LOCUS       NM_152997                513 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens follicular dendritic cell secreted protein (FDCSP),
            mRNA.
ACCESSION   NM_152997
VERSION     NM_152997.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Iwai,Y., Noda,K., Yamazaki,M., Kato,A., Mezawa,M., Takai,H.,
            Nakayama,Y. and Ogata,Y.
  TITLE     Tumor necrosis factor-alpha regulates human follicular dendritic
            cell-secreted protein gene transcription in gingival epithelial
            cells
  JOURNAL   Genes Cells 23 (3), 161-171 (2018)
   PUBMED   29356241
  REMARK    GeneRIF: These studies show that TNF-alpha stimulates human FDC-SP
            gene transcription by targeting YY1, GATA, C/EBP2 and C/EBP3 in the
            FDC-SP gene promoter.
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Liu,J., Bian,H., Ding,R., Chi,X. and Wang,Y.
  TITLE     Follicular dendritic cell-secreted protein may enhance
            osteoclastogenesis in periodontal disease
  JOURNAL   Connect Tissue Res 57 (1), 38-43 (2016)
   PUBMED   26577469
  REMARK    GeneRIF: LPS-induced upregulation of FDC-SP expression in human
            periodontal ligament cells may enhance osteoclastogenesis in
            periodontal disease.
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Meng,H.X., Li,H.N., Geng,J.S., Ohe,R., Yu,X.Y., E,X.Q., Ye,F.,
            Yang,S.R., Kato,T., Zhang,L., Ishida,A., Ohta,N., Jin,X.M.,
            Kakehata,S., Geng,J.S. and Yamakawa,M.
  TITLE     Decreased expression of follicular dendritic cell-secreted protein
            correlates with increased immunoglobulin A production in the
            tonsils of individuals with immunoglobulin A nephropathy
  JOURNAL   Transl Res 166 (3), 281-291 (2015)
   PUBMED   25953661
  REMARK    GeneRIF: FDC-SP may be involved in IgA production in the tonsils of
            Immunoglobulin A nephropathy patients.
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Xiang,L., Ma,L., He,Y., Wei,N. and Gong,P.
  TITLE     Transfection with follicular dendritic cell secreted protein to
            affect phenotype expression of human periodontal ligament cells
  JOURNAL   J Cell Biochem 115 (5), 940-948 (2014)
   PUBMED   24357406
  REMARK    GeneRIF: Our findings demonstrate that transfection with FDC-SP has
            negligible adverse effect on proliferation of hPDLCs and imply the
            biological function of FDC-SP as a fibroblastic phenotype
            stabilizer
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Wang,C., Zhou,L., Li,S., Wei,J., Wang,W., Zhou,T., Liao,S.,
            Weng,D., Deng,D., Weng,Y., Wang,S. and Ma,D.
  TITLE     C4orf7 contributes to ovarian cancer metastasis by promoting cancer
            cell migration and invasion
  JOURNAL   Oncol Rep 24 (4), 933-939 (2010)
   PUBMED   20811673
  REMARK    GeneRIF: The role of C4orf7 in ovarian cancer cell morphology,
            motility and invasion was demonstrated.
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Al-Alwan,M., Du,Q., Hou,S., Nashed,B., Fan,Y., Yang,X. and
            Marshall,A.J.
  TITLE     Follicular dendritic cell secreted protein (FDC-SP) regulates
            germinal center and antibody responses
  JOURNAL   J Immunol 178 (12), 7859-7867 (2007)
   PUBMED   17548624
  REMARK    GeneRIF: These results provide the first evidence for
            immunomodulatory activities of FDC-SP and implicate this molecule
            as a regulator of B cell responses.
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Nakamura,S., Terashima,T., Yoshida,T., Iseki,S., Takano,Y.,
            Ishikawa,I. and Shinomura,T.
  TITLE     Identification of genes preferentially expressed in periodontal
            ligament: specific expression of a novel secreted protein, FDC-SP
  JOURNAL   Biochem Biophys Res Commun 338 (2), 1197-1203 (2005)
   PUBMED   16259954
  REMARK    GeneRIF: Since only normal tissue was examined, these findings
            suggest that FDC-SP plays an important but previously unsuspected
            role within oral connective tissue.
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Marshall,A.J., Du,Q., Draves,K.E., Shikishima,Y., HayGlass,K.T. and
            Clark,E.A.
  TITLE     FDC-SP, a novel secreted protein expressed by follicular dendritic
            cells
  JOURNAL   J Immunol 169 (5), 2381-2389 (2002)
   PUBMED   12193705
  REMARK    GeneRIF: FDC-SP has a very restricted tissue distribution,
            expressed by activated FDCs from tonsils and TNF-alpha-activated
            FDC-like cell lines, but not by B cell lines, primary germinal
            center B cells, or anti-CD40 plus IL-4-activated B cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY190326.1.
            
            On May 17, 2019 this sequence version replaced NM_152997.3.
            
            Summary: This gene encodes a small secreted protein that is
            expressed in follicular dendritic cells. This protein specifically
            binds to activated B cells, and functions as a regulator of
            antibody responses. It is also thought to contribute to tumor
            metastases by promoting cancer cell migration and invasion.
            [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY190326.1, AF086120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317987.6/ ENSP00000318437.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AY190326.1         54-566
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..513
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /note="follicular dendritic cell secreted protein"
                     /db_xref="GeneID:260436"
                     /db_xref="HGNC:HGNC:19215"
                     /db_xref="MIM:607241"
     exon            1..59
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..317
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /note="follicular dendritic cell secreted peptide; FDC
                     secreted protein"
                     /codon_start=1
                     /product="follicular dendritic cell secreted peptide
                     precursor"
                     /protein_id="NP_694542.1"
                     /db_xref="CCDS:CCDS3537.1"
                     /db_xref="GeneID:260436"
                     /db_xref="HGNC:HGNC:19215"
                     /db_xref="MIM:607241"
                     /translation="MKKVLLLITAILAVAVGFPVSQDQEREKRSISDSDELASGFFVF
                     PYPYPFRPLPPIPFPRFPWFRRNFPIPIPESAPTTPLPSEK"
     exon            60..116
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            117..149
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            150..345
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            346..513
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      470..475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /note="hexamer: AATAAA"
     polyA_site      487
                     /gene="FDCSP"
                     /gene_synonym="C4orf7; FDC-SP"
                     /note="major polyA site"
ORIGIN      
        1 agtcacttgc catttctcat aacagcgtca gagagaaaga actgactgaa acgtttgaga
       61 tgaagaaagt tctcctcctg atcacagcca tcttggcagt ggctgttggt ttcccagtct
      121 ctcaagacca ggaacgagaa aaaagaagta tcagtgacag cgatgaatta gcttcagggt
      181 tttttgtgtt cccttaccca tatccatttc gcccacttcc accaattcca tttccaagat
      241 ttccatggtt tagacgtaat tttcctattc caatacctga atctgcccct acaactcccc
      301 ttcctagcga aaagtaaaca agaaggaaaa gtcacgataa acctggtcac ctgaaattga
      361 aattgagcca cttccttgaa gaatcaaaat tcctgttaat aaaagaaaaa caaatgtaat
      421 tgaaatagca cacagcattc tctagtcaat atctttagtg atcttcttta ataaacttga
      481 aagcaaagat tttggtttct taatttccac aaa
//
