LOCUS       NM_004109               3144 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ferredoxin 1 (FDX1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_004109
VERSION     NM_004109.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3144)
  AUTHORS   Sun,B., Ding,P., Song,Y., Zhou,J., Chen,X., Peng,C. and Liu,S.
  TITLE     FDX1 downregulation activates mitophagy and the PI3K/AKT signaling
            pathway to promote hepatocellular carcinoma progression by inducing
            ROS production
  JOURNAL   Redox Biol 75, 103302 (2024)
   PUBMED   39128228
  REMARK    GeneRIF: FDX1 downregulation activates mitophagy and the PI3K/AKT
            signaling pathway to promote hepatocellular carcinoma progression
            by inducing ROS production.
REFERENCE   2  (bases 1 to 3144)
  AUTHORS   Liu,M., Wu,S., Wu,H., Zhou,Y., Zhang,X., Zhu,D. and Jiang,J.
  TITLE     Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma
            progression through activation of the GPRIN2 signaling pathway
  JOURNAL   J Transl Med 22 (1), 510 (2024)
   PUBMED   38802900
  REMARK    GeneRIF: Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma
            progression through activation of the GPRIN2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3144)
  AUTHORS   Dai,L., Zhou,P., Lyu,L. and Jiang,S.
  TITLE     Systematic analysis based on the cuproptosis-related genes
            identifies ferredoxin 1 as an immune regulator and therapeutic
            target for glioblastoma
  JOURNAL   BMC Cancer 23 (1), 1249 (2023)
   PUBMED   38114959
  REMARK    GeneRIF: Systematic analysis based on the cuproptosis-related genes
            identifies ferredoxin 1 as an immune regulator and therapeutic
            target for glioblastoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3144)
  AUTHORS   Qian,S., Liu,J., Liao,W. and Wang,F.
  TITLE     METTL3 promotes non-small-cell lung cancer growth and metastasis by
            inhibiting FDX1 through copper death-associated pri-miR-21-5p
            maturation
  JOURNAL   Epigenomics 15 (23), 1237-1255 (2023)
   PUBMED   38126112
  REMARK    GeneRIF: METTL3 promotes non-small-cell lung cancer growth and
            metastasis by inhibiting FDX1 through copper death-associated
            pri-miR-21-5p maturation.
REFERENCE   5  (bases 1 to 3144)
  AUTHORS   Jay,N., McGlohon,J.E. and Estrada,D.F.
  TITLE     Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by
            NMR; modulation by cytochrome P450 substrate and by truncation of
            the C-terminal tail
  JOURNAL   J Inorg Biochem 249, 112370 (2023)
   PUBMED   37734220
  REMARK    GeneRIF: Interactions of human mitochondrial Ferredoxin 1
            (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and
            by truncation of the C-terminal tail.
REFERENCE   6  (bases 1 to 3144)
  AUTHORS   Wada,A. and Waterman,M.R.
  TITLE     Identification by site-directed mutagenesis of two lysine residues
            in cholesterol side chain cleavage cytochrome P450 that are
            essential for adrenodoxin binding
  JOURNAL   J Biol Chem 267 (32), 22877-22882 (1992)
   PUBMED   1429635
REFERENCE   7  (bases 1 to 3144)
  AUTHORS   Coghlan,V.M. and Vickery,L.E.
  TITLE     Site-specific mutations in human ferredoxin that affect binding to
            ferredoxin reductase and cytochrome P450scc
  JOURNAL   J Biol Chem 266 (28), 18606-18612 (1991)
   PUBMED   1917982
REFERENCE   8  (bases 1 to 3144)
  AUTHORS   Skjeldal,L., Markley,J.L., Coghlan,V.M. and Vickery,L.E.
  TITLE     1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine
            resonances suggest different electron delocalization patterns from
            plant ferredoxins
  JOURNAL   Biochemistry 30 (37), 9078-9083 (1991)
   PUBMED   1909889
REFERENCE   9  (bases 1 to 3144)
  AUTHORS   Sparkes,R.S., Klisak,I. and Miller,W.L.
  TITLE     Regional mapping of genes encoding human steroidogenic enzymes:
            P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase
            to 17q24-q25; and P450c17 to 10q24-q25
  JOURNAL   DNA Cell Biol 10 (5), 359-365 (1991)
   PUBMED   1863359
REFERENCE   10 (bases 1 to 3144)
  AUTHORS   Chang,C.Y., Wu,D.A., Mohandas,T.K. and Chung,B.C.
  TITLE     Structure, sequence, chromosomal location, and evolution of the
            human ferredoxin gene family
  JOURNAL   DNA Cell Biol 9 (3), 205-212 (1990)
   PUBMED   2340092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB459133.1, BC010284.1,
            CN333249.1 and AA505582.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004109.4.
            
            Summary: This gene encodes a small iron-sulfur protein that
            transfers electrons from NADPH through ferredoxin reductase to
            mitochondrial cytochrome P450, involved in steroid, vitamin D, and
            bile acid metabolism. Pseudogenes of this functional gene are found
            on chromosomes 20 and 21. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010284.1, SRR1803617.201753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000260270.3/
                                                  ENSP00000260270.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB459133.1         12-31
            21-2537             BC010284.1         1-2517
            2538-2755           CN333249.1         372-589
            2756-3141           BC010284.1         2736-3121
            3142-3144           AA505582.1         2-4                 c
FEATURES             Location/Qualifiers
     source          1..3144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..3144
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="ferredoxin 1"
                     /db_xref="GeneID:2230"
                     /db_xref="HGNC:HGNC:3638"
                     /db_xref="MIM:103260"
     exon            1..358
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..728
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="adrenodoxin, mitochondrial; mitochondrial
                     adrenodoxin; hepatoredoxin; adrenal ferredoxin"
                     /codon_start=1
                     /product="adrenodoxin, mitochondrial precursor"
                     /protein_id="NP_004100.1"
                     /db_xref="CCDS:CCDS8344.1"
                     /db_xref="GeneID:2230"
                     /db_xref="HGNC:HGNC:3638"
                     /db_xref="MIM:103260"
                     /translation="MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPG
                     GSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDG
                     FGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSM
                     DNMTVRVPETVADARQSIDVGKTS"
     exon            359..483
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /inference="alignment:Splign:2.1.0"
     exon            484..613
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /inference="alignment:Splign:2.1.0"
     exon            614..3144
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      795..800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: ATTAAA"
     polyA_site      825
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="major polyA site"
     regulatory      937..942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: ATTAAA"
     polyA_site      965
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="major polyA site"
     regulatory      1307..1312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="major polyA site"
     regulatory      1393..1398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: ACTAAA"
     polyA_site      1413
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="major polyA site"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: TATAAA"
     polyA_site      1516
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="major polyA site"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: AATAAA"
     polyA_site      1751
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
                     /note="hexamer: ATTAAA"
     polyA_site      3144
                     /gene="FDX1"
                     /gene_synonym="ADX; FDX; LOH11CR1D"
ORIGIN      
        1 acgcggaacc tcggcgcggt gcttccagca gggtctctcc gccactccag ccccgcgccc
       61 ctcgccgcgg ccctcgggcg tctgcgccgc agctgccgcc cccgcctctt tggagtctct
      121 cgcggcctca aagcgcggcc tgcgtcgctt ccggcagttc ccgaccgcgg gcgatggctg
      181 ccgctggggg cgcccggctg ctgcgcgccg cttctgctgt cctcggcggc ccggccggcc
      241 ggtggctgca ccacgctggg tcccgcgctg gatccagcgg cctgctgagg aaccgggggc
      301 cgggcgggag cgcggaggcg agccggtcgc tgagcgtgtc ggcgcgggcc cggagcagct
      361 cagaagataa aataacagtc cactttataa accgtgatgg tgaaacatta acaaccaaag
      421 gaaaagttgg tgattctctg ctagatgttg tggttgaaaa taatctagat attgatggct
      481 ttggtgcatg tgagggaacc ctggcttgtt caacctgtca cctcatcttt gaagatcaca
      541 tatatgagaa gttagatgca atcactgatg aggagaatga catgctcgat ctggcatatg
      601 gactaacaga cagatcacgg ttgggctgcc aaatctgttt gacaaaatct atggacaata
      661 tgactgttcg agtgcctgaa acagtggctg atgccagaca atccattgat gtgggcaaga
      721 cctcctgaac tagaacaaat aggaatattt tcatggaatt ttacctattt ttataattat
      781 tatttcttaa agtgattaaa tgagaacatg gatgagtgga cttcatatta tgactagctt
      841 tactatttta attcaccttg cataactact gaattttgtc attcttgaaa gtatgcaatt
      901 tttattttgg ttatattaca aaaatgtcaa tcaaatatta aaaaatagtt aatgtgatag
      961 aaaaacctta catatttttt tcttatgttt gtttagcgac tttagcaaaa tgttttcata
     1021 taatctcatc tgtttaccta gaagataggt taaggaaata tattattatt cctgtttgat
     1081 gtgggtgaag gcagagatct aacctggctt gtttagggcc ataccactaa ttagaaaatc
     1141 tgtgctagaa cctgtgtctt attcctataa gctatgtgtt cagactgaaa ctggagaaat
     1201 tatgactatt ttatttatag tagtagttaa atctgaatgt gtatggacaa aaatatttaa
     1261 ttgctcagta aactgcttaa cttcaaagat agttattgac cttataaata aatatttcaa
     1321 aattttgatt cggaagacta agtctggacg tagacattat aatgctatca aagaagtttg
     1381 atctctgttt tgactaaact agaggaaaaa tgattggatg tgtttattct tttctaagca
     1441 gaatggttta actttgtact ctttgaaaaa taatgctgat ttataaatct ctgcctataa
     1501 cagaatggaa accttatgaa tgaattgtgt ttctctgtcc tgagctggag aagggaatga
     1561 gcaggctgac acgttgcaca gccccaggtg gcgccattct ctcacgcaag gatggggctg
     1621 cagggtgagc agcgtgggct gcagtgtgtc agtcccagga gtgagggagt ggcaagcacc
     1681 acagattacc acgtatgtgt ggaagacatt cgtactctta tctttactat aaataaattc
     1741 ataaaagtta acaaaggggt acacagtatg gtctttggaa atataataaa acatcaacta
     1801 acttggacta attgtgagga agagcagaac aaattagtag aaagaggtta taagacaatt
     1861 gagttagctt catgtgtatt attgcagctt gatcatttat ataaatattt gtctagtaca
     1921 atgcttgaca tacagcattg tgttatgccc attggggaca cagaggtgaa caagacaagg
     1981 aatgccatca gggaattcac cttttattag gaaaatataa aatatgtatg tatgtgcaga
     2041 taatttgctt gaactaaact gactagttct gctaaataag attttaaact aattcatatg
     2101 taaaaagtga ttaggaagaa cttgaagtat catttgatgc ttaataacta ttgagtagtt
     2161 tttttttttt ttttttggtg gggggagcgg gggacagggt cttactctgt cactcaggcc
     2221 agagtacaat agtatgatct cggctcactg caacttctgc ctcccagttt caagggattc
     2281 tcgtgcctca gcctcccagg tagctggtac tacaggcacg gaccaccacg cctggctaat
     2341 ttttgtattt tttctaggga cagggtttta ccacgttgcc caggctggtc ttgaactttt
     2401 gagctcgagt gatccaccca cctcagcctc ccaaaatgct gggattacag atgtgagcca
     2461 ccgtgcttgg ccataactat tgaatgcttt ctatgtggag agtgcttgtc ttaattttct
     2521 gttgctataa tagaataaca cagactgggt aatttataaa gaaaagagat ttatttggat
     2581 catggttctg gaggctggga ggtccaagag catggtacca gcatctgctt ggcatctggt
     2641 gacagctttc ttgctgcatc attacatggt ggaagggcaa gagaatgcga gtgagagcaa
     2701 gagggcaaaa tgattatcct tttatcagga gcccacttct gacataacta acccacacct
     2761 gagataacgg cattaatcca ttcatgaggt ctctgctctt aaaggagatc acctcttaaa
     2821 ggacccacct ttcaatgcca ttacactggc aatttaattt caagatgagt tttggagggg
     2881 acattcaaac catagcagtg ctataatttt aaagtacttc aaagccaatt tattctctta
     2941 attagcttca ttattcttgt ctttgtgtgt ggattaccta aactctcctt ccagagctac
     3001 tttaatgatt atattcaacc aaagcactct aaaatttaga gtataaattg tcttatattt
     3061 caaattagaa aagttcaaat gaagtttaat tgtgttattt tataaaacct tctaaaatta
     3121 ttaaatggag gatataatct ataa
//
