LOCUS       NM_005449               2962 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 1, mRNA.
ACCESSION   NM_005449
VERSION     NM_005449.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 2962)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 2962)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2962)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006401.2, BP338035.1, CB158779.1, AA769146.1 and AI524407.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005449.4.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292007.1, SRR1803612.254343.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367091.8/ ENSP00000356058.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1893              BC006401.2         58-1950
            1894-2139           BP338035.1         291-536
            2140-2601           CB158779.1         1-462
            2602-2937           AA769146.1         67-402              c
            2938-2962           AI524407.1         56-80               c
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2962
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..124
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1260
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; Fc fragment of IgM receptor; IgM Fc receptor;
                     immunoglobulin mu Fc receptor; regulator of Fas-induced
                     apoptosis Toso; Fas apoptotic inhibitory molecule 3; IgM
                     Fc fragment receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform a
                     precursor"
                     /protein_id="NP_005440.1"
                     /db_xref="CCDS:CCDS1473.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHV
                     RIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVY
                     ACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFV
                     TRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEG
                     LLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAV
                     ERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAP
                     VPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA"
     exon            125..460
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            461..574
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            575..797
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            798..928
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1072
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1131
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..2962
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      1908
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      1919
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      2390..2395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2412
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2962
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 agattgtgaa gggttcctga gtaagcagcg tgtctccatc cccctctcta ggggctcttg
       61 gatggacctt gcactctaga agggacaatg gacttctggc tttggccact ttacttcctg
      121 ccagtatcgg gggccctgag gatcctccca gaagtaaagg tagaggggga gctgggcgga
      181 tcagttacca tcaagtgccc acttcctgaa atgcatgtga ggatatatct gtgccgggag
      241 atggctggat ctggaacatg tggtaccgtg gtatccacca ccaacttcat caaggcagaa
      301 tacaagggcc gagttactct gaagcaatac ccacgcaaga atctgttcct agtggaggta
      361 acacagctga cagaaagtga cagcggagtc tatgcctgcg gagcgggcat gaacacagac
      421 cggggaaaga cccagaaagt caccctgaat gtccacagtg aatacgagcc atcatgggaa
      481 gagcagccaa tgcctgagac tccaaaatgg tttcatctgc cctatttgtt ccagatgcct
      541 gcatatgcca gttcttccaa attcgtaacc agagttacca caccagctca aaggggcaag
      601 gtccctccag ttcaccactc ctcccccacc acccaaatca cccaccgccc tcgagtgtcc
      661 agagcatctt cagtagcagg tgacaagccc cgaaccttcc tgccatccac tacagcctca
      721 aaaatctcag ctctggaggg gctgctcaag ccccagacgc ccagctacaa ccaccacacc
      781 aggctgcaca ggcagagagc actggactat ggctcacagt ctgggaggga aggccaagga
      841 tttcacatcc tgatcccgac catcctgggc cttttcctgc tggcacttct ggggctggtg
      901 gtgaaaaggg ccgttgaaag gaggaaagcc ctctccaggc gggcccgccg actggccgtg
      961 aggatgcgcg ccctggagag ctcccagagg ccccgcgggt cgccgcgacc gcgctcccaa
     1021 aacaacatct acagcgcctg cccgcggcgc gctcgtggag cggacgctgc aggcacaggg
     1081 gaggcccccg ttcccggccc cggagcgccg ttgccccccg ccccgctgca ggtgtctgaa
     1141 tctccctggc tccatgcccc atctctgaag accagctgtg aatacgtgag cctctaccac
     1201 cagcctgccg ccatgatgga ggacagtgat tcagatgact acatcaatgt tcctgcctga
     1261 caactcccca gctatccccc aaccccaggc tcggactgtg gtgccaagga gtctcatcta
     1321 tctgctgatg tccaatacct gcttcatgtg ttctcagagc cctcatcact tcccatgccc
     1381 catctcgact cccatcccca tctatctgtg ccctgagcat ggctctgccc ccaggtcgtc
     1441 ttgcacacct tggcagcccc ctgtagttga caggtaagct gtaggcatgt agagcaattg
     1501 tcccaatgcc acttgcttcc tttccaagcc gtcgaacaga ctgtgggatt tgcagagtgt
     1561 ttcttccatg tctttgacca cagggttgtt gctgcccagg ctctagatca catggcatca
     1621 ggctggggca gaggcatagc tattgtctcg ggcatccttc ccagggttgg gtcttacaca
     1681 aatagaaggc tcttgctctg agttatgtga catgcctcag ccccatggac taagcagggg
     1741 tctggtataa aaacactcct ggaaacgcct ttgccctgat ccaaatgtta gcacttgcta
     1801 gtgaacgtct acttatctca agttctatgc taaaggcaat ttatcttgat gtgatgataa
     1861 accaaactta ttagcaagat atgcatatat atccataaat tctctttact ctgtctccat
     1921 cacttgatgc acataagtgc cctgacctca gcatctcccc tctaaaaaaa aaaaaaaaaa
     1981 agtatctctt tatctttctt ccatagcctg acactgatat ttgtgcactt accttaactt
     2041 tggtctattt tattcatcca aaaccattac atttcttggt tttcacaaat gttccccatt
     2101 tcttagccag ttccagacaa tgtatagcaa gcaggggaag gaaagcagtc aggagttcct
     2161 gggtggccac ggctctgcaa tagcacttat gtcatggaag tgatatccca cctcctacat
     2221 atactctttg cctaggtttt tggaacaagg ttatagtcag acactgtatc tttagattga
     2281 tgtcgaccac aaagttcagc cagagcttga ggctagatgc acagccttgc tattgggaag
     2341 aaggcctttt ctagctgtac aacacagtct cactgggcat tcatccagaa atagagaaga
     2401 aagtctgcca gacttgagtt atgttgtctt ttattagcag ggaatgtcat cacagattgg
     2461 atagtacatc caggtgcaat gtcaccatca gcaaggtcag cttgacactc aagtggaaga
     2521 ttagggaaga atgactagga taaaaaaaaa aggagggcac caagggaaag ggatgatggg
     2581 gtgagctggc gagtgtgggt gggaaatgaa atgtttattg aggatctgct ttgtgctggg
     2641 cactttaatc cacattttat cgtttacttt tcaaacagat gcaccttacc cccaccccaa
     2701 tgctctgtcc ctgcagatat cagaagacag tgtgattttc atgctctgaa gttcagtttt
     2761 acatccaagc atccctctct gttttttaac aatccaaaga caggccaaaa aaagcaccac
     2821 agtttattaa gtacttacta agcacccatc cactgcccca cactgtggca aggattgtga
     2881 ggggtaaaga agcatggggc acaatattct gctgccttca tgtaacttac agtctcacaa
     2941 ataaatagaa cttcagttga aa
//
