LOCUS       NM_030764               2589 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Fc receptor like 2 (FCRL2), transcript variant 1,
            mRNA.
ACCESSION   NM_030764
VERSION     NM_030764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Zhong,Z., Shi,D., Xiao,M., Fu,D., Feng,S., Kong,Q., Li,J. and Li,Z.
  TITLE     Expression profile of Fc receptor-like molecules in patients with
            IgA nephropathy
  JOURNAL   Hum Immunol 82 (3), 186-192 (2021)
   PUBMED   33597097
  REMARK    GeneRIF: Expression profile of Fc receptor-like molecules in
            patients with IgA nephropathy.
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Shea,L.K., Honjo,K., Redden,D.T., Tabengwa,E., Li,R., Li,F.J.,
            Shakhmatov,M., Chiorazzi,N. and Davis,R.S.
  TITLE     Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and
            refines prognostication based on IGHV mutation status
  JOURNAL   Blood Cancer J 9 (6), 47 (2019)
   PUBMED   31092813
  REMARK    GeneRIF: we have shown that FCRL2 is a powerful predictor of both
            TFT and OS in CLL and have validated the prognostic significance of
            FCRL2 in a new cohort of patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   Polson,A.G., Zheng,B., Elkins,K., Chang,W., Du,C., Dowd,P., Yen,L.,
            Tan,C., Hongo,J.A., Koeppen,H. and Ebens,A.
  TITLE     Expression pattern of the human FcRH/IRTA receptors in normal
            tissue and in B-chronic lymphocytic leukemia
  JOURNAL   Int Immunol 18 (9), 1363-1373 (2006)
   PUBMED   16849395
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   Guselnikov,S.V., Ershova,S.A., Mechetina,L.V., Najakshin,A.M.,
            Volkova,O.Y., Alabyev,B.Y. and Taranin,A.V.
  TITLE     A family of highly diverse human and mouse genes structurally links
            leukocyte FcR, gp42 and PECAM-1
  JOURNAL   Immunogenetics 54 (2), 87-95 (2002)
   PUBMED   12037601
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Miller,I., Hatzivassiliou,G., Cattoretti,G., Mendelsohn,C. and
            Dalla-Favera,R.
  TITLE     IRTAs: a new family of immunoglobulinlike receptors differentially
            expressed in B cells
  JOURNAL   Blood 99 (8), 2662-2669 (2002)
   PUBMED   11929751
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Davis,R.S., Wang,Y.H., Kubagawa,H. and Cooper,M.D.
  TITLE     Identification of a family of Fc receptor homologs with
            preferential B cell expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9772-9777 (2001)
   PUBMED   11493702
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Xu,M.J., Zhao,R. and Zhao,Z.J.
  TITLE     Molecular cloning and characterization of SPAP1, an inhibitory
            receptor
  JOURNAL   Biochem Biophys Res Commun 280 (3), 768-775 (2001)
   PUBMED   11162587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK303549.1, AY358130.1 and
            AF459633.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030764.3.
            
            Summary: This gene encodes a member of the immunoglobulin receptor
            superfamily and is one of several Fc receptor-like glycoproteins
            clustered on the long arm of chromosome 1. The encoded protein has
            four extracellular C2-type immunoglobulin domains, a transmembrane
            domain and a cytoplasmic domain that contains one
            immunoreceptor-tyrosine activation motif and two
            immunoreceptor-tyrosine inhibitory motifs. This protein may be a
            prognostic marker for chronic lymphocytic leukemia. Alternatively
            spliced transcript variants have been described, but their
            biological validity has not been determined. [provided by RefSeq,
            Apr 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459633.1, AY043465.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361516.8/ ENSP00000355157.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK303549.1         1-10
            11-1830             AY358130.1         1-1820
            1831-2589           AF459633.1         1819-2577
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2589
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /note="Fc receptor like 2"
                     /db_xref="GeneID:79368"
                     /db_xref="HGNC:HGNC:14875"
                     /db_xref="MIM:606509"
     exon            1..90
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1586
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; SH2 domain containing phosphatase anchor
                     protein 1; immune receptor translocation-associated
                     protein 4; immunoglobulin superfamily Fc receptor, gp42;
                     fc receptor-like protein 2; IFGP family protein 4; fc
                     receptor homolog 2; immunoglobulin receptor
                     translocation-associated protein 4"
                     /codon_start=1
                     /product="Fc receptor-like protein 2 isoform 1 precursor"
                     /protein_id="NP_110391.2"
                     /db_xref="CCDS:CCDS1168.1"
                     /db_xref="GeneID:79368"
                     /db_xref="HGNC:HGNC:14875"
                     /db_xref="MIM:606509"
                     /translation="MLLWSLLVIFDAVTEQADSLTLVAPSSVFEGDSIVLKCQGEQNW
                     KIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKV
                     QELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSP
                     ELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTE
                     GQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCR
                     ADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQF
                     YHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGPDGY
                     RRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPRGASRPNPQEFTYSS
                     PTPDMEELQPVYVNVGSVDVDVVYSQVWSMQQPESSANIRTLLENKDSQVIYSSVKKS
                     "
     exon            91..111
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            112..369
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            370..654
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            655..942
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1221
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1338
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1366
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1452
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1518
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1547
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..2589
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /note="hexamer: AATAAA"
     polyA_site      2589
                     /gene="FCRL2"
                     /gene_synonym="CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A;
                     SPAP1B; SPAP1C"
                     /note="major polyA site"
ORIGIN      
        1 agagtctcca gttggtgacc aagagtacat ctcttttcaa atagctggat taggtcctca
       61 tgctgctgtg gtcattgctg gtcatctttg atgcagtcac tgaacaggca gattcgctga
      121 cccttgtggc gccctcttct gtcttcgaag gagacagcat cgttctgaaa tgccagggag
      181 aacagaactg gaaaattcag aagatggctt accataagga taacaaagag ttatctgttt
      241 tcaaaaaatt ctcagatttc cttatccaaa gtgcagtttt aagtgacagt ggtaactatt
      301 tctgtagtac caaaggacaa ctctttctct gggataaaac ttcaaatata gtaaagataa
      361 aagtccaaga gctctttcaa cgtcctgtgc tgactgccag ctccttccag cccatcgaag
      421 ggggtccagt gagcctgaaa tgtgagaccc ggctctctcc acagaggttg gatgttcaac
      481 tccagttctg cttcttcaga gaaaaccagg tcctggggtc aggctggagc agctctccgg
      541 agctccagat ttctgccgtg tggagtgaag acacagggtc ttactggtgc aaggcagaaa
      601 cggtgactca caggatcaga aaacagagcc tccaatccca gattcacgtg cagagaatcc
      661 ccatctctaa tgtaagcttg gagatccggg cccccggggg acaggtgact gaaggacaaa
      721 aactgatcct gctctgctca gtggctgggg gtacaggaaa tgtcacattc tcctggtaca
      781 gagaggccac aggaaccagt atgggaaaga aaacccagcg ttccctgtca gcagagctgg
      841 agatcccagc tgtgaaagag agtgatgccg gcaaatatta ctgtagagct gacaacggcc
      901 atgtgcctat ccagagcaag gtggtgaata tccctgtgag aattccagtg tctcgccctg
      961 tcctcaccct caggtctcct ggggcccagg ctgcagtggg ggacctgctg gagcttcact
     1021 gtgaggccct gagaggctct cccccaatct tgtaccaatt ttatcatgag gatgtcaccc
     1081 ttgggaacag ctcggccccc tctggaggag gggcctcctt caacctctct ttgactgcag
     1141 aacattctgg aaactactcc tgtgaggcca acaacggcct gggggcccag tgcagtgagg
     1201 cagtgccagt ctccatctca ggacctgatg gctatagaag agacctcatg acagctggag
     1261 ttctctgggg actgtttggt gtccttggtt tcactggtgt tgctttgctg ttgtatgcct
     1321 tgttccacaa gatatcagga gaaagttctg ccactaatga acccagaggg gcttccaggc
     1381 caaatcctca agagttcacc tattcaagcc caaccccaga catggaggag ctgcagccag
     1441 tgtatgtcaa tgtgggctct gtagatgtgg atgtggttta ttctcaggtc tggagcatgc
     1501 agcagccaga aagctcagca aacatcagga cacttctgga gaacaaggac tcccaagtca
     1561 tctactcttc tgtgaagaaa tcataacact tggaggaatc agaagggaag atcaacagca
     1621 aggatggggc atcattaaga cttgctataa aaccttatga aaatgcttga ggcttatcac
     1681 ctgccacagc cagaacgtgc ctcaggaggc acctcctgtc atttttgtcc tgatgatgtt
     1741 tcttctccaa tatcttcttt tacctatcaa tattcattga actgctgcta catccagaca
     1801 ctgtgcaaat aaattatttc tgctaccttc tcttaagcaa tcagtgtgta aagatttgag
     1861 ggaagaatga ataagagata caaggtctca ccttcatcta ctgtgaagtg atgagaacag
     1921 gacttgatag tggtgtatta acttatttat gtgctgctgg atacagtttg ctaatatttt
     1981 gttgagaatt tttgcaaata tgttcattgg gaatattggc ctgaaatttt cttttccact
     2041 gtgtctctgc cagaatgttt gtatcaggct gatgctggct tcatagaatg agttaggcag
     2101 gagcccttcc tccttgattt tttggcatag tttcagcagg attggtacca gttattcttt
     2161 ctgcatcttg tagaattcag ctatgaatcc atctggtcta gggcttttgt gttggttggt
     2221 aagtttttta ttactaattc aacttcagcg cttgatattg gtctaggagg ggtttctgtc
     2281 tcttcctggt tcaatcttgg gagattgtgt gtttccagga atttagccgt ttcctccaga
     2341 ttttcttctt tatgtgcatc gacttgagtg taaacataac ttatatgcac tgggaaacca
     2401 aaaaatctgt gtgacttgct ttattgcagc atttgtttta ttttggtagt ctggaactga
     2461 acctgcaata tcaccaaagt atgcatatag ttgcaaaaat gtgatttttg acatagtaaa
     2521 tatgagtatt tgcaataaac tatgatatta cttttgtaag tatatagaat aaaatgtaaa
     2581 taatctata
//
