LOCUS       NM_033449               4319 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens FCH and double SH3 domains 1 (FCHSD1), mRNA.
ACCESSION   NM_033449
VERSION     NM_033449.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4319)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 4319)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4319)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FCHSD1 and FCHSD2
            genes in silico
  JOURNAL   Int J Mol Med 13 (5), 749-754 (2004)
   PUBMED   15067381
REFERENCE   4  (bases 1 to 4319)
  AUTHORS   Coyle,I.P., Koh,Y.H., Lee,W.C., Slind,J., Fergestad,T.,
            Littleton,J.T. and Ganetzky,B.
  TITLE     Nervous wreck, an SH3 adaptor protein that interacts with Wsp,
            regulates synaptic growth in Drosophila
  JOURNAL   Neuron 41 (4), 521-534 (2004)
   PUBMED   14980202
REFERENCE   5  (bases 1 to 4319)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 4319)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY217346.1 and AC008781.7.
            
            On Nov 22, 2018 this sequence version replaced NM_033449.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY217346.1, AK000007.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435817.7/ ENSP00000399259.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3946              AY217346.1         2-3947
            3947-4085           AC008781.7         11423-11561
            4086-4319           AY217346.1         4087-4320
FEATURES             Location/Qualifiers
     source          1..4319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4319
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /note="FCH and double SH3 domains 1"
                     /db_xref="GeneID:89848"
                     /db_xref="HGNC:HGNC:25463"
                     /db_xref="MIM:617555"
     exon            1..71
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2123
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /note="FCH and double SH3 domains protein 1; nervous wreck
                     homolog 2; protein nervous wreck 2"
                     /codon_start=1
                     /product="F-BAR and double SH3 domains protein 1"
                     /protein_id="NP_258260.1"
                     /db_xref="CCDS:CCDS47295.1"
                     /db_xref="GeneID:89848"
                     /db_xref="HGNC:HGNC:25463"
                     /db_xref="MIM:617555"
                     /translation="MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSK
                     QRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQ
                     ASDRYRDLAGGTGRSAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWAL
                     AQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVAT
                     NAHLDHYYQEELPALLKALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQ
                     VSWEQDLKLFLQEPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTS
                     RAARDYKIQNHGHRVLQRLEQRRQQASEREAPSIEQRLQEVRESIRRAQVSQVKGAAR
                     LALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECE
                     ETGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVK
                     ARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELS
                     FPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLP
                     SPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFLDMMAPRLRPMRPPPPPPAKAPD
                     PGHPDPLT"
     exon            72..169
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..215
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..283
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..425
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..562
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..626
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..755
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..878
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..974
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1094
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1199
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1361
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1490
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1574
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1692
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1913
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2001
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2057
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..4319
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2639
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /note="major polyA site"
     regulatory      4296..4301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
                     /note="hexamer: AATAAA"
     polyA_site      4319
                     /gene="FCHSD1"
                     /gene_synonym="NWK2"
ORIGIN      
        1 gcttcctcca gttccggagt ccagtggctg accgccttgc tggagcggag atgcagccgc
       61 cgccccgaaa agtgaagccg gcccaggagg tgaagcttcg cttcctggaa cagctgagca
      121 tccttcagac ctggcagcag agggaggcgg atctgctgga ggacatcaga tcctacagca
      181 agcagagggc agccattgaa cgggagtatg ggcaggcact ccagaaactg gctggcccat
      241 tcctgaagag ggaagggcac cggagcggtg agatggacag caggggcagg acagtgttcg
      301 gtgcctggcg ctgcctgctg gatgccaccg tggctggggg ccaaacccga ctccaggcgt
      361 ctgaccgata ccgtgaccta gcagggggta cagggcggag cgccaaggag caggtgctta
      421 ggaagggaac agagaacctc cagagggcgc aggctgaggt gctgcagtct gtccgggagc
      481 tgagccgaag tcggaagctg tatgggcagc gggaacgtgt gtgggccttg gcacaggaga
      541 aggcggctga tgtccaggcc aggctaaacc gaagtgacca tgggatcttc cactctcgga
      601 ccagtctcca gaaactgagc accaagctgt ccgcccagtc agcccagtac tcccagcagc
      661 tgcaagcagc ccgcaatgag tacctgctta acttggtggc taccaatgcc cacctcgacc
      721 attactacca ggaggaactg ccagctctgc tcaaggccct ggtcagtgag ctgtcagagc
      781 acttgaggga ccccctgacc tccctgagcc acactgagct ggaagccgca gaggtcatcc
      841 tggagcatgc ccaccgcggg gagcagacaa cctcccaggt aagctgggag caagacctga
      901 agctgtttct tcaggagcct ggtgtatttt cccccacccc acctcagcag tttcagccag
      961 cagggactga tcaggtgtgt gtcctggagt ggggagcaga aggcgtggct ggcaagagtg
     1021 gcctggagaa agaggttcag cgcttgacca gccgagctgc ccgtgactac aagatccaga
     1081 accatgggca tcgggtactg caacgactgg agcagaggcg gcagcaggct tcagagcggg
     1141 aggctccaag catagaacag aggttacagg aagtgcgaga gagcatccgc cgggcacagg
     1201 tgagccaggt gaagggggct gcccggctgg ccctgctgca gggggctggc ttagatgtgg
     1261 agcgctggct gaagccagcc atgacccagg cccaggatga ggtggagcag gagcggcggc
     1321 tcagtgaggc tcggctgtcc cagagggacc tctctccaac cgctgaggat gctgagcttt
     1381 ctgactttga ggaatgtgag gagacgggag agctctttga ggagcctgcc ccccaagccc
     1441 tggccacgag ggccctcccc tgccctgcac acgtggtatt tcgctatcag gcagggcgtg
     1501 aggatgagct gacaatcacg gagggtgagt ggctggaggt catagaggag ggagatgctg
     1561 acgaatgggt caaggctcgg aaccagcacg gcgaggtagg ctttgtccct gagcgatatc
     1621 tcaacttccc ggacctctcc ctcccagaga gcagccaaga cagtgacaat ccctgcgggg
     1681 cagagcccac agcattcctg gcacaggccc tgtacagcta caccggacag agtgcagagg
     1741 agctgagctt ccctgagggg gcactcatcc gtctgctgcc ccgggcccaa gatggagtag
     1801 atgacggctt ctggagggga gaatttgggg gccgtgttgg ggtcttcccc tccctgctgg
     1861 tggaagagct gcttggcccc ccagggccac ctgaactctc tgaccctgaa cagatgctgc
     1921 cgtccccttc tcctcccagc ttctccccac ctgcacctac ctctgtgttg gatgggcccc
     1981 ctgcacctgt cctgcctggg gacaaagccc tggacttccc tgggttcctg gacatgatgg
     2041 cacctcgact caggccgatg cgtccaccac ctcccccgcc ggctaaagcc ccggatcctg
     2101 gccacccaga tcccctcacc tgaaggccag ggaagccttg acccccagtg atgctgctgt
     2161 ccctatcttc aagctgtcag accacaccat caatgatcca gagcaacaca gccaaaagct
     2221 ggaatcgccc ttatttccac cctcacctcc aagggtggaa acttgcccct tcccatttct
     2281 agagctggaa cccactcctt tttttcccat tgttctatca tctctaggac cggaactacc
     2341 ttctcttctg tcatgaccct atctagggtg gtgaaatgcc tgaaatctct ggggctggaa
     2401 accatccatc aaggtctcta gtagttctgg cccacctctt tccccaccct ggctccatga
     2461 cccaccccac tctggatgcc agggtcactg gggttgggct ggggagagga acaggccttg
     2521 ggaatcagga gctggagcca ggatgcgaag cagctgtaat ggtctgagcg gatttattga
     2581 caatgaataa agggcacgaa ggccaggcca gggcctgggc ctcttgtgct aagagggcag
     2641 ggggcctacg gtgctattgc tttaggggcc caccacgggc aggggcctgc tcccagctgc
     2701 cacgctctat catatggagc gaggtgttgg ggaaggcggg gcaggcagcc tgttgcaggc
     2761 aggggaagga gaagagactg aggggctgtg acctctcctg aggcccccag cctgagactg
     2821 tgcaactcca ggtggaagta gagctggtcc ctcagctggg gggcagtgct gtccagtgga
     2881 ggggagggct ttcacgccca cccaccccct ggccctgcca gctggtagtc catcagcaca
     2941 atgaaggaga cttggagaag aggaagaata acactgttgc ttcctgttca agctgtgtcc
     3001 agcttttccc ctggggctcc aggaccttcc ctacctccac caccaaacca agggatttat
     3061 agcaaaggct aagcctgcag tttactcggg gggttcaggg agccgaaagg cttaaatagt
     3121 ttaagtaggt gatgggaaga tgagattacc tcatttaggg ctcaggcaga ctcacctcac
     3181 atactccctg ctccctgtgg tagagacacc tgagagaaag gggaggggtc aacaatgaga
     3241 gaccaggagt aggtcctatc agtgcccccc agagtagaga gcaataagag cccagcccag
     3301 tgcagtcccg gctgtgtttt cctacctggt gatcagaagt gtctggtttg cttggctgcc
     3361 catttgcctc ttgagtgggc agccctgggc ttgggcccct ccctccggcc ctcagtgttg
     3421 gctctgcaga agctctgggg ttcccttcaa gtgcacgagg ggttaggctg ctgtccctga
     3481 gtcctccatt ctgtactggg gggctggcta ggacctgggg ctgtggcctc tcagggggca
     3541 gcctctccat ggcaggcatc cctgccttgg gctgccctcc cccagacccc tgaccacccc
     3601 ctgggtcctg tcccccacca gagccccagc tcctgtctgt gggggagcca tcacggtgtt
     3661 cgtgcagtcc atagcgcttc tcaatgtgtg tcacccggaa cctgggaggg gagggaacac
     3721 tggggtttag gaccacaact cagaggctgc ttggccctcc cctctgacca gggacatcct
     3781 gagtttggtg gctacttccc tctggcctaa ggtaggggag gccttctcag attgtggggc
     3841 acattgtgta gcctgacttc tgccggagct cccagtccag gaggaaagag ccaaggccca
     3901 cttttgggat caggtgcctg atcactgggc cccctacctc agcccccctt tccctggagc
     3961 acctgcccca cctgcccaca gagaacacag tggtctcccc tgtccggggg cggctttttc
     4021 cttccttgga gcgtccctga cggacaagtg gaggcctctt gctgcggctg caatggaggc
     4081 aaggggctgc agagcccagg tgcactgtgt gatgatggga gggggctccg tcctgcaggc
     4141 tggaggtggc atccacactg gacagcaggg aggaggggag tgagggtaac atttccattt
     4201 cccttcatgt tttgtttctt acgttctttc agcatgctcc ttaaaacccc agaagcccca
     4261 atttccccaa gccccatttt ttcttgtctt tatctaataa actcaatatt aagatgtta
//
