LOCUS       NM_000569               2100 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens Fc gamma receptor IIIa (FCGR3A), transcript variant 1,
            mRNA.
ACCESSION   NM_000569 XM_001133750 XM_005275865 XM_006710063
VERSION     NM_000569.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Andreeva,I., Kolb,P., Rodon,L., Blank,N., Lorenz,H.M. and Merkt,W.
  TITLE     Fcgamma-receptor-IIIA bioactivity of circulating and synovial
            immune complexes in rheumatoid arthritis
  JOURNAL   RMD Open 10 (3), e004190 (2024)
   PUBMED   39209371
  REMARK    GeneRIF: Fcgamma-receptor-IIIA bioactivity of circulating and
            synovial immune complexes in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Constantinides,M., Robert,N., Multrier,C., Coenon,L.,
            Campos-Mora,M., Jacquard,C., Gao,F., Zemiti,S., Presumey,J.,
            Cartron,G., Moreaux,J. and Villalba,M.
  TITLE     FCGR3A F158V alleles frequency differs in multiple myeloma patients
            from healthy population
  JOURNAL   Oncoimmunology 13 (1), 2388306 (2024)
   PUBMED   39175948
  REMARK    GeneRIF: FCGR3A F158V alleles frequency differs in multiple myeloma
            patients from healthy population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Karaselek,M.A., Kurar,E., Keles,S., Guner,S.N. and Reisli,I.
  TITLE     Association of NK cell subsets and cytotoxicity with FCGR3A gene
            polymorphism in functional NK cell deficiency
  JOURNAL   Rev Assoc Med Bras (1992) 70 (2), e20230872 (2024)
   PUBMED   38422319
  REMARK    GeneRIF: Association of NK cell subsets and cytotoxicity with
            FCGR3A gene polymorphism in functional NK cell deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Canossi,A., Aureli,A., Del Beato,T., Novelli,G., Buonomo,O.,
            Rossi,P., Venditti,A., Papola,F. and Sconocchia,G.
  TITLE     Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and
            FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage
  JOURNAL   Curr Mol Med 24 (7), 920-930 (2024)
   PUBMED   37461339
  REMARK    GeneRIF: Impact of HLA Class I Antigen, Killer Inhibitory Receptor,
            and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor
            Stage.
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Sugawara,S., Hueber,B., Woolley,G., Terry,K., Kroll,K.,
            Manickam,C., Ram,D.R., Ndhlovu,L.C., Goepfert,P., Jost,S. and
            Reeves,R.K.
  TITLE     Multiplex interrogation of the NK cell signalome reveals global
            downregulation of CD16 signaling during lentivirus infection
            through an IL-18/ADAM17-dependent mechanism
  JOURNAL   PLoS Pathog 19 (9), e1011629 (2023)
   PUBMED   37669308
  REMARK    GeneRIF: Multiplex interrogation of the NK cell signalome reveals
            global downregulation of CD16 signaling during lentivirus infection
            through an IL-18/ADAM17-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Wu,J., Mishra,H.K. and Walcheck,B.
  TITLE     Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and
            as a potential target for cancer immunotherapy
  JOURNAL   J Leukoc Biol 105 (6), 1297-1303 (2019)
   PUBMED   30786043
  REMARK    GeneRIF: Role of ADAM17 as a regulatory checkpoint of CD16A in NK
            cells and as a potential target for cancer immunotherapy.
            Review article
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Lanier,L.L., Yu,G. and Phillips,J.H.
  TITLE     Analysis of Fc gamma RIII (CD16) membrane expression and
            association with CD3 zeta and Fc epsilon RI-gamma by site-directed
            mutation
  JOURNAL   J Immunol 146 (5), 1571-1576 (1991)
   PUBMED   1825220
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Qiu,W.Q., de Bruin,D., Brownstein,B.H., Pearse,R. and Ravetch,J.V.
  TITLE     Organization of the human and mouse low-affinity Fc gamma R genes:
            duplication and recombination
  JOURNAL   Science 248 (4956), 732-735 (1990)
   PUBMED   2139735
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Anderson,P., Caligiuri,M., O'Brien,C., Manley,T., Ritz,J. and
            Schlossman,S.F.
  TITLE     Fc gamma receptor type III (CD16) is included in the zeta NK
            receptor complex expressed by human natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2274-2278 (1990)
   PUBMED   2138330
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Le Coniat,M., Kinet,J.P. and Berger,R.
  TITLE     The human genes for the alpha and gamma subunits of the mast cell
            receptor for immunoglobulin E are located on human chromosome band
            1q23
  JOURNAL   Immunogenetics 32 (3), 183-186 (1990)
   PUBMED   2146219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302126.1 and BC033678.1.
            
            On Mar 9, 2020 this sequence version replaced NM_000569.7.
            
            Summary: This gene encodes a receptor for the Fc portion of
            immunoglobulin G, and it is involved in the removal of
            antigen-antibody complexes from the circulation, as well as other
            responses, including antibody dependent cellular mediated
            cytotoxicity and antibody dependent enhancement of virus
            infections. This gene (FCGR3A) is highly similar to another nearby
            gene (FCGR3B) located on chromosome 1. The receptor encoded by this
            gene is expressed on natural killer (NK) cells as an integral
            membrane glycoprotein anchored through a transmembrane peptide,
            whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN)
            where the receptor is anchored through a phosphatidylinositol (PI)
            linkage. Mutations in this gene are associated with
            immunodeficiency 20, and have been linked to susceptibility to
            recurrent viral infections, susceptibility to systemic lupus
            erythematosus, and alloimmune neonatal neutropenia. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) retains an intron in its 5'
            UTR and 5' coding region compared to variant 3. Variants 1, 3, 4
            and 6 encode the same isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036723.1, AK223268.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000443193.6/ ENSP00000392047.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1219              AK302126.1         286-1504
            1220-2100           BC033678.1         1161-2041
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2100
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="Fc gamma receptor IIIa"
                     /db_xref="GeneID:2214"
                     /db_xref="HGNC:HGNC:3619"
                     /db_xref="MIM:146740"
     exon            1..122
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..847
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="isoform c precursor is encoded by transcript
                     variant 1; Fc fragment of IgG, low affinity III, receptor
                     for (CD16); low affinity immunoglobulin gamma Fc region
                     receptor III-A; Fc fragment of IgG, low affinity IIIa,
                     receptor (CD16a); immunoglobulin G Fc receptor III;
                     Fc-gamma receptor III-2 (CD 16); Fc-gamma RIII-alpha;
                     neutrophil-specific antigen NA; low affinity
                     immunoglobulin gamma Fc region receptor III-B;
                     FcgammaRIIIA; IgG Fc receptor III-A; low affinity
                     immunoglobulin gamma receptor III-a Fc fragment; Fc gamma
                     receptor III-A; Fc fragment of IgG receptor IIIa; Fc-gamma
                     receptor IIIb (CD16); CD16a antigen; igG Fc receptor
                     III-2; low affinity immunoglobulin gamma Fc region
                     receptor III-A/III-B recombinant"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor III-A isoform c precursor"
                     /protein_id="NP_000560.7"
                     /db_xref="CCDS:CCDS44266.1"
                     /db_xref="GeneID:2214"
                     /db_xref="HGNC:HGNC:3619"
                     /db_xref="MIM:146740"
                     /translation="MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVT
                     LKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQL
                     EVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIP
                     KATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLL
                     FAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK"
     exon            123..143
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /inference="alignment:Splign:2.1.0"
     exon            144..401
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /inference="alignment:Splign:2.1.0"
     exon            402..659
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /inference="alignment:Splign:2.1.0"
     exon            660..2100
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="hexamer: AATAAA"
     polyA_site      2037
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="major polyA site"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="hexamer: AATAAA"
     polyA_site      2100
                     /gene="FCGR3A"
                     /gene_synonym="CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII;
                     FcGRIIIA; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20"
                     /note="major polyA site"
ORIGIN      
        1 gtttacttcc tcctgtctag tcggtttggt ccctttaggg ctccggatat ctttggtgac
       61 ttgtccactc cagtgtggca tcatgtggca gctgctcctc ccaactgctc tgctacttct
      121 agtttcagct ggcatgcgga ctgaagatct cccaaaggct gtggtgttcc tggagcctca
      181 atggtacagg gtgctcgaga aggacagtgt gactctgaag tgccagggag cctactcccc
      241 tgaggacaat tccacacagt ggtttcacaa tgagagcctc atctcaagcc aggcctcgag
      301 ctacttcatt gacgctgcca cagtcgacga cagtggagag tacaggtgcc agacaaacct
      361 ctccaccctc agtgacccgg tgcagctaga agtccatatc ggctggctgt tgctccaggc
      421 ccctcggtgg gtgttcaagg aggaagaccc tattcacctg aggtgtcaca gctggaagaa
      481 cactgctctg cataaggtca catatttaca gaatggcaaa ggcaggaagt attttcatca
      541 taattctgac ttctacattc caaaagccac actcaaagac agcggctcct acttctgcag
      601 ggggcttttt gggagtaaaa atgtgtcttc agagactgtg aacatcacca tcactcaagg
      661 tttggcagtg tcaaccatct catcattctt tccacctggg taccaagtct ctttctgctt
      721 ggtgatggta ctcctttttg cagtggacac aggactatat ttctctgtga agacaaacat
      781 tcgaagctca acaagagact ggaaggacca taaatttaaa tggagaaagg accctcaaga
      841 caaatgaccc ccatcccatg ggggtaataa gagcagtagc agcagcatct ctgaacattt
      901 ctctggattt gcaaccccat catcctcagg cctctctaca agcagcagga aacatagaac
      961 tcagagccag atcccttatc caactctcga cttttccttg gtctccagtg gaagggaaaa
     1021 gcccatgatc ttcaagcagg gaagccccag tgagtagctg cattcctaga aattgaagtt
     1081 tcagagctac acaaacactt tttctgtccc aaccgttccc tcacagcaaa gcaacaatac
     1141 aggctaggga tggtaatcct ttaaacatac aaaaattgct cgtgttataa attacccagt
     1201 ttagagggga aaaaaaaaca attattccta aataaatgga taagtagaat taatggttga
     1261 ggcaggacca tacagagtgt gggaactgct ggggatctag ggaattcagt gggaccaatg
     1321 aaagcatggc tgagaaatag caggtagtcc aggatagtct aagggaggtg ttcccatctg
     1381 agcccagaga taagggtgtc ttcctagaac attagccgta gtggaattaa caggaaatca
     1441 tgagggtgac gtagaattga gtcttccagg ggactctatc agaactggac catctccaag
     1501 tatataacga tgagtcctct taatgctagg agtagaaaat ggtcctagga aggggactga
     1561 ggattgcggt ggggggtggg gtggaaaaga aagtacagaa caaaccctgt gtcactgtcc
     1621 caagttgcta agtgaacaga actatctcag catcagaatg agaaagcctg agaagaaaga
     1681 accaaccaca agcacacagg aaggaaagcg caggaggtga aaatgctttc ttggccaggg
     1741 tagtaagaat tagaggttaa tgcagggact gtaaaaccac cttttctgct tcaatatcta
     1801 attcctgtgt agctttgttc attgcattta ttaaacaaat gttgtataac caatactaaa
     1861 tgtactactg agcttcgctg agttaagtta tgaaactttc aaatccttca tcatgtcagt
     1921 tccaatgagg tggggatgga gaagacaatt gttgcttatg aaagaaagct ttagctgtct
     1981 ctgttttgta agctttaagc gcaacatttc ttggttccaa taaagcattt tacaagatct
     2041 tgcatgctac tcttagatag aagatgggaa aaccatggta ataaaatatg aatgataaaa
//
