LOCUS       NM_001394477            2133 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Fc gamma receptor IIb (FCGR2B), transcript variant 14,
            mRNA.
ACCESSION   NM_001394477
VERSION     NM_001394477.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Knorr,D.A., Blanchard,L., Leidner,R.S., Jensen,S.M., Meng,R.,
            Jones,A., Ballesteros-Merino,C., Bell,R.B., Baez,M., Marino,A.,
            Sprott,D., Bifulco,C.B., Piening,B., Dahan,R., Osorio,J.C.,
            Fox,B.A. and Ravetch,J.V.
  TITLE     FcgammaRIIB Is an Immune Checkpoint Limiting the Activity of
            Treg-Targeting Antibodies in the Tumor Microenvironment
  JOURNAL   Cancer Immunol Res 12 (3), 322-333 (2024)
   PUBMED   38147316
  REMARK    GeneRIF: FcgammaRIIB Is an Immune Checkpoint Limiting the Activity
            of Treg-Targeting Antibodies in the Tumor Microenvironment.
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Jiang,J., Peng,Z., Wang,J., Chen,M., Wan,Y., Huang,H., Liu,Z.,
            Wang,J. and Hou,J.
  TITLE     C-reactive protein impairs immune response of CD8+ T cells via
            FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma
  JOURNAL   J Immunother Cancer 11 (10) (2023)
   PUBMED   37844994
  REMARK    GeneRIF: C-reactive protein impairs immune response of CD8[+] T
            cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma.
            Erratum:[J Immunother Cancer. 2023 Dec 14;11(12):e007593corr1. doi:
            10.1136/jitc-2023-007593corr1.. PMID: 38101865]
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Gao,X., Ma,H., Niu,J. and Li,D.
  TITLE     FcgammaRIIB expression increases during primary biliary cholangitis
  JOURNAL   Mol Immunol 162, 30-37 (2023)
   PUBMED   37634276
  REMARK    GeneRIF: FcgammaRIIB expression increases during primary biliary
            cholangitis.
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Sun,Z., Sun,X., Yuan,Y., Li,H., Li,X. and Yao,Z.
  TITLE     FCGR2B as a prognostic and immune microenvironmental marker for
            gliomas based on transcriptomic analysis
  JOURNAL   Medicine (Baltimore) 102 (37), e35084 (2023)
   PUBMED   37713871
  REMARK    GeneRIF: FCGR2B as a prognostic and immune microenvironmental
            marker for gliomas based on transcriptomic analysis.
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Bennion,K.B., Tariq,M., Wyatt,M.M., Duneton,C., Baecher,K.M.,
            Paulos,C.M., Kudchadkar,R.R., Lowe,M.C. and Ford,M.L.
  TITLE     FcgammaRIIB expressed on CD8+ T cells limits responsiveness to PD-1
            checkpoint inhibition in cancer
  JOURNAL   Sci Transl Med 15 (710), eadd1868 (2023)
   PUBMED   37611081
  REMARK    GeneRIF: FcgammaRIIB expressed on CD8[+] T cells limits
            responsiveness to PD-1 checkpoint inhibition in cancer.
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Engelhardt,W., Geerds,C. and Frey,J.
  TITLE     Distribution, inducibility and biological function of the cloned
            and expressed human beta Fc receptor II
  JOURNAL   Eur J Immunol 20 (6), 1367-1377 (1990)
   PUBMED   2142460
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Qiu,W.Q., de Bruin,D., Brownstein,B.H., Pearse,R. and Ravetch,J.V.
  TITLE     Organization of the human and mouse low-affinity Fc gamma R genes:
            duplication and recombination
  JOURNAL   Science 248 (4956), 732-735 (1990)
   PUBMED   2139735
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   Stuart,S.G., Simister,N.E., Clarkson,S.B., Kacinski,B.M.,
            Shapiro,M. and Mellman,I.
  TITLE     Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in
            macrophages, lymphocytes and IgG-transporting placental epithelium
  JOURNAL   EMBO J 8 (12), 3657-3666 (1989)
   PUBMED   2531080
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Brooks,D.G., Qiu,W.Q., Luster,A.D. and Ravetch,J.V.
  TITLE     Structure and expression of human IgG FcRII(CD32). Functional
            heterogeneity is encoded by the alternatively spliced products of
            multiple genes
  JOURNAL   J Exp Med 170 (4), 1369-1385 (1989)
   PUBMED   2529342
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   Seki,T.
  TITLE     Identification of multiple isoforms of the low-affinity human IgG
            Fc receptor
  JOURNAL   Immunogenetics 30 (1), 5-12 (1989)
   PUBMED   2526077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451067.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a low affinity
            receptor for the Fc region of immunoglobulin gamma complexes. The
            encoded protein is involved in the phagocytosis of immune complexes
            and in the regulation of antibody production by B-cells. Variations
            in this gene may increase susceptibilty to systemic lupus
            erythematosus (SLE). Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2010].
            
            Transcript Variant: Variants 1 and 14 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031992.1, AF543826.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358671.10/ ENSP00000351497.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL451067.12        127843-128053
            212-232             AL451067.12        134952-134972
            233-490             AL451067.12        136092-136349
            491-745             AL451067.12        137675-137929
            746-859             AL451067.12        138660-138773
            860-916             AL451067.12        139957-140013
            917-954             AL451067.12        142028-142065
            955-2133            AL451067.12        142176-143354
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2133
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="Fc gamma receptor IIb"
                     /db_xref="GeneID:2213"
                     /db_xref="HGNC:HGNC:3618"
                     /db_xref="MIM:604590"
     exon            1..211
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1032
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 14; Fc fragment of IgG, low affinity II, receptor
                     for (CD32); Fc fragment of IgG, low affinity IIb, receptor
                     for (CD32); Low affinity immunoglobulin gamma Fc region
                     receptor II-c; IgG Fc receptor II-c; Fc-gamma RII-c; Fc
                     fragment of IgG receptor IIb; Fc-gamma-RIIc; low affinity
                     immunoglobulin gamma Fc region receptor II-b; Fc gamma
                     RIIb; CDw32; fcRII-b; fc-gamma-RIIb; fc-gamma RII-b; igG
                     Fc receptor II-b; Fc fragment of IgG, low affinity IIb,
                     receptor (CD32)"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b isoform 1 precursor"
                     /protein_id="NP_001381406.1"
                     /db_xref="CCDS:CCDS30924.1"
                     /db_xref="GeneID:2213"
                     /db_xref="HGNC:HGNC:3618"
                     /db_xref="MIM:604590"
                     /translation="MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTP
                     AAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFK
                     ANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPL
                     VKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPS
                     SSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPT
                     NPDEADKVGAENTITYSLLMHPDALEEPDDQNRI"
     exon            212..232
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..490
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..745
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..859
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..916
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..954
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2133
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      1534
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="major polyA site"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="FCGR2B"
                     /gene_synonym="CD32; CD32B; FCG2; FcgammaRIIb; FCGR2;
                     FCGR2C; FcGRIIB; FcRII-c; IGFR2"
                     /note="major polyA site"
ORIGIN      
        1 agactccaga atttgtttgc cctctagggt agaatccgcc aagctttgag agaaggctgt
       61 gactgctgtg ctctgggcgc cagctcgctc cagggagtga tgggaatcct gtcattctta
      121 cctgtccttg ccactgagag tgactgggct gactgcaagt ccccccagcc ttggggtcat
      181 atgcttctgt ggacagctgt gctattcctg gctcctgttg ctgggacacc tgcagctccc
      241 ccaaaggctg tgctgaaact cgagccccag tggatcaacg tgctccagga ggactctgtg
      301 actctgacat gccgggggac tcacagccct gagagcgact ccattcagtg gttccacaat
      361 gggaatctca ttcccaccca cacgcagccc agctacaggt tcaaggccaa caacaatgac
      421 agcggggagt acacgtgcca gactggccag accagcctca gcgaccctgt gcatctgact
      481 gtgctttctg agtggctggt gctccagacc cctcacctgg agttccagga gggagaaacc
      541 atcgtgctga ggtgccacag ctggaaggac aagcctctgg tcaaggtcac attcttccag
      601 aatggaaaat ccaagaaatt ttcccgttcg gatcccaact tctccatccc acaagcaaac
      661 cacagtcaca gtggtgatta ccactgcaca ggaaacatag gctacacgct gtactcatcc
      721 aagcctgtga ccatcactgt ccaagctccc agctcttcac cgatggggat cattgtggct
      781 gtggtcactg ggattgctgt agcggccatt gttgctgctg tagtggcctt gatctactgc
      841 aggaaaaagc ggatttcagc tctcccagga taccctgagt gcagggaaat gggagagacc
      901 ctccctgaga aaccagccaa tcccactaat cctgatgagg ctgacaaagt tggggctgag
      961 aacacaatca cctattcact tctcatgcac ccggatgctc tggaagagcc tgatgaccag
     1021 aaccgtattt agtctccatt gtcttgcatt gggatttgag aagaaaatca gagagggaag
     1081 atctggtatt tcctggccta aattcccctt ggggaggaca gggagatgct gcagttccaa
     1141 aagagaaggt ttcttccaga gtcatctacc tgagtcctga agctccctgt cctgaaagcc
     1201 acagacaata tggtcccaaa taaccgactg caccttctgt gcttcagctc ttcttgacat
     1261 caaggctctt ccgttccaca tccacacagc caatccaatt aatcaaacca ctgttattaa
     1321 cagataatag caacttggga aatgcttatg ttacaggtta cgtgagaaca atcatgtaaa
     1381 tctatatgat ttcagaaatg ttaaaataga ctaacctcta ccagcacatt aaaagtgatt
     1441 gtttctgggt gataaaatta ttgatgattt ttattttctt tatttttcta taaagatcat
     1501 atattacttt tataataaaa cattataaaa acaacattct gtttaccttt tcaaggctgt
     1561 attggttgga gtgtagactg aactgcctgg ggtctgtttc tcttcagtga tgagactctt
     1621 aggaaggcag gaatggatag gataggggga ggagaggaga gatggggatt tagaatgtag
     1681 agtgagtgcc ccttttctta aaactgaata cagtcacgca ccacataatg atgtttagtt
     1741 caacaacaga ctgcatatat gatggtgatc ccataaaatt ataataccat atttctattg
     1801 taccttttct attcctatgt ttagatatat gagtacttac cattgtgtta caattgccta
     1861 aagtattcag tacagtagca tgctgtacag gtttgtagcc taggggcaat aggctatacg
     1921 ctacagccta ggtgtgtagt aggccacacc atttaggttt gtataagtac ctgctatgat
     1981 gttcacacaa caaaattgcc tgcatttctc aaaatgtatc cccatatttc aacaatgcat
     2041 gactgtactc ttctgccaat gaccttgtat tcttgtttcc atgtcttctt ctctttcctc
     2101 ctatggcaaa taaaacactg ttttgcaaca caa
//
