LOCUS       NM_001002901            1996 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc receptor like B (FCRLB), transcript variant 1,
            mRNA.
ACCESSION   NM_001002901 XM_005244894
VERSION     NM_001002901.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Zhou,X.J., Cheng,F.J., Qi,Y.Y., Zhao,Y.F., Hou,P., Zhu,L., Lv,J.C.
            and Zhang,H.
  TITLE     FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy
  JOURNAL   PLoS One 8 (4), e61208 (2013)
   PUBMED   23593433
  REMARK    GeneRIF: The aim of the study was to associate multiple
            polymorphisms within FCGR gene locus with IgA nephropathy in a
            large Chinese cohort.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Masuda,K., Davis,R.S., Maruyama,T., Zhang,J., He,T., Cooper,M.D.,
            O-Wang,J. and Burrows,P.D.
  TITLE     FcRY, an Fc receptor related gene differentially expressed during B
            lymphocyte development and activation
  JOURNAL   Gene 363, 32-40 (2005)
   PUBMED   16263223
  REMARK    GeneRIF: Fcry is upregulated by short-term treatment with
            BAFF/BLyS, which promotes B cell survival rather than proliferation
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Wilson,T.J. and Colonna,M.
  TITLE     A new Fc receptor homolog, FREB2, found in germinal center B cells
  JOURNAL   Genes Immun 6 (4), 341-346 (2005)
   PUBMED   15815692
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Chikaev,N.A., Bykova,E.A., Najakshin,A.M., Mechetina,L.V.,
            Volkova,O.Y., Peklo,M.M., Shevelev,A.Y., Vlasik,T.N., Roesch,A.,
            Vogt,T. and Taranin,A.V.
  TITLE     Cloning and characterization of the human FCRL2 gene
  JOURNAL   Genomics 85 (2), 264-272 (2005)
   PUBMED   15676285
  REMARK    GeneRIF: Expression analysis revealed FCRL2 mRNA only in
            placenta.FCRL2 is differentially expressed by transformed B cell
            lines.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359541.11.
            
            On Jun 29, 2021 this sequence version replaced NM_001002901.3.
            
            Summary: FCRL2 belongs to the Fc receptor family. Fc receptors are
            involved in phagocytosis, antibody-dependent cell cytotoxicity,
            immediate hypersensitivity, and transcytosis of immunoglobulins via
            their ability to bind immunoglobulin (Ig) constant regions (Chikaev
            et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ021957.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367948.7/ ENSP00000356925.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL359541.11        70503-70620         c
            119-214             AL359541.11        70314-70409         c
            215-265             AL359541.11        69461-69511         c
            266-286             AL359541.11        69155-69175         c
            287-541             AL359541.11        68543-68797         c
            542-808             AL359541.11        66077-66343         c
            809-1099            AL359541.11        65171-65461         c
            1100-1996           AL359541.11        64021-64917         c
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1996
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /note="Fc receptor like B"
                     /db_xref="GeneID:127943"
                     /db_xref="HGNC:HGNC:26431"
                     /db_xref="MIM:609251"
     exon            1..118
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..214
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..265
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1515
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fc receptor-like protein 2; fc receptor-related
                     protein Y; fc receptor-like and mucin-like protein 2; fc
                     receptor homolog expressed in B cells protein 2"
                     /codon_start=1
                     /product="Fc receptor-like B isoform 1 precursor"
                     /protein_id="NP_001002901.1"
                     /db_xref="CCDS:CCDS30927.1"
                     /db_xref="GeneID:127943"
                     /db_xref="HGNC:HGNC:26431"
                     /db_xref="MIM:609251"
                     /translation="MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKC
                     DGYHPLLLELQPISTLWYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSN
                     DWLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARA
                     SDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLR
                     CDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSV
                     RKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNT
                     TSTGLQFPASGAPTAGPPACAPPTPLEQSAGALKPDVDLLLREMQLLKGLLSRVVLEL
                     KEPQALRELRGTPETPTSHFAVSPGTPETTPVES"
     exon            266..286
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..541
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..808
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1099
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1996
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="FCRLB"
                     /gene_synonym="FCRL2; FCRLM2; FCRLY; FcRY; FREB-2; FREB2"
                     /note="major polyA site"
ORIGIN      
        1 caggcatcag caagagggga agatactatc ttcctgggag ttgacagtac ctgataattg
       61 atctccttcc catcagattt ccaagggatc aaggtgcccc ggttctaaac aaccacaggt
      121 acggtcacat ggctcagaaa gcacaagaag tagagccccg aggtcagatc tgagaggctt
      181 ctgaggggcc gatgcagtga cttctctgct gcagctgctg cagtcagatc catcatgtgg
      241 ccactgacag cccttctgct cctggttcca agcagtgggc aagctgctac tctggagaag
      301 cccatattgt ctctacatcc accttggacc accatcttca aaggggagcg ggtaactttg
      361 aagtgtgatg gataccaccc actgctcctg gagctccagc ccatcagcac tctctggtat
      421 ttgggccacc tacttctgcc ctctcacaag aagagcattg aggtgcagac accaggggtg
      481 tatcgatgcc agacacgggg agcacccgtc agtgacccca tccacctctc tgtatccaat
      541 gattggctga ttctgcaagt gccctatgcg ccagtgttcg agggtgagcc gctagtcctg
      601 cgctgccgcg gctggtacga caaggtggtc tacaagcttc actactacca cgacggccag
      661 gccgtgcgct acttccactc cagcgccaac tacactgtgt tacaggcgcg tgccagcgac
      721 agcgggcgct accagtgctc gggcaccatg cgcatcccgg tggagagcgc gcccatgttc
      781 tccgctaagg tggctgtgac agtgcaagag ctgttccggg cgccggtgct gagggtgatg
      841 ggtccgcggg aggcccgcgg cgcggcgctg ggtggggtgg tgctgcgctg cgacacgcgc
      901 ctgcacccgc agaagcgcga cacgccgctg cagttcgcgt tttacaagta cagccgcgcg
      961 gtgcgccgct tcgactgggg cgccgagtac acagtcccgg agcccgaggt cgaggagctc
     1021 gaatcgtact ggtgcgaggc ggctaccgcc acccgcagtg tccggaaacg cagtccgtgg
     1081 ctgcagctcc cggggccggg ttctcccctg gacccggcct ccaccaccgc cccagctcca
     1141 tgggccgcag ccttggctcc tggtaatagg ccgctttcct tcagaaagcc cccggtgtcc
     1201 agatcggtcc cgttggtcac ctccgtccgg aacaccacct ccaccgggct gcagttcccg
     1261 gcgagcggcg ccccgactgc ggggccaccc gcctgcgctc cgccgacgcc cttggaacaa
     1321 tcggctggag ccctgaaacc cgacgtggac cttctgctcc gagaaatgca gctgctcaaa
     1381 ggccttctga gccgggtggt cctggaatta aaggagccac aggccctccg ggagctcagg
     1441 ggaacgcccg agacccccac ctctcacttt gctgtgagcc cgggaacccc agagaccact
     1501 cctgtggaga gctgaggggg cggctaccgt cccctctgca ggctcattcc tccttggtct
     1561 cctgcttccc ctcacgcgaa tttctttcaa agccatctgt ttgcatcctt gtgttttgct
     1621 gtggttttta aaggagcgcc cacgaagtgt agtggctgac gatttcaacc tcacacagca
     1681 gtttgtaacc gcaagcattc tctttgaatt ctcacagaat tcagcaagaa gtagaaacct
     1741 gttatttact acattgtgat ttaactttgg atgtgaattt agtcaccctt agcccttcag
     1801 ataagcctag ccagtacata tttcagcaca ggcagttttt ttggtattta agtacattga
     1861 ggtaactgag cacttgagaa tattttaggg tcaaagtgta attattcata atgaatttac
     1921 tctgttgata ttaaaaagac gttcagtcct attactgatg agtttacatc ttcaaataaa
     1981 tcctgggttc tattta
//
