LOCUS       NM_003665               1032 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ficolin 3 (FCN3), transcript variant 1, mRNA.
ACCESSION   NM_003665
VERSION     NM_003665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Zheng,G., Wu,L., Bouamar,H., Cserhati,M., Chiu,Y.C., Hinck,C.S.,
            Wieteska,L., Zeballos Torrez,C.R., Hu,R., Easley,A., Chen,Y.,
            Hinck,A.P., Cigarroa,F.G. and Sun,L.Z.
  TITLE     Ficolin-3 induces apoptosis and suppresses malignant property of
            hepatocellular carcinoma cells via the complement pathway
  JOURNAL   Life Sci 357, 123103 (2024)
   PUBMED   39357793
  REMARK    GeneRIF: Ficolin-3 induces apoptosis and suppresses malignant
            property of hepatocellular carcinoma cells via the complement
            pathway.
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Yuan,Y., Xu,J., Jiang,Q., Yang,C., Wang,N., Liu,X., Piao,H.L.,
            Lu,S., Zhang,X., Han,L., Liu,Z., Cai,J., Liu,F., Chen,S. and Liu,J.
  TITLE     Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP
            axis-mediated MUFA synthesis
  JOURNAL   J Exp Clin Cancer Res 43 (1), 133 (2024)
   PUBMED   38698462
  REMARK    GeneRIF: Ficolin 3 promotes ferroptosis in HCC by downregulating
            IR/SREBP axis-mediated MUFA synthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Lindelof,L., Rantapaa-Dahlqvist,S., Lundtoft,C., Sandling,J.K.,
            Leonard,D., Sayadi,A., Ronnblom,L., Enocsson,H., Sjowall,C.,
            Jonsen,A., Bengtsson,A.A., Hong,M.G., Diaz-Gallo,L.M., Bianchi,M.,
            Kozyrev,S.V., Lindblad-Toh,K., Nilsson Ekdahl,K., Nilsson,B.,
            Gunnarsson,I., Svenungsson,E. and Eriksson,O.
  CONSRTM   DISSECT consortium; ImmunoArray consortium
  TITLE     A survey of ficolin-3 activity in Systemic Lupus Erythematosus
            reveals a link to hematological disease manifestations and
            autoantibody profile
  JOURNAL   J Autoimmun 143, 103166 (2024)
   PUBMED   38219652
  REMARK    GeneRIF: A survey of ficolin-3 activity in Systemic Lupus
            Erythematosus reveals a link to hematological disease
            manifestations and autoantibody profile.
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Chen,C.C., Yu,T.H., Wu,C.C., Hung,W.C., Lee,T.L., Tang,W.H.,
            Tsai,I.T., Chung,F.M., Lee,Y.J. and Hsu,C.C.
  TITLE     Loss of ficolin-3 expression is associated with poor prognosis in
            patients with hepatocellular carcinoma
  JOURNAL   Int J Med Sci 20 (8), 1091-1096 (2023)
   PUBMED   37484802
  REMARK    GeneRIF: Loss of ficolin-3 expression is associated with poor
            prognosis in patients with hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Tereshchenko,S.Y., Smolnikova,M.V. and Freidin,M.B.
  TITLE     Ficolin-3 and MASP-2 gene variants in Siberian arctic populations:
            Summarized evidence of selective pressure for the high frequency of
            lectin complement pathway deficiency
  JOURNAL   Scand J Immunol 97 (3), e13249 (2023)
   PUBMED   36574978
  REMARK    GeneRIF: Ficolin-3 and MASP-2 gene variants in Siberian arctic
            populations: Summarized evidence of selective pressure for the high
            frequency of lectin complement pathway deficiency.
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Matsushita,M., Kuraya,M., Hamasaki,N., Tsujimura,M., Shiraki,H. and
            Fujita,T.
  TITLE     Activation of the lectin complement pathway by H-ficolin (Hakata
            antigen)
  JOURNAL   J Immunol 168 (7), 3502-3506 (2002)
   PUBMED   11907111
  REMARK    GeneRIF: Hakata antigen, a ficolin associated with MBL-associated
            serine proteases and small MBL-associated protein, activates the
            lectin complement pathway.
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Akaiwa,M., Yae,Y., Sugimoto,R., Suzuki,S.O., Iwaki,T., Izuhara,K.
            and Hamasaki,N.
  TITLE     Hakata antigen, a new member of the ficolin/opsonin p35 family, is
            a novel human lectin secreted into bronchus/alveolus and bile
  JOURNAL   J Histochem Cytochem 47 (6), 777-786 (1999)
   PUBMED   10330454
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Sugimoto,R., Yae,Y., Akaiwa,M., Kitajima,S., Shibata,Y., Sato,H.,
            Hirata,J., Okochi,K., Izuhara,K. and Hamasaki,N.
  TITLE     Cloning and characterization of the Hakata antigen, a member of the
            ficolin/opsonin p35 lectin family
  JOURNAL   J Biol Chem 273 (33), 20721-20727 (1998)
   PUBMED   9694814
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Yae,Y., Inaba,S., Sato,H., Okochi,K., Tokunaga,F. and Iwanaga,S.
  TITLE     Isolation and characterization of a thermolabile beta-2
            macroglycoprotein ('thermolabile substance' or 'Hakata antigen')
            detected by precipitating (auto) antibody in sera of patients with
            systemic lupus erythematosus
  JOURNAL   Biochim Biophys Acta 1078 (3), 369-376 (1991)
   PUBMED   1859827
REFERENCE   10 (bases 1 to 1032)
  AUTHORS   Inaba,S., Okochi,K., Yae,Y., Niklasson,F. and de Verder,C.H.
  TITLE     Serological studies of an SLE-associated antigen-antibody system
            discovered as a precipitation reaction in agarose gel: the HAKATA
            antigen-antibody system
  JOURNAL   Fukuoka Igaku Zasshi 81 (9), 284-291 (1990)
   PUBMED   2276712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG546674.1, CR456808.1 and
            AY358081.1.
            
            On Feb 12, 2020 this sequence version replaced NM_003665.3.
            
            Summary: Ficolins are a group of proteins which consist of a
            collagen-like domain and a fibrinogen-like domain. In human serum,
            there are two types of ficolins, both of which have lectin
            activity. The protein encoded by this gene is a thermolabile
            beta-2-macroglycoprotein found in all human serum and is a member
            of the ficolin/opsonin p35 lectin family. The protein, which was
            initially identified based on its reactivity with sera from
            patients with systemic lupus erythematosus, has been shown to have
            a calcium-independent lectin activity. The protein can activate the
            complement pathway in association with MASPs and sMAP, thereby
            aiding in host defense through the activation of the lectin
            pathway. Alternative splicing occurs at this locus and two
            variants, each encoding a distinct isoform, have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR456808.1, DRR138527.726325.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270879.9/ ENSP00000270879.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BG546674.1         30-35
            7-572               CR456808.1         1-566
            573-1032            AY358081.1         529-988
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1032
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /note="ficolin 3"
                     /db_xref="GeneID:8547"
                     /db_xref="HGNC:HGNC:3625"
                     /db_xref="MIM:604973"
     exon            1..97
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..906
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagen/fibrinogen domain-containing lectin 3
                     p35; collagen/fibrinogen domain-containing protein 3;
                     H-ficolin; ficolin (collagen/fibrinogen domain containing)
                     3 (Hakata antigen)"
                     /codon_start=1
                     /product="ficolin-3 isoform 1 precursor"
                     /protein_id="NP_003656.2"
                     /db_xref="CCDS:CCDS300.1"
                     /db_xref="GeneID:8547"
                     /db_xref="HGNC:HGNC:3625"
                     /db_xref="MIM:604973"
                     /translation="MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLP
                     SCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGAT
                     LSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESE
                     FWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGT
                     AGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHK
                     YGIDWASGRGVGHPYRRVRMMLR"
     exon            98..193
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..238
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..271
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..399
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..529
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..664
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1032
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1008..1013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /note="hexamer: AATAAA"
     polyA_site      1032
                     /gene="FCN3"
                     /gene_synonym="FCNH; HAKA1"
                     /note="major polyA site"
ORIGIN      
        1 agcaagatgg atctactgtg gatcctgccc tccctgtggc ttctcctgct tggggggcct
       61 gcctgcctga agacccagga acaccccagc tgcccaggac ccagggaact ggaagccagc
      121 aaagttgtcc tcctgcccag ttgtcccgga gctccaggaa gtcctgggga gaagggagcc
      181 ccaggtcctc aagggccacc tggaccacca ggcaagatgg gccccaaggg tgagccagga
      241 gatccagtga acctgctccg gtgccaggaa ggccccagaa actgccggga gctgttgagc
      301 cagggcgcca ccttgagcgg ctggtaccat ctgtgcctac ctgagggcag ggccctccca
      361 gtcttttgtg acatggacac cgaggggggc ggctggctgg tgtttcagag gcgccaggat
      421 ggttctgtgg atttcttccg ctcttggtcc tcctacagag caggttttgg gaaccaagag
      481 tctgaattct ggctgggaaa tgagaatttg caccagctta ctctccaggg taactgggag
      541 ctgcgggtag agctggaaga ctttaatggt aaccgtactt tcgcccacta tgcgaccttc
      601 cgcctcctcg gtgaggtaga ccactaccag ctggcactgg gcaagttctc agagggcact
      661 gcaggggatt ccctgagcct ccacagtggg aggcccttta ccacctatga cgctgaccac
      721 gattcaagca acagcaactg tgcagtgatt gtccacggtg cctggtggta tgcatcctgt
      781 taccgatcaa atctcaatgg tcgctatgca gtgtctgagg ctgccgccca caaatatggc
      841 attgactggg cctcaggccg tggtgtgggc cacccctacc gcagggttcg gatgatgctt
      901 cgatagggca ctctggcagc cagtgccctt atctctcctg tacagcttcc ggatcgtcag
      961 ccaccttgcc tttgccaacc acctctgctt gcctgtccac atttaaaaat aaaatcattt
     1021 tagccctttc aa
//
