LOCUS       NM_001004310            1966 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc receptor like 6 (FCRL6), transcript variant 1,
            mRNA.
ACCESSION   NM_001004310 XM_291569
VERSION     NM_001004310.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Reiner,A.P., Beleza,S., Franceschini,N., Auer,P.L., Robinson,J.G.,
            Kooperberg,C., Peters,U. and Tang,H.
  TITLE     Genome-wide association and population genetic analysis of
            C-reactive protein in African American and Hispanic American women
  JOURNAL   Am J Hum Genet 91 (3), 502-512 (2012)
   PUBMED   22939635
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Kulemzin,S.V., Zamoshnikova,A.Y., Yurchenko,M.Y., Vitak,N.Y.,
            Najakshin,A.M., Fayngerts,S.A., Chikaev,N.A., Reshetnikova,E.S.,
            Kashirina,N.M., Peclo,M.M., Rutkevich,P.N., Shevelev,A.Y.,
            Yanushevskaya,E.V., Baranov,K.O., Mamonkin,M., Vlasik,T.N.,
            Sidorenko,S.P., Taranin,A.V. and Mechetina,L.V.
  TITLE     FCRL6 receptor: expression and associated proteins
  JOURNAL   Immunol Lett 134 (2), 174-182 (2011)
   PUBMED   20933011
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Schreeder,D.M., Cannon,J.P., Wu,J., Li,R., Shakhmatov,M.A. and
            Davis,R.S.
  TITLE     Cutting edge: FcR-like 6 is an MHC class II receptor
  JOURNAL   J Immunol 185 (1), 23-27 (2010)
   PUBMED   20519654
  REMARK    GeneRIF: Human FCRL6 receptor, selectively expressed by cytotoxic T
            and natural killer (NK) cells, directly binds the major
            histocompatibility complex (MHC) class II molecule HLA-DR.
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Schreeder,D.M., Pan,J., Li,F.J., Vivier,E. and Davis,R.S.
  TITLE     FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated
            in patients with B-cell chronic lymphocytic leukemia
  JOURNAL   Eur J Immunol 38 (11), 3159-3166 (2008)
   PUBMED   18991291
  REMARK    GeneRIF: FCRL6 is a distinct indicator of cytotoxic effector
            lymphocytes that is upregulated in diseases characterized by
            chronic immune stimulation.
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Wilson,T.J., Presti,R.M., Tassi,I., Overton,E.T., Cella,M. and
            Colonna,M.
  TITLE     FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly
            expressed by lymphocytes following HIV-1 infection
  JOURNAL   Blood 109 (9), 3786-3793 (2007)
   PUBMED   17213291
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590560.9, DA959587.1, AY513661.1, AK131201.1 and AI631310.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001004310.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY654628.1, AY513661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368106.4/ ENSP00000357086.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL590560.9         27332-27354
            24-65               DA959587.1         1-42
            66-1370             AY513661.1         1-1305
            1371-1688           AK131201.1         1408-1725
            1689-1689           AL590560.9         40952-40952
            1690-1960           AK131201.1         1727-1997
            1961-1966           AI631310.1         2-7                 c
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1966
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /note="Fc receptor like 6"
                     /db_xref="GeneID:343413"
                     /db_xref="HGNC:HGNC:31910"
                     /db_xref="MIM:613562"
     exon            1..96
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1370
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IFGP6; fc receptor-like protein 6; IgSF type I
                     transmembrane receptor; leukocyte receptor; Fc
                     receptor-like protein 7; fcR-like protein 6; fc receptor
                     homolog 6"
                     /codon_start=1
                     /product="Fc receptor-like protein 6 isoform 1 precursor"
                     /protein_id="NP_001004310.2"
                     /db_xref="CCDS:CCDS30912.1"
                     /db_xref="GeneID:343413"
                     /db_xref="HGNC:HGNC:31910"
                     /db_xref="MIM:613562"
                     /translation="MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKN
                     TPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAM
                     VQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRG
                     PHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADP
                     AVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSC
                     EAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWR
                     KAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGR
                     KDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC"
     exon            97..117
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            118..384
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            385..669
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            670..951
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1074
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1140
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1212
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1244
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1966
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /note="hexamer: AATAAA"
     polyA_site      1966
                     /gene="FCRL6"
                     /gene_synonym="FcRH6"
                     /note="major polyA site"
ORIGIN      
        1 ctctgccggc ttcgccctga cctgtttctg acctgtgttc cctccgctgt gccagaacag
       61 gccccatgct gctctggacg gctgtgctgc tctttgttcc ctgtgttggg aaaactgtct
      121 ggctgtacct ccaagcctgg ccaaaccctg tgtttgaagg agatgccctg actctgcgat
      181 gtcagggatg gaagaataca ccactgtctc aggtgaagtt ctacagagat ggaaaattcc
      241 ttcatttctc taaggaaaac cagactctgt ccatgggagc agcaacagtg cagagccgtg
      301 gccagtacag ctgctctggg caggtgatgt atattccaca gacattcaca caaacttcag
      361 agactgccat ggttcaagtc caagagctgt ttccacctcc tgtgctgagt gccatcccct
      421 ctcctgagcc ccgagagggt agcctggtga ccctgagatg tcagacaaag ctgcaccccc
      481 tgaggtcagc cttgaggctc cttttctcct tccacaagga cggccacacc ttgcaggaca
      541 ggggccctca cccagaactc tgcatcccgg gagccaagga gggagactct gggctttact
      601 ggtgtgaggt ggcccctgag ggtggccagg tccagaagca gagcccccag ctggaggtca
      661 gagtgcaggc tcctgtatcc cgtcctgtgc tcactctgca ccacgggcct gctgaccctg
      721 ctgtggggga catggtgcag ctcctctgtg aggcacagag gggctcccct ccgatcctgt
      781 attccttcta ccttgatgag aagattgtgg ggaaccactc agctccctgt ggtggaacca
      841 cctccctcct cttcccagtg aagtcagaac aggatgctgg gaactactcc tgcgaggctg
      901 agaacagtgt ctccagagag aggagtgagc ccaagaagct gtctctgaag ggttctcaag
      961 tcttgttcac tcccgccagc aactggctgg ttccttggct tcctgcgagc ctgcttggcc
     1021 tgatggttat tgctgctgca cttctggttt atgtgagatc ctggagaaaa gctgggcccc
     1081 ttccatccca gataccaccc acagctccag gtggagagca gtgcccacta tatgccaacg
     1141 tgcatcacca gaaagggaaa gatgaaggtg ttgtctactc tgtggtgcat agaacctcaa
     1201 agaggagtga agccaggtct gctgagttca ccgtggggag aaaggacagt tctatcatct
     1261 gtgcggaggt gagatgcctg cagcccagtg aggtttcatc cacggaggtg aatatgagaa
     1321 gcaggactct ccaagaaccc cttagcgact gtgaggaggt tctctgctag tgatggtgtt
     1381 ctcctatcaa cacacgccca cccccagtct ccagtgctcc tcaggaagac agtggggtcc
     1441 tcaactcttt ctgtgggtcc ttcagttccc aagcccagca tcacagagcc ccctgagccc
     1501 ttgtcctggt caggagcacc tgaaccctgg gttcttttct tagcagaaga ccaaccaatg
     1561 gaatgggaag ggagatgctc ccaccaacac acacacttag gttcaatcag tgacactgga
     1621 cacataagcc acagatgtct tctttccata caagcatgtt agttcgcccc aatatacata
     1681 tatatatgaa atagtcatgt gccgcataac aacatttcag tcagtgatag actgcataca
     1741 caacagtggt cccataagac tgtaatggag tttaaaaatt cctactgcct agtgatatca
     1801 tagttgcctt aacatcataa cacaacacat ttctcacgcg tttgtggtga tgctggtaca
     1861 aacaagctac agcgccgcta gtcatataca aatatagcac atacaattat gtacagtaca
     1921 ctatacttga taatgataat aaacaactat gttactggtt tatgta
//
