LOCUS       NM_004108               1062 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ficolin 2 (FCN2), transcript variant SV0, mRNA.
ACCESSION   NM_004108
VERSION     NM_004108.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Nyangiri,O.A., Mulindwa,J., Namulondo,J., Kitibwa,A., Nassuuna,J.,
            Elliott,A., Kimuda,M.P., Boobo,A., Nerima,B., Adriko,M.,
            Dunton,N.J., Madhan,G.K., Kristiansen,M., Casacuberta-Partal,M.,
            Noyes,H. and Matovu,E.
  CONSRTM   TrypanoGEN+ Research group of the H3Africa consortium
  TITLE     Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are
            associated with Schistosoma mansoni worm burden in the Albert Nile
            region of Uganda
  JOURNAL   PLoS Negl Trop Dis 17 (11), e0011796 (2023)
   PUBMED   38033168
  REMARK    GeneRIF: Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci
            are associated with Schistosoma mansoni worm burden in the Albert
            Nile region of Uganda.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1062)
  AUTHORS   Mayilyan,K.R., Krarup,A., Soghoyan,A.F., Jensenius,J.C. and
            Sim,R.B.
  TITLE     l-ficolin-MASP arm of the complement system in schizophrenia
  JOURNAL   Immunobiology 228 (2), 152349 (2023)
   PUBMED   36805857
  REMARK    GeneRIF: l-ficolin-MASP arm of the complement system in
            schizophrenia.
REFERENCE   3  (bases 1 to 1062)
  AUTHORS   Gazdzicka,J., Golabek,K., Hudy,D., Miskiewicz-Orczyk,K., Zieba,N.,
            Tynior,W., Asman,M., Misiolek,M. and Strzelczyk,J.K.
  TITLE     Selected SNPs of FCN2 Associated with Chronic Tonsillitis in the
            Polish Adult Population
  JOURNAL   Genes (Basel) 14 (2), 242 (2023)
   PUBMED   36833169
  REMARK    GeneRIF: Selected SNPs of FCN2 Associated with Chronic Tonsillitis
            in the Polish Adult Population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1062)
  AUTHORS   Szala-Pozdziej,A., Swierzko,A.S., Gajek,G., Kufelnicka-Babout,M.,
            Chojnacka,K., Kobiela,P., Jarych,D., Sobczuk,K., Mazela,J.,
            Domzalska-Popadiuk,I., Kalinka,J., Sekine,H., Matsushita,M. and
            Cedzynski,M.
  TITLE     Association of the FCN2 Gene Promoter Region Polymorphisms with
            Very Low Birthweight in Preterm Neonates
  JOURNAL   Int J Mol Sci 23 (23), 15336 (2022)
   PUBMED   36499663
  REMARK    GeneRIF: Association of the FCN2 Gene Promoter Region Polymorphisms
            with Very Low Birthweight in Preterm Neonates.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1062)
  AUTHORS   Nahm,M.H., Yu,J., Calix,J.J. and Ganaie,F.
  TITLE     Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific
            Innate Immunity Against Invasive Pneumococcal Disease
  JOURNAL   Front Immunol 13, 841062 (2022)
   PUBMED   35418983
  REMARK    GeneRIF: Ficolin-2 Lectin Complement Pathway Mediates
            Capsule-Specific Innate Immunity Against Invasive Pneumococcal
            Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1062)
  AUTHORS   Lu,J. and Le,Y.
  TITLE     Ficolins and the fibrinogen-like domain
  JOURNAL   Immunobiology 199 (2), 190-199 (1998)
   PUBMED   9777405
  REMARK    Review article
REFERENCE   7  (bases 1 to 1062)
  AUTHORS   Le,Y., Tan,S.M., Lee,S.H., Kon,O.L. and Lu,J.
  TITLE     Purification and binding properties of a human ficolin-like protein
  JOURNAL   J Immunol Methods 204 (1), 43-49 (1997)
   PUBMED   9202708
REFERENCE   8  (bases 1 to 1062)
  AUTHORS   Endo,Y., Sato,Y., Matsushita,M. and Fujita,T.
  TITLE     Cloning and characterization of the human lectin P35 gene and its
            related gene
  JOURNAL   Genomics 36 (3), 515-521 (1996)
   PUBMED   8884275
REFERENCE   9  (bases 1 to 1062)
  AUTHORS   Matsushita,M., Endo,Y., Taira,S., Sato,Y., Fujita,T., Ichikawa,N.,
            Nakata,M. and Mizuochi,T.
  TITLE     A novel human serum lectin with collagen- and fibrinogen-like
            domains that functions as an opsonin
  JOURNAL   J Biol Chem 271 (5), 2448-2454 (1996)
   PUBMED   8576206
REFERENCE   10 (bases 1 to 1062)
  AUTHORS   Edgar,P.F.
  TITLE     Hucolin, a new corticosteroid-binding protein from human plasma
            with structural similarities to ficolins, transforming growth
            factor-beta 1-binding proteins
  JOURNAL   FEBS Lett 375 (1-2), 159-161 (1995)
   PUBMED   7498469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603650.10, BC069572.1 and
            AI052239.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004108.2.
            
            Summary: The product of this gene belongs to the ficolin family of
            proteins. This family is characterized by the presence of a leader
            peptide, a short N-terminal segment, followed by a collagen-like
            region, and a C-terminal fibrinogen-like domain. This gene is
            predominantly expressed in the liver, and has been shown to have
            carbohydrate binding and opsonic activities. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (SV0) represents the longer
            transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290843.1, D49353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291744.11/ ENSP00000291744.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL603650.10        105819-105820
            3-1004              BC069572.1         1-1002
            1005-1059           AI052239.1         59-113              c
            1060-1062           AL603650.10        112530-112532
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1062
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /note="ficolin 2"
                     /db_xref="GeneID:2220"
                     /db_xref="HGNC:HGNC:3624"
                     /db_xref="MIM:601624"
     exon            1..112
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..954
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /note="isoform a precursor is encoded by transcript
                     variant SV0; ficolin B; serum lectin p35; L-ficolin;
                     collagen/fibrinogen domain-containing protein 2;
                     ficolin-beta; 37 kDa elastin-binding protein; ficolin
                     (collagen/fibrinogen domain containing lectin) 2
                     (hucolin)"
                     /codon_start=1
                     /product="ficolin-2 isoform a precursor"
                     /protein_id="NP_004099.2"
                     /db_xref="CCDS:CCDS6983.1"
                     /db_xref="GeneID:2220"
                     /db_xref="HGNC:HGNC:3624"
                     /db_xref="MIM:601624"
                     /translation="MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSD
                     KLTILRGCPGLPGAPGPKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGP
                     RTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWA
                     TYKQGFGSRLGEFWLGNDNIHALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEK
                     YNLVLGAFVEGSAGDSLTFHNNQSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLN
                     GRYLRGTHGSFANGINWKSGKGYNYSYKVSEMKVRPA"
     exon            113..226
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            227..280
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            281..313
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            314..441
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            442..571
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            572..706
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1062
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /note="hexamer: AAGAAA"
     polyA_site      1062
                     /gene="FCN2"
                     /gene_synonym="EBP-37; FCNL; ficolin-2; P35"
                     /note="major polyA site"
ORIGIN      
        1 agaccagaag agatggagct ggacagagct gtgggggtcc tgggcgctgc caccctgctg
       61 ctctctttcc tgggcatggc ctgggctctc caggcggcag acacctgtcc agaggtgaag
      121 atggtgggcc tggagggctc tgacaagctc accattctcc gaggctgtcc ggggctgcct
      181 ggggcccctg ggcccaaggg agaggcaggc accaatggaa agagaggaga acgtggcccc
      241 cctggacctc ctgggaaggc aggaccacct gggcccaacg gagcacctgg ggagccccag
      301 ccgtgcctga caggcccgcg tacctgcaag gacctgctag accgagggca cttcctgagc
      361 ggctggcaca ccatctacct gcccgactgc cggcccctga ctgtgctctg tgacatggac
      421 acggacggag ggggctggac cgttttccag cggagggtgg atggctctgt ggacttctac
      481 cgggactggg ccacgtacaa gcagggcttc ggcagtcggc tgggggagtt ctggctgggg
      541 aatgacaaca tccacgccct gaccgcccag ggaaccagcg agctccgtgt agacctggtg
      601 gactttgagg acaactacca gtttgctaag tacagatcat tcaaggtggc cgacgaggcg
      661 gagaagtaca atctggtcct gggggccttc gtggagggca gtgcgggaga ttccctgacg
      721 ttccacaaca accagtcctt ctccaccaaa gaccaggaca atgatcttaa caccggaaat
      781 tgtgctgtga tgtttcaggg agcttggtgg tacaaaaact gccatgtgtc aaacctgaat
      841 ggtcgctacc tcagggggac tcatggcagc tttgcaaatg gcatcaactg gaagtcgggg
      901 aaaggataca attatagcta caaggtgtca gagatgaagg tgcgacctgc ctagcccagg
      961 ccggcctcag ggtcaggacg cctccacaca tagttggttg gggggtaggg ttgggagctt
     1021 ggccctacgg tttgtaaaag aaacacatgt cgtgattcta aa
//
