LOCUS       NM_001405864            2820 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 8, mRNA.
ACCESSION   NM_001405864
VERSION     NM_001405864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098935.2.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.934400.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC098935.2         75176-75225         c
            51-123              AC098935.2         73847-73919         c
            124-459             AC098935.2         65788-66123         c
            460-573             AC098935.2         64958-65071         c
            574-796             AC098935.2         63759-63981         c
            797-930             AC098935.2         61754-61887         c
            931-989             AC098935.2         61491-61549         c
            990-2820            AC098935.2         55346-57176         c
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2820
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..50
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            51..123
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1118
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform e precursor is encoded by transcript
                     variant 8; Fc fragment of IgM receptor; IgM Fc receptor;
                     immunoglobulin mu Fc receptor; regulator of Fas-induced
                     apoptosis Toso; Fas apoptotic inhibitory molecule 3; IgM
                     Fc fragment receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform e
                     precursor"
                     /protein_id="NP_001392793.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHV
                     RIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVY
                     ACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFV
                     TRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEG
                     LLKPQTPSYNHHTRLHRQRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRAR
                     GADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSD
                     SDDYINVPA"
     exon            124..459
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            460..573
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            574..796
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            797..930
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            931..989
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            990..2820
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      1766
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      1777
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2270
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2820
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 acaaccactg tggagcccgg gtctgtcagg cacatccccc cagaaacagt gggctcttgg
       61 atggaccttg cactctagaa gggacaatgg acttctggct ttggccactt tacttcctgc
      121 cagtatcggg ggccctgagg atcctcccag aagtaaaggt agagggggag ctgggcggat
      181 cagttaccat caagtgccca cttcctgaaa tgcatgtgag gatatatctg tgccgggaga
      241 tggctggatc tggaacatgt ggtaccgtgg tatccaccac caacttcatc aaggcagaat
      301 acaagggccg agttactctg aagcaatacc cacgcaagaa tctgttccta gtggaggtaa
      361 cacagctgac agaaagtgac agcggagtct atgcctgcgg agcgggcatg aacacagacc
      421 ggggaaagac ccagaaagtc accctgaatg tccacagtga atacgagcca tcatgggaag
      481 agcagccaat gcctgagact ccaaaatggt ttcatctgcc ctatttgttc cagatgcctg
      541 catatgccag ttcttccaaa ttcgtaacca gagttaccac accagctcaa aggggcaagg
      601 tccctccagt tcaccactcc tcccccacca cccaaatcac ccaccgccct cgagtgtcca
      661 gagcatcttc agtagcaggt gacaagcccc gaaccttcct gccatccact acagcctcaa
      721 aaatctcagc tctggagggg ctgctcaagc cccagacgcc cagctacaac caccacacca
      781 ggctgcacag gcagaggcgg gcccgccgac tggccgtgag gatgcgcgcc ctggagagct
      841 cccagaggcc ccgcgggtcg ccgcgaccgc gctcccaaaa caacatctac agcgcctgcc
      901 cgcggcgcgc tcgtggagcg gacgctgcag gcacagggga ggcccccgtt cccggccccg
      961 gagcgccgtt gccccccgcc ccgctgcagg tgtctgaatc tccctggctc catgccccat
     1021 ctctgaagac cagctgtgaa tacgtgagcc tctaccacca gcctgccgcc atgatggagg
     1081 acagtgattc agatgactac atcaatgttc ctgcctgaca actccccagc tatcccccaa
     1141 ccccaggctc ggactgtggt gccaaggagt ctcatctatc tgctgatgtc caatacctgc
     1201 ttcatgtgtt ctcagagccc tcatcacttc ccatgcccca tctcgactcc catccccatc
     1261 tatctgtgcc ctgagcatgg ctctgccccc aggtcgtctt gcacaccttg gcagccccct
     1321 gtagttgaca ggtaagctgt aggcatgtag agcaattgtc ccaatgccac ttgcttcctt
     1381 tccaagccgt cgaacagact gtgggatttg cagagtgttt cttccatgtc tttgaccaca
     1441 gggttgttgc tgcccaggct ctagatcaca tggcatcagg ctggggcaga ggcatagcta
     1501 ttgtctcggg catccttccc agggttgggt cttacacaaa tagaaggctc ttgctctgag
     1561 ttatgtgaca tgcctcagcc ccatggacta agcaggggtc tggtataaaa acactcctgg
     1621 aaacgccttt gccctgatcc aaatgttagc acttgctagt gaacgtctac ttatctcaag
     1681 ttctatgcta aaggcaattt atcttgatgt gatgataaac caaacttatt agcaagatat
     1741 gcatatatat ccataaattc tctttactct gtctccatca cttgatgcac ataagtgccc
     1801 tgacctcagc atctcccctc taaaaaaaaa aaaaaaaaag tatctcttta tctttcttcc
     1861 atagcctgac actgatattt gtgcacttac cttaactttg gtctatttta ttcatccaaa
     1921 accattacat ttcttggttt tcacaaatgt tccccatttc ttagccagtt ccagacaatg
     1981 tatagcaagc aggggaagga aagcagtcag gagttcctgg gtggccacgg ctctgcaata
     2041 gcacttatgt catggaagtg atatcccacc tcctacatat actctttgcc taggtttttg
     2101 gaacaaggtt atagtcagac actgtatctt tagattgatg tcgaccacaa agttcagcca
     2161 gagcttgagg ctagatgcac agccttgcta ttgggaagaa ggccttttct agctgtacaa
     2221 cacagtctca ctgggcattc atccagaaat agagaagaaa gtctgccaga cttgagttat
     2281 gttgtctttt attagcaggg aatgtcatca cagattggat agtacatcca ggtgcaatgt
     2341 caccatcagc aaggtcagct tgacactcaa gtggaagatt agggaagaat gactaggata
     2401 aaaaaaaaag gagggcacca agggaaaggg atgatggggt gagctggcga gtgtgggtgg
     2461 gaaatgaaat gtttattgag gatctgcttt gtgctgggca ctttaatcca cattttatcg
     2521 tttacttttc aaacagatgc accttacccc caccccaatg ctctgtccct gcagatatca
     2581 gaagacagtg tgattttcat gctctgaagt tcagttttac atccaagcat ccctctctgt
     2641 tttttaacaa tccaaagaca ggccaaaaaa agcaccacag tttattaagt acttactaag
     2701 cacccatcca ctgccccaca ctgtggcaag gattgtgagg ggtaaagaag catggggcac
     2761 aatattctgc tgccttcatg taacttacag tctcacaaat aaatagaact tcagttgaaa
//
