J., Woo,D.,
            Dorrance,A.M. and Demel,S.L.
  TITLE     Rs10230207 genotype confers changes in HDAC9 and TWIST1, but not
            FERD3L in lymphoblasts from patients with intracranial aneurysm
  JOURNAL   Neurogenetics 20 (2), 83-89 (2019)
   PUBMED   30919159
  REMARK    GeneRIF: the risk allele Rs10230207 for patients with intracranial
            aneurysm is not associated with changes in FERD3L gene expression,
            but is associated with increased HDAC9 and decrease in TWIST1 mRNA
            expression
REFERENCE   4  (bases 1 to 640)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 640)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 640)
  AUTHORS   Liu,A., Wang,Y., Zhang,D., Wang,X., Song,H., Dang,C., Yao,Q. and
            Chen,K.
  TITLE     Classification and evolutionary analysis of the basic
            helix-loop-helix gene family in the green anole lizard, Anolis
            carolinensis
  JOURNAL   Mol Genet Genomics 288 (7-8), 365-380 (2013)
   PUBMED   23756994
REFERENCE   7  (bases 1 to 640)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 640)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 640)
  AUTHORS   Verzi,M.P., Anderson,J.P., Dodou,E., Kelly,K.K., Greene,S.B.,
            North,B.J., Cripps,R.M. and Black,B.L.
  TITLE     N-twist, an evolutionarily conserved bHLH protein expressed in the
            developing CNS, functions as a transcriptional inhibitor
  JOURNAL   Dev Biol 249 (1), 174-190 (2002)
   PUBMED   12217327
REFERENCE   10 (bases 1 to 640)
  AUTHORS   Segev,E., Halachmi,N., Salzberg,A. and Ben-Arie,N.
  TITLE     Nato3 is an evolutionarily conserved bHLH transcription factor
            expressed in the CNS of Drosophila and mouse
  JOURNAL   Mech Dev 106 (1-2), 197-202 (2001)
   PUBMED   11472856
  REMARK    GeneRIF: Identification and genomic structure of Nato3 in fly,
            mouse and man. Nervous system expression detected in fly and mouse.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF517122.1.
            
            On Dec 19, 2003 this sequence version replaced NM_152898.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF517122.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275461.3/ ENSP00000275461.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-640               AF517122.1         12-651
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..640
                     /gene="FERD3L"
                     /gene_synonym="bHLHa31; N-TWIST; NATO3; NTWIST; PTFB"
                     /note="Fer3 like bHLH transcription factor"
                     /db_xref="GeneID:222894"
                     /db_xref="HGNC:HGNC:16660"
                     /db_xref="MIM:617578"
     exon            1..640
                     /gene="FERD3L"
                     /gene_synonym="bHLHa31; N-TWIST; NATO3; NTWIST; PTFB"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..560
                     /gene="FERD3L"
                     /gene_synonym="bHLHa31; N-TWIST; NATO3; NTWIST; PTFB"
                     /note="nephew of atonal 3; pancreas-specific transcription
                     factor b; neuronal twist; basic helix-loop-helix protein
                     N-twist; class A basic helix-loop-helix protein 31"
                     /codon_start=1
                     /product="fer3-like protein"
                     /protein_id="NP_690862.1"
                     /db_xref="CCDS:CCDS5368.1"
                     /db_xref="GeneID:222894"
                     /db_xref="HGNC:HGNC:16660"
                     /db_xref="MIM:617578"
                     /translation="MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPAL
                     ALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQ
                     RQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESC
                     EKKESG"
ORIGIN      
        1 accagcaacc tcgcccctcc ctgcggaaaa ccgatgagag gcagggccaa gccgaagcga
       61 tggcggccta tccggagagc tgcgtggaca ctacggtgct ggacttcgtc gcagacctgt
      121 ccctggcctc cccgagacgc cctctcctct gcgacttcgc acccggggtc tccttggggg
      181 acccagccct tgcgctccga gagggaagac ccaggaggat ggcgcggttt gaagaggggg
      241 acccagaaga agaggagtgc gaagtggacc agggggacgg agaagaggag gaggaagagg
      301 agcgcggaag aggtgtctcc ctattaggcc gccccaagag gaaaagggtg atcacctacg
      361 cccagcgcca ggccgccaac atccgcgaaa ggaagcggat gttcaacctc aacgaggcct
      421 ttgaccagct gcggaggaag gtgcccacgt ttgcttacga gaaaaggctg tcccggatcg
      481 agaccctccg cctggccatc gtctatatct ccttcatgac cgagctcttg gagagctgtg
      541 agaagaagga aagcggctga gcctggtgtg gagagtctgc ccttcctcgt ctggtagtgc
      601 tggggtgtgt caggaccggg cactgggtga ggctaaaggg
//
