LOCUS       NM_001405871            2961 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 2, mRNA.
ACCESSION   NM_001405871
VERSION     NM_001405871.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 2961)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 2961)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2961)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098935.2.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1118402.1,
                                           SRR14038191.4532420.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC098935.2         75176-75225         c
            51-123              AC098935.2         73847-73919         c
            124-459             AC098935.2         65788-66123         c
            460-573             AC098935.2         64958-65071         c
            574-796             AC098935.2         63759-63981         c
            797-927             AC098935.2         62239-62369         c
            928-1071            AC098935.2         61754-61897         c
            1072-1130           AC098935.2         61491-61549         c
            1131-2961           AC098935.2         55346-57176         c
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2961
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..50
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            51..123
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1259
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; Fc fragment of IgM receptor; IgM Fc receptor;
                     immunoglobulin mu Fc receptor; regulator of Fas-induced
                     apoptosis Toso; Fas apoptotic inhibitory molecule 3; IgM
                     Fc fragment receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform a
                     precursor"
                     /protein_id="NP_001392800.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHV
                     RIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVY
                     ACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFV
                     TRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEG
                     LLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAV
                     ERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAP
                     VPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA"
     exon            124..459
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            460..573
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            574..796
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            797..927
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1071
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1130
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..2961
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      1907
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      1918
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2411
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      2943..2948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2961
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 acaaccactg tggagcccgg gtctgtcagg cacatccccc cagaaacagt gggctcttgg
       61 atggaccttg cactctagaa gggacaatgg acttctggct ttggccactt tacttcctgc
      121 cagtatcggg ggccctgagg atcctcccag aagtaaaggt agagggggag ctgggcggat
      181 cagttaccat caagtgccca cttcctgaaa tgcatgtgag gatatatctg tgccgggaga
      241 tggctggatc tggaacatgt ggtaccgtgg tatccaccac caacttcatc aaggcagaat
      301 acaagggccg agttactctg aagcaatacc cacgcaagaa tctgttccta gtggaggtaa
      361 cacagctgac agaaagtgac agcggagtct atgcctgcgg agcgggcatg aacacagacc
      421 ggggaaagac ccagaaagtc accctgaatg tccacagtga atacgagcca tcatgggaag
      481 agcagccaat gcctgagact ccaaaatggt ttcatctgcc ctatttgttc cagatgcctg
      541 catatgccag ttcttccaaa ttcgtaacca gagttaccac accagctcaa aggggcaagg
      601 tccctccagt tcaccactcc tcccccacca cccaaatcac ccaccgccct cgagtgtcca
      661 gagcatcttc agtagcaggt gacaagcccc gaaccttcct gccatccact acagcctcaa
      721 aaatctcagc tctggagggg ctgctcaagc cccagacgcc cagctacaac caccacacca
      781 ggctgcacag gcagagagca ctggactatg gctcacagtc tgggagggaa ggccaaggat
      841 ttcacatcct gatcccgacc atcctgggcc ttttcctgct ggcacttctg gggctggtgg
      901 tgaaaagggc cgttgaaagg aggaaagccc tctccaggcg ggcccgccga ctggccgtga
      961 ggatgcgcgc cctggagagc tcccagaggc cccgcgggtc gccgcgaccg cgctcccaaa
     1021 acaacatcta cagcgcctgc ccgcggcgcg ctcgtggagc ggacgctgca ggcacagggg
     1081 aggcccccgt tcccggcccc ggagcgccgt tgccccccgc cccgctgcag gtgtctgaat
     1141 ctccctggct ccatgcccca tctctgaaga ccagctgtga atacgtgagc ctctaccacc
     1201 agcctgccgc catgatggag gacagtgatt cagatgacta catcaatgtt cctgcctgac
     1261 aactccccag ctatccccca accccaggct cggactgtgg tgccaaggag tctcatctat
     1321 ctgctgatgt ccaatacctg cttcatgtgt tctcagagcc ctcatcactt cccatgcccc
     1381 atctcgactc ccatccccat ctatctgtgc cctgagcatg gctctgcccc caggtcgtct
     1441 tgcacacctt ggcagccccc tgtagttgac aggtaagctg taggcatgta gagcaattgt
     1501 cccaatgcca cttgcttcct ttccaagccg tcgaacagac tgtgggattt gcagagtgtt
     1561 tcttccatgt ctttgaccac agggttgttg ctgcccaggc tctagatcac atggcatcag
     1621 gctggggcag aggcatagct attgtctcgg gcatccttcc cagggttggg tcttacacaa
     1681 atagaaggct cttgctctga gttatgtgac atgcctcagc cccatggact aagcaggggt
     1741 ctggtataaa aacactcctg gaaacgcctt tgccctgatc caaatgttag cacttgctag
     1801 tgaacgtcta cttatctcaa gttctatgct aaaggcaatt tatcttgatg tgatgataaa
     1861 ccaaacttat tagcaagata tgcatatata tccataaatt ctctttactc tgtctccatc
     1921 acttgatgca cataagtgcc ctgacctcag catctcccct ctaaaaaaaa aaaaaaaaaa
     1981 gtatctcttt atctttcttc catagcctga cactgatatt tgtgcactta ccttaacttt
     2041 ggtctatttt attcatccaa aaccattaca tttcttggtt ttcacaaatg ttccccattt
     2101 cttagccagt tccagacaat gtatagcaag caggggaagg aaagcagtca ggagttcctg
     2161 ggtggccacg gctctgcaat agcacttatg tcatggaagt gatatcccac ctcctacata
     2221 tactctttgc ctaggttttt ggaacaaggt tatagtcaga cactgtatct ttagattgat
     2281 gtcgaccaca aagttcagcc agagcttgag gctagatgca cagccttgct attgggaaga
     2341 aggccttttc tagctgtaca acacagtctc actgggcatt catccagaaa tagagaagaa
     2401 agtctgccag acttgagtta tgttgtcttt tattagcagg gaatgtcatc acagattgga
     2461 tagtacatcc aggtgcaatg tcaccatcag caaggtcagc ttgacactca agtggaagat
     2521 tagggaagaa tgactaggat aaaaaaaaaa ggagggcacc aagggaaagg gatgatgggg
     2581 tgagctggcg agtgtgggtg ggaaatgaaa tgtttattga ggatctgctt tgtgctgggc
     2641 actttaatcc acattttatc gtttactttt caaacagatg caccttaccc ccaccccaat
     2701 gctctgtccc tgcagatatc agaagacagt gtgattttca tgctctgaag ttcagtttta
     2761 catccaagca tccctctctg ttttttaaca atccaaagac aggccaaaaa aagcaccaca
     2821 gtttattaag tacttactaa gcacccatcc actgccccac actgtggcaa ggattgtgag
     2881 gggtaaagaa gcatggggca caatattctg ctgccttcat gtaacttaca gtctcacaaa
     2941 taaatagaac ttcagttgaa a
//
