LOCUS       NM_018708               9540 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fem-1 homolog A (FEM1A), mRNA.
ACCESSION   NM_018708
VERSION     NM_018708.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9540)
  AUTHORS   Yan,X., Wang,X., Li,Y., Zhou,M., Li,Y., Song,L., Mi,W., Min,J. and
            Dong,C.
  TITLE     Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition
            of C-degron
  JOURNAL   Nat Chem Biol 17 (3), 263-271 (2021)
   PUBMED   33398170
  REMARK    GeneRIF: Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated
            recognition of C-degron.
REFERENCE   2  (bases 1 to 9540)
  AUTHORS   Chen,X., Liao,S., Makaros,Y., Guo,Q., Zhu,Z., Krizelman,R.,
            Dahan,K., Tu,X., Yao,X., Koren,I. and Xu,C.
  TITLE     Molecular basis for arginine C-terminal degron recognition by
            Cul2FEM1 E3 ligase
  JOURNAL   Nat Chem Biol 17 (3), 254-262 (2021)
   PUBMED   33398168
  REMARK    GeneRIF: Molecular basis for arginine C-terminal degron recognition
            by Cul2(FEM1) E3 ligase.
REFERENCE   3  (bases 1 to 9540)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9540)
  AUTHORS   Koren,I., Timms,R.T., Kula,T., Xu,Q., Li,M.Z. and Elledge,S.J.
  TITLE     The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
            C-Terminal Degrons
  JOURNAL   Cell 173 (7), 1622-1635 (2018)
   PUBMED   29779948
REFERENCE   5  (bases 1 to 9540)
  AUTHORS   Dankert,J.F., Pagan,J.K., Starostina,N.G., Kipreos,E.T. and
            Pagano,M.
  TITLE     FEM1 proteins are ancient regulators of SLBP degradation
  JOURNAL   Cell Cycle 16 (6), 556-564 (2017)
   PUBMED   28118078
  REMARK    GeneRIF: FEM1 proteins are ancient regulators of Stem-Loop Binding
            Protein.
REFERENCE   6  (bases 1 to 9540)
  AUTHORS   Maher,J.F., Hines,R.S., Futterweit,W., Crawford,S., Lu,D., Shen,P.,
            Oefner,P., Kazi,M., Wilson,J.G., Subauste,J.S. and Cowan,B.D.
  TITLE     FEM1A is a candidate gene for polycystic ovary syndrome
  JOURNAL   Gynecol Endocrinol 21 (6), 330-335 (2005)
   PUBMED   16390781
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9540)
  AUTHORS   Ventura-Holman,T., Hahn,H., Subauste,J.S. and Maher,J.F.
  TITLE     The Fem1a gene is downregulated in Rhabdomyosarcoma
  JOURNAL   Tumour Biol 26 (6), 294-299 (2005)
   PUBMED   16254458
  REMARK    GeneRIF: Fem1a downregulation may be involved in, and/or a marker
            of, an early cell fate defect fundamental to rhabdomyosarcoma
            pathogenesis
REFERENCE   8  (bases 1 to 9540)
  AUTHORS   Krakow,D., Sebald,E., King,L.M. and Cohn,D.H.
  TITLE     Identification of human FEM1A, the ortholog of a C. elegans
            sex-differentiation gene
  JOURNAL   Gene 279 (2), 213-219 (2001)
   PUBMED   11733146
REFERENCE   9  (bases 1 to 9540)
  AUTHORS   Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex-determining protein FEM-2 and its
            human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
            kinase phosphatases that promote apoptosis
  JOURNAL   J Biol Chem 276 (47), 44193-44202 (2001)
   PUBMED   11559703
REFERENCE   10 (bases 1 to 9540)
  AUTHORS   Ventura-Holman,T., Seldin,M.F., Li,W. and Maher,J.F.
  TITLE     The murine fem1 gene family: homologs of the Caenorhabditis elegans
            sex-determination protein FEM-1
  JOURNAL   Genomics 54 (2), 221-230 (1998)
   PUBMED   9828124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005523.1.
            
            On May 17, 2019 this sequence version replaced NM_018708.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660807.165968.1,
                                        SRR1660803.252491.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269856.5/ ENSP00000269856.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3826              AC005523.1         24615-28440
            3827-9540           AC005523.1         28441-34154
FEATURES             Location/Qualifiers
     source          1..9540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..9540
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /note="fem-1 homolog A"
                     /db_xref="GeneID:55527"
                     /db_xref="HGNC:HGNC:16934"
                     /db_xref="MIM:613538"
     exon            1..9540
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2131
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /note="prostaglandin E receptor 4-associated protein;
                     FEM1-alpha"
                     /codon_start=1
                     /product="protein fem-1 homolog A"
                     /protein_id="NP_061178.1"
                     /db_xref="CCDS:CCDS12135.1"
                     /db_xref="GeneID:55527"
                     /db_xref="HGNC:HGNC:16934"
                     /db_xref="MIM:613538"
                     /translation="MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTP
                     LLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSL
                     LRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK
                     GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTP
                     LLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSS
                     PEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGE
                     YLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYY
                     IRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRA
                     AKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV
                     ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKV
                     LLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEK
                     LLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH"
     regulatory      3804..3809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      3826
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /note="major polyA site"
     regulatory      9517..9522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      9540
                     /gene="FEM1A"
                     /gene_synonym="EPRAP"
ORIGIN      
        1 gaggagaccc taagatggcg gcgaggggga cggtgaaggt tgcctcccgc ccgtccgggc
       61 tctgatcctc cgtctccccg tcccccggcg gccggcccat ggcctggcgg aggcccgaac
      121 catggacctc cgcaccgccg tgtacaacgc cgcccgtgat ggcaagctgc agctgctcca
      181 gaagctgctc agcggccgga gccgggagga actggacgag ctgacgggcg aggtggccgg
      241 cgggggaacg ccgctactca tcgccgcccg ctacggccac ctggacgtgg tggagtacct
      301 ggtggaccgg tgcggcgcga gcgtggaggc cggtggctcg gtgcacttcg atggcgagac
      361 catcgagggc gcgccgccgc tgtgggccgc ctccgcagcc ggccacctgg acgtggtgcg
      421 gagcctgctg cgccgcgggg cctcggtgaa ccgcaccacg cgcaccaact ccacgcctct
      481 ccgcgccgcc tgcttcgacg gccacctgga ggtggtgcgc tacctggtcg gcgagcacca
      541 ggccgacctg gaggtggcca accggcacgg ccacacgtgc ctcatgatct cgtgctacaa
      601 gggccaccgt gagatcgccc gctacctgct ggagcagggc gcccaggtga accggcgcag
      661 cgccaagggc aacacggccc tgcatgactg cgccgagtcc ggcagcctgg agatcctgca
      721 gctgctgctg gggtgcaagg cccgcatgga acgtgacggc tacggcatga ccccgctgct
      781 cgcggccagc gtgacgggcc acaccaacat cgtggagtac ctcatccagg agcagcccgg
      841 ccaggagcag gtcgcagggg gagaggctca gcctgggctg ccccaagaag acccctccac
      901 cagccagggg tgtgcgcagc ctcagggggc tccgtgctgc agctcctccc cagaggaacc
      961 actgaacggg gaatcttacg aaagctgctg tcccaccagc cgggaagctg ccgtggaagc
     1021 cttggaattg ctgggagcta cgtatgtgga taagaaacga gatctgcttg gggcccttaa
     1081 acactggagg cgggccatgg agctgcgtca ccaggggggc gagtacctgc ccaaaccgga
     1141 gcccccacag ctggtcctgg cctatgacta ttccagggag gtcaacacca ccgaggagct
     1201 ggaggcgctg atcaccgacc cggatgagat gcgcatgcag gccctgttga tccgggagcg
     1261 catcctcggt ccctcgcacc cggacacttc ctattacatc cgttacaggg gtgccgtgta
     1321 cgccgactcg ggcaatttcg agcgctgcat ccgcttgtgg aagtacgccc tggacatgca
     1381 acagagcaac ctggagcctc tgagccccat gaccgccagc agcttcctct ccttcgcgga
     1441 actcttctcc tacgtgcttc aggaccgggc cgccaaaggc agcctgggca cccagatcgg
     1501 ctttgcagac ctcatggggg ttctcaccaa aggggtccgg gaagtggaac gggccctgca
     1561 gctgcccagg gagcccggag actcagccca gttcaccaag gcgctggcca tcatcctcca
     1621 cctgctctac ctgctggaga aagtggagtg cacccccagc caggagcacc tgaagcacca
     1681 gaccgtctac cgcctgctca agtgcgcgcc caggggcaag aacggcttca cccctctgca
     1741 catggctgtg gacaaggaca ccacaaacgt gggccgctat cccgtgggca gattcccctc
     1801 cctgcacgtg gtcaaagtgc tgctcgactg cggggccgac ccggacagca gggattttga
     1861 caacaacacc ccgctacaca tagcagccca gaacaactgc ccggccatca tgaatgccct
     1921 gatcgaagca ggggcccaca tggacgccac caatgccttc aagaagacgg cctacgagct
     1981 gctggacgag aagctgctgg ccaggggtac catgcagccc ttcaactacg tgaccctgca
     2041 gtgccttgcg gcccgggccc tggataagaa caagatccct tacaagggct tcatcccgga
     2101 agatctggag gcgttcatcg aactgcactg acctgcccag aacgcctgca ccctcacctc
     2161 tcccctctcc tgctgagatg ggggaaatcc ggctgcggca tagcagatgc tcgttcttgc
     2221 ctccttcagg caccaatcag gagaagggtt ctgcctccca tcccctctac ctgcagacag
     2281 ggtcggaggt gttagcgagc ctttggtgct agaagcctgc ggggtcatgt gctaagagga
     2341 cagtctttct ccgggagccc gctcactcat tctgagttag gaaaagacac aagaccttcc
     2401 ccacatcctg tctgcctggg ttagggaggc ctttgccttg ttacctagag gcggagggac
     2461 tgaagccatt gcgttccttc cctgctagaa acacaggaag aagttgagga ctgtctgcct
     2521 tccctcgtcc ctttacctgg ccagataact ccagccgctg aatacagtgt taggactggg
     2581 ggctcctgag atgagagttt gagattcagg gaatgagacc acctctcatt tcttccagca
     2641 tgatcgcgcc ctgctcccgt gccaccgtag tccctggcag acaggcaggg ctctgcccag
     2701 ggcagcctgc cacttgcata gctttcggtt ggtttggtgt tctgtttatt taataagtgg
     2761 gcaggttgca agcgttgcac agaaattctg agattttact gccttttttt ttttttttaa
     2821 gaaagttgtt tgttggactc cataagtgaa tttcaagcag tgaggatttt gtggtgcctg
     2881 agatggccga gggcacaggg agtgagctgt atgtgtgagg aatttggtga gcgagataaa
     2941 agtccacggt gtcaacccct aaaacatggg tgaccgtaca tttttataca tctccactct
     3001 acggcctttt acaggctttc cgattttaca ggcctttcca agtttccatt ctccttagag
     3061 agagaactgt gcttccaaac agaaatcagg agtgaccaca aagcctgaaa acactttgcc
     3121 acccagcaaa gaactggcac aattggtttg ggtctgcatt gccatagtgc ccgagttaaa
     3181 actgcaggcc actctgcctt gcagtggcct ctgatttcat tgtgggtgca tccacaggtg
     3241 gcccgagctg ttctttcagc tgctccaagg attgagaccc aagtcatcat gaaaaaggcc
     3301 caagtacagt cttaatgcga taaatccact agctaagacg tcgagtgcca agaccagcct
     3361 tccagccgag gtttggacaa agtctcaggt tcccgtgact cagggtaagg tgctggggct
     3421 gccagaggac ctgccccagc aagatttttg tcaagagcga gactccatca gcccaggcag
     3481 acgggagcag gttcttggcc agcgtagaca gcagcaaaca gcagcaggga agccattctc
     3541 actgcatcct ccctgcagta gccacggcca ggcccttagg aggagcagtg accgggggtg
     3601 tccagaaata tcctgtccct ggatggaaac taggtctcgt ttggattttt tttttttttt
     3661 gccgtgttag gaaattattt attaatttac aagacaggtt ttaactcagc cgaggtggga
     3721 aatggtgtcc ctgtccctcc caaagcacag agcacagaaa tgaggccgtt tacatggcga
     3781 gtctccgtgc tggtgtttaa gtcattaaaa agatactcaa agagaatggc ctgcctgatg
     3841 cgtccttggc gtgggttaac tggggaagtc ggaggtgggt gagtcagtcc atggcattgg
     3901 tgtgagtgaa cagagagccc tagggccacc tcccctagcc agaggggttt ctgtgttaca
     3961 tactggggct tttttttttt ttttgagaca gagtctcacc ctgtccccca ggctggagtg
     4021 caatggcgcg atctcagctc actgcaacct ctgcctcctg ggttcaaaca attctgcttc
     4081 agcctcctga gtagctgaga ttacaggcac ctgccactat gcccagctaa tttttgtatt
     4141 ttctgtagag gcaggttttg ccatgttggc caggctggtc tcaaactcct gaactcaagc
     4201 gatcctccca cctcagcctc ccaaagtgct ggaattacaa gcatgaacca ctgcacctgg
     4261 cctctatgtt acatactggg gctttgtgta aaatttcatt tgaaaaacag tatgttgctc
     4321 tttgaaaaaa agcctgggca acatagtgag agcctgtctt tacaaaaata aaaaataggc
     4381 tgggtacggt ggctcacatc tgtaatctca gcaccttggg aagcctgggc aacatagtaa
     4441 gacctctgtc tctacatttt tttttttttt ttttttgaga tggagtcttg ctctgtcacc
     4501 caggctggag tgcagtgacg ccatctcggc tcactgcaac cgctgcctcc cgggttcaag
     4561 tgattctcct gcctcagcct cctgagcatc tgggactaca ggcatacacc accatgcctg
     4621 gctaattgtg tatttttagc agagacgggg tttcaccata ttggccatgc tggtctcaaa
     4681 ctcctgacct tgtgatccac tcgcctcggc ctcctaaagt gctgggatta taggtgtgag
     4741 ccaccacgcc tggccctttt ttgttttcct ttatctgcca tctcatctca cctccttgtg
     4801 taaacttgtt ccattctaaa attctggttt tctccatatc agaacagtca aacccccacc
     4861 agaaagcacc accccgttag ctgggtccat gggattttgc tgagcccctg ccatgtgcca
     4921 ggcaggtttc aggccccctt ggggataagg attgagctgt cgatatgaac gtccggttaa
     4981 tccctgtgcg cccgcctcac gtggcagtgg ggagaggccc tgctgtgggg caccgcatgc
     5041 tgcttccatg gtgcattggg ttggagggct cttctcccga gggtgggtgt ctcccatctc
     5101 ttgccttcac acacctgctg tcttgtttca tttgggactg gacagtccca caggtgacag
     5161 ctgttgggct gttgtatgcc tgtttggtgt tgcatcaaag gagtgggttt gaatcagcag
     5221 gtgctctcaa agctgtctcc tgggagacac agtactagtg agcatttatt gagcacctac
     5281 tgtatgccag gcaccatttt ctgtggttaa atgcactgcc tgtttacaca acagccctct
     5341 aaaggaggaa aaacatatca gagtcccatg gatggaagaa aaataatgaa gtaggaaaaa
     5401 cggccctctt aagatgaagg tcatcttttt tttttttttt tttttttttt gagacggagt
     5461 ctctgtcgct caggctggag tgcagtggtg tgatctcggc tcactgcaag ctcagcctcc
     5521 cgggttcaca ccattctcct gcctcagcct cccgagtagc tgggactaca ggcacctgcc
     5581 accatgcccg gctaattttt tgtattttta gtagagatgg ggtttcaccg tgttaggata
     5641 gtcttgatct cctgacctca tgatccgccc acctcggcct cccaaagtgc tgggattaca
     5701 ggcatgagcc accgcacccg accagatgaa ggccatctta aagctcaacc agtttcaggt
     5761 gagggctgat ccagcagatc ccaattattc ctaaagacct ggttgatagc tcccttgaga
     5821 ctggggtggg gtgggtgtcc caagatgacc gccagcagaa aagagagcat ctttctccca
     5881 gtcaaaagcc aaagtaggac ctatctaaag taagtcctgg ccgggcacgg tggctcacac
     5941 ctgtaatccc agcaccttgg gaggctgagg ctggaggatc gcttgagcct gggagtttga
     6001 gaccatcatg ggcagcaaag tgagatcctg tctctacaaa aaaaaaaaaa aaaaaaaatt
     6061 agccatgtgt agtgatatgt agtcccagct gctactgggg aggctgaagc aggaggattg
     6121 attgagccca ggagtttgag gctgcagtga gccttaatgg caccatcaca ctccagcctg
     6181 ggcaacagag tgagaccctg tttcaaaaaa acaaagcagg gccgggcgca ggggctcacg
     6241 ccagtaatcc cagcactttg ggaggccaag gcgggcggat cacgaggtca ggagatcgag
     6301 accatcctgg ctaacacggt gaaaccccgt ctctactaaa aatacaaaaa ttagccgggt
     6361 gtggtggcag gtgcctgtag tcccagctac tccggagtct gaggcaggag aatggcgtga
     6421 acccgggagg cggagcttgc agtgagccga gatcgcacca ctgcactcca gcctgggcga
     6481 cagagcgaga ctccgtctca aaaaacaaac aaacaaacaa acaaaacaaa gcaggtccgg
     6541 tatggcaggc gggggaactg aggctactaa gagacattaa gatgcttaag gacagccggg
     6601 cgcggtggca gacgcctgta atcccagcac tttgggaggc tgaggcgggc ggatcacgag
     6661 gtcaggagac caagaccatc ctggctaaca cggtgaaacc ccgtctctct actaaaagca
     6721 caaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagctactcg ggaggctgag
     6781 gcaggagaat ggtgtgaact caggaggcgg agcttgcagt gagccgagat cgcaccactg
     6841 cactccagcc tgggcgacag agcacaagac tccatctcaa aaaaaaaaaa aagaaagaaa
     6901 aatgcctaag gacacagcgc atgaaggaag ggtcgagatt ggaacccagg accgtcagag
     6961 ttcatacctt gtgctgattc tccatccggg acgccagaca catggatccc tttcccctgc
     7021 tttctggtgt tgttttggca caagctctcc catccctggg gcaggtggcc atcctgcctc
     7081 cgcatcctga gcgtctgttt ccctcgggga tctgccagac tcagccccct aaccccaaga
     7141 aaatcactca caaaaatcat ctgagctaaa tgcttgcttt gaaagctcag acctggggat
     7201 tgtaacttta gcctcatacc ttctaatgaa ggccatctta aagctctacc agtttcagct
     7261 gagggccgat ccagcagatc ccagttgttc ctaaagacct ggttgctagc tcctctgaga
     7321 ctggggtggg gtgggtgtcc caaggtgatg accaggagaa aagagagcgt cttcctccca
     7381 gtcacatccc aagattcgtg accgagcgcg gtggctcacg cctgtaattc cagcactttg
     7441 ggagaccgag gcaggtggat cacgaggtca ggagttcgag accagcctgg tcaacatggt
     7501 gaaaccctat ctattctaaa aatacaaaaa attagccagg cacggtggca ggcacctgta
     7561 atcccagcta cttgggaggc tgaggaagga gaatcgcttg aacccgggag atggaggttg
     7621 cagtgagccg agattgcacc actgcactcc agcctgggca acagagcaag actctgtctc
     7681 aaaacaaaac aaaacaaaca aacaaacaaa caaacaaaaa actaaaaaca tcaagatacg
     7741 ctctgattgg accagcctgg gtcccatgtt cttccatgac ccaatcctag tagcccagga
     7801 gtgggatgtg ccaattggct tggcctgagg agggccccca gagggtctgt aatccatgtg
     7861 taactggagt tgctgtaaaa tggggccatc tggctgggtg cggtggctca cgcctgtaat
     7921 cccaacactt tgggaggccg aggcgggcgg atcacgaggt caggagatca agaccatcct
     7981 ggctaacacg gtgaaacccc gtctctacta aaaatacaaa aaattagccg ggcgtcgtgg
     8041 caggcgcctg tagtcccagt tactcgggag gctgaggcag gagagtggcg tgaacccggg
     8101 aggcggagtt acagtgagcc gagatcgcgc cactgcactc cagcctgggt gacatagcaa
     8161 gactctgtct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa tggggccatc aatgccatgg
     8221 agggtagcaa aaaatgttca caatagtaaa atgactacct gccgttgatc agtgaagaaa
     8281 aaagctcaga gagctcaagt ggagtaccta aggccacaca gccaagaggg agagccaagt
     8341 cgtttgtggt taaatgtcct gcctgtttac acagcagccc tctaaaggcg gaaaaacatg
     8401 tcagagtccc atggacggga gaaaaataag aataataata aagtaggaaa aacagccctc
     8461 ttaagaggaa ggccatctta aagctctacc agcttcaggt gagggctgat ccagcagatc
     8521 ccagagaaac aggctcacag agaggggagg gggcttgtct aagcttaccc agcccggaag
     8581 catcggggtc aaagcttaac cccctgctgg aaggtgtcga gagccaggca gccaagcctg
     8641 acctgggaga tggggaagtg ggggcccccc caagctcgcc gactgccctt cccagcctgc
     8701 tgccagtctg attccacaga actgaagtcg ggacctggag ttctgctcat tcgctcatct
     8761 actcagtgac tttcttagac cctccccagc actttgaggg tgtcagtcac tgctgcgtcc
     8821 tcagcaccca cgccagggtc tgtcccacgc caggtggcct gtaaatatgg gctgagcaag
     8881 cgaacagtga acgagttggg aattcacatc ctcctctgac tacttggggc agcagcaggg
     8941 gacacaagca ggcccctatg gctttgccag accccgggtg ccgccgcccc catggaattg
     9001 caggactgtt atctgagcaa cgtcgacggg ggagaacacc cctgcccgag gttaaagata
     9061 gcaccgctcg aatcacatca caggccgaaa aggccagatg acccaccagg gacattgaat
     9121 ccgtgtcccg agaggggtgg ggcgggggtg tggattcctg cggggagctt cgggactgga
     9181 aaaaacagag ggtgctctga ccgagtgttt accaaaacat gtattaggca agacccgggc
     9241 cgaatgtggg tggcaccgcc cctgtgctgg gccaggagaa tgtgcccgca ccggtcccag
     9301 atcctgtttc cccagtgggt tgtacaagac accttgaact tctgcatgaa ctgggacatt
     9361 cagaattccc tggagcaacc ccctccctcc accctgtgcc ttgatatctc ctattaaagc
     9421 ttgtgtttga atgtctgtta atagacatga tttaattatt gatattaatt caaatgtatt
     9481 aatttgaatt attaacttat taatcatttg atgtcgatta aagcaatgat cttgatccaa
//
