LOCUS       NM_138378               2774 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ferredoxin-fold anticodon binding domain containing 1
            (FDXACB1), transcript variant 1, mRNA.
ACCESSION   NM_138378
VERSION     NM_138378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2774)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127680.1, CN260853.1, BC006136.1 and AW296845.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138378.2.
            
            Summary: This gene encodes a protein which contains a
            ferredoxin-fold anticodon-binding domain which is contained in a
            subset of phenylalanyl tRNA synthetases. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.58289.1,
                                           SRR1660805.31236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260257.9/ ENSP00000260257.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               BC127680.1         16-307
            293-293             CN260853.1         292-292
            294-2235            BC006136.1         265-2206
            2236-2631           BC006136.1         2208-2603
            2632-2774           AW296845.1         16-158              c
FEATURES             Location/Qualifiers
     source          1..2774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..2774
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /note="ferredoxin-fold anticodon binding domain containing
                     1"
                     /db_xref="GeneID:91893"
                     /db_xref="HGNC:HGNC:25110"
     exon            1..205
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1908
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /note="FDX-ACDB domain-containing protein 1; hypothetical
                     protein BC006136"
                     /codon_start=1
                     /product="ferredoxin-fold anticodon-binding
                     domain-containing protein 1"
                     /protein_id="NP_612387.1"
                     /db_xref="CCDS:CCDS44729.1"
                     /db_xref="GeneID:91893"
                     /db_xref="HGNC:HGNC:25110"
                     /translation="MAPRRLLLVGEGNFSFAAALSETLDQSTQLTATCLQRPAELARD
                     PLAWENLQCLRERGIDVRFGVDCTQLADVFELHEREFDQIYFIFPHCGRKAGVAKNRE
                     LLAKFFQSCADVLAEEGEVHVALCRGQGGTPADKPQREWHNSWQVVAMAALGGLILSD
                     VYPFSCKAVAGYKCTGYRSQDKSFHVEGALNHIFTRSLPFEGSQPRIFRIKLGNQWFS
                     FPEPEALVGKLNRGFLEAPSCHPIKTINEKLIAELGKVFPLKRLKCSYPLLPQEGTSV
                     LPFWNCDFLSAAFWISLHEDNSNSESLTGGTSQDVEDFLVSFSELSLLKNPGRDGKEE
                     ACEGTCGQAKICLRPSLLVHVQDVIEVPDFLSGSLHILSGPVFQKCHILPFTMPAFHE
                     TLFILGVNQNLKDGCLQSLLDHLKGILDSLLTQTLPESSKLSSLVKFVLQSNGKDYMI
                     RVKTHNFSPDCTEDLIIGSVITSATSVIHKDQCFVFVSMNLDLLAMLVWCISDWRMLW
                     TFDNRFLKNFVPGKIEPFKSHSLYPPCYVHDVSFWIDQKKGFDELEFHTVARAVSQDT
                     IISIQFLSRFQHPKTQQVSLCYRLTYQTCDKALTQQQVASMQSQFRKEIQQHLYVIPR
                     "
     exon            206..362
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /inference="alignment:Splign:2.1.0"
     exon            363..566
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /inference="alignment:Splign:2.1.0"
     exon            567..725
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2774
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /note="hexamer: AATAAA"
     polyA_site      2774
                     /gene="FDXACB1"
                     /gene_synonym="hCG_2033039"
                     /note="major polyA site"
ORIGIN      
        1 acagagaacg cgagccggga gtccgtggag gccatggccc ctcggcgcct cctgttggtt
       61 ggggagggga atttctcctt cgccgccgct ctgagcgaaa ccctggatca gagcactcaa
      121 cttaccgcca cctgcctcca gcgcccggcc gagttggctc gggatccact ggcctgggag
      181 aatctgcagt gcctgcgcga gcgaggtatc gatgtacgtt tcggtgtgga ctgcacccag
      241 ctggcagatg tctttgaact gcacgagaga gaatttgatc aaatttattt catcttcccg
      301 cattgtggac gcaaagctgg cgtagctaag aacagggaac tgcttgccaa atttttccaa
      361 agctgtgcag acgttcttgc agaggaagga gaagtccacg tggcattatg tagaggacaa
      421 ggtggaactc ctgcggataa gccccagaga gaatggcaca acagttggca agtggttgcc
      481 atggcagccc tgggggggct cattttaagc gacgtgtatc cattcagctg taaggctgtg
      541 gcagggtaca agtgcactgg atataggagt caagataagt cctttcatgt agaaggtgct
      601 ttgaaccata tcttcaccag gagcttacct tttgaaggtt ctcaacccag aatcttcagg
      661 atcaaactgg gtaaccagtg gttttccttt ccagaaccag aagcacttgt aggaaagttg
      721 aacaggggtt tcctggaagc accttcatgt catcctatca aaaccataaa tgagaaactc
      781 attgctgaat taggcaaagt tttcccgcta aaaaggctga agtgttccta ccctttgctg
      841 ccacaggaag gtaccagtgt tcttcctttc tggaattgtg actttctgtc agctgctttt
      901 tggattagtc tccatgaaga taactcaaat tctgagtccc tgactggtgg gacatcacaa
      961 gatgtggaag actttctagt gtcattttca gaacttagcc ttctcaagaa tcctggaaga
     1021 gatggtaaag aagaagcttg tgaaggaacc tgtggccagg ccaagatctg ccttagacct
     1081 tctctcctag tgcatgttca ggatgtcatc gaagtaccag acttcctctc aggttctctg
     1141 cacatcctca gtggacctgt ctttcagaag tgccacattt tgcctttcac aatgccagca
     1201 tttcatgaaa ctttatttat ccttggggtt aatcaaaatc tgaaggatgg ctgtcttcaa
     1261 tcactgctgg atcatctgaa gggcattcta gatagcctgc tgacccagac attgccggag
     1321 agctctaagc tgagcagttt agtcaaattt gtccttcagt caaatggaaa ggattatatg
     1381 attcgtgtga agactcataa ttttagccca gattgtactg aggatctaat tattgggtct
     1441 gttatcacat ctgccactag tgttatacat aaagaccagt gttttgtgtt tgtgtctatg
     1501 aacttggact tattagccat gcttgtctgg tgtatctctg actggagaat gttgtggacg
     1561 tttgataacc gtttcctgaa aaattttgtc cctggcaaaa tagaaccctt taaaagtcat
     1621 tctctgtatc ctccatgtta tgtgcatgat gttagttttt ggatagatca gaagaaagga
     1681 tttgatgaac tagagtttca cactgtggcc cgagcagtgt ctcaggacac tattatatcc
     1741 atacagtttc ttagccgttt ccagcatcca aagactcaac aggtcagtct ctgctataga
     1801 ttgacctacc agacctgtga caaggccctc acccagcagc aagtagcatc aatgcagtcc
     1861 cagtttagga aggagattca acaacaccta tatgttatac ctcggtagtt tggtaaatcc
     1921 ttttctgcag tgtgatcctt cattgcgggg gatgtggagg aaaattacca acttgcaacc
     1981 agtagtcctt tctggatttt tgtttttgta aaatctttta ctttgtgacc atagctactg
     2041 ttcgttgatc tttttttttt tttttttttg agacggagtc ttgctctgcc gcccaggcgg
     2101 gagtgcagtg gcagtggcat gatatcagct cactataagc tccacctccc aggttcatgc
     2161 cattctcctg cctcagcctc ccgagtagct gggactacag gcacctgcca ccacgcctgg
     2221 ctaatttttt tttttgtatt tttagtagag acgaggtttc accgtgttag ccaggatggt
     2281 ctcaatctcc cggcctcgtg atctgcctgc gtcggcctcc caaagtgctg ggattataga
     2341 tgtgagccac cgcgcccggc ctactgttag ttgatcttaa agataccttg actctattac
     2401 tgaaacttat agattataat gtgattggtg acatttggag ttgtgtaata ttttggtccc
     2461 gagaagtgac taaaacaata aacaaaacag catcttgtac tttagatgct ctattgttga
     2521 acaggcagta gaacttaagt gtctcatcaa atataaatat gttttccaca ctgtcaatta
     2581 ctcttccctt aactttgttg tatcatttca ttaaatcacc ttatgagagt agtttttggc
     2641 atcagactaa catttattag cttgggaaat tgcaaatatt ccacattaat tttggtatta
     2701 ttattataat catcaccatt ttaattctgt ggttgaaagt catggaacga ataaagtgtc
     2761 agatttaggg ttaa
//
