LOCUS       NM_001405887            2625 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 13, mRNA.
ACCESSION   NM_001405887
VERSION     NM_001405887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2625)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 2625)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 2625)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2625)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 2625)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 2625)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 2625)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 2625)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 2625)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2625)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098935.2.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2439157.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC098935.2         75176-75225         c
            51-123              AC098935.2         73847-73919         c
            124-237             AC098935.2         64958-65071         c
            238-460             AC098935.2         63759-63981         c
            461-591             AC098935.2         62239-62369         c
            592-735             AC098935.2         61754-61897         c
            736-794             AC098935.2         61491-61549         c
            795-2625            AC098935.2         55346-57176         c
FEATURES             Location/Qualifiers
     source          1..2625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2625
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..50
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            51..123
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..923
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform b is encoded by transcript variant 13; Fc
                     fragment of IgM receptor; IgM Fc receptor; immunoglobulin
                     mu Fc receptor; regulator of Fas-induced apoptosis Toso;
                     Fas apoptotic inhibitory molecule 3; IgM Fc fragment
                     receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform b"
                     /protein_id="NP_001392816.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPEYEPSWEEQPMPETPKWFHLPYLFQMPAYASS
                     SKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKIS
                     ALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVV
                     KRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGT
                     GEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINV
                     PA"
     exon            124..237
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            238..460
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            461..591
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            592..735
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            736..794
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            795..2625
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1519..1524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      1571
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      1582
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2075
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2625
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 acaaccactg tggagcccgg gtctgtcagg cacatccccc cagaaacagt gggctcttgg
       61 atggaccttg cactctagaa gggacaatgg acttctggct ttggccactt tacttcctgc
      121 cagaatacga gccatcatgg gaagagcagc caatgcctga gactccaaaa tggtttcatc
      181 tgccctattt gttccagatg cctgcatatg ccagttcttc caaattcgta accagagtta
      241 ccacaccagc tcaaaggggc aaggtccctc cagttcacca ctcctccccc accacccaaa
      301 tcacccaccg ccctcgagtg tccagagcat cttcagtagc aggtgacaag ccccgaacct
      361 tcctgccatc cactacagcc tcaaaaatct cagctctgga ggggctgctc aagccccaga
      421 cgcccagcta caaccaccac accaggctgc acaggcagag agcactggac tatggctcac
      481 agtctgggag ggaaggccaa ggatttcaca tcctgatccc gaccatcctg ggccttttcc
      541 tgctggcact tctggggctg gtggtgaaaa gggccgttga aaggaggaaa gccctctcca
      601 ggcgggcccg ccgactggcc gtgaggatgc gcgccctgga gagctcccag aggccccgcg
      661 ggtcgccgcg accgcgctcc caaaacaaca tctacagcgc ctgcccgcgg cgcgctcgtg
      721 gagcggacgc tgcaggcaca ggggaggccc ccgttcccgg ccccggagcg ccgttgcccc
      781 ccgccccgct gcaggtgtct gaatctccct ggctccatgc cccatctctg aagaccagct
      841 gtgaatacgt gagcctctac caccagcctg ccgccatgat ggaggacagt gattcagatg
      901 actacatcaa tgttcctgcc tgacaactcc ccagctatcc cccaacccca ggctcggact
      961 gtggtgccaa ggagtctcat ctatctgctg atgtccaata cctgcttcat gtgttctcag
     1021 agccctcatc acttcccatg ccccatctcg actcccatcc ccatctatct gtgccctgag
     1081 catggctctg cccccaggtc gtcttgcaca ccttggcagc cccctgtagt tgacaggtaa
     1141 gctgtaggca tgtagagcaa ttgtcccaat gccacttgct tcctttccaa gccgtcgaac
     1201 agactgtggg atttgcagag tgtttcttcc atgtctttga ccacagggtt gttgctgccc
     1261 aggctctaga tcacatggca tcaggctggg gcagaggcat agctattgtc tcgggcatcc
     1321 ttcccagggt tgggtcttac acaaatagaa ggctcttgct ctgagttatg tgacatgcct
     1381 cagccccatg gactaagcag gggtctggta taaaaacact cctggaaacg cctttgccct
     1441 gatccaaatg ttagcacttg ctagtgaacg tctacttatc tcaagttcta tgctaaaggc
     1501 aatttatctt gatgtgatga taaaccaaac ttattagcaa gatatgcata tatatccata
     1561 aattctcttt actctgtctc catcacttga tgcacataag tgccctgacc tcagcatctc
     1621 ccctctaaaa aaaaaaaaaa aaaagtatct ctttatcttt cttccatagc ctgacactga
     1681 tatttgtgca cttaccttaa ctttggtcta ttttattcat ccaaaaccat tacatttctt
     1741 ggttttcaca aatgttcccc atttcttagc cagttccaga caatgtatag caagcagggg
     1801 aaggaaagca gtcaggagtt cctgggtggc cacggctctg caatagcact tatgtcatgg
     1861 aagtgatatc ccacctccta catatactct ttgcctaggt ttttggaaca aggttatagt
     1921 cagacactgt atctttagat tgatgtcgac cacaaagttc agccagagct tgaggctaga
     1981 tgcacagcct tgctattggg aagaaggcct tttctagctg tacaacacag tctcactggg
     2041 cattcatcca gaaatagaga agaaagtctg ccagacttga gttatgttgt cttttattag
     2101 cagggaatgt catcacagat tggatagtac atccaggtgc aatgtcacca tcagcaaggt
     2161 cagcttgaca ctcaagtgga agattaggga agaatgacta ggataaaaaa aaaaggaggg
     2221 caccaaggga aagggatgat ggggtgagct ggcgagtgtg ggtgggaaat gaaatgttta
     2281 ttgaggatct gctttgtgct gggcacttta atccacattt tatcgtttac ttttcaaaca
     2341 gatgcacctt acccccaccc caatgctctg tccctgcaga tatcagaaga cagtgtgatt
     2401 ttcatgctct gaagttcagt tttacatcca agcatccctc tctgtttttt aacaatccaa
     2461 agacaggcca aaaaaagcac cacagtttat taagtactta ctaagcaccc atccactgcc
     2521 ccacactgtg gcaaggattg tgaggggtaa agaagcatgg ggcacaatat tctgctgcct
     2581 tcatgtaact tacagtctca caaataaata gaacttcagt tgaaa
//
