LOCUS       NM_001136219            2646 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens Fc gamma receptor IIa (FCGR2A), transcript variant 1,
            mRNA.
ACCESSION   NM_001136219
VERSION     NM_001136219.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Scarfo,R., Randolph,L.N., Abou Alezz,M., El Khoury,M., Gersch,A.,
            Li,Z.Y., Luff,S.A., Tavosanis,A., Ferrari Ramondo,G., Valsoni,S.,
            Cascione,S., Didelon,E., Passerini,L., Amodio,G., Brandas,C.,
            Villa,A., Gregori,S., Merelli,I., Freund,J.N., Sturgeon,C.M.,
            Tavian,M. and Ditadi,A.
  TITLE     CD32 captures committed haemogenic endothelial cells during human
            embryonic development
  JOURNAL   Nat Cell Biol 26 (5), 719-730 (2024)
   PUBMED   38594587
  REMARK    GeneRIF: CD32 captures committed haemogenic endothelial cells
            during human embryonic development.
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Luo,J., Jin,G., Cui,S., Wang,H. and Liu,Q.
  TITLE     Regulatory mechanism of FCGR2A in macrophage polarization and its
            effects on intervertebral disc degeneration
  JOURNAL   J Physiol 602 (7), 1341-1369 (2024)
   PUBMED   38544414
  REMARK    GeneRIF: Regulatory mechanism of FCGR2A in macrophage polarization
            and its effects on intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Levi-Monsalve,A., Flores,S.V., Manriquez,G. and Roco-Videla,A.
  TITLE     New candidate SNPs for genetic association with Alzheimer's
            disease: a linkage disequilibrium analysis for the FCGRIIB and
            PILRA genes
  JOURNAL   Medwave 24 (1) (2024)
   PUBMED   38408113
  REMARK    GeneRIF: New candidate SNPs for genetic association with
            Alzheimer's disease: a linkage disequilibrium analysis for the
            FCGRIIB and PILRA genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Catarino,J.D.S., de Oliveira,R.F., Silva,M.V., Sales-Campos,H., de
            Vito,F.B., da Silva,D.A.A., Naves,L.L., Oliveira,C.J.F.,
            Rodrigues,D.B.R. and Rodrigues,V. Jr.
  TITLE     Genetic variation of FcgammaRIIa induces higher uptake of
            Leishmania infantum and modulates cytokine production by adherent
            mononuclear cells in vitro
  JOURNAL   Front Immunol 15, 1343602 (2024)
   PUBMED   38455048
  REMARK    GeneRIF: Genetic variation of FcgammaRIIa induces higher uptake of
            Leishmania infantum and modulates cytokine production by adherent
            mononuclear cells in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Adamian,R., McCleary,P., Sharma,T. and Schneider,D.J.
  TITLE     Platelet FcgammaRIIa expression in patients with stable coronary
            artery disease
  JOURNAL   J Invasive Cardiol 36 (2) (2024)
   PUBMED   38335505
  REMARK    GeneRIF: Platelet FcgammaRIIa expression in patients with stable
            coronary artery disease.
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Ernst,L.K., van de Winkel,J.G., Chiu,I.M. and Anderson,C.L.
  TITLE     Three genes for the human high affinity Fc receptor for IgG (Fc
            gamma RI) encode four distinct transcription products
  JOURNAL   J Biol Chem 267 (22), 15692-15700 (1992)
   PUBMED   1379234
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Qiu,W.Q., de Bruin,D., Brownstein,B.H., Pearse,R. and Ravetch,J.V.
  TITLE     Organization of the human and mouse low-affinity Fc gamma R genes:
            duplication and recombination
  JOURNAL   Science 248 (4956), 732-735 (1990)
   PUBMED   2139735
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Brooks,D.G., Qiu,W.Q., Luster,A.D. and Ravetch,J.V.
  TITLE     Structure and expression of human IgG FcRII(CD32). Functional
            heterogeneity is encoded by the alternatively spliced products of
            multiple genes
  JOURNAL   J Exp Med 170 (4), 1369-1385 (1989)
   PUBMED   2529342
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Hessian,P.A., Highton,J. and Palmer,D.G.
  TITLE     Quantification of macrophage cell surface molecules in rheumatoid
            arthritis
  JOURNAL   Clin Exp Immunol 77 (1), 47-51 (1989)
   PUBMED   2527651
  REMARK    Erratum:[Clin Exp Immunol 1990 Feb;79(2):314]
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Seki,T.
  TITLE     Identification of multiple isoforms of the low-affinity human IgG
            Fc receptor
  JOURNAL   Immunogenetics 30 (1), 5-12 (1989)
   PUBMED   2526077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315225.1, AL590385.23 and
            AA634082.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 21, 2019 this sequence version replaced NM_001136219.2.
            
            Summary: This gene encodes one member of a family of immunoglobulin
            Fc receptor genes found on the surface of many immune response
            cells. The protein encoded by this gene is a cell surface receptor
            found on phagocytic cells such as macrophages and neutrophils, and
            is involved in the process of phagocytosis and clearing of immune
            complexes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X62572.1, M28697.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271450.12/ ENSP00000271450.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-965               AK315225.1         1-965
            966-1968            AL590385.23        74808-75810
            1969-2646           AA634082.1         7-684               c
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2646
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /note="Fc gamma receptor IIa"
                     /db_xref="GeneID:2212"
                     /db_xref="HGNC:HGNC:3616"
                     /db_xref="MIM:146790"
     exon            1..96
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..965
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Immunoglobulin G Fc receptor II; low affinity
                     immunoglobulin gamma Fc region receptor II-a; fcRII-a;
                     fc-gamma-RIIa; igG Fc receptor II-a; Fc fragment of IgG,
                     low affinity IIa, receptor (CD32); Fc gamma receptor
                     RIIa3; Fc fragment of IgG receptor IIa"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-a isoform 1 precursor"
                     /protein_id="NP_001129691.1"
                     /db_xref="CCDS:CCDS44264.1"
                     /db_xref="GeneID:2212"
                     /db_xref="HGNC:HGNC:3616"
                     /db_xref="MIM:146790"
                     /translation="MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLK
                     LEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEY
                     TCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNG
                     KSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGI
                     IVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEE
                     TNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN"
     exon            97..117
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            118..375
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..630
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..753
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..791
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..2646
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      1398
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /note="major polyA site"
     regulatory      2621..2626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="FCGR2A"
                     /gene_synonym="CD32; CD32A; CDw32; FCG2; FcgammaRIIa;
                     FcGR; FCGR2; FCGR2A1; IGFR2"
ORIGIN      
        1 acagtgctgg gatgactatg gagacccaaa tgtctcagaa tgtatgtccc agaaacctgt
       61 ggctgcttca accattgaca gttttgctgc tgctggcttc tgcagacagt caagctgcag
      121 ctcccccaaa ggctgtgctg aaacttgagc ccccgtggat caacgtgctc caggaggact
      181 ctgtgactct gacatgccag ggggctcgca gccctgagag cgactccatt cagtggttcc
      241 acaatgggaa tctcattccc acccacacgc agcccagcta caggttcaag gccaacaaca
      301 atgacagcgg ggagtacacg tgccagactg gccagaccag cctcagcgac cctgtgcatc
      361 tgactgtgct ttccgaatgg ctggtgctcc agacccctca cctggagttc caggagggag
      421 aaaccatcat gctgaggtgc cacagctgga aggacaagcc tctggtcaag gtcacattct
      481 tccagaatgg aaaatcccag aaattctccc atttggatcc caccttctcc atcccacaag
      541 caaaccacag tcacagtggt gattaccact gcacaggaaa cataggctac acgctgttct
      601 catccaagcc tgtgaccatc actgtccaag tgcccagcat gggcagctct tcaccaatgg
      661 ggatcattgt ggctgtggtc attgcgactg ctgtagcagc cattgttgct gctgtagtgg
      721 ccttgatcta ctgcaggaaa aagcggattt cagccaattc cactgatcct gtgaaggctg
      781 cccaatttga gccacctgga cgtcaaatga ttgccatcag aaagagacaa cttgaagaaa
      841 ccaacaatga ctatgaaaca gctgacggcg gctacatgac tctgaacccc agggcaccta
      901 ctgacgatga taaaaacatc tacctgactc ttcctcccaa cgaccatgtc aacagtaata
      961 actaaagagt aacgttatgc catgtggtca tactctcagc ttgctgagtg gatgacaaaa
     1021 agaggggaat tgttaaagga aaatttaaat ggagactgga aaaatcctga gcaaacaaaa
     1081 ccacctggcc cttagaaata gctttaactt tgcttaaact acaaacacaa gcaaaacttc
     1141 acggggtcat actacataca agcataagca aaacttaact tggatcattt ctggtaaatg
     1201 cttatgttag aaataagaca accccagcca atcacaagca gcctactaac atataattag
     1261 gtgactaggg actttctaag aagataccta cccccaaaaa acaattatgt aattgaaaac
     1321 caaccgattg cctttatttt gcttccacat tttcccaata aatacttgcc tgtgacattt
     1381 tgccactgga acactaaact tcatgaattg cgcctcagat ttttccttta acatcttttt
     1441 tttttttgac agagtctcaa tctgttaccc aggctggagt gcagtggtgc tatcttggct
     1501 cactgcaaac ccgcctccca ggtttaagcg attctcatgc ctcagcctcc cagtagctgg
     1561 gattagaggc atgtgccatc atacccagct aatttttgta ttttttattt ttttttttta
     1621 gtagagacag ggtttcgcaa tgttggccag gccgatctcg aacttctggc ctctagcgat
     1681 ctgcccgcct cggcctccca aagtgctggg atgaccagca tcagccccaa tgtccagcct
     1741 ctttaacatc ttctttccta tgccctctct gtggatccct actgctggtt tctgccttct
     1801 ccatgctgag aacaaaatca cctattcact gcttatgcag tcggaagctc cagaagaaca
     1861 aagagcccaa ttaccagaac cacattaagt ctccattgtt ttgccttggg atttgagaag
     1921 agaattagag aggtgaggat ctggtatttc ctggactaaa ttccccttgg ggaagacgaa
     1981 gggatgctgc agttccaaaa gagaaggact cttccagagt catctacctg agtcccaaag
     2041 ctccctgtcc tgaaagccac agacaatatg gtcccaaatg actgactgca ccttctgtgc
     2101 ctcagccgtt cttgacatca agaatcttct gttccacatc cacacagcca atacaattag
     2161 tcaaaccact gttattaaca gatgtagcaa catgagaaac gcttatgtta caggttacat
     2221 gagagcaatc atgtaagtct atatgacttc agaaatgtta aaatagacta acctctaaca
     2281 acaaattaaa agtgattgtt tcaaggtgat gcaattattg atgacctatt ttatttttct
     2341 ataatgatca tatattacct ttgtaataaa acattataac caaaacattc tgtttacctt
     2401 ttcagggctg tattgattgg ggtgtagact gaactatccg gggtctgttt cttttcggtg
     2461 atgaaagtct tgagaaggta gtaatggata agatgtgagg gagaggagag agggagattt
     2521 ggagtgtagg gtgagtgccc ctcttcttag aactgaatac tcttcttcta atgaacttgt
     2581 attcttgttt ccatgtcttc ttccctttcc ttctatagca aataaagcat tcactttgtt
     2641 ttggaa
//
