LOCUS       NM_001405863            3055 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc mu receptor (FCMR), transcript variant 5, mRNA.
ACCESSION   NM_001405863
VERSION     NM_001405863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Kubagawa,H., Skopnik,C.M., Al-Qaisi,K., Calvert,R.A., Honjo,K.,
            Kubagawa,Y., Teuber,R., Aliabadi,P.M., Enghard,P., Radbruch,A. and
            Sutton,B.J.
  TITLE     Differences between Human and Mouse IgM Fc Receptor (FcmicroR)
  JOURNAL   Int J Mol Sci 22 (13), 7024 (2021)
   PUBMED   34209905
  REMARK    GeneRIF: Differences between Human and Mouse IgM Fc Receptor
            (FcmicroR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Zhang,Y.R., Yu,Z., Xiong,W.J., Liu,X.X., Liu,H.M., Cui,R., Wang,Q.,
            Chen,W.M., Qiu,L.G. and Yi,S.H.
  TITLE     TOSO interacts with SYK and enhances BCR pathway activation in
            chronic lymphocytic leukemia
  JOURNAL   Chin Med J (Engl) 133 (17), 2090-2097 (2020)
   PUBMED   32784334
  REMARK    GeneRIF: TOSO interacts with SYK and enhances BCR pathway
            activation in chronic lymphocytic leukemia.
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Jiang,J., Wu,R.H., Zhou,H.L., Li,Z.M., Kou,D., Deng,Z., Dong,M. and
            Chen,L.H.
  TITLE     TGIF2 promotes cervical cancer metastasis by negatively regulating
            FCMR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5953-5962 (2020)
   PUBMED   32572908
  REMARK    GeneRIF: TGIF2 promotes cervical cancer metastasis by negatively
            regulating FCMR.
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Pallasch,C.P., Schulz,A., Kutsch,N., Schwamb,J., Hagist,S.,
            Kashkar,H., Ultsch,A., Wickenhauser,C., Hallek,M. and Wendtner,C.M.
  TITLE     Overexpression of TOSO in CLL is triggered by B-cell receptor
            signaling and associated with progressive disease
  JOURNAL   Blood 112 (10), 4213-4219 (2008)
   PUBMED   18708628
  REMARK    GeneRIF: association with unmutated IgV(H) and the specific
            induction of TOSO via the BCR suggest autoreactive BCR signaling as
            a key mediator of apoptosis resistance in CLL.
            Erratum:[Blood. 2018 May 17;131(20):2272. doi:
            10.1182/blood-2018-04-843490.. PMID: 29773545]
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Proto-Siqueira,R., Panepucci,R.A., Careta,F.P., Lee,A., Clear,A.,
            Morris,K., Owen,C., Rizzatti,E.G., Silva,W.A. Jr., Falcao,R.P.,
            Zago,M.A. and Gribben,J.G.
  TITLE     SAGE analysis demonstrates increased expression of TOSO
            contributing to Fas-mediated resistance in CLL
  JOURNAL   Blood 112 (2), 394-397 (2008)
   PUBMED   18434611
  REMARK    GeneRIF: demonstrated a 5.6-fold increase of TOSO protein in
            circulating CLL cells and lymph nodes
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Sigruener,A., Buechler,C., Bared,S.M., Grandl,M., Aslanidis,C.,
            Ugocsai,P., Gehrmann,M. and Schmitz,G.
  TITLE     E-LDL upregulates TOSO expression and enhances the survival of
            human macrophages
  JOURNAL   Biochem Biophys Res Commun 359 (3), 723-728 (2007)
   PUBMED   17553462
  REMARK    GeneRIF: enzymatically modified-LDL-generated foam cells are
            protected from cell death most likely through the expression of
            TOSO by a FLIP(L) independent mechanism
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Hitoshi,Y., Lorens,J., Kitada,S.I., Fisher,J., LaBarge,M.,
            Ring,H.Z., Francke,U., Reed,J.C., Kinoshita,S. and Nolan,G.P.
  TITLE     Toso, a cell surface, specific regulator of Fas-induced apoptosis
            in T cells
  JOURNAL   Immunity 8 (4), 461-471 (1998)
   PUBMED   9586636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098935.2.
            
            Summary: Fc receptors specifically bind to the Fc region of
            immunoglobulins (Igs) to mediate the unique functions of each Ig
            class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020)
            (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010
            [PubMed 20042454]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.525929.1,
                                           SRR1163658.265790.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC098935.2         73847-73970         c
            125-217             AC098935.2         73370-73462         c
            218-553             AC098935.2         65788-66123         c
            554-667             AC098935.2         64958-65071         c
            668-890             AC098935.2         63759-63981         c
            891-1021            AC098935.2         62239-62369         c
            1022-1165           AC098935.2         61754-61897         c
            1166-1224           AC098935.2         61491-61549         c
            1225-3055           AC098935.2         55346-57176         c
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3055
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="Fc mu receptor"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
     exon            1..124
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1353
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="isoform d is encoded by transcript variant 5; Fc
                     fragment of IgM receptor; IgM Fc receptor; immunoglobulin
                     mu Fc receptor; regulator of Fas-induced apoptosis Toso;
                     Fas apoptotic inhibitory molecule 3; IgM Fc fragment
                     receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform d"
                     /protein_id="NP_001392792.1"
                     /db_xref="GeneID:9214"
                     /db_xref="HGNC:HGNC:14315"
                     /db_xref="MIM:606015"
                     /translation="MDFWLWPLYFLPEMESCCVAQDGLELVALSDPPGSASQSAGITV
                     SGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAE
                     YKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPS
                     WEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHR
                     PRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQS
                     GREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPR
                     GSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLK
                     TSCEYVSLYHQPAAMMEDSDSDDYINVPA"
     exon            125..217
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            218..553
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            554..667
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            668..890
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1021
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1165
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1224
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..3055
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: GATAAA"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: CATAAA"
     polyA_site      2001
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     polyA_site      2012
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="major polyA site"
     regulatory      2483..2488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      2505
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
                     /note="hexamer: AATAGA"
     polyA_site      3055
                     /gene="FCMR"
                     /gene_synonym="FAIM3; FcmuR; IgM FcR; TOSO"
ORIGIN      
        1 agattgtgaa gggttcctga gtaagcagcg tgtctccatc cccctctcta ggggctcttg
       61 gatggacctt gcactctaga agggacaatg gacttctggc tttggccact ttacttcctg
      121 ccagagatgg agtcttgctg tgttgcccag gatggtcttg aacttgtggc cttaagtgat
      181 cctcctggct cagcttcaca aagcgctggg attacagtat cgggggccct gaggatcctc
      241 ccagaagtaa aggtagaggg ggagctgggc ggatcagtta ccatcaagtg cccacttcct
      301 gaaatgcatg tgaggatata tctgtgccgg gagatggctg gatctggaac atgtggtacc
      361 gtggtatcca ccaccaactt catcaaggca gaatacaagg gccgagttac tctgaagcaa
      421 tacccacgca agaatctgtt cctagtggag gtaacacagc tgacagaaag tgacagcgga
      481 gtctatgcct gcggagcggg catgaacaca gaccggggaa agacccagaa agtcaccctg
      541 aatgtccaca gtgaatacga gccatcatgg gaagagcagc caatgcctga gactccaaaa
      601 tggtttcatc tgccctattt gttccagatg cctgcatatg ccagttcttc caaattcgta
      661 accagagtta ccacaccagc tcaaaggggc aaggtccctc cagttcacca ctcctccccc
      721 accacccaaa tcacccaccg ccctcgagtg tccagagcat cttcagtagc aggtgacaag
      781 ccccgaacct tcctgccatc cactacagcc tcaaaaatct cagctctgga ggggctgctc
      841 aagccccaga cgcccagcta caaccaccac accaggctgc acaggcagag agcactggac
      901 tatggctcac agtctgggag ggaaggccaa ggatttcaca tcctgatccc gaccatcctg
      961 ggccttttcc tgctggcact tctggggctg gtggtgaaaa gggccgttga aaggaggaaa
     1021 gccctctcca ggcgggcccg ccgactggcc gtgaggatgc gcgccctgga gagctcccag
     1081 aggccccgcg ggtcgccgcg accgcgctcc caaaacaaca tctacagcgc ctgcccgcgg
     1141 cgcgctcgtg gagcggacgc tgcaggcaca ggggaggccc ccgttcccgg ccccggagcg
     1201 ccgttgcccc ccgccccgct gcaggtgtct gaatctccct ggctccatgc cccatctctg
     1261 aagaccagct gtgaatacgt gagcctctac caccagcctg ccgccatgat ggaggacagt
     1321 gattcagatg actacatcaa tgttcctgcc tgacaactcc ccagctatcc cccaacccca
     1381 ggctcggact gtggtgccaa ggagtctcat ctatctgctg atgtccaata cctgcttcat
     1441 gtgttctcag agccctcatc acttcccatg ccccatctcg actcccatcc ccatctatct
     1501 gtgccctgag catggctctg cccccaggtc gtcttgcaca ccttggcagc cccctgtagt
     1561 tgacaggtaa gctgtaggca tgtagagcaa ttgtcccaat gccacttgct tcctttccaa
     1621 gccgtcgaac agactgtggg atttgcagag tgtttcttcc atgtctttga ccacagggtt
     1681 gttgctgccc aggctctaga tcacatggca tcaggctggg gcagaggcat agctattgtc
     1741 tcgggcatcc ttcccagggt tgggtcttac acaaatagaa ggctcttgct ctgagttatg
     1801 tgacatgcct cagccccatg gactaagcag gggtctggta taaaaacact cctggaaacg
     1861 cctttgccct gatccaaatg ttagcacttg ctagtgaacg tctacttatc tcaagttcta
     1921 tgctaaaggc aatttatctt gatgtgatga taaaccaaac ttattagcaa gatatgcata
     1981 tatatccata aattctcttt actctgtctc catcacttga tgcacataag tgccctgacc
     2041 tcagcatctc ccctctaaaa aaaaaaaaaa aaaagtatct ctttatcttt cttccatagc
     2101 ctgacactga tatttgtgca cttaccttaa ctttggtcta ttttattcat ccaaaaccat
     2161 tacatttctt ggttttcaca aatgttcccc atttcttagc cagttccaga caatgtatag
     2221 caagcagggg aaggaaagca gtcaggagtt cctgggtggc cacggctctg caatagcact
     2281 tatgtcatgg aagtgatatc ccacctccta catatactct ttgcctaggt ttttggaaca
     2341 aggttatagt cagacactgt atctttagat tgatgtcgac cacaaagttc agccagagct
     2401 tgaggctaga tgcacagcct tgctattggg aagaaggcct tttctagctg tacaacacag
     2461 tctcactggg cattcatcca gaaatagaga agaaagtctg ccagacttga gttatgttgt
     2521 cttttattag cagggaatgt catcacagat tggatagtac atccaggtgc aatgtcacca
     2581 tcagcaaggt cagcttgaca ctcaagtgga agattaggga agaatgacta ggataaaaaa
     2641 aaaaggaggg caccaaggga aagggatgat ggggtgagct ggcgagtgtg ggtgggaaat
     2701 gaaatgttta ttgaggatct gctttgtgct gggcacttta atccacattt tatcgtttac
     2761 ttttcaaaca gatgcacctt acccccaccc caatgctctg tccctgcaga tatcagaaga
     2821 cagtgtgatt ttcatgctct gaagttcagt tttacatcca agcatccctc tctgtttttt
     2881 aacaatccaa agacaggcca aaaaaagcac cacagtttat taagtactta ctaagcaccc
     2941 atccactgcc ccacactgtg gcaaggattg tgaggggtaa agaagcatgg ggcacaatat
     3001 tctgctgcct tcatgtaact tacagtctca caaataaata gaacttcagt tgaaa
//
