LOCUS       NM_138782               4921 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens FCH and mu domain containing endocytic adaptor 2
            (FCHO2), transcript variant 1, mRNA.
ACCESSION   NM_138782 XM_291142
VERSION     NM_138782.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4921)
  AUTHORS   Yang,Y., Li,J., Wei,C., Wang,L., Gao,Z., Shen,K., Li,Y., Ren,M.,
            Zhu,Y., Ding,Y., Wei,C., Zhang,T., Zheng,S., Lu,N. and Gu,J.
  TITLE     Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation
            of melanoma by directly binding to DND1
  JOURNAL   Cell Biol Toxicol 40 (1), 9 (2024)
   PUBMED   38311675
  REMARK    GeneRIF: Circular RNA circFCHO2(hsa_circ_0002490) promotes the
            proliferation of melanoma by directly binding to DND1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4921)
  AUTHORS   Zhang,Z., Sun,C., Zheng,Y. and Gong,Y.
  TITLE     circFCHO2 promotes gastric cancer progression by activating the
            JAK1/STAT3 pathway via sponging miR-194-5p
  JOURNAL   Cell Cycle 21 (20), 2145-2164 (2022)
   PUBMED   35708677
  REMARK    GeneRIF: circFCHO2 promotes gastric cancer progression by
            activating the JAK1/STAT3 pathway via sponging miR-194-5p.
            Erratum:[Cell Cycle. 2024 Feb;23(3):338. doi:
            10.1080/15384101.2024.2317629.. PMID: 38526078]
REFERENCE   3  (bases 1 to 4921)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4921)
  AUTHORS   El Alaoui,F., Casuso,I., Sanchez-Fuentes,D., Arpin-Andre,C.,
            Rathar,R., Baecker,V., Castro,A., Lorca,T., Viaud,J.,
            Vassilopoulos,S., Carretero-Genevrier,A. and Picas,L.
  TITLE     Structural organization and dynamics of FCHo2 docking on membranes
  JOURNAL   Elife 11, e73156 (2022)
   PUBMED   35044298
  REMARK    GeneRIF: Structural organization and dynamics of FCHo2 docking on
            membranes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4921)
  AUTHORS   Day,K.J., Kago,G., Wang,L., Richter,J.B., Hayden,C.C., Lafer,E.M.
            and Stachowiak,J.C.
  TITLE     Liquid-like protein interactions catalyse assembly of endocytic
            vesicles
  JOURNAL   Nat Cell Biol 23 (4), 366-376 (2021)
   PUBMED   33820972
  REMARK    GeneRIF: Liquid-like protein interactions catalyse assembly of
            endocytic vesicles.
REFERENCE   6  (bases 1 to 4921)
  AUTHORS   Uezu,A., Umeda,K., Tsujita,K., Suetsugu,S., Takenawa,T. and
            Nakanishi,H.
  TITLE     Characterization of the EFC/F-BAR domain protein, FCHO2
  JOURNAL   Genes Cells 16 (8), 868-878 (2011)
   PUBMED   21762413
REFERENCE   7  (bases 1 to 4921)
  AUTHORS   Henne,W.M., Boucrot,E., Meinecke,M., Evergren,E., Vallis,Y.,
            Mittal,R. and McMahon,H.T.
  TITLE     FCHo proteins are nucleators of clathrin-mediated endocytosis
  JOURNAL   Science 328 (5983), 1281-1284 (2010)
   PUBMED   20448150
REFERENCE   8  (bases 1 to 4921)
  AUTHORS   Brehme,M., Hantschel,O., Colinge,J., Kaupe,I., Planyavsky,M.,
            Kocher,T., Mechtler,K., Bennett,K.L. and Superti-Furga,G.
  TITLE     Charting the molecular network of the drug target Bcr-Abl
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7414-7419 (2009)
   PUBMED   19380743
REFERENCE   9  (bases 1 to 4921)
  AUTHORS   Henne,W.M., Kent,H.M., Ford,M.G., Hegde,B.G., Daumke,O.,
            Butler,P.J., Mittal,R., Langen,R., Evans,P.R. and McMahon,H.T.
  TITLE     Structure and analysis of FCHo2 F-BAR domain: a dimerizing and
            membrane recruitment module that effects membrane curvature
  JOURNAL   Structure 15 (7), 839-852 (2007)
   PUBMED   17540576
  REMARK    GeneRIF: This structure shows a distant relationship to
            curvature-sensing BAR modules, and suggests how similar coiled-coil
            architectures in the BAR superfamily have evolved to expand the
            repertoire of membrane-sculpting possibilities
REFERENCE   10 (bases 1 to 4921)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FCHO2 and mouse Fcho2
            genes in silico
  JOURNAL   Int J Mol Med 14 (2), 327-331 (2004)
   PUBMED   15254787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137070.1 and AL832928.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138782.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831971.1, SRR1660809.60615.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430046.7/ ENSP00000393776.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2565              BC137070.1         61-2625
            2566-4921           AL832928.1         967-3322
FEATURES             Location/Qualifiers
     source          1..4921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..4921
                     /gene="FCHO2"
                     /note="FCH and mu domain containing endocytic adaptor 2"
                     /db_xref="GeneID:115548"
                     /db_xref="HGNC:HGNC:25180"
                     /db_xref="MIM:613438"
     exon            1..89
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2489
                     /gene="FCHO2"
                     /note="isoform a is encoded by transcript variant 1; FCH
                     domain only protein 2; F-BAR domain only protein 2; FCH
                     domain only 2"
                     /codon_start=1
                     /product="F-BAR domain only protein 2 isoform a"
                     /protein_id="NP_620137.2"
                     /db_xref="CCDS:CCDS47230.1"
                     /db_xref="GeneID:115548"
                     /db_xref="HGNC:HGNC:25180"
                     /db_xref="MIM:613438"
                     /translation="MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERAT
                     IEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQ
                     KYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQ
                     REIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIG
                     SLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDTA
                     SAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPETNQNDT
                     KENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSPAISR
                     HSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSAR
                     PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAES
                     SSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCI
                     VKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSN
                     TKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSAS
                     TTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSS
                     ISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIK
                     KRFATGRYLADC"
     exon            90..181
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..256
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..398
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..551
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..656
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..755
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..852
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..897
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..970
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..995
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1053
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1229
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1241
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1266
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1309
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1401
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1505
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1635
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1747
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1903
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2036
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2236
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2301
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2466
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..4921
                     /gene="FCHO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4898..4903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCHO2"
                     /note="hexamer: AATAAA"
     polyA_site      4921
                     /gene="FCHO2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacac agcggcgggc gggcgcggac gcggaacccg gcgcggcggc ggcacgatgg
       61 tcatggcgta tttcgtcgag aatttttggg gggaaaaaaa tagtggcttt gatgtcctct
      121 accataatat gaaacatgga cagatatcaa caaaagaact agcagatttt gtaagggaac
      181 gagctaccat agaggaggca tactccaggt caatgacaaa actagcaaaa tctgcaagca
      241 attattcaca acttggaaca tttgcaccag tatgggatgt attcaaaaca tctacagaga
      301 aattagcaaa ttgtcacttg gatcttgtta gaaaattaca agaattaata aaggaagttc
      361 agaagtatgg agaagaacaa gtaaagtctc ataaaaagac taaagaagaa gttgcaggaa
      421 ctctggaagc tgtccaaacc attcagagca taactcaggc cctccagaaa tccaaggaaa
      481 attacaatgc caagtgtgta gaacaggagc gtttgaaaaa ggaaggagct acacaaagag
      541 aaatagaaaa ggcagctgtt aaatctaaga aagctacaga tacctataaa ctctatgtgg
      601 aaaaatatgc attagcaaaa gctgatttcg aacagaaaat gacagaaaca gctcagaaat
      661 ttcaagatat tgaagaaact catctcattc acataaagga aattatagga tccttgtcaa
      721 atgctataaa ggaaattcat ttgcagatag gccaggtcca tgaagaattt ataaataaca
      781 tggctaatac tacagttgaa agtttgatac aaaaatttgc tgagtcaaaa ggcactggga
      841 aggaaagacc tggcctcatt gaatttgaag aatgtgacac tgctagtgca gttgaaggta
      901 taaaaccaag gaaaagaaag acctttgctt tgccaggaat cattaaaaag gaaaaagatg
      961 cagaatctgt ggaatgtcct gatgcagatt cattgaacat tcctgatgta gatgaagaag
     1021 gctacagtat taaaccagaa acaaatcaga atgataccaa agagaaccat ttctactcat
     1081 ctagtgattc tgactccgaa gatgaagaac caaagaagta tcggatagaa attaagccta
     1141 tgcatccaaa taactcacat cacacaatgg cttctttgga tgaattaaaa gtatctatag
     1201 ggaatataac actctcccca gcaatatcta gacacagtcc agtacagatg aatcggaatt
     1261 tgtctaatga ggagttaaca aaatcaaagc catctgctcc acccaatgaa aaaggaacca
     1321 gtgatttact tgcttgggac cccctatttg gaccatctct tgattcatct tcttcatctt
     1381 cactaacttc atcatcatca gccaggccca caactcctct ttctgtaggc accattgtcc
     1441 cacctccgag gcctgcttcc agaccaaagc ttacttcagg caaactcagt gggattaatg
     1501 aaatacccag gccattcagc ccacctgtaa cttccaacac cagcccacct cctgctgcac
     1561 cattagcccg ggcagaaagt tcttcttcta tctcatcatc tgcttcattg agtgctgcca
     1621 atactccaac agtaggtgtg tcacggggtc ccagccctgt cagccttgga aatcaggata
     1681 ccttacctgt ggcagttgcc cttacagaat ctgttaatgc ctactttaaa ggagcagatc
     1741 ccaccaagtg tattgtgaag atcactggtg atatgacaat gtcatttcca agtggaatta
     1801 ttaaagtctt caccagcaat ccaactccag ctgtgttgtg cttcagggtg aaaaatatca
     1861 gcagactaga gcagattctt ccaaatgcac agcttgtgtt cagtgatcca tcacaatgtg
     1921 attccaacac aaaagatttt tggatgaaca tgcaagctgt tacagtctac ctcaagaagc
     1981 tgtcagagca aaatccagct gcttcttatt ataatgtaga tgtattaaag tatcaggtat
     2041 catcaaatgg tattcagtcc actcctctga atcttgcaac atactggaaa tgtagtgcta
     2101 gcaccacaga tcttagagtg gattataaat acaatccaga agctatggtg gcacctagtg
     2161 tgctttccaa catacaggtg gtggtaccag tggatggagg agtaacgaac atgcagtccc
     2221 ttccccctgc aatatggaat gcagaacaaa tgaaagcctt ttggaaattg tctagtattt
     2281 cagaaaaatc agaaaatgga ggttctgggt ccctccgagc aaaatttgat ctttcagaag
     2341 gacctagtaa acccacgaca cttgcagtac aattcctcag cgagggaagt accctttcag
     2401 gagtagattt cgaacttgtg ggcactggct ataggctttc cttaataaag aagcggtttg
     2461 ctactggacg atacctggcg gattgttgat ggacctggga aagtgatgtg gcttcaggga
     2521 ttacaaacct gccattctgc attatctgtt ctttccaaac actattttaa cttgtatgat
     2581 gtctttcaaa cttagacata tttgagagct gactacaaac attaaatcgc acttttaaag
     2641 tgagtcattg aaataaatag tactgaaatg attctctatg ttgtaaatga tcaactacaa
     2701 tattcaggaa gcacatttat tcagattctc agtaaaaatg aagtttttgt aggattaatt
     2761 tttaaattat ttccagtgtc tatgttgaaa aaaagggtta tagtgtaata tcaggcctaa
     2821 agtttcagaa gagcaagcac aaagtaattt agctttccat acatttttag agtcagagat
     2881 aactttgaaa tttcataagt ttgatattca gtggatacaa atagaacatg aattctaagt
     2941 tttgggtaat gttaactcag aacacttaat caaattgagc tatgtgccat aaggtaatca
     3001 gaccagagtc caagttgtat gcaaaaaatc tataatttga ttctcataaa catattaata
     3061 aagtataagt gatgttttat atgattttta aaaaaaattc tcaagtgcaa tgtgttttaa
     3121 aataagcttg caaatgacag cagagacatt tacttctgca gttagttaac tttataggag
     3181 ttgtgatttt tttgatgaat taatgctgta gatttaattt atttttatat ggaattgcat
     3241 aatgtgtgcc ttttaaaaca ataacaaaaa ccagagatgt gcctatacaa tttgtgttca
     3301 ttaatgtgcc tcactttttt tctcagtctg aatcttctgt tcagaatctt acagtgatca
     3361 agcattttta taagatattt gcaatttttg taaatatttt tggcctgcaa ctgggaaggg
     3421 gattcagagt cataaagcct aacttaagaa tcctggctca cttctttggt gatacactgt
     3481 agccactaga aagagaaata aacccaatgg catgtgttta caggaagaaa gattaccttc
     3541 agatacttga cattaacctc atcaaaagtg tgtgaatttt aaaacaaatt ctaaaaaaac
     3601 tatagtgcta aattggtaac tggtatttta actctcaatt tagcattttc cttgatactt
     3661 tatcattgaa aatttatgca tttatttact gattgtgttg tgaacatgag ttttatggta
     3721 ttttgtgagg gatgcatttt ttaaaagatt aattttggaa acagaaggag aagcactgcc
     3781 atttgttttt atttcaacaa ttggaaaaat taccaatttg tacattttaa ttattcaatt
     3841 tctactttgt aaaaataggg aaattatttg aagtgatata tttggttaaa catttctaaa
     3901 aataaactac caatactaaa tagtaagaaa cctaacttta gtagcaaatc ttgattaatt
     3961 gaagaaataa aatatttcgg ataaggtttc ataatttaca aatgggaatt tcatttataa
     4021 taataaatat gagtgtcctt tatttgccta gtagaagtga taaattgtgt tatatatgat
     4081 aatttatata aaaccactaa ttgttccgtt aagcttcaca gaaaataaaa cctctattac
     4141 tagacattta tgtaacatct tgctgtacta aatacagcag aaaatctact ctttagcaat
     4201 atataacaca gtatatgctt ttttatatat tcaatgttag cccaagtctg aatttacatt
     4261 tgactaaagc agcacataag ataatttgct aaaatgctaa tctttactaa atagtgagct
     4321 aaattagaat ttctaactct tatattgtgc tcttttaaat gccaattaca gtcccttact
     4381 ggaattctaa ctgtaatttg ctttgcaatc aaactgcttt tagggcagcc aatattttat
     4441 tattggaatt cagacactgt tcttaccgtg tttgttttta atcaaatatt acctaaaaat
     4501 gtacaaatta gtgaaatggt taaacttctg cactttctta gttaccacag tcttcatacc
     4561 aagtattggg tacaggttac aattttgaag ccatatgagt ttatattgat tttttttttc
     4621 catttaaaaa tccactaatg gtgtaaaaga gaccagtaga ttttcaatgg gaaatgtacc
     4681 tagcaagctg gttcttgctt atatatagtg ataaactttg tagctgcctc tttaaccaag
     4741 aatttgtaaa cacaactcta ataaatgtga gttttaaagg attgttattt actactttgg
     4801 attgtaatta gaacaatgca catctgtctt ccaagatttt gtaaatattt ttgatttttt
     4861 tcattaaatg taaattttac ataaaagttg tgctcttaat aaacatgtaa tatataattt
     4921 a
//
