LOCUS       NM_031282               3466 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc receptor like 4 (FCRL4), mRNA.
ACCESSION   NM_031282
VERSION     NM_031282.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3466)
  AUTHORS   Carlsen,E.D., Bhavsar,S., Cook,J.R. and Swerdlow,S.H.
  TITLE     IRTA1 positivity helps identify a MALT-lymphoma-like subset of
            primary cutaneous marginal zone lymphomas, largely but not
            exclusively defined by IgM expression
  JOURNAL   J Cutan Pathol 49 (1), 55-60 (2022)
   PUBMED   34309899
  REMARK    GeneRIF: IRTA1 positivity helps identify a MALT-lymphoma-like
            subset of primary cutaneous marginal zone lymphomas, largely but
            not exclusively defined by IgM expression.
REFERENCE   2  (bases 1 to 3466)
  AUTHORS   Du,W., Han,M., Zhu,X., Xiao,F., Huang,E., Che,N., Tang,X., Zou,H.,
            Jiang,Q. and Lu,L.
  TITLE     The Multiple Roles of B Cells in the Pathogenesis of Sjogren's
            Syndrome
  JOURNAL   Front Immunol 12, 684999 (2021)
   PUBMED   34168653
  REMARK    GeneRIF: The Multiple Roles of B Cells in the Pathogenesis of
            Sjogren's Syndrome.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3466)
  AUTHORS   Li,H., Dement-Brown,J., Liao,P.J., Mazo,I., Mills,F., Kraus,Z.,
            Fitzsimmons,S. and Tolnay,M.
  TITLE     Fc receptor-like 4 and 5 define human atypical memory B cells
  JOURNAL   Int Immunol 32 (12), 755-770 (2020)
   PUBMED   32805738
  REMARK    GeneRIF: Fc receptor-like 4 and 5 define human atypical memory B
            cells.
REFERENCE   4  (bases 1 to 3466)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3466)
  AUTHORS   Falini,B., Tiacci,E., Pucciarini,A., Bigerna,B., Kurth,J.,
            Hatzivassiliou,G., Droetto,S., Galletti,B.V., Gambacorta,M.,
            Orazi,A., Pasqualucci,L., Miller,I., Kuppers,R., Dalla-Favera,R.
            and Cattoretti,G.
  TITLE     Expression of the IRTA1 receptor identifies intraepithelial and
            subepithelial marginal zone B cells of the mucosa-associated
            lymphoid tissue (MALT)
  JOURNAL   Blood 102 (10), 3684-3692 (2003)
   PUBMED   12881317
  REMARK    GeneRIF: role of IRTA1 in the immune function of B cells within
            epithelia
REFERENCE   6  (bases 1 to 3466)
  AUTHORS   Lestou,V.S., Ludkovski,O., Connors,J.M., Gascoyne,R.D., Lam,W.L.
            and Horsman,D.E.
  TITLE     Characterization of the recurrent translocation
            t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding
            and fluorescence in situ hybridization analysis
  JOURNAL   Genes Chromosomes Cancer 36 (4), 375-381 (2003)
   PUBMED   12619161
REFERENCE   7  (bases 1 to 3466)
  AUTHORS   Guselnikov,S.V., Ershova,S.A., Mechetina,L.V., Najakshin,A.M.,
            Volkova,O.Y., Alabyev,B.Y. and Taranin,A.V.
  TITLE     A family of highly diverse human and mouse genes structurally links
            leukocyte FcR, gp42 and PECAM-1
  JOURNAL   Immunogenetics 54 (2), 87-95 (2002)
   PUBMED   12037601
REFERENCE   8  (bases 1 to 3466)
  AUTHORS   Miller,I., Hatzivassiliou,G., Cattoretti,G., Mendelsohn,C. and
            Dalla-Favera,R.
  TITLE     IRTAs: a new family of immunoglobulinlike receptors differentially
            expressed in B cells
  JOURNAL   Blood 99 (8), 2662-2669 (2002)
   PUBMED   11929751
  REMARK    GeneRIF: Characterization and comparison of the structure and
            B-cell expression pattern of the entire family of IRTA genes, which
            includes 5 members contiguously located on chromosome.
REFERENCE   9  (bases 1 to 3466)
  AUTHORS   Davis,R.S., Wang,Y.H., Kubagawa,H. and Cooper,M.D.
  TITLE     Identification of a family of Fc receptor homologs with
            preferential B cell expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9772-9777 (2001)
   PUBMED   11493702
REFERENCE   10 (bases 1 to 3466)
  AUTHORS   Hatzivassiliou,G., Miller,I., Takizawa,J., Palanisamy,N., Rao,P.H.,
            Iida,S., Tagawa,S., Taniwaki,M., Russo,J., Neri,A., Cattoretti,G.,
            Clynes,R., Mendelsohn,C., Chaganti,R.S. and Dalla-Favera,R.
  TITLE     IRTA1 and IRTA2, novel immunoglobulin superfamily receptors
            expressed in B cells and involved in chromosome 1q21 abnormalities
            in B cell malignancy
  JOURNAL   Immunity 14 (3), 277-289 (2001)
   PUBMED   11290337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135929.5, AF343659.1 and
            AF343661.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031282.2.
            
            Summary: This gene encodes a member of the immunoglobulin receptor
            superfamily and is one of several Fc receptor-like glycoproteins
            clustered on the long arm of chromosome 1. The encoded protein has
            four extracellular C2-type immunoglobulin domains, a transmembrane
            domain and a cytoplasmic domain that contains three immune-receptor
            tyrosine-based inhibitory motifs. This protein may play a role in
            the function of memory B-cells in the epithelia. Aberrations in the
            chromosomal region encoding this gene are associated with
            non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF343661.1, AF343660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271532.2/ ENSP00000271532.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL135929.5         47950-47954
            6-124               AF343659.1         1-119
            125-125             AL135929.5         48074-48074
            126-656             AF343659.1         121-651
            657-657             AL135929.5         58124-58124
            658-1706            AF343659.1         653-1701
            1707-1956           AL135929.5         70529-70778
            1957-3464           AF343661.1         1952-3459
            3465-3466           AL135929.5         72287-72288
FEATURES             Location/Qualifiers
     source          1..3466
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..3466
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="Fc receptor like 4"
                     /db_xref="GeneID:83417"
                     /db_xref="HGNC:HGNC:18507"
                     /db_xref="MIM:605876"
     exon            1..172
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1689
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="immunoglobulin superfamily receptor translocation
                     associated 1; immunoglobulin superfamily Fc receptor,
                     gp42; fc receptor-like protein 4; hIFGP2; fcR-like protein
                     4; IFGP family protein 2; fc receptor homolog 4; immune
                     receptor translocation-associated protein 1"
                     /codon_start=1
                     /product="Fc receptor-like protein 4 precursor"
                     /protein_id="NP_112572.1"
                     /db_xref="CCDS:CCDS1166.1"
                     /db_xref="GeneID:83417"
                     /db_xref="HGNC:HGNC:18507"
                     /db_xref="MIM:605876"
                     /translation="MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTC
                     NGFQFYATEKTTWYHRHYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSS
                     DSLILQAPYSVFEGDTLVLRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSN
                     NNGNYRCIGYGDENDVFRSNFKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPP
                     ERSDTPLHFNFFRDGEVILSDWSTYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPS
                     LQIHVQRIPVSGVLLETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGR
                     KTQRSLRAELELPAIRQSHAGGYYCTADNSYGPVQSMVLNVTVRETPGNRDGLVAAGA
                     TGGLLSALLLAVALLFHCWRRRKSGVGFLGDETRLPPAPGPGESSHSICPAQVELQSL
                     YVDVHPKKGDLVYSEIQTTQLGEEEEANTSRTLLEDKDVSVVYSEVKTQHPDNSAGKI
                     SSKDEES"
     exon            173..193
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..448
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..703
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..988
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1276
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1390
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1418
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1501
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1570
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1602
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3466
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="major polyA site"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="hexamer: AATAAA"
     polyA_site      3326
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
     regulatory      3446..3451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
                     /note="hexamer: ATTAAA"
     polyA_site      3466
                     /gene="FCRL4"
                     /gene_synonym="CD307d; FCRH4; IGFP2; IRTA1"
ORIGIN      
        1 attatctcaa tcagctttat gcagagaaga agcttactga gctcactgct ggtgctggtg
       61 taggcaagtg ctgctttggc aatctgggct gacctggctt gtctcctcag aactccttct
      121 ccaatcctgg agcaggcttc catgctgctg tgggcgtcct tgctggcctt tgctccagtc
      181 tgtggacaat ctgcagctgc acacaaacct gtgatttccg tccatcctcc atggaccaca
      241 ttcttcaaag gagagagagt gactctgact tgcaatggat ttcagttcta tgcaacagag
      301 aaaacaacat ggtatcatcg gcactactgg ggagaaaagt tgaccctgac cccaggaaac
      361 accctcgagg ttcgggaatc tggactgtac agatgccagg cccggggctc cccacgaagt
      421 aaccctgtgc gcttgctctt ttcttcagac tccttaatcc tgcaggcacc atattctgtg
      481 tttgaaggtg acacattggt tctgagatgc cacagaagaa ggaaagagaa attgactgct
      541 gtgaaatata cttggaatgg aaacattctt tccatttcta ataaaagctg ggatcttctt
      601 atcccacaag caagttcaaa taacaatggc aattatcgat gcattggata tggagacgag
      661 aatgatgtat ttagatcaaa tttcaaaata attaaaattc aagaactatt tccacatcca
      721 gagctgaaag ctacagactc tcagcctaca gaggggaatt ctgtaaacct gagctgtgaa
      781 acacagcttc ctccagagcg gtcagacacc ccacttcact tcaacttctt cagagatggc
      841 gaggtcatcc tgtcagactg gagcacgtac ccggaactcc agctcccaac cgtctggaga
      901 gaaaactcag gatcctattg gtgtggtgct gaaacagtga ggggtaacat ccacaagcac
      961 agtccctcgc tacagatcca tgtgcagcgg atccctgtgt ctggggtgct cctggagacc
     1021 cagccctcag ggggccaggc tgttgaaggg gagatgctgg tccttgtctg ctccgtggct
     1081 gaaggcacag gggataccac attctcctgg caccgagagg acatgcagga gagtctgggg
     1141 aggaaaactc agcgttccct gagagcagag ctggagctcc ctgccatcag acagagccat
     1201 gcagggggat actactgtac agcagacaac agctacggcc ctgtccagag catggtgctg
     1261 aatgtcactg tgagagagac cccaggcaac agagatggcc ttgtcgccgc gggagccact
     1321 ggagggctgc tcagtgctct tctcctggct gtggccctgc tgtttcactg ctggcgtcgg
     1381 aggaagtcag gagttggttt cttgggagac gaaaccaggc tccctcccgc tccaggccca
     1441 ggagagtcct cccattccat ctgccctgcc caggtggagc ttcagtcgtt gtatgttgat
     1501 gtacacccca aaaagggaga tttggtatac tctgagatcc agactactca gctgggagaa
     1561 gaagaggaag ctaatacctc caggacactt ctagaggata aggatgtctc agttgtctac
     1621 tctgaggtaa agacacaaca cccagataac tcagctggaa agatcagctc taaggatgaa
     1681 gaaagttaag agaatgaaaa gttacgagaa cgtcctactc atgtgatttc tcccttgtcc
     1741 aaagtcccag gcccagtgca gtccttgcgg cccctggaat gatcaactca ttccagcttt
     1801 ctaattcttc tcatgcatat gcattcactc ccaggaatac tcattcgtct actctgatgt
     1861 tgggatggaa tggcctctga aagacttcac taaaatgacc aggatccaca gttaagagaa
     1921 gaccctgtag tatttgctgt gggcctgacc taatgtattc cctagggtct gctttagaga
     1981 agggggataa agagagagaa ggactgttat gaaaaacaga agcacaaatt ttggtgaatt
     2041 gggatttgca gagatgaaaa agactgggtg acctggatct ctgcttaata catctacaac
     2101 cattgtctca ctggagactc acttgcatca gtttgtttaa ctgtgagtgg ctgcacaggc
     2161 actgtgcaaa caatgaaaag ccccttcact tctgcctgca cagcttacac tgtcaggatt
     2221 cagttgcaga ttaaagaacc catctggaat ggtttacaga gagaggaatt taaaagagga
     2281 catcagaaga gctggagatg caagctctag gctgcgcttc caaaagcaaa tgataattat
     2341 gttaatgtca ttagtgacaa agatttgcaa cattagagaa aagagacaca aatataaaat
     2401 taaaaactta agtaccaact ctccaaaact aaatttgaac ttaaaatatt agtataaact
     2461 cataataaac tctgccttta aaaaaagata aatatttcct acgtctgttc actgaaataa
     2521 ttaccaaccc cttagcaata agcactcctt gcagagaggt tttattctct aaataccatt
     2581 cccttctcaa aggaaataag gttgcttttc ttgtaggaac tgtgtctttg agttactaat
     2641 tagtttatat gagaataatt cttgcaataa atgaagaagg aataaaagaa ataggaagcc
     2701 acaaatttgt atggatattt catgatacac ctactggtta aataattgac aaaaaccagc
     2761 agccaaatat tagaggtctc ctgatggaag tgtacaatac cacctacaaa ttatccatgc
     2821 cccaagtgtt aaaactgaat ccattcaagt ctttctaact gaatacttgt tttatagaaa
     2881 atgcatggag aaaaggaatt tgtttaaata acattatggg attgcaacca gcaaaacata
     2941 aactgagaaa aagttctata gggcaaatca cctggcttct ataacaaata aatgggaaaa
     3001 aaatgaaata aaaagaagag agggaggaag aaagggagag agaagaaaag aaaaatgaag
     3061 aaaagtaatt agaatatttt caacataaag aaaagacgaa tatttaaggt gacagatatc
     3121 ccaactacgc tgatttgatc tttacaaatt atatgagtgt atgaatttgt cacatgtatc
     3181 acccccaaaa aaagagaaaa agaaaaatag aagacatata aattaaatga gacgagacat
     3241 gtcgaccaaa aggaatgtgt gggtcttgtt tggatcctga ctcaaattaa gaaaaaataa
     3301 aactacctac gaaatactaa gaaaaatttg tatactaata ttaagaaatt gttgtgtgtt
     3361 ttggatataa gtgatagttt attgtagtga tgtttttata aaagcaaaag gatattcact
     3421 ttcagcgctt atactgaagt attagattaa agcttattaa cgtaaa
//
