LOCUS       NM_015322               7177 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fem-1 homolog B (FEM1B), mRNA.
ACCESSION   NM_015322
VERSION     NM_015322.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7177)
  AUTHORS   Lecoquierre,F., Punt,A.M., Ebstein,F., Wallaard,I., Verhagen,R.,
            Studencka-Turski,M., Duffourd,Y., Moutton,S., Tran Mau-Them,F.,
            Philippe,C., Dean,J., Tennant,S., Brooks,A.S., van
            Slegtenhorst,M.A., Jurgens,J.A., Barry,B.J., Chan,W.M.,
            England,E.M., Martinez Ojeda,M., Engle,E.C., Robson,C.D.,
            Morrow,M., Innes,A.M., Lamont,R., Sanderson,M., Kruger,E.,
            Thauvin,C., Distel,B., Faivre,L., Elgersma,Y. and Vitobello,A.
  TITLE     A recurrent missense variant in the E3 ubiquitin ligase substrate
            recognition subunit FEM1B causes a rare syndromic
            neurodevelopmental disorder
  JOURNAL   Genet Med 26 (6), 101119 (2024)
   PUBMED   38465576
  REMARK    GeneRIF: A recurrent missense variant in the E3 ubiquitin ligase
            substrate recognition subunit FEM1B causes a rare syndromic
            neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 7177)
  AUTHORS   Dai,Z., Liang,L., Wang,W., Zuo,P., Yu,S., Liu,Y., Zhao,X., Lu,Y.,
            Jin,Y., Zhang,F., Ding,D., Deng,W. and Yin,Y.
  TITLE     Structural insights into the ubiquitylation strategy of the
            oligomeric CRL2FEM1B E3 ubiquitin ligase
  JOURNAL   EMBO J 43 (6), 1089-1109 (2024)
   PUBMED   38360992
  REMARK    GeneRIF: Structural insights into the ubiquitylation strategy of
            the oligomeric CRL2[FEM1B] E3 ubiquitin ligase.
REFERENCE   3  (bases 1 to 7177)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 7177)
  AUTHORS   Zhao,S., Ru,W., Chen,X., Liao,S., Zhu,Z., Zhang,J. and Xu,C.
  TITLE     Structural insights into SMCR8 C-degron recognition by FEM1B
  JOURNAL   Biochem Biophys Res Commun 557, 236-239 (2021)
   PUBMED   33892462
  REMARK    GeneRIF: Structural insights into SMCR8 C-degron recognition by
            FEM1B.
REFERENCE   5  (bases 1 to 7177)
  AUTHORS   Sun,T.P. and Shieh,S.Y.
  TITLE     Human FEM1B is required for Rad9 recruitment and CHK1 activation in
            response to replication stress
  JOURNAL   Oncogene 28 (18), 1971-1981 (2009)
   PUBMED   19330022
  REMARK    GeneRIF: FEM1B is required for Rad9 recruitment and CHK1 activation
            in response to replication stress.
REFERENCE   6  (bases 1 to 7177)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   7  (bases 1 to 7177)
  AUTHORS   Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex-determining protein FEM-2 and its
            human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
            kinase phosphatases that promote apoptosis
  JOURNAL   J Biol Chem 276 (47), 44193-44202 (2001)
   PUBMED   11559703
REFERENCE   8  (bases 1 to 7177)
  AUTHORS   Chan,S.L., Yee,K.S., Tan,K.M. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex determination protein FEM-1 is a
            CED-3 substrate that associates with CED-4 and mediates apoptosis
            in mammalian cells
  JOURNAL   J Biol Chem 275 (24), 17925-17928 (2000)
   PUBMED   10764728
REFERENCE   9  (bases 1 to 7177)
  AUTHORS   Ventura-Holman,T. and Maher,J.F.
  TITLE     Sequence, organization, and expression of the human FEM1B gene
  JOURNAL   Biochem Biophys Res Commun 267 (1), 317-320 (2000)
   PUBMED   10623617
REFERENCE   10 (bases 1 to 7177)
  AUTHORS   Chan,S.L., Tan,K.O., Zhang,L., Yee,K.S., Ronca,F., Chan,M.Y. and
            Yu,V.C.
  TITLE     F1Aalpha, a death receptor-binding protein homologous to the
            Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase
            substrate that mediates apoptosis
  JOURNAL   J Biol Chem 274 (45), 32461-32468 (1999)
   PUBMED   10542291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107871.10, BC010122.2,
            AC021553.14, AB007856.2 and BF112021.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015322.4.
            
            Summary: This gene encodes an ankyrin repeat protein that belongs
            to the death receptor-associated family of proteins and plays a
            role in mediating apoptosis. The encoded protein is also thought to
            function in the replication stress-induced checkpoint signaling
            pathway via interaction with checkpoint kinase 1. [provided by
            RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.169560.1,
                                           SRR1660807.20143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306917.5/ ENSP00000307298.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC107871.10        166384-166441
            59-2151             BC010122.2         1-2093
            2152-2152           AC021553.14        48692-48692
            2153-2617           BC010122.2         2095-2559
            2618-6998           AB007856.2         1945-6325
            6999-7177           BF112021.1         14-192              c
FEATURES             Location/Qualifiers
     source          1..7177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..7177
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /note="fem-1 homolog B"
                     /db_xref="GeneID:10116"
                     /db_xref="HGNC:HGNC:3649"
                     /db_xref="MIM:613539"
     exon            1..921
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             674..2557
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /note="FEM-1-like death receptor binding protein;
                     fem-1-like death receptor-binding protein alpha;
                     fem-1-like in apoptotic pathway protein alpha"
                     /codon_start=1
                     /product="protein fem-1 homolog B"
                     /protein_id="NP_056137.1"
                     /db_xref="CCDS:CCDS10228.1"
                     /db_xref="GeneID:10116"
                     /db_xref="HGNC:HGNC:3649"
                     /db_xref="MIM:613539"
                     /translation="MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGG
                     QRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFE
                     VVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMI
                     AAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH
                     GMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYL
                     YLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRER
                     ILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVF
                     SQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYL
                     VCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCS
                     FPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHT
                     DMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFV
                     GFH"
     exon            922..7177
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6971..6976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /note="hexamer: AATAAA"
     polyA_site      6998
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
     regulatory      7159..7164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /note="hexamer: AGTAAA"
     polyA_site      7177
                     /gene="FEM1B"
                     /gene_synonym="F1A-ALPHA; F1AA; FEM1-beta"
                     /note="major polyA site"
ORIGIN      
        1 ctctcctccc ggccctgtct gcgaaagctc gtcttcctcc ccgcccaagt tccggcgccg
       61 ctcttgcggg agcgttccgc atcgccccgg gggcccctac gcgaggatct ccggggccgt
      121 tggcagcgcc tggcacttct gagctcggcg gacgagagcc tgcaggtttc ctccagtcag
      181 ggacggcgaa gggcggaaag cgcaggagga ggcagtgtta ggccttaggc cgggtgggcc
      241 gggtcaggag agacgcgccc atctttcgcc atccggggtg cgcgaggtcc tctcgggacc
      301 cggccggcga cccgtagctc gggcacgcgc ctgtcgcatc ccgcaggaag gaggggtccg
      361 gcctgaggcc cggggcggcg tccgccatgg agatcccctc ggtccagggc cggcgcctgg
      421 gacctggcgg gcggccctga ccgccttcct ccctgcgcgg gctgggtcgc ggacgtgccc
      481 ttcgcggcac tcggcctcct ctgcgtctcc gccttccctg ggccgcactg ctgcctgggc
      541 gcggcggcgg cgacggcgcc ctgttgaatg ggctgtgagg gcccaggttt aaagcgctgg
      601 cgaacgcggc ctccgggggc gcacggcagc tgcagcggtg gcgaccaaac gggtgttgga
      661 gttggcggcg gccatggagg gcctggctgg ctatgtatac aaggcggcca gcgagggcaa
      721 ggtgctgact ctggccgcct tgcttctcaa ccggtctgaa agcgacatcc gctatctgct
      781 tggctatgtc agccagcagg gagggcagcg ctccacgccc ctcatcatcg cagcccgcaa
      841 tggacacgca aaggtggtac gcttgctctt agaacattac cgggtgcaga ctcagcagac
      901 tggcaccgtc cgcttcgacg ggtatgtcat tgatggtgcc actgctcttt ggtgtgcagc
      961 tggagcagga cattttgaag ttgttaaact tctagtcagc catggagcca acgtgaacca
     1021 taccacagta actaattcaa cccccctgcg ggcagcatgc tttgatggca gactggacat
     1081 tgtgaaatac ttggttgaaa ataatgccaa catcagcatt gccaacaaat atgacaacac
     1141 ctgcctaatg attgcggcat ataagggaca cactgatgtg gtcagatacc ttttagaaca
     1201 acgtgctgat cccaatgcca aagcacattg tggagccaca gcattgcact ttgcagctga
     1261 agctgggcac atagatattg tgaaagagct gataaaatgg cgtgctgcta tagtagtgaa
     1321 tggccatggg atgacgccat tgaaagtagc tgccgaaagc tgtaaagctg atgtcgtaga
     1381 actgttactc tctcatgctg attgcgaccg aagaagtcgg attgaagctt tggaactctt
     1441 gggtgcctcc tttgcaaatg accgtgagaa ctatgacatc ataaagacat accactatct
     1501 atatttagcc atgttagaga ggttccaaga tggtgataac attctcgaaa aagaggttct
     1561 tccaccaatc catgcttatg ggaatagaac tgaatgtaga aatcctcagg aactggagtc
     1621 cattcggcaa gacagagatg ctcttcatat ggaaggcctt atagttcggg aacggatttt
     1681 aggtgctgac aatattgatg tttctcatcc catcatttac agaggagctg tttatgcgga
     1741 taatatggaa tttgagcagt gtatcaagtt gtggcttcat gccctgcacc tcagacaaaa
     1801 aggtaacagg aacacccaca aggatcttct tcgatttgct caagttttct cacaaatgat
     1861 acatttgaat gaaactgtga aggccccaga catagaatgt gttttgagat gcagtgtttt
     1921 ggaaatagaa caaagtatga acagagtgaa aaatatttca gatgctgatg tccacaatgc
     1981 tatggacaat tatgaatgta atctctatac ctttctgtat ttagtgtgca tctctaccaa
     2041 aacacagtgc agcgaagaag atcagtgcaa aattaacaag cagatctaca acctgattca
     2101 ccttgatccc agaactcgtg aaggtttcac cttgctgcat ctggctgtca attccaatac
     2161 tccagttgat gatttccaca ccaatgacgt ctgcagcttt ccaaatgcac ttgtcacaaa
     2221 gctcctgctg gactgtggtg ctgaggtgaa tgccgtggac aatgagggaa acagtgccct
     2281 tcatattatc gttcagtaca acaggcccat cagtgatttt ttgaccttgc actccatcat
     2341 cattagccta gttgaagccg gagctcacac tgacatgacg aataaacaga ataagactcc
     2401 gctagacaaa agtacaactg gggtatctga aatactgctt aaaactcaaa tgaagatgag
     2461 tctcaagtgc ctggctgccc gagcagttcg ggctaatgac attaactacc aagaccagat
     2521 ccccagaact cttgaagagt ttgttggatt tcattaagtg actggatatg taaagtcgtt
     2581 taatgtggtg ctaaaaagta aaggactttt aatcacagac agtagaatta tgtgttcata
     2641 aattctgctt ttctttccac tacccttcct cccatcccat ccttccttag ttctgtattt
     2701 gtttttcttg cctcatggta attgatttca gacagacttt aacaaaacca cattgttttg
     2761 gtgtaactat aaggtatttg catattggtt acctatttgt ctttcttttt tttaaaggaa
     2821 cagatataaa atgttttgtt tatgtaacaa gggacattta taatttcaag ttgataatgt
     2881 tttaaacagc tgcttacaaa agtatttctg ttaagcctat gtcagcatgt tatccatgca
     2941 gcagttttga ggattttatg aagaaaaaga gctaaaaagg aacattaaga ggaatgggat
     3001 atccaggtgt tctgcacatg ccaaactgct gtagatagtt tacactcttc cattatttat
     3061 acggagtgat gcagcacatt ttagcattca ggaggatttt taaaaaatag ctgcagatta
     3121 atctggaaaa tgtgctaatt taataatagt tacaaattta taaatttaaa tccatttgaa
     3181 attgttgcat tatgctgggt agtatataca aaatggttat catcttaaac caacttttca
     3241 gagaatcttg atggactctg cctttaggct tgaattcttc aaagtctatt ttaatgaaat
     3301 ttatctaaat tgcagcagtc tatttgattc agctcataga catgtaaaaa ttatgaatgc
     3361 tgttttctta tgaaacaaat tgtcacagtg tagttataca ttctattttt gtcccctttt
     3421 ccctttttct cctgtatctt ttaaaatttg gaaactactt ttccagaagg cattatttat
     3481 gcctccctaa taaggtattt tacttatgac agatgaaaag gaaccaggat atgtttgaat
     3541 tttttcactt tcttagtctg tgacaagaag tagaaatatc actagtgtgg tataggaact
     3601 tacatgtttt ttatgatgaa aataattctc aatgccactt gaaaggtaat tgtgtctgag
     3661 agctgcaaat ttttcaacca caaaatgtca cttattccta caggctatac agaggtcttt
     3721 atggtttttt tgttttgttt taatggcaac attgtaactg tcaaactaaa agggtattct
     3781 gtgattatct tttaagcatt acagaaattc aagtgaaagt tatatgctta tttctattga
     3841 tgttaaaaat gataatgaaa gcaaaattag ctgtatctgt aattttctct ctagtgccaa
     3901 atgaatgcct tagctactca tagtgcatgg tactgtaagt gaagacctgt agcttttttt
     3961 ttttctttaa tgaaaagcat tataatgatg tagcagcatc agatataaac ttaaaaaaaa
     4021 aggtttcaat taacatttta tatatggata atgctttgta aagtgtaaga gaaaggttgc
     4081 agttggatca gtataaaaca atgaccaagc caaaatcagc accctagggc cttaaataaa
     4141 atagagatac cccacaaaat gaaatatttt gaaggatggg aggggacaga aggggggact
     4201 atcccccaag gatgcaagat actttttaca gttgctatca ttatactttg tcttcttgct
     4261 tcagttagga aggttttgat ggtaaattct gtcatggtaa tagataccta ttttcctaac
     4321 ctgagatttt acaaggaagg tttttaggtt ggcttaaatg gaggtattta tttgagtgag
     4381 ccctaatttg aaaattacca gacttgatcc tcctggtatg aatcaaggaa atactgtacc
     4441 ttgctcttag caactctcag tggcctgaaa gagaaaatgc acttcttcaa ggtgagtgaa
     4501 tcatgctttt tccacagttc agatcagacc ctttattttt caaactacaa ggcctgctta
     4561 ttggacagtc taaggaatag ctttgatact tggtattcag ttggttccat tattaatgta
     4621 tattattttt atttaaacat caaaacttaa aatatcagat aatgttgcat gttttaaaaa
     4681 cacatttcat ccctttggct acccaggacc agcactattt aagacactgc ttatttataa
     4741 aatgagaata atgattatat gtacatattc agacatcaaa atttaatgac attctatttt
     4801 gagaagggaa gacaatgctg aagaaagtaa aactgttgat tgaaatgctg acagggtgga
     4861 gaacgaattt gaagacagtg gaataaacta tgaactatgc taatggtaat tagatttttt
     4921 gtttgtttag tatagtggta aattgtgtag tatcttgctg agaatctaat tctatcttgt
     4981 aaaatcaatc caaatgtgta ttgtgaaaca cctgtataaa atcatttttg aaataagtga
     5041 tctacatgcc tgttttttta aaatgttttt ggtagaattg tttgaaaata tgtttagcca
     5101 gacccttccc caacttaatt tttttttaaa aaaggaaaat aggtaagaaa atgatagttc
     5161 tatatctcag ccctctgtga actctaggct gtctccattt tgcagccact ttggtcattt
     5221 gatgtttact attggtatac ttatgctttg aattgtaaat cttcattgat ggtattacag
     5281 attcaaccaa aacttctctg tcctgttcag taattgttat ataaatctgg atgagctagg
     5341 gaggcccagg tggatgtttt cattcgcaaa tcatgagaaa cttaagtggg ttttatgcac
     5401 ttgatagagt tggcaaaatt gaactatgaa gttaactatt taactcaagg aatgggcggc
     5461 aaacccatcc cctcgattga taaagaaggg gaacattttt acattagaac tgacactgaa
     5521 aacatagctt tttcagtcca ccctggttgc tctagtagcc cacagcccaa tcacgttaag
     5581 gttctttgct gtgggaattt taaataaacc aaaccccaaa gcagaccatc tgtaagcttt
     5641 ggtctgcttg tttctgagaa gggttttatt tcattatact aatagtggac taataattgg
     5701 taattgtgag aacttaggta tgataacatt gtttgaagta aaatatgatt tgggggcagc
     5761 agctttctaa ataccaactc tgtttgacaa atgttttgaa aattaaaatt tcaagtgagc
     5821 aacaccctgt taagagtttt cactatagtt gaggcagcta ctttatgaat aagaccactt
     5881 tgggttattt aagcagaagc gtttcttttt tttttttgga atggggtggg atgaggagtg
     5941 agttgccaga cctttgatta gtttgctggt ttagaaacag ccagtggctg aattagtgag
     6001 taaatgaatg aaagtataaa ggacttgttt tttatgatag attttctgta agaatcttaa
     6061 atgttccttt tcaaattaga tgtgttgatg cacacatgac tattctgttt ttctcactga
     6121 ctatataaca ttaaaaaggg gttaaagaaa acaaaactct gccttttgtg ctatgaaata
     6181 tttttagtcc agaggtttta agctgtgtgt ccattcctac tctgaaaatg catagctttg
     6241 ttctggatgt catctcttga aagtagaaaa ctcctatgtg tttatcacat tgcagggctt
     6301 tcttatgtat ttctggcaga cttgcccaaa tctttagatg ggctgggtta tacagcatgc
     6361 cctcccccaa ataagggatc tgaaataaat actacactat tgatagtgga gatatattaa
     6421 tttttaaaac tgtaaagtaa atgtggtctc taggtttgtg gtgtgtacct ttgtgttaat
     6481 gtgtagggaa gagacagtga cttgatggtt atggggagtg tatcttgatg tgtgtatagg
     6541 ggtaagtatt gctaaattat ttacagcttt tattcagggt gagtcatgtg atgaatggcc
     6601 taatcagaaa agtgaaggag cgaagatgca agcttgccaa atgatgaaat gaacaagatt
     6661 ttgtatctat tttttatcag gtgttgtaaa atttgtgcat ggctttttgt tgttgttgct
     6721 tagtaactgg tagaggagaa aagatgagga aagaaactca gctttcctca cagtcttttc
     6781 aaaggtacac agttggggag taaaatctga ctggcctaat cgatggaaaa gaccctgtcc
     6841 ttttcacccc atcctgcaat cctccgtgca gaggaactac actgttgtat tctagtaatt
     6901 cactgtgatt tataacaaac cggtgatgtc attctattgt gcacttttgt caaaccattt
     6961 atgtgacttt aataaacata gtaaacttgc tgactgcacc agaggtccat tagtgattta
     7021 tatattgcat gacattttct atttgagttt gacatgtaga gtcattttta gtttcatggc
     7081 aattgacagt cctaataact cagctaattt gaaactaaca atcttgctgt gtaaaaggaa
     7141 aaaatggtgt ttgtgttcag taaatgtttg aaaaaaa
//
