LOCUS       NM_052939               4638 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens Fc receptor like 3 (FCRL3), transcript variant 1,
            mRNA.
ACCESSION   NM_052939
VERSION     NM_052939.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Yu,K., Jiang,R., Li,Z., Ren,X., Jiang,H. and Zhao,Z.
  TITLE     Integrated analyses of single-cell transcriptome and Mendelian
            randomization reveal the protective role of FCRL3 in multiple
            sclerosis
  JOURNAL   Front Immunol 15, 1428962 (2024)
   PUBMED   39076991
  REMARK    GeneRIF: Integrated analyses of single-cell transcriptome and
            Mendelian randomization reveal the protective role of FCRL3 in
            multiple sclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Bahabayi,A., Zhang,Y.H., Yuan,Z., Wang,Y., Zhang,Z., Zeng,X.,
            Guan,Z., Wang,P. and Liu,C.
  TITLE     FCRL3 expression is upregulated and closely correlates with TIGIT
            expression in regulatory T cells of patients with systemic lupus
            erythematosus
  JOURNAL   Eur J Immunol 54 (5), e2350739 (2024)
   PUBMED   38461541
  REMARK    GeneRIF: FCRL3 expression is upregulated and closely correlates
            with TIGIT expression in regulatory T cells of patients with
            systemic lupus erythematosus.
REFERENCE   3  (bases 1 to 4638)
  AUTHORS   Bianchi,E., Jimenez-Movilla,M., Cots-Rodriguez,P., Viola,C. and
            Wright,G.J.
  TITLE     No evidence for a direct extracellular interaction between human Fc
            receptor-like 3 (MAIA) and the sperm ligand IZUMO1
  JOURNAL   Sci Adv 10 (8), eadk6352 (2024)
   PUBMED   38381819
  REMARK    GeneRIF: No evidence for a direct extracellular interaction between
            human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1.
REFERENCE   4  (bases 1 to 4638)
  AUTHORS   Balunathan,N., Rani,G. U, Perumal,V. and Kumarasamy,P.
  TITLE     Single nucleotide polymorphisms of Interleukin - 4, Interleukin-18,
            FCRL3 and sPLA2IIa genes and their association in pathogenesis of
            endometriosis
  JOURNAL   Mol Biol Rep 50 (5), 4239-4252 (2023)
   PUBMED   36905404
  REMARK    GeneRIF: Single nucleotide polymorphisms of Interleukin - 4,
            Interleukin-18, FCRL3 and sPLA2IIa genes and their association in
            pathogenesis of endometriosis.
REFERENCE   5  (bases 1 to 4638)
  AUTHORS   Zhong,Z., Shi,D., Xiao,M., Fu,D., Feng,S., Kong,Q., Li,J. and Li,Z.
  TITLE     Expression profile of Fc receptor-like molecules in patients with
            IgA nephropathy
  JOURNAL   Hum Immunol 82 (3), 186-192 (2021)
   PUBMED   33597097
  REMARK    GeneRIF: Expression profile of Fc receptor-like molecules in
            patients with IgA nephropathy.
REFERENCE   6  (bases 1 to 4638)
  AUTHORS   Kochi,Y., Yamada,R., Suzuki,A., Harley,J.B., Shirasawa,S.,
            Sawada,T., Bae,S.C., Tokuhiro,S., Chang,X., Sekine,A.,
            Takahashi,A., Tsunoda,T., Ohnishi,Y., Kaufman,K.M., Kang,C.P.,
            Kang,C., Otsubo,S., Yumura,W., Mimori,A., Koike,T., Nakamura,Y.,
            Sasazuki,T. and Yamamoto,K.
  TITLE     A functional variant in FCRL3, encoding Fc receptor-like 3, is
            associated with rheumatoid arthritis and several autoimmunities
  JOURNAL   Nat Genet 37 (5), 478-485 (2005)
   PUBMED   15838509
  REMARK    Erratum:[Nat Genet. 2005 Jun;37(6):652]
REFERENCE   7  (bases 1 to 4638)
  AUTHORS   Xu,M.J., Zhao,R., Cao,H. and Zhao,Z.J.
  TITLE     SPAP2, an Ig family receptor containing both ITIMs and ITAMs
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1037-1046 (2002)
   PUBMED   12051764
  REMARK    GeneRIF: molecular cloning and characterization of SPAP2
REFERENCE   8  (bases 1 to 4638)
  AUTHORS   Miller,I., Hatzivassiliou,G., Cattoretti,G., Mendelsohn,C. and
            Dalla-Favera,R.
  TITLE     IRTAs: a new family of immunoglobulinlike receptors differentially
            expressed in B cells
  JOURNAL   Blood 99 (8), 2662-2669 (2002)
   PUBMED   11929751
REFERENCE   9  (bases 1 to 4638)
  AUTHORS   Davis,R.S., Dennis,G. Jr., Kubagawa,H. and Cooper,M.D.
  TITLE     Fc receptor homologs (FcRH1-5) extend the Fc receptor family
  JOURNAL   Curr Top Microbiol Immunol 266, 85-112 (2002)
   PUBMED   12014205
  REMARK    Review article
REFERENCE   10 (bases 1 to 4638)
  AUTHORS   Davis,R.S., Wang,Y.H., Kubagawa,H. and Cooper,M.D.
  TITLE     Identification of a family of Fc receptor homologs with
            preferential B cell expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9772-9777 (2001)
   PUBMED   11493702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF459027.1, CD690165.1 and
            AL356276.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_052939.3.
            
            Summary: This gene encodes a member of the immunoglobulin receptor
            superfamily and is one of several Fc receptor-like glycoproteins
            clustered on the long arm of chromosome 1. The encoded protein
            contains immunoreceptor-tyrosine activation motifs and
            immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain
            and may play a role in regulation of the immune system. Mutations
            in this gene have been associated with rheumatoid arthritis,
            autoimmune thyroid disease, and systemic lupus erythematosus.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459027.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368184.8/ ENSP00000357167.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2882              AF459027.1         89-2970
            2883-2931           CD690165.1         492-540
            2932-4638           AL356276.9         30547-32253         c
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..4638
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="Fc receptor like 3"
                     /db_xref="GeneID:115352"
                     /db_xref="HGNC:HGNC:18506"
                     /db_xref="MIM:606510"
     exon            1..108
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..235
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2409
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; SH2 domain-containing phosphatase anchor
                     protein 2; Fc receptor homolog 3; immunoglobulin
                     superfamily receptor translocation associated protein 3;
                     hIFGP3; fcR-like protein 3; IFGP family protein 3; immune
                     receptor translocation-associated protein 3"
                     /codon_start=1
                     /product="Fc receptor-like protein 3 isoform 1 precursor"
                     /protein_id="NP_443171.2"
                     /db_xref="CCDS:CCDS1167.1"
                     /db_xref="GeneID:115352"
                     /db_xref="HGNC:HGNC:18506"
                     /db_xref="MIM:606510"
                     /translation="MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALIC
                     SSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWL
                     ILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSK
                     YHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQ
                     RPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRS
                     QIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRK
                     TQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRA
                     HTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYS
                     CDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILY
                     WFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTS
                     RNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSS
                     SRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMH
                     QEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH"
     exon            236..256
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..502
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..763
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1048
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1336
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1615
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1894
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2014
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2042
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2161
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2230
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2262
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..4638
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="hexamer: TATAAA"
     polyA_site      2798
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="major polyA site"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="hexamer: AATAAA"
     polyA_site      4638
                     /gene="FCRL3"
                     /gene_synonym="CD307c; FCRH3; IFGP3; IRTA3; MAIA; SPAP2"
                     /note="major polyA site"
ORIGIN      
        1 acagtcttgg agacattact cctgagagac tgcagctgat ggaagatgag ccccaacttc
       61 taaaaatgta tcactaccgg gattgagata caaacagcat ttaggaaggt ctcatctgag
      121 tagcagcttc ctgccctcct tcttggagat aagtcgggct tttggtgaga cagactttcc
      181 caaccctctg cccggccggt gcccatgctt ctgtggctgc tgctgctgat cctgactcct
      241 ggaagagaac aatcaggggt ggccccaaaa gctgtacttc tcctcaatcc tccatggtcc
      301 acagccttca aaggagaaaa agtggctctc atatgcagca gcatatcaca ttccctagcc
      361 cagggagaca catattggta tcacgatgag aagttgttga aaataaaaca tgacaagatc
      421 caaattacag agcctggaaa ttaccaatgt aagacccgag gatcctccct cagtgatgcc
      481 gtgcatgtgg aattttcacc tgactggctg atcctgcagg ctttacatcc tgtctttgaa
      541 ggagacaatg tcattctgag atgtcagggg aaagacaaca aaaacactca tcaaaaggtt
      601 tactacaagg atggaaaaca gcttcctaat agttataatt tagagaagat cacagtgaat
      661 tcagtctcca gggataatag caaatatcat tgtactgctt ataggaagtt ttacatactt
      721 gacattgaag taacttcaaa acccctaaat atccaagttc aagagctgtt tctacatcct
      781 gtgctgagag ccagctcttc cacgcccata gaggggagtc ccatgaccct gacctgtgag
      841 acccagctct ctccacagag gccagatgtc cagctgcaat tctccctctt cagagatagc
      901 cagaccctcg gattgggctg gagcaggtcc cccagactcc agatccctgc catgtggact
      961 gaagactcag ggtcttactg gtgtgaggtg gagacagtga ctcacagcat caaaaaaagg
     1021 agcctgagat ctcagatacg tgtacagaga gtccctgtgt ctaatgtgaa tctagagatc
     1081 cggcccaccg gagggcagct gattgaagga gaaaatatgg tccttatttg ctcagtagcc
     1141 cagggttcag ggactgtcac attctcctgg cacaaagaag gaagagtaag aagcctgggt
     1201 agaaagaccc agcgttccct gttggcagag ctgcatgttc tcaccgtgaa ggagagtgat
     1261 gcagggagat actactgtgc agctgataac gttcacagcc ccatcctcag cacgtggatt
     1321 cgagtcaccg tgagaattcc ggtatctcac cctgtcctca ccttcagggc tcccagggcc
     1381 cacactgtgg tgggggacct gctggagctt cactgtgagt ccctgagagg ctctcccccg
     1441 atcctgtacc gattttatca tgaggatgtc accctgggga acagctcagc cccctctgga
     1501 ggaggagcct ccttcaacct ctctctgact gcagaacatt ctggaaacta ctcctgtgat
     1561 gcagacaatg gcctgggggc ccagcacagt catggagtga gtctcagggt cacagttccg
     1621 gtgtctcgcc ccgtcctcac cctcagggct cccggggccc aggctgtggt gggggacctg
     1681 ctggagcttc actgtgagtc cctgagaggc tccttcccga tcctgtactg gttttatcac
     1741 gaggatgaca ccttggggaa catctcggcc cactctggag gaggggcatc cttcaacctc
     1801 tctctgacta cagaacattc tggaaactac tcatgtgagg ctgacaatgg cctgggggcc
     1861 cagcacagta aagtggtgac actcaatgtt acaggaactt ccaggaacag aacaggcctt
     1921 accgctgcgg gaatcacggg gctggtgctc agcatcctcg tccttgctgc tgctgctgct
     1981 ctgctgcatt acgccagggc ccgaaggaaa ccaggaggac tttctgccac tggaacatct
     2041 agtcacagtc ctagtgagtg tcaggagcct tcctcgtcca ggccttccag gatagaccct
     2101 caagagccca ctcactctaa accactagcc ccaatggagc tggagccaat gtacagcaat
     2161 gtaaatcctg gagatagcaa cccgatttat tcccagatct ggagcatcca gcatacaaaa
     2221 gaaaactcag ctaattgtcc aatgatgcat caagagcatg aggaacttac agtcctctat
     2281 tcagaactga agaagacaca cccagacgac tctgcagggg aggctagcag cagaggcagg
     2341 gcccatgaag aagatgatga agaaaactat gagaatgtac cacgtgtatt actggcctca
     2401 gaccactagc cccttaccca gagtggccca caggaaacag cctgcaccat ttttttttct
     2461 gttctctcca accacacatc atccatctct ccagactctg cctcctacga ggctgggctg
     2521 cagggtatgt gaggctgagc aaaaggtctg caaatctccc ctgtgcctga tctgtgtgtt
     2581 ccccaggaag agagcaggca gcctctgagc aagcactgtg ttattttcac agtggagaca
     2641 cgtggcaagg caggagggcc ctcagctcct agggctgtcg aatagaggag gagagagaaa
     2701 tggtctagcc agggttacaa gggcacaatc atgaccattt gatccaagtg tgatcgaaag
     2761 ctgttaatgt gctctctgta taaacaattt gctccaaata ttttgtttcc cttttttgtg
     2821 tggctggtag tggcattgct gatgttttgg tgtatatgct gtatccttgc taccatattg
     2881 ggaacagcca aaagaagtta tagaacaaga atttaaggtg actctatctg aagtgtattt
     2941 ttgtacttac agggtgacat tcccaaccaa attaccctag ttatgatgaa aaataacttc
     3001 agcatttcat taaagactct gctagtttaa tatgtgactt gtatccccac tgcaaagacc
     3061 ttatgtgtga agaatcacat taattgtaat ttttgcttca tgacatagtc tcatcatttg
     3121 ccatacatga tagatttcta gtcagtcagt tttattctta taagcaccca ttaaccccga
     3181 gacaataacc tactatatct atgtggcttc tcccattctc ttcctctacc tcactccatc
     3241 tgataaaaaa ccattctaaa tctcatgttc attattccca tgctctccta tttctatcat
     3301 attaatgtat ctacatgttt tccttaaata tgtttttata ttagttttaa ctataagtta
     3361 aagaccatat tgttgtagat aatttttttt agtactttct cttcatgttg tatttctaag
     3421 attcatccat attgttgcgt gttgctatag ttcatttgtt tttattgctg tttagtattt
     3481 acttgtgtaa aatatctggc ttaatgtttt cctagctatc accatcaaaa actctttcca
     3541 cagtgtgttg aatttttaat atgacaaaaa tgaaaatgta ccaacaattt tcagtgactt
     3601 cacctccatt ctgaaatcct gatgtttcca aatatctctg aacacctcaa gtcctaggga
     3661 caactgagat tatattaaca ttaatctctg aatgttgcca attctaggcc ttcacttggt
     3721 tcatgtagga acaccaagtc cctttcaaag caccacatct tcctctaatc aatatttctt
     3781 ggagtcccta gggaatgtct tacatgcatt caaacaatca ccatttctgg agatacacta
     3841 cagggtcacc ataaactctg ctacccttag gttccatcac tatggaagct gagtttcacc
     3901 agaaggcact tttgtcctcc attacgacca gcaaagccag ctaagccaca gctgctggcc
     3961 tcaaaaaatg tgatgatcaa tccacactgc tcccactggc ctctgttacc cttatcctgg
     4021 cctttgagtg cagggcatga tgtcctgccc gtactgagat gctgatctct gccagttcat
     4081 gttcatattg gcattaaaat tttaaggtcc cttgaagagg gaggaggcaa atgtctctgt
     4141 cttctatgtg atacattctg ctgttttttt ctctatggtg aaaatatgta aaccggtttt
     4201 gggtaccaac caccaggctg tatatggagg ctctcctcct ttctaaccct gctgctgatt
     4261 tggaattacc ttgccaagcc cctttgtgcc ttatagtgaa ctttctctaa gggacctgtc
     4321 atctcttatc attgtttatc cattttctag attctgaacc caagaaagaa caaagttcaa
     4381 gattttccat gtctttgtaa cacttagccc tgtgcaaatc agagtatgtg agtggaagaa
     4441 ggggtgagtc ctaactgtac atctcggata taacaaatgt gcaaattctg attgattgcc
     4501 ctgtaaaatg aattattctc atgcagtgct ctacttgact tttatctttg aattcacaac
     4561 taaaaaccca tagcccagaa atctaaaaaa agtaatttta gtggagcctt tgaaaataaa
     4621 agaccattgg aaaaagta
//
