LOCUS       NM_001405888            2512 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 14, mRNA.
ACCESSION   NM_001405888
VERSION     NM_001405888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098935.2.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1582335.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC098935.2         73847-73970         c
            125-347             AC098935.2         63759-63981         c
            348-478             AC098935.2         62239-62369         c
            479-622             AC098935.2         61754-61897         c
            623-681             AC098935.2         61491-61549         c
            682-2512            AC098935.2         55346-57176         c
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2512
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..124
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..810
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform j is encoded by transcript variant 14; Fc
                     fragment of IgM receptor; IgM Fc receptor; immunoglobulin
                     mu Fc receptor; regulator of Fas-induced apoptosis Toso;
                     Fas apoptotic inhibitory molecule 3; IgM Fc fragment
                     receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform j"
                     /protein_id="NP_001392817.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPVTTPAQRGKVPPVHHSSPTTQITHRPRVSRAS
                     SVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGF
                     HILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRS
                     QNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVS
                     LYHQPAAMMEDSDSDDYINVPA"
     exon            125..347
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            348..478
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            479..622
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            623..681
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            682..2512
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      1458
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      1469
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      1962
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2512
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 agattgtgaa gggttcctga gtaagcagcg tgtctccatc cccctctcta ggggctcttg
       61 gatggacctt gcactctaga agggacaatg gacttctggc tttggccact ttacttcctg
      121 ccagttacca caccagctca aaggggcaag gtccctccag ttcaccactc ctcccccacc
      181 acccaaatca cccaccgccc tcgagtgtcc agagcatctt cagtagcagg tgacaagccc
      241 cgaaccttcc tgccatccac tacagcctca aaaatctcag ctctggaggg gctgctcaag
      301 ccccagacgc ccagctacaa ccaccacacc aggctgcaca ggcagagagc actggactat
      361 ggctcacagt ctgggaggga aggccaagga tttcacatcc tgatcccgac catcctgggc
      421 cttttcctgc tggcacttct ggggctggtg gtgaaaaggg ccgttgaaag gaggaaagcc
      481 ctctccaggc gggcccgccg actggccgtg aggatgcgcg ccctggagag ctcccagagg
      541 ccccgcgggt cgccgcgacc gcgctcccaa aacaacatct acagcgcctg cccgcggcgc
      601 gctcgtggag cggacgctgc aggcacaggg gaggcccccg ttcccggccc cggagcgccg
      661 ttgccccccg ccccgctgca ggtgtctgaa tctccctggc tccatgcccc atctctgaag
      721 accagctgtg aatacgtgag cctctaccac cagcctgccg ccatgatgga ggacagtgat
      781 tcagatgact acatcaatgt tcctgcctga caactcccca gctatccccc aaccccaggc
      841 tcggactgtg gtgccaagga gtctcatcta tctgctgatg tccaatacct gcttcatgtg
      901 ttctcagagc cctcatcact tcccatgccc catctcgact cccatcccca tctatctgtg
      961 ccctgagcat ggctctgccc ccaggtcgtc ttgcacacct tggcagcccc ctgtagttga
     1021 caggtaagct gtaggcatgt agagcaattg tcccaatgcc acttgcttcc tttccaagcc
     1081 gtcgaacaga ctgtgggatt tgcagagtgt ttcttccatg tctttgacca cagggttgtt
     1141 gctgcccagg ctctagatca catggcatca ggctggggca gaggcatagc tattgtctcg
     1201 ggcatccttc ccagggttgg gtcttacaca aatagaaggc tcttgctctg agttatgtga
     1261 catgcctcag ccccatggac taagcagggg tctggtataa aaacactcct ggaaacgcct
     1321 ttgccctgat ccaaatgtta gcacttgcta gtgaacgtct acttatctca agttctatgc
     1381 taaaggcaat ttatcttgat gtgatgataa accaaactta ttagcaagat atgcatatat
     1441 atccataaat tctctttact ctgtctccat cacttgatgc acataagtgc cctgacctca
     1501 gcatctcccc tctaaaaaaa aaaaaaaaaa agtatctctt tatctttctt ccatagcctg
     1561 acactgatat ttgtgcactt accttaactt tggtctattt tattcatcca aaaccattac
     1621 atttcttggt tttcacaaat gttccccatt tcttagccag ttccagacaa tgtatagcaa
     1681 gcaggggaag gaaagcagtc aggagttcct gggtggccac ggctctgcaa tagcacttat
     1741 gtcatggaag tgatatccca cctcctacat atactctttg cctaggtttt tggaacaagg
     1801 ttatagtcag acactgtatc tttagattga tgtcgaccac aaagttcagc cagagcttga
     1861 ggctagatgc acagccttgc tattgggaag aaggcctttt ctagctgtac aacacagtct
     1921 cactgggcat tcatccagaa atagagaaga aagtctgcca gacttgagtt atgttgtctt
     1981 ttattagcag ggaatgtcat cacagattgg atagtacatc caggtgcaat gtcaccatca
     2041 gcaaggtcag cttgacactc aagtggaaga ttagggaaga atgactagga taaaaaaaaa
     2101 aggagggcac caagggaaag ggatgatggg gtgagctggc gagtgtgggt gggaaatgaa
     2161 atgtttattg aggatctgct ttgtgctggg cactttaatc cacattttat cgtttacttt
     2221 tcaaacagat gcaccttacc cccaccccaa tgctctgtcc ctgcagatat cagaagacag
     2281 tgtgattttc atgctctgaa gttcagtttt acatccaagc atccctctct gttttttaac
     2341 aatccaaaga caggccaaaa aaagcaccac agtttattaa gtacttacta agcacccatc
     2401 cactgcccca cactgtggca aggattgtga ggggtaaaga agcatggggc acaatattct
     2461 gctgccttca tgtaacttac agtctcacaa ataaatagaa cttcagttga aa
//
