LOCUS       NM_020177               5697 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fem-1 homolog C (FEM1C), mRNA.
ACCESSION   NM_020177
VERSION     NM_020177.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5697)
  AUTHORS   Yan,X., Wang,X., Li,Y., Zhou,M., Li,Y., Song,L., Mi,W., Min,J. and
            Dong,C.
  TITLE     Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition
            of C-degron
  JOURNAL   Nat Chem Biol 17 (3), 263-271 (2021)
   PUBMED   33398170
  REMARK    GeneRIF: Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated
            recognition of C-degron.
REFERENCE   2  (bases 1 to 5697)
  AUTHORS   Chen,X., Liao,S., Makaros,Y., Guo,Q., Zhu,Z., Krizelman,R.,
            Dahan,K., Tu,X., Yao,X., Koren,I. and Xu,C.
  TITLE     Molecular basis for arginine C-terminal degron recognition by
            Cul2FEM1 E3 ligase
  JOURNAL   Nat Chem Biol 17 (3), 254-262 (2021)
   PUBMED   33398168
  REMARK    GeneRIF: Molecular basis for arginine C-terminal degron recognition
            by Cul2(FEM1) E3 ligase.
REFERENCE   3  (bases 1 to 5697)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5697)
  AUTHORS   Perez-Sanz,F., Revilla-Nuin,B., Martinez-Alarcon,L., Herrero,J.I.,
            Ramirez,P., Pons,J.A. and Baroja-Mazo,A.
  TITLE     Tolerance Biomarkers in Liver Transplantation: Independent External
            Validation of the Predictive Strength of SENP6 and FEM1C Gene
            Expression
  JOURNAL   Transplantation 103 (9), 1887-1892 (2019)
   PUBMED   30720688
  REMARK    GeneRIF: SENP6 and FEM1C gene expression in liver transplantation
            predicts transplantation tolerance.
REFERENCE   5  (bases 1 to 5697)
  AUTHORS   Koren,I., Timms,R.T., Kula,T., Xu,Q., Li,M.Z. and Elledge,S.J.
  TITLE     The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
            C-Terminal Degrons
  JOURNAL   Cell 173 (7), 1622-1635 (2018)
   PUBMED   29779948
REFERENCE   6  (bases 1 to 5697)
  AUTHORS   Dankert,J.F., Pagan,J.K., Starostina,N.G., Kipreos,E.T. and
            Pagano,M.
  TITLE     FEM1 proteins are ancient regulators of SLBP degradation
  JOURNAL   Cell Cycle 16 (6), 556-564 (2017)
   PUBMED   28118078
  REMARK    GeneRIF: FEM1 proteins are ancient regulators of Stem-Loop Binding
            Protein.
REFERENCE   7  (bases 1 to 5697)
  AUTHORS   Lin,H.C., Ho,S.C., Chen,Y.Y., Khoo,K.H., Hsu,P.H. and Yen,H.C.
  TITLE     SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins
            produced by failed UGA/Sec decoding
  JOURNAL   Science 349 (6243), 91-95 (2015)
   PUBMED   26138980
REFERENCE   8  (bases 1 to 5697)
  AUTHORS   Goodarzi,M.O., Maher,J.F., Cui,J., Guo,X., Taylor,K.D. and Azziz,R.
  TITLE     FEM1A and FEM1B: novel candidate genes for polycystic ovary
            syndrome
  JOURNAL   Hum Reprod 23 (12), 2842-2849 (2008)
   PUBMED   18757445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5697)
  AUTHORS   Ventura-Holman,T., Lu,D., Si,X., Izevbigie,E.B. and Maher,J.F.
  TITLE     The Fem1c genes: conserved members of the Fem1 gene family in
            vertebrates
  JOURNAL   Gene 314, 133-139 (2003)
   PUBMED   14527725
REFERENCE   10 (bases 1 to 5697)
  AUTHORS   Krakow,D., Sebald,E., King,L.M. and Cohn,D.H.
  TITLE     Identification of human FEM1A, the ortholog of a C. elegans
            sex-differentiation gene
  JOURNAL   Gene 279 (2), 213-219 (2001)
   PUBMED   11733146
  REMARK    GeneRIF: The identification of a human homolog of this conserved
            gene suggests a potential role for this sex-determining molecule in
            humans.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028369.2, AB058688.1, W07603.1 and AC008628.6.
            
            On Nov 22, 2018 this sequence version replaced NM_020177.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028369.2, SRR7346977.2738196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274457.5/ ENSP00000274457.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1579              BC028369.2         122-1700
            1580-2618           AB058688.1         1227-2265
            2619-2652           BC028369.2         2740-2773
            2653-3856           AB058688.1         2299-3502
            3857-3873           W07603.1           146-162
            3874-5694           AB058688.1         3519-5339
            5695-5697           AC008628.6         88485-88487         c
FEATURES             Location/Qualifiers
     source          1..5697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..5697
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="fem-1 homolog C"
                     /db_xref="GeneID:56929"
                     /db_xref="HGNC:HGNC:16933"
                     /db_xref="MIM:608767"
     exon            1..253
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            254..987
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..2297
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="FEM1-gamma"
                     /codon_start=1
                     /product="protein fem-1 homolog C"
                     /protein_id="NP_064562.1"
                     /db_xref="CCDS:CCDS4118.1"
                     /db_xref="GeneID:56929"
                     /db_xref="HGNC:HGNC:16933"
                     /db_xref="MIM:608767"
                     /translation="MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATP
                     LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL
                     LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG
                     HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPL
                     LSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMR
                     YSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSH
                     PDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSF
                     MLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLIC
                     LLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSL
                     QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASD
                     LLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR"
     exon            988..5697
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="hexamer: AATAAA"
     polyA_site      3864
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="major polyA site"
     regulatory      5681..5686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="hexamer: ATTAAA"
     polyA_site      5697
                     /gene="FEM1C"
                     /gene_synonym="EUROIMAGE686608; EUROIMAGE783647; FEM1A"
                     /note="major polyA site"
ORIGIN      
        1 acaccatccg tcgcagcagt cgctgcagcc gctgcagtcc gagccgacta agggcgggag
       61 gcagctcggg tggcggggcg tggcgaacag cgcggccgga ttcattcctt tggggcgcgg
      121 agcatggagg agctgtgcgg ccgcaggcgg agcagggcgg cccgggcggc ggtggggaca
      181 acggtttccc tttgaagggg acggacaaag cccgagtgac cagcggcggc ggggaggact
      241 agtccccggg cagtttggtg ccctggttgt cagatgttgg aaagcagtag gacggaacat
      301 actcttcgtg gttgtgtatc cgttctgggg tgcagcaatt aacattggac tttggttcct
      361 gtgactcttg cctgtgtcga tagagttaaa ctggagctct gctttgaaag ataaataaag
      421 cacagcctct caactggaca taaatggatc taaagacagc agtatttaac gcagctcggg
      481 atggcaaact ccggcttctc accaaattgt tggcaagcaa atccaaagag gaggtttcct
      541 ccttgatctc tgaaaaaaca aatggggcca cgccactctt gatggccgcc aggtatgggc
      601 accttgacat ggtggaattc ctcctagagc aatgcagtgc ctccatagaa gttgggggct
      661 ccgtcaattt tgatggcgaa accattgagg gggctccccc tttatgggcc gcttctgcag
      721 caggacatct gaaggtggtc cagtccttgt taaatcatgg agcatctgtc aacaacacga
      781 ctttaaccaa ttcaactcct cttcgagctg cgtgtttcga tggccatttg gaaatagtga
      841 agtaccttgt agaacacaaa gctgatttgg aagtgtcaaa ccgacatggg catacgtgct
      901 tgatgatttc atgttacaaa ggacataaag agattgctca gtatttactt gaaaaggggg
      961 cagatgttaa tagaaaaagt gtcaaaggta atactgcatt gcatgattgt gcagaatctg
     1021 gaagtttgga catcatgaag atgcttctta tgtattgtgc caagatggaa aaggatggtt
     1081 atggaatgac tccccttctc tcagcaagtg tgactggtca cacaaatatt gtggattttc
     1141 tgacacacca tgcacagacc agcaagacag aacgtattaa tgctctagag cttctgggag
     1201 ctacatttgt agacaaaaaa agagatctgc ttggggcttt gaaatactgg aaaaaggcaa
     1261 tgaacatgag gtacagtgat aggactaata ttattagtaa accagtgcca cagacactaa
     1321 taatggctta tgattatgcc aaggaagtga acagtgcaga agagctagaa ggtcttattg
     1381 ctgatcctga tgagatgaga atgcaggcac tattaatcag agaacgtatt cttggtcctt
     1441 ctcatcctga tacctcttac tatattagat atagaggcgc tgtctatgca gactctggaa
     1501 atttcaaacg atgcatcaac ctatggaagt atgctttgga tatgcagcag agcaatttgg
     1561 atcctttaag cccaatgacc gccagcagct tattatcttt tgcagaacta ttctccttta
     1621 tgctacagga tagggctaaa ggcctgctgg gtactactgt tacatttgat gatcttatgg
     1681 gcatactttg caaaagcgtc cttgaaatag agcgagctat caaacaaact cagtgtccag
     1741 ctgacccatt acagttaaat aaggcccttt ctattatttt gcacttaatt tgcttgttag
     1801 agaaagttcc ttgtactcta gaacaagacc atttcaaaaa gcagactata tacaggtttc
     1861 ttaagctgca tccaagggga aagaataact tcagccctct tcatctggct gtggacaaga
     1921 atactacatg tgtagggcgg taccctgttt gtaaatttcc atctctacaa gttactgcaa
     1981 tactgataga atgtggtgct gatgtgaacg tcagagactc ggatgacaac agtcccctgc
     2041 atatcgctgc tcttaacaac catccagaca tcatgaatct ccttattaaa tcaggtgcac
     2101 attttgatgc cacaaacttg cacaaacaaa ctgctagtga cttgctggat gagaaggaaa
     2161 tagctaaaaa tttaatccag cctataaatc ataccacatt gcagtgtctt gctgctcgtg
     2221 tcatagtgaa tcatagaata tattataaag ggcatatccc agaaaagcta gagacttttg
     2281 tttcccttca tagatgataa cttgactgta ttttagcact gttaaagcac gaattggtaa
     2341 cagttgtttc ataaatgagc actgttgtga taacaccagc attcatttag cttgattgat
     2401 atcattgtgc tctcattggc taaagcatta taagcatcaa atttacaaca ttggtttccc
     2461 aatatttaat ataaatatac catataatat attgtttgtg aattattgag aaatgtaaca
     2521 ttcaaatttc taaaattgtc tgccaaaggc ttattcattc tggttttgtt tgctgttggg
     2581 tgtttggggc agagttaacc atttctccat ggtgtcttta tactttactg gtttgtgaat
     2641 tttatacaat tgaaagtctt tttttcttgc ttctttcttc tcttctcaag tttcccccct
     2701 gtttctactt tattgtttgt cctaaccatt tctactacag ttttttcctt atggacccat
     2761 actaggttgt acaaacctta aggactcgtt accatttgca gttaccataa gtgctttatc
     2821 ttctctatgc acaggcttaa acttgactgt tgtatgttag catattttct atgcagcagt
     2881 tggtcaactt caactcaaaa cactgttttc ttatgtttgt tacaaactta attttttgaa
     2941 agtactctgt agcatgacaa tttttagagc tgcaggttag ctattatagc tcaagctttt
     3001 ttgtttgttt ttttcttcac tttcttcaca tctgaggttt ctttctctaa tccactgaaa
     3061 ttattgtgtg ctaaatttgg gaaacagatc tattctaact cattaaccca gttgaaattt
     3121 aggtctgtca tcttaatata tcatgcagta aaaggaagaa tctttttaaa gtgacccacc
     3181 tttcatgctg ctccagcatt gtcctgcttg tgctgatggt gtgattaggt gtagagaatt
     3241 tgcttaaatt taacttcaaa gttcatcaca cagcttaatg agtcacattg aaatactcag
     3301 taattgaact gcaaatcact tttagttaca aaaagagcta aagcatgtca gtggcatgat
     3361 gcttgccaag ccagatctag gcatctagga taattaaggt attttagtat gcaatttact
     3421 gccataatat caaaggtcag taacagtgtt ctttctttct tcaagcttat gtataccttt
     3481 aaagataact tgcatgaatt actttgatta ctttggtctc aattatttgt caccccagtt
     3541 aaacatgaaa ggttgcagtg cttcctgttc ccttactgga agttagcttt ttcttttctc
     3601 tttcttcctt tctttctctc actctttctt tctctttctc tttctctctc tctctctctc
     3661 tcactcactc actcacagat ttgctaatgc cacagaaagg gctcttttaa cttaagataa
     3721 gtgaaaagta ctaaaaaaga ttcaggtaat tatcattcag cactttattg taattcagaa
     3781 taaaatttat gatggcatat ttgccctgca aatgtcttaa tgaagttgtt ctcaataaaa
     3841 agctccttat tgatttgaga aaaactcagt ttacctgtga gttcaatgag ctggatcact
     3901 cacttggatt tttgtgttga cattttattc tgagggttga tgttacacta tttaaggagt
     3961 catcaatgca aacagtcaca ttaggtatgt catcatcttt agtcagtaaa aaccttgtaa
     4021 tgaggagtag taaataaaca agagaacatt agactttttg gttaaataat tgagatttaa
     4081 tttttaaaag atattcttac tcatttgcta ggttgtaaat ttgatttcac cattaagaaa
     4141 aggtaaattg gatataaatg aacgatctcc aactttttga tgaagaggtt ttactatctc
     4201 tcactgtggg aaaatttgat gaaatatttg aactgtcaca tatattaaga atactttatg
     4261 atttagacca atattctaga aatatcaaat gtcagtatct tgaaatcatc tgcctctaac
     4321 tttgtggtat aagaattata tatgaataag ctattatttt tataaaggaa aactttgcca
     4381 ttatagtaaa ttacattagt tgatctcgat aatttgagga taacagatga caattgaatt
     4441 tttaattgat ttagtatttc ctcctcctct ttgggggctg ggtgggaggg cttacatgct
     4501 cttatagtga ggcacatctc actgttttgc agcagaattt gaattgtgca actcctgtgt
     4561 aaagtaagga tttctttaaa tagcattttt gcaccagtaa aaatagataa cttagaactc
     4621 agtcttgata actgaaatga cttatttcac ttagaataca tttctccctt ctctgccatc
     4681 tccacaaatg ccattgggag gttttgaaaa accagttaat ttaatagctc aaaattgtcc
     4741 ctgattttat tttcttttag ggaaaattgt ttcataaatg tgacactgat aaagcctttg
     4801 tcagaaagta ttctcacaat tatgagatgg attataataa aatacttaaa tttgtgttat
     4861 tttttgaacc acagatgagt aaatttaata atgaaccaat tacactcttg agtctaacta
     4921 aactgtacac tgtagcacgg tgttattgac tggagttaat gtgtaagtta ttaacatttc
     4981 tatgaaaatg cccttttggg gcctcctgaa ttttagatgt tccactgttt tgatcatttc
     5041 tataaaagaa atggtcattt tacttagatg ccagtctact ttataaagac aaatggatta
     5101 tagacttaaa aatagtcatt tttcttattc ataaatctga caggcataaa cccaaatcaa
     5161 agataatttg gtgcccatta tgaatttgaa gttaagtgat agctcacttg taaagtgact
     5221 accttaatgt gtatagagac cccagtctac tattatttgg gaaaattgtt taggttatat
     5281 gggaaaagta gctctttaaa aatcatattg cccaacagaa accttaggct gaatttacag
     5341 gtatgataat ttttgtaatt aattttctta gaattgtgca ggctggatga gataatgaca
     5401 tactctttta cactgtaaca gcagcattat tgcctagaac tttaaccatt ttagagttag
     5461 atactaagga aacaaactaa ttggtcatca tcattttctt tttttctttt tctttttttt
     5521 ttttttgccc ttatgtgtca ctaaacaact agtttctctc ccttttgtca gttcccattg
     5581 tgtatttttt caaaagaagt actgtattcg gatgccagct aataaattgt cacacaatgg
     5641 aaaatcatat gccacaacat tcattgtaag gtttaataaa attaaatttg caccaaa
//
