LOCUS       NM_001244753            2103 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc gamma receptor IIIb (FCGR3B), transcript variant 1,
            mRNA.
ACCESSION   NM_001244753
VERSION     NM_001244753.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Aslam,M.M., John,P., Fan,K.H., Malik,J.M., Feingold,E.,
            Demirci,F.Y. and Kamboh,M.I.
  TITLE     Association of Fc Gamma Receptor 3B Gene Copy Number Variation with
            Rheumatoid Arthritis Susceptibility
  JOURNAL   Genes (Basel) 13 (12), 2238 (2022)
   PUBMED   36553504
  REMARK    GeneRIF: Association of Fc Gamma Receptor 3B Gene Copy Number
            Variation with Rheumatoid Arthritis Susceptibility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Minguela,A., Salido,E.J., Soto-Ramirez,M.F., Olga,M.A., Leal,J.D.,
            Garcia-Garay,M.C., Periago,A., Berenguer,M., Blanque,M. and
            Campillo,J.A.
  TITLE     Low-affinity immunoglobulin gamma Fc region receptor III-B
            (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune
            system disorders
  JOURNAL   Br J Haematol 195 (5), 743-747 (2021)
   PUBMED   34544201
  REMARK    GeneRIF: Low-affinity immunoglobulin gamma Fc region receptor III-B
            (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune
            system disorders.
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Nasr,A., Aljada,A., Hamid,O., Elsheikh,H.A., Masuadi,E.,
            Al-Bawab,A., Alenazi,T.H., Abushouk,A. and Salah,A.M.
  TITLE     Significant differences in FcgammaRIIa, FcgammaRIIIa and
            FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass
            pattern are associated with severe Plasmodium falciparum malaria in
            Saudi children
  JOURNAL   Malar J 20 (1), 376 (2021)
   PUBMED   34551786
  REMARK    GeneRIF: Significant differences in FcgammaRIIa, FcgammaRIIIa and
            FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass
            pattern are associated with severe Plasmodium falciparum malaria in
            Saudi children.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Moraru,M., Perez-Portilla,A., Al-Akioui Sanz,K.,
            Blazquez-Moreno,A., Arnaiz-Villena,A., Reyburn,H.T. and Vilches,C.
  TITLE     FCGR Genetic Variation in Two Populations From Ecuador
            Highlands-Extensive Copy-Number Variation, Distinctive Distribution
            of Functional Polymorphisms, and a Novel, Locally Common, Chimeric
            FCGR3B/A (CD16B/A) Gene
  JOURNAL   Front Immunol 12, 615645 (2021)
   PUBMED   34108956
  REMARK    GeneRIF: FCGR Genetic Variation in Two Populations From Ecuador
            Highlands-Extensive Copy-Number Variation, Distinctive Distribution
            of Functional Polymorphisms, and a Novel, Locally Common, Chimeric
            FCGR3B/A (CD16B/A) Gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Lanier,L.L., Yu,G. and Phillips,J.H.
  TITLE     Analysis of Fc gamma RIII (CD16) membrane expression and
            association with CD3 zeta and Fc epsilon RI-gamma by site-directed
            mutation
  JOURNAL   J Immunol 146 (5), 1571-1576 (1991)
   PUBMED   1825220
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Qiu,W.Q., de Bruin,D., Brownstein,B.H., Pearse,R. and Ravetch,J.V.
  TITLE     Organization of the human and mouse low-affinity Fc gamma R genes:
            duplication and recombination
  JOURNAL   Science 248 (4956), 732-735 (1990)
   PUBMED   2139735
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Ravetch,J.V. and Perussia,B.
  TITLE     Alternative membrane forms of Fc gamma RIII(CD16) on human natural
            killer cells and neutrophils. Cell type-specific expression of two
            genes that differ in single nucleotide substitutions
  JOURNAL   J Exp Med 170 (2), 481-497 (1989)
   PUBMED   2526846
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Scallon,B.J., Scigliano,E., Freedman,V.H., Miedel,M.C., Pan,Y.C.,
            Unkeless,J.C. and Kochan,J.P.
  TITLE     A human immunoglobulin G receptor exists in both
            polypeptide-anchored and phosphatidylinositol-glycan-anchored forms
  JOURNAL   Proc Natl Acad Sci U S A 86 (13), 5079-5083 (1989)
   PUBMED   2525780
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Peltz,G.A., Grundy,H.O., Lebo,R.V., Yssel,H., Barsh,G.S. and
            Moore,K.W.
  TITLE     Human Fc gamma RIII: cloning, expression, and identification of the
            chromosomal locus of two Fc receptors for IgG
  JOURNAL   Proc Natl Acad Sci U S A 86 (3), 1013-1017 (1989)
   PUBMED   2521732
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Simmons,D. and Seed,B.
  TITLE     The Fc gamma receptor of natural killer cells is a
            phospholipid-linked membrane protein
  JOURNAL   Nature 333 (6173), 568-570 (1988)
   PUBMED   2967436
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M24854.1, AL451067.12, X16863.1
            and AJ581669.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 31, 2018 this sequence version replaced NM_001244753.1.
            
            Summary: The protein encoded by this gene is a low affinity
            receptor for the Fc region of gamma immunoglobulins (IgG). The
            encoded protein acts as a monomer and can bind either monomeric or
            aggregated IgG. This gene may function to capture immune complexes
            in the peripheral circulation. Several transcript variants encoding
            different isoforms have been found for this gene. A highly-similar
            gene encoding a related protein is also found on chromosome 1.
            [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (2). Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ581669.1, SRR1660805.239720.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650385.1/ ENSP00000497461.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               M24854.1           17-291
            276-276             AL451067.12        94603-94603         c
            277-842             X16863.1           228-793
            843-843             AL451067.12        89156-89156         c
            844-862             X16863.1           795-813
            863-1740            AL451067.12        88259-89136         c
            1741-2103           AJ581669.1         1693-2055
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2103
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="Fc gamma receptor IIIb"
                     /db_xref="GeneID:2215"
                     /db_xref="HGNC:HGNC:3620"
                     /db_xref="MIM:610665"
     exon            1..122
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            123..143
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            144..401
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            402..659
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            660..2103
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="hexamer: AACAAA"
     polyA_site      1856
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="major polyA site"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="hexamer: AATAAA"
     polyA_site      2040
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="major polyA site"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="hexamer: AATAAA"
     polyA_site      2103
                     /gene="FCGR3B"
                     /gene_synonym="CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3;
                     FCGR3A; FCR-10; FCRIII; FCRIIIb"
                     /note="major polyA site"
ORIGIN      
        1 gtttactccc tcctgtctag tcggcttggt ccctttaggg ctccggatat ctttggtgac
       61 ttgtccactc cagtgtggca tcatgtggca gctgctcctc ccaactgctc tgctacttct
      121 agtttcagct ggcatgcgga ctgaagatct cccaaaggct gtggtgttcc tggagcctca
      181 atggtacagc gtgcttgaga aggacagtgt gactctgaag tgccagggag cctactcccc
      241 tgaggacaat tccacacagt ggtttcacaa tgagaacctc atctcaagcc aggcctcgag
      301 ctacttcatt gacgctgcca cagtcaacga cagtggagag tacaggtgcc agacaaacct
      361 ctccaccctc agtgacccgg tgcagctaga agtccatatc ggctggctgt tgctccaggc
      421 ccctcggtgg gtgttcaagg aggaagaccc tattcacctg aggtgtcaca gctggaagaa
      481 cactgctctg cataaggtca catatttaca gaatggcaaa gacaggaagt attttcatca
      541 taattctgac ttccacattc caaaagccac actcaaagat agcggctcct acttctgcag
      601 ggggcttgtt gggagtaaaa atgtgtcttc agagactgtg aacatcacca tcactcaagg
      661 tttggcagtg tcaaccatct catcattctc tccacctggg taccaagtct ctttctgctt
      721 ggtgatggta ctcctttttg cagtggacac aggactatat ttctctgtga agacaaacat
      781 ttgaagctca acaagagact ggaaggacca taaacttaaa tggagaaagg accctcaaga
      841 cacatgaccc ccatcccatg ggggtaataa gagcagtggc agcagcatct ctgaacattt
      901 ctctggattt gcaaccccat catcctcagg cctctctaca agcagcagga aacatagaac
      961 tcagagccag atcctttatc caactctcga tttttccttg gtctccagtg gaagggaaaa
     1021 gcccatgatc ttcaagcagg gaagccccag tgagtagctg cattcctaga aattgaagtt
     1081 tcagagctac acaaacactt tttctgtccc aaccattccc tcacagcaaa gcaacaatac
     1141 aggctaggga tggtaatcct ttaaacatac aaaaattgct cgtattataa attacccagt
     1201 ttagagggaa aaaaagaaaa taattattcc taaacaaatg gataagtaga attaatggtt
     1261 gaggcaggac cctacagagt gtgggaactg ctggggatct agagaattca gtgggaccaa
     1321 tgaaagcatg gctgagaaat agcagggtag tccaggatag tctaagggag gtgttcccat
     1381 ctgagcccag agataagggt gtcttcctag aacattagcc gtagtggaat taacaggaaa
     1441 tcatgagggt gacgtagaat tgagtcttcc aggggactct atcagaactg gaccatttcc
     1501 aagtatataa cgatgagtcc tctaatgcta ggagtagaaa atggtcctag gaaggggact
     1561 gaggattggg gtgggggtgg ggtggaaaag aaagtacaga acaaaccctg tgtcactgtc
     1621 tcaagttaag ctaagtgaac agaactatct cagcatcaga atgagaaagc ctgagaagaa
     1681 agaaccaacc agaagcacac aggaaggaaa gcgcaggagg tgaaaatgct ttcttggccg
     1741 gggtagtaag aattagaggt taatgcaggg actgtaaaac caccttttct gcttcaatgt
     1801 ctagttcctg tatagctttg ttcattgcat ttattaaaca aatgttgtat aaccaatact
     1861 aaatgtacta ctgagcttca ctgagttacg ctgtgaaact ttcaaatcct tcttcatgtc
     1921 agttccaatg aggtggggat ggagaagaca attgttgctt atgaaagaaa gctttagctg
     1981 tctctgtttt gtaagctttc agtgcaacat ttcttggttc caataaagca ttttacaaga
     2041 tcttgcatgc tactcttaga tagaagatgg caaaaccatg gtaataaaat atgaatgata
     2101 aaa
//
