LOCUS       NM_001136019            1511 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens Fc gamma receptor and transporter (FCGRT), transcript
            variant 1, mRNA.
ACCESSION   NM_001136019
VERSION     NM_001136019.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Haga,K., Tokui,T., Miyamoto,K., Takai-Todaka,R., Kudo,S.,
            Ishikawa,A., Ishiyama,R., Kato,A., Yokoyama,M., Katayama,K. and
            Nakanishi,A.
  TITLE     Neonatal Fc receptor is a functional receptor for classical human
            astrovirus
  JOURNAL   Genes Cells 29 (11), 983-1001 (2024)
   PUBMED   39266307
  REMARK    GeneRIF: Neonatal Fc receptor is a functional receptor for
            classical human astrovirus.
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Qian,S., Zhang,D., Yang,Z., Li,R., Zhang,X., Gao,F. and Yu,L.
  TITLE     The role of immunoglobulin transport receptor, neonatal Fc receptor
            in mucosal infection and immunity and therapeutic intervention
  JOURNAL   Int Immunopharmacol 138, 112583 (2024)
   PUBMED   38971109
  REMARK    GeneRIF: The role of immunoglobulin transport receptor, neonatal Fc
            receptor in mucosal infection and immunity and therapeutic
            intervention.
            Review article
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Boulard,P., Azzopardi,N., Levard,R., Cornec,J.M., Lamamy,J.,
            Prieur,B., Demattei,M.V., Watier,H., Gatault,P. and
            Gouilleux-Gruart,V.
  TITLE     Albumin influences leucocyte FcRn expression in the early days of
            kidney transplantation
  JOURNAL   Clin Exp Immunol 216 (3), 307-317 (2024)
   PUBMED   38353127
  REMARK    GeneRIF: Albumin influences leucocyte FcRn expression in the early
            days of kidney transplantation.
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Haddad,G. and Blaine,J.
  TITLE     Identification of Four Mouse FcRn Splice Variants and FcRn-Specific
            Vesicles
  JOURNAL   Cells 13 (7), 594 (2024)
   PUBMED   38607033
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Mikulska,J.E., Pablo,L., Canel,J. and Simister,N.E.
  TITLE     Cloning and analysis of the gene encoding the human neonatal Fc
            receptor
  JOURNAL   Eur J Immunogenet 27 (4), 231-240 (2000)
   PUBMED   10998088
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Vaughn,D.E. and Bjorkman,P.J.
  TITLE     Structural basis of pH-dependent antibody binding by the neonatal
            Fc receptor
  JOURNAL   Structure 6 (1), 63-73 (1998)
   PUBMED   9493268
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Kivela,J., Parkkila,S., Waheed,A., Parkkila,A.K., Sly,W.S. and
            Rajaniemi,H.
  TITLE     Secretory carbonic anhydrase isoenzyme (CA VI) in human serum
  JOURNAL   Clin Chem 43 (12), 2318-2322 (1997)
   PUBMED   9439449
REFERENCE   8  (bases 1 to 1511)
  AUTHORS   Leach,J.L., Sedmak,D.D., Osborne,J.M., Rahill,B., Lairmore,M.D. and
            Anderson,C.L.
  TITLE     Isolation from human placenta of the IgG transporter, FcRn, and
            localization to the syncytiotrophoblast: implications for
            maternal-fetal antibody transport
  JOURNAL   J Immunol 157 (8), 3317-3322 (1996)
   PUBMED   8871627
REFERENCE   9  (bases 1 to 1511)
  AUTHORS   Kandil,E., Egashira,M., Miyoshi,O., Niikawa,N., Ishibashi,T. and
            Kasahara,M.
  TITLE     The human gene encoding the heavy chain of the major
            histocompatibility complex class I-like Fc receptor (FCGRT) maps to
            19q13.3
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 97-98 (1996)
   PUBMED   8646894
  REMARK    Erratum:[Cytogenet Cell Genet 1998;81(3-4):179. Miyosi O [corrected
            to Miyoshi O]]
REFERENCE   10 (bases 1 to 1511)
  AUTHORS   Story,C.M., Mikulska,J.E. and Simister,N.E.
  TITLE     A major histocompatibility complex class I-like Fc receptor cloned
            from human placenta: possible role in transfer of immunoglobulin G
            from mother to fetus
  JOURNAL   J Exp Med 180 (6), 2377-2381 (1994)
   PUBMED   7964511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC091487.1, AC010619.7 and
            BE245284.1.
            
            On May 17, 2019 this sequence version replaced NM_001136019.2.
            
            Summary: This gene encodes a receptor that binds the Fc region of
            monomeric immunoglobulin G. The encoded protein transfers
            immunoglobulin G antibodies from mother to fetus across the
            placenta. This protein also binds immunoglobulin G to protect the
            antibody from degradation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647163.1, BC091487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221466.10/ ENSP00000221466.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               BC091487.1         299-963
            666-666             AC010619.7         101618-101618
            667-1416            BC091487.1         964-1713
            1417-1511           BE245284.1         569-663
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1511
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /note="Fc gamma receptor and transporter"
                     /db_xref="GeneID:2217"
                     /db_xref="HGNC:HGNC:3621"
                     /db_xref="MIM:601437"
     exon            1..90
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     exon            91..177
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1202
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neonatal Fc-receptor for Ig; immunoglobulin
                     receptor, intestinal, heavy chain; IgG receptor FcRn large
                     subunit p51; major histocompatibility complex class I-like
                     Fc receptor; IgG Fc fragment receptor transporter alpha
                     chain; FcRn alpha chain; Fc fragment of IgG receptor and
                     transporter; neonatal Fc receptor; Fc fragment of IgG,
                     receptor, transporter, alpha; heavy chain of the major
                     histocompatibility complex class I-like Fc receptor;
                     transmembrane alpha chain of the neonatal receptor;
                     neonatal fragment crystallizable Fc receptor FcRn"
                     /codon_start=1
                     /product="IgG receptor FcRn large subunit p51 isoform 1
                     precursor"
                     /protein_id="NP_001129491.1"
                     /db_xref="CCDS:CCDS12770.1"
                     /db_xref="GeneID:2217"
                     /db_xref="HGNC:HGNC:3621"
                     /db_xref="MIM:601437"
                     /translation="MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGT
                     PAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAF
                     KALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAI
                     SQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSV
                     LTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCI
                     VQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWIS
                     LRGDDTGVLLPTPGEAQDADLKDVNVIPATA"
     exon            178..429
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     exon            430..705
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     exon            706..975
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1092
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1511
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1392..1397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /note="hexamer: AATATA"
     polyA_site      1416
                     /gene="FCGRT"
                     /gene_synonym="alpha-chain; FcgammaRn; FCRN"
                     /note="major polyA site"
ORIGIN      
        1 aggatgtgag agaggaactg gggtctccag tcacgggagc caggagccgg ccagggccgc
       61 aggcaggaag ggagcgaggc tgaagggaac gtcgtcctct cagcatgggg gtcccgcggc
      121 ctcagccctg ggcgctgggg ctcctgctct ttctccttcc tgggagcctg ggcgcagaaa
      181 gccacctctc cctcctgtac caccttaccg cggtgtcctc gcctgccccg gggactcctg
      241 ccttctgggt gtccggctgg ctgggcccgc agcagtacct gagctacaat agcctgcggg
      301 gcgaggcgga gccctgtgga gcttgggtct gggaaaacca ggtgtcctgg tattgggaga
      361 aagagaccac agatctgagg atcaaggaga agctctttct ggaagctttc aaagctttgg
      421 ggggaaaagg tccctacact ctgcagggcc tgctgggctg tgaactgggc cctgacaaca
      481 cctcggtgcc caccgccaag ttcgccctga acggcgagga gttcatgaat ttcgacctca
      541 agcagggcac ctggggtggg gactggcccg aggccctggc tatcagtcag cggtggcagc
      601 agcaggacaa ggcggccaac aaggagctca ccttcctgct attctcctgc ccgcaccgcc
      661 tgcgggagca cctggagagg ggccgcggaa acctggagtg gaaggagccc ccctccatgc
      721 gcctgaaggc ccgacccagc agccctggct tttccgtgct tacctgcagc gccttctcct
      781 tctaccctcc ggagctgcaa cttcggttcc tgcggaatgg gctggccgct ggcaccggcc
      841 agggtgactt cggccccaac agtgacggat ccttccacgc ctcgtcgtca ctaacagtca
      901 aaagtggcga tgagcaccac tactgctgca ttgtgcagca cgcggggctg gcgcagcccc
      961 tcagggtgga gctggaatct ccagccaagt cctccgtgct cgtggtggga atcgtcatcg
     1021 gtgtcttgct actcacggca gcggctgtag gaggagctct gttgtggaga aggatgagga
     1081 gtgggctgcc agccccttgg atctcccttc gtggagacga caccggggtc ctcctgccca
     1141 ccccagggga ggcccaggat gctgatttga aggatgtaaa tgtgattcca gccaccgcct
     1201 gaccatccgc cattccgact gctaaaagcg aatgtagtca ggcccctttc atgctgtgag
     1261 acctcctgga acactggcat ctctgagcct ccagaagggg ttctgggcct agttgtcctc
     1321 cctctggagc cccgtcctgt ggtctgcctc agtttcccct cctaatacat atggctgttt
     1381 tccacctcga taatataaca cgagtttggg cccgaatcag tgtgttctca tcatttttca
     1441 ggcaggggag gtaagggaat aagtcggggg actgaatggc ggctgggcct cggatctctc
     1501 ctacaggtaa c
//
