LOCUS       NM_032738               2088 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens Fc receptor like A (FCRLA), transcript variant 2,
            mRNA.
ACCESSION   NM_032738
VERSION     NM_032738.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Liu,J.P., Jiang,Y.F., Liu,J.W., Tian,C.J., Lin,Y.Z., Yang,Y.Z.,
            Zhang,Z.K., Fang,Y.L., Huang,B. and Lin,H.
  TITLE     Fc receptor-like A promotes malignant behavior in renal cell
            carcinoma and correlates with tumor immune infiltration
  JOURNAL   Cancer Med 13 (15), e70072 (2024)
   PUBMED   39108036
  REMARK    GeneRIF: Fc receptor-like A promotes malignant behavior in renal
            cell carcinoma and correlates with tumor immune infiltration.
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Liu,Y., Chen,Y., Hu,X., Meng,J. and Li,X.
  TITLE     Development and Validation of the B Cell-Associated Fc
            Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous
            Melanoma
  JOURNAL   Biomed Res Int 2020, 8509805 (2020)
   PUBMED   32908921
  REMARK    GeneRIF: Development and Validation of the B Cell-Associated Fc
            Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous
            Melanoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Santiago,T., Kulemzin,S.V., Reshetnikova,E.S., Chikaev,N.A.,
            Volkova,O.Y., Mechetina,L.V., Zhao,M., Davis,R.S., Taranin,A.V.,
            Najakshin,A.M., Hendershot,L.M. and Burrows,P.D.
  TITLE     FCRLA is a resident endoplasmic reticulum protein that associates
            with intracellular Igs, IgM, IgG and IgA
  JOURNAL   Int Immunol 23 (1), 43-53 (2011)
   PUBMED   21149418
  REMARK    GeneRIF: The studies reported here demonstrate that FCRLA is more
            broadly expressed among human B lineage cells than originally
            reported; it is found at significant levels in resting blood B
            cells and at varying levels in all B-cell subsets in tonsil.
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Wilson,T.J., Gilfillan,S. and Colonna,M.
  TITLE     Fc receptor-like A associates with intracellular IgG and IgM but is
            dispensable for antigen-specific immune responses
  JOURNAL   J Immunol 185 (5), 2960-2967 (2010)
   PUBMED   20668221
  REMARK    GeneRIF: Analysis of human cell lines has confirmed that FcRLA is
            not secreted but is maintained as an intracellular protein in B
            cells where it interacts with immunoglobulins.
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Wilson,T.J. and Colonna,M.
  TITLE     A new Fc receptor homolog, FREB2, found in germinal center B cells
  JOURNAL   Genes Immun 6 (4), 341-346 (2005)
   PUBMED   15815692
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Inozume,T., Matsuzaki,Y., Kurihara,S., Fujita,T., Yamamoto,A.,
            Aburatani,H., Shimada,S. and Kawakami,Y.
  TITLE     Novel melanoma antigen, FCRL/FREB, identified by cDNA profile
            comparison using DNA chip are immunogenic in multiple melanoma
            patients
  JOURNAL   Int J Cancer 114 (2), 283-290 (2005)
   PUBMED   15551350
  REMARK    GeneRIF: FCRL/FREB may function in melanocytes and melanoma and may
            be useful for development of diagnostic methods for various pigment
            disorders and immunotherapy of melanoma.
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Davis,R.S., Li,H., Chen,C.C., Wang,Y.H., Cooper,M.D. and
            Burrows,P.D.
  TITLE     Definition of an Fc receptor-related gene (FcRX) expressed in human
            and mouse B cells
  JOURNAL   Int Immunol 14 (9), 1075-1083 (2002)
   PUBMED   12202404
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Facchetti,F., Cella,M., Festa,S., Fremont,D.H. and Colonna,M.
  TITLE     An unusual Fc receptor-related protein expressed in human
            centroblasts
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3776-3781 (2002)
   PUBMED   11891275
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Mechetina,L.V., Najakshin,A.M., Volkova,O.Y., Guselnikov,S.V.,
            Faizulin,R.Z., Alabyev,B.Y., Chikaev,N.A., Vinogradova,M.S. and
            Taranin,A.V.
  TITLE     FCRL, a novel member of the leukocyte Fc receptor family possesses
            unique structural features
  JOURNAL   Eur J Immunol 32 (1), 87-96 (2002)
   PUBMED   11754007
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359541.11.
            
            On May 22, 2019 this sequence version replaced NM_032738.3.
            
            Summary: This gene encodes a protein similar to receptors for the
            Fc fragment of gamma immunoglobulin (IgG). These receptors,
            referred to as FCGRs, mediate the destruction of IgG-coated
            antigens and of cells induced by antibodies. This encoded protein
            is selectively expressed in B cells, and may be involved in their
            development. This protein may also be involved in the development
            of lymphomas. Multiple alternatively spliced transcript variants
            that encode different protein isoforms have been described for this
            gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2) lacks an alternate, in-frame
            segment, compared to variant 1. The resulting protein (isoform 2)
            is shorter when it is compared to isoform 1. This variant has also
            been called FCRLa.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF426461.1, SRR1803616.58256.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236938.12/ ENSP00000236938.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL359541.11        84821-84935         c
            116-268             AL359541.11        81252-81404         c
            269-535             AL359541.11        80690-80956         c
            536-820             AL359541.11        79946-80230         c
            821-2088            AL359541.11        77812-79079         c
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2088
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /note="Fc receptor like A"
                     /db_xref="GeneID:84824"
                     /db_xref="HGNC:HGNC:18504"
                     /db_xref="MIM:606891"
     exon            1..115
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1116
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Fc receptor-like and mucin-like 1; Fc receptor
                     related protein X; Fc receptor homolog expressed in B
                     cells (FREB); fc receptor-like protein; fc
                     receptor-related protein X; fc receptor homolog expressed
                     in B-cells; fc receptor-like and mucin-like protein 1"
                     /codon_start=1
                     /product="Fc receptor-like A isoform 2 precursor"
                     /protein_id="NP_116127.4"
                     /db_xref="CCDS:CCDS30926.2"
                     /db_xref="GeneID:84824"
                     /db_xref="HGNC:HGNC:18504"
                     /db_xref="MIM:606891"
                     /translation="MKLGCVLMAWALYLSLGVLWVAQMLLAASFETLQCEGPVCTEES
                     SCHTEDDLTDAREAGFQVKAYTFSEPFHLIVSYDWLILQGPAKPVFEGDLLVLRCQAW
                     QDWPLTQVTFYRDGSALGPPGPNREFSITVVQKADSGHYHCSGIFQSPGPGIPETASV
                     VAITVQELFPAPILRAVPSAEPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQS
                     RGLSSEFQIPTASEDHSGSYWCEAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAP
                     QKSAAPGTAPEEAPGPLPPPPTPSSEDPGFSSPLGMPDPHLYHQMGLLLKHMQDVRVL
                     LGHLLMELRELSGHRKPGTTKATAE"
     exon            116..268
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /inference="alignment:Splign:2.1.0"
     exon            269..535
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /inference="alignment:Splign:2.1.0"
     exon            536..820
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /inference="alignment:Splign:2.1.0"
     exon            821..2088
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /note="hexamer: AATAAA"
     polyA_site      2088
                     /gene="FCRLA"
                     /gene_synonym="FCRL; FCRL1; FCRLb; FCRLc1; FCRLc2; FCRLd;
                     FCRLe; FCRLM1; FCRLX; FCRX; FREB"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgggg ttgcaggaga cctaaacaca gtcaccatga agctgggctg tgtcctcatg
       61 gcctgggccc tctacctttc ccttggtgtg ctctgggtgg cccagatgct actggctgcc
      121 agttttgaga cgctgcagtg tgagggacct gtctgcactg aggagagcag ctgccacacg
      181 gaggatgact tgactgatgc aagggaagct ggcttccagg tcaaggccta cactttcagt
      241 gaacccttcc acctgattgt gtcctatgac tggctgatcc tccaaggtcc agccaagcca
      301 gtttttgaag gggacctgct ggttctgcgc tgccaggcct ggcaagactg gccactgact
      361 caggtgacct tctaccgaga tggctcagct ctgggtcccc ccgggcctaa cagggaattc
      421 tccatcaccg tggtacaaaa ggcagacagc gggcactacc actgcagtgg catcttccag
      481 agccctggtc ctgggatccc agaaacagca tctgttgtgg ctatcacagt ccaagaactg
      541 tttccagcgc caattctcag agctgtaccc tcagctgaac cccaagcagg aagccccatg
      601 accctgagtt gtcagacaaa gttgcccctg cagaggtcag ctgcccgcct cctcttctcc
      661 ttctacaagg atggaaggat agtgcaaagc agggggctct cctcagaatt ccagatcccc
      721 acagcttcag aagatcactc cgggtcatac tggtgtgagg cagccactga ggacaaccaa
      781 gtttggaaac agagccccca gctagagatc agagtgcagg gtgcttccag ctctgctgca
      841 cctcccacat tgaatccagc tcctcagaaa tcagctgctc caggaactgc tcctgaggag
      901 gcccctgggc ctctgcctcc gccgccaacc ccatcttctg aggatccagg cttttcttct
      961 cctctgggga tgccagatcc tcatctgtat caccagatgg gccttcttct caaacacatg
     1021 caggatgtga gagtcctcct cggtcacctg ctcatggagt tgagggaatt atctggccac
     1081 cggaagcctg ggaccacaaa ggctactgct gaatagaagt aaacagttca tccatgatct
     1141 cacttaacca ccccaataaa tctgattctt tattttctct tcctgtcctg cacatatgca
     1201 taagtacttt tacaagttgt cccagtgttt tgttagaata atgtagttag gtgagtgtaa
     1261 ataaatttat ataaagtgag aattagagtt tagctataat tgtgtattct ctcttaacac
     1321 aacagaattc tgctgtctag atcaggaatt tctatctgtt atatcgacca gaatgttgtg
     1381 atttaaagag aactaatgga agtggattga atacagcagt ctcaactggg ggcaattttg
     1441 ccccccagag gacattgggc aatgtttgga gacattttgg tcattatact tggggggttg
     1501 ggggatggtg ggatgtgtgt gctactggca tccagtaaat agaagccagg ggtgccgcta
     1561 aacatcctat aatgcacagg gcagtacccc acaacgaaaa ataatctggc ccaaaatgtc
     1621 agttgtactg agtttgagaa accccagcct aatgaaaccc taggtgttgg gctctggaat
     1681 gggactttgt cccttctaat tattatctct ttccagcctc attcagctat tcttactgac
     1741 ataccagtct ttagctggtg ctatggtctg ttctttagtt ctagtttgta tcccctcaaa
     1801 agccattatg ttgaaatcct aatccccaag gtgatggcat taagaagtgg gcctttggga
     1861 agtgattaga tcaggagtgc agagccctca tgattaggat tagtgccctt atttaaaaag
     1921 gccccagaga gctaactcac ccttccacca tatgaggacg tggcaagaag atgacatgta
     1981 tgagaaccaa aaaacagctg tcgccaaaca ccgactctgt cgttgccttg atcttgaact
     2041 tccagcctcc agaactatga gaaataaaat tctgttgttt gtaagcta
//
