LOCUS       NM_052938               3069 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc receptor like 1 (FCRL1), transcript variant 1,
            mRNA.
ACCESSION   NM_052938
VERSION     NM_052938.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Mamidi,M.K., Huang,J., Honjo,K., Li,R., Tabengwa,E.M., Neeli,I.,
            Randall,N.L., Ponnuchetty,M.V., Radic,M., Leu,C.M. and Davis,R.S.
  TITLE     FCRL1 immunoregulation in B cell development and malignancy
  JOURNAL   Front Immunol 14, 1251127 (2023)
   PUBMED   37822931
  REMARK    GeneRIF: FCRL1 immunoregulation in B cell development and
            malignancy.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   DeLuca,J.M., Murphy,M.K., Wang,X. and Wilson,T.J.
  TITLE     FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2
  JOURNAL   J Immunol 207 (11), 2688-2698 (2021)
   PUBMED   34697226
  REMARK    GeneRIF: FCRL1 Regulates B Cell Receptor-Induced ERK Activation
            through GRB2.
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Zhong,Z., Shi,D., Xiao,M., Fu,D., Feng,S., Kong,Q., Li,J. and Li,Z.
  TITLE     Expression profile of Fc receptor-like molecules in patients with
            IgA nephropathy
  JOURNAL   Hum Immunol 82 (3), 186-192 (2021)
   PUBMED   33597097
  REMARK    GeneRIF: Expression profile of Fc receptor-like molecules in
            patients with IgA nephropathy.
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Rivera,N.V., Patasova,K., Kullberg,S., Diaz-Gallo,L.M., Iseda,T.,
            Bengtsson,C., Alfredsson,L., Eklund,A., Kockum,I., Grunewald,J. and
            Padyukov,L.
  TITLE     A Gene-Environment Interaction Between Smoking and Gene
            polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis
  JOURNAL   Sci Rep 9 (1), 18633 (2019)
   PUBMED   31819081
  REMARK    GeneRIF: A Gene-Environment Interaction Between Smoking and Gene
            polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Rostamzadeh,D., Dabbaghmanesh,M.H., Shabani,M., Hosseini,A. and
            Amirghofran,Z.
  TITLE     Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules
            in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's
            Thyroiditis and Graves' Disease
  JOURNAL   Horm Metab Res 47 (9), 693-698 (2015)
   PUBMED   25738996
  REMARK    GeneRIF: FCRL1 gene expression down-regulates in both Hashimoto and
            Graves disease patients compared to normal subjects.
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Polson,A.G., Zheng,B., Elkins,K., Chang,W., Du,C., Dowd,P., Yen,L.,
            Tan,C., Hongo,J.A., Koeppen,H. and Ebens,A.
  TITLE     Expression pattern of the human FcRH/IRTA receptors in normal
            tissue and in B-chronic lymphocytic leukemia
  JOURNAL   Int Immunol 18 (9), 1363-1373 (2006)
   PUBMED   16849395
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Leu,C.M., Davis,R.S., Gartland,L.A., Fine,W.D. and Cooper,M.D.
  TITLE     FcRH1: an activation coreceptor on human B cells
  JOURNAL   Blood 105 (3), 1121-1126 (2005)
   PUBMED   15479727
  REMARK    GeneRIF: FcRH1 thus has the potential to serve as an activating
            coreceptor on B cells.
REFERENCE   8  (bases 1 to 3069)
  AUTHORS   Guselnikov,S.V., Ershova,S.A., Mechetina,L.V., Najakshin,A.M.,
            Volkova,O.Y., Alabyev,B.Y. and Taranin,A.V.
  TITLE     A family of highly diverse human and mouse genes structurally links
            leukocyte FcR, gp42 and PECAM-1
  JOURNAL   Immunogenetics 54 (2), 87-95 (2002)
   PUBMED   12037601
REFERENCE   9  (bases 1 to 3069)
  AUTHORS   Miller,I., Hatzivassiliou,G., Cattoretti,G., Mendelsohn,C. and
            Dalla-Favera,R.
  TITLE     IRTAs: a new family of immunoglobulinlike receptors differentially
            expressed in B cells
  JOURNAL   Blood 99 (8), 2662-2669 (2002)
   PUBMED   11929751
REFERENCE   10 (bases 1 to 3069)
  AUTHORS   Davis,R.S., Wang,Y.H., Kubagawa,H. and Cooper,M.D.
  TITLE     Identification of a family of Fc receptor homologs with
            preferential B cell expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9772-9777 (2001)
   PUBMED   11493702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA939902.1, AY043464.1,
            AL356276.9 and AL833674.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052938.4.
            
            Summary: This gene encodes a member of the immunoglobulin receptor
            superfamily and is one of several Fc receptor-like glycoproteins
            clustered on the long arm of chromosome 1. The encoded protein
            contains three extracellular C2-like immunoglobulin domains, a
            transmembrane domain and a cytoplasmic domain with two
            immunoreceptor-tyrosine activation motifs. This protein may play a
            role in the regulation of cancer cell growth. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033690.1, AF459634.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368176.8/ ENSP00000357158.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA939902.1         31-45
            16-793              AY043464.1         1-778
            794-794             AL356276.9         156156-156156       c
            795-2053            AY043464.1         780-2038
            2054-2298           AL356276.9         149240-149484       c
            2299-3069           AL833674.1         1372-2142
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..3069
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /note="Fc receptor like 1"
                     /db_xref="GeneID:115350"
                     /db_xref="HGNC:HGNC:18509"
                     /db_xref="MIM:606508"
     exon            1..114
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1373
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immune receptor translocation-associated
                     protein 5; immunoglobulin superfamily Fc receptor, gp42;
                     hIFGP1; fcR-like protein 1; IFGP family protein 1; fc
                     receptor homolog 1"
                     /codon_start=1
                     /product="Fc receptor-like protein 1 isoform 1 precursor"
                     /protein_id="NP_443170.1"
                     /db_xref="CCDS:CCDS1170.1"
                     /db_xref="GeneID:115350"
                     /db_xref="HGNC:HGNC:18509"
                     /db_xref="MIM:606508"
                     /translation="MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQ
                     SSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQ
                     INVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKT
                     QRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQ
                     AAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSC
                     EANNGLGAQRSEAVTLNFTVPTGARSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKI
                     GRRSARDPLRSLPSPLPQEFTYLNSPTPGQLQPIYENVNVVSGDEVYSLAYYNQPEQE
                     SVAAETLGTHMEDKVSLDIYSRLRKANITDVDYEDAM"
     exon            115..135
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            136..402
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            403..690
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            691..969
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1086
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1114
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1197
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1269
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1301
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3069
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2913..2918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /note="hexamer: ATTAAA"
     polyA_site      2936
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /note="major polyA site"
     regulatory      3035..3040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
                     /note="hexamer: AATAAA"
     polyA_site      3069
                     /gene="FCRL1"
                     /gene_synonym="CD307a; FCRH1; IFGP1; IRTA5"
ORIGIN      
        1 gatgagctgc tgctgctcga ctctgaggtg cattcttttt ttgatgagag gcatctctag
       61 gtaccatccc tgacctggtc ctcatgctgc cgaggctgtt gctgttgatc tgtgctccac
      121 tctgtgaacc tgccgagctg tttttgatag ccagcccctc ccatcccaca gaggggagcc
      181 cagtgaccct gacgtgtaag atgccctttc tacagagttc agatgcccag ttccagttct
      241 gctttttcag agacacccgg gccttgggcc caggctggag cagctccccc aagctccaga
      301 tcgctgccat gtggaaagaa gacacagggt catactggtg cgaggcacag acaatggcgt
      361 ccaaagtctt gaggagcagg agatcccaga taaatgtgca cagggtccct gtcgctgatg
      421 tgagcttgga gactcagccc ccaggaggac aggtgatgga gggagacagg ctggtcctca
      481 tctgctcagt tgctatgggc acaggagaca tcaccttcct ttggtacaaa ggggctgtag
      541 gtttaaacct tcagtcaaag acccagcgtt cactgacagc agagtatgag attccttcag
      601 tgagggagag tgatgctgag caatattact gtgtagctga aaatggctat ggtcccagcc
      661 ccagtgggct ggtgagcatc actgtcagaa tcccggtgtc tcgcccaatc ctcatgctca
      721 gggctcccag ggcccaggct gcagtggagg atgtgctgga gcttcactgt gaggccctga
      781 gaggctctcc tccgatcctg tactggtttt atcacgagga tatcaccctg gggagcaggt
      841 cggccccctc tggaggagga gcctccttca acctttccct gactgaagaa cattctggaa
      901 actactcctg tgaggccaac aatggcctgg gggcccagcg cagtgaggcg gtgacactca
      961 acttcacagt gcctactggg gccagaagca atcatcttac ctcaggagtc attgaggggc
     1021 tgctcagcac ccttggtcca gccaccgtgg ccttattatt ttgctacggc ctcaaaagaa
     1081 aaataggaag acgttcagcc agggatccac tcaggagcct tcccagccct ctaccccaag
     1141 agttcaccta cctcaactca cctaccccag ggcagctaca gcctatatat gaaaatgtga
     1201 atgttgtaag tggggatgag gtttattcac tggcgtacta taaccagccg gagcaggaat
     1261 cagtagcagc agaaaccctg gggacacata tggaggacaa ggtttcctta gacatctatt
     1321 ccaggctgag gaaagcaaac attacagatg tggactatga agatgctatg taaggttatg
     1381 gaagattctg ctctttgaaa accatccatg accccaagcc tcaggcctga tatgttcttc
     1441 agagatcctg gggcattagc tttccagtat acctcttctg gatgccattc tccatggcac
     1501 tattccttca tctactgtga agtgaagttg gcgcagccct gaagaaacta cctaggagaa
     1561 ctaatagaca caggagtgac agggactttg ttatcagaac cagattcctg ccggctcctt
     1621 tgaaaacagg tcatattgtg ctcttctgtt tacaagagga aacaagatgg aataaaagaa
     1681 attgggatct tgggttggag ggacagtgaa gcttagagca catgaactca aggttagtga
     1741 ctctgcagga cttcacagag agagctgtgc ccatcattca gtccaagtgc tttctctgcc
     1801 cagacagcac agaactccag ccccgctact tacatggatc atcgagtttc cacctaaaat
     1861 atgattctat ttattttgag tcactgttac caaattagaa ctaaaacaaa gttacataaa
     1921 aagttattgt gactccactt aattttagtg acgtattttt gtatatatag gccaacctat
     1981 accacatcca aaattatgta tctattacag cccctagaag ctttataaat acagtgtgtc
     2041 ttcttttatt cacaaaattt ttgaaatcgt ggtaatatgg tttgaaacct gtatcttaat
     2101 tatttttttt ttaaattgag acagggtctc actctgtcac tcaatctgga atgcagtggc
     2161 acaatcttgc ctcactgcaa cgcctgcctc tcaggctcaa gcaaacctct cacctcagcc
     2221 tgctgagtag ctgggactac aggcacatgc caccaaactt ggccattttt tgtcttacgt
     2281 agagacaaga tttcaccgtt ttgcccaggc tggtctcaaa ctcctgggct caagcaatgt
     2341 attgaatttt aaaataacca ggcactcact cttatgaatt aataaacatt tggaggtata
     2401 taaagtaaaa agttaaagtc tttcctgtaa gttaacacaa atgttaacta ttgttaaaaa
     2461 ctttacaggt agctctctag atatttttct atttttgtat gtatacttat gcatacatgt
     2521 aagtatataa acatttagaa gtgtacctat ctaacaaact attatgaaat actttcaaat
     2581 ctgtaaatag atctattata ctattttaaa agtctctata gtagtgtgtt atatagataa
     2641 atcataactt ttttcttttt ttattgtagt aaatatgcac aacataaaat tgatcatttt
     2701 aaccattttt aagtgtacaa ttcagtggca ttaagtacta tcataatata ttttaatcct
     2761 tctcatcact ggtggacatt aaggagactc tcaaaaaatt catattataa aaacaaagtt
     2821 caaacaaatg tctttgtact agcatattat ggcactcctg ctggattatc tgaaggataa
     2881 atttgtaaat ctagtattgc tagattatgc atattaaata ttcttgttaa atagtcttca
     2941 atgtctctca ggtaaggctg tatcaattta tatcttcacc aacaacgtct gggaaatcag
     3001 tttgtggggt gtattactta gttttcacat tgctaataaa gacatatcca agactgggta
     3061 atttataaa
//
