LOCUS       NM_000566               1333 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc gamma receptor Ia (FCGR1A), transcript variant 2,
            mRNA.
ACCESSION   NM_000566
VERSION     NM_000566.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Huang,X., Wu,L., Ouyang,Q., Huang,Y., Hong,L., Liu,S., Yang,K.,
            Ning,D. and Tan,C.C.
  TITLE     Neutrophil CD64 index as a new early predictive biomarker for
            infected pancreatic necrosis in acute pancreatitis
  JOURNAL   J Transl Med 22 (1), 218 (2024)
   PUBMED   38424643
  REMARK    GeneRIF: Neutrophil CD64 index as a new early predictive biomarker
            for infected pancreatic necrosis in acute pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1333)
  AUTHORS   Cretin,J., Adjemout,M., Dieppois,C., Gallardo,F., Torres,M.,
            Merard,Z., Sawadogo,S.A., Picard,C., Rihet,P. and Paul,P.
  TITLE     A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the
            1q23 Gene Cluster Is Associated with Plasmodium falciparum
            Infection in Children Residing in Burkina Faso
  JOURNAL   Int J Mol Sci 24 (21), 15711 (2023)
   PUBMED   37958695
  REMARK    GeneRIF: A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant
            within the 1q23 Gene Cluster Is Associated with Plasmodium
            falciparum Infection in Children Residing in Burkina Faso.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1333)
  AUTHORS   Dimitrov,E., Halacheva,K., Minkov,G., Enchev,E. and Yovtchev,Y.
  TITLE     Prognostic performance of neutrophil CD64 expression in patients
            with complicated intra-abdominal infections - a prospective study
  JOURNAL   Scand J Clin Lab Invest 83 (5), 323-329 (2023)
   PUBMED   37352378
  REMARK    GeneRIF: Prognostic performance of neutrophil CD64 expression in
            patients with complicated intra-abdominal infections - a
            prospective study.
REFERENCE   4  (bases 1 to 1333)
  AUTHORS   Maresco,D.L., Chang,E., Theil,K.S., Francke,U. and Anderson,C.L.
  TITLE     The three genes of the human FCGR1 gene family encoding Fc gamma RI
            flank the centromere of chromosome 1 at 1p12 and 1q21
  JOURNAL   Cytogenet Cell Genet 73 (3), 157-163 (1996)
   PUBMED   8697799
REFERENCE   5  (bases 1 to 1333)
  AUTHORS   Takai,S., Kasama,M., Yamada,K., Kai,N., Hirayama,N., Namiki,H. and
            Taniyama,T.
  TITLE     Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome
            1q21.2-q21.3 by fluorescence in situ hybridization
  JOURNAL   Hum Genet 93 (1), 13-15 (1994)
   PUBMED   8270248
REFERENCE   6  (bases 1 to 1333)
  AUTHORS   Porges,A.J., Redecha,P.B., Doebele,R., Pan,L.C., Salmon,J.E. and
            Kimberly,R.P.
  TITLE     Novel Fc gamma receptor I family gene products in human mononuclear
            cells
  JOURNAL   J Clin Invest 90 (5), 2102-2109 (1992)
   PUBMED   1430234
REFERENCE   7  (bases 1 to 1333)
  AUTHORS   Benech,P.D., Sastry,K., Iyer,R.R., Eichbaum,Q.G., Raveh,D.P. and
            Ezekowitz,R.A.
  TITLE     Definition of interferon gamma-response elements in a novel human
            Fc gamma receptor gene (Fc gamma RIb) and characterization of the
            gene structure
  JOURNAL   J Exp Med 176 (4), 1115-1123 (1992)
   PUBMED   1402657
REFERENCE   8  (bases 1 to 1333)
  AUTHORS   Ernst,L.K., van de Winkel,J.G., Chiu,I.M. and Anderson,C.L.
  TITLE     Three genes for the human high affinity Fc receptor for IgG (Fc
            gamma RI) encode four distinct transcription products
  JOURNAL   J Biol Chem 267 (22), 15692-15700 (1992)
   PUBMED   1379234
REFERENCE   9  (bases 1 to 1333)
  AUTHORS   Pearse,R.N., Feinman,R. and Ravetch,J.V.
  TITLE     Characterization of the promoter of the human gene encoding the
            high-affinity IgG receptor: transcriptional induction by
            gamma-interferon is mediated through common DNA response elements
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11305-11309 (1991)
   PUBMED   1837149
REFERENCE   10 (bases 1 to 1333)
  AUTHORS   Allen,J.M. and Seed,B.
  TITLE     Nucleotide sequence of three cDNAs for the human high affinity Fc
            receptor (FcRI)
  JOURNAL   Nucleic Acids Res 16 (24), 11824 (1988)
   PUBMED   2974947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243772.2.
            
            On Mar 11, 2020 this sequence version replaced NM_000566.3.
            
            Summary: This gene encodes a protein that plays an important role
            in the immune response. This protein is a high-affinity Fc-gamma
            receptor. The gene is one of three related gene family members
            located on chromosome 1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032634.1, X14356.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369168.5/ ENSP00000358165.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC243772.2         205492-205572
            82-102              AC243772.2         205968-205988
            103-357             AC243772.2         206801-207055
            358-609             AC243772.2         211164-211415
            610-894             AC243772.2         212852-213136
            895-1333            AC243772.2         214035-214473
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..1333
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /note="Fc gamma receptor Ia"
                     /db_xref="GeneID:2209"
                     /db_xref="HGNC:HGNC:3613"
                     /db_xref="MIM:146760"
     exon            1..81
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1175
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Fc fragment of IgG, high affinity Ia, receptor
                     for (CD64); Fc-gamma receptor I A1; Fc fragment of IgG
                     receptor Ia; high affinity immunoglobulin gamma Fc
                     receptor I; Fc-gamma RI; IgG Fc receptor I; fcgammaRIa;
                     fc-gamma RIA; Fc fragment of IgG, high affinity Ia,
                     receptor (CD64)"
                     /codon_start=1
                     /product="high affinity immunoglobulin gamma Fc receptor I
                     isoform 2 precursor"
                     /protein_id="NP_000557.1"
                     /db_xref="CCDS:CCDS933.1"
                     /db_xref="GeneID:2209"
                     /db_xref="HGNC:HGNC:3613"
                     /db_xref="MIM:146760"
                     /translation="MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCE
                     VLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHR
                     GWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNI
                     SHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLL
                     QRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPEL
                     ELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHE
                     KKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT"
     exon            82..102
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..357
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..609
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..894
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1333
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1308..1313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="FCGR1A"
                     /gene_synonym="CD64; CD64A; FCG1; FcgammaRI; FCGR1; FCRI;
                     IGFR1"
                     /note="major polyA site"
ORIGIN      
        1 aatatcttgc atgttacaga tttcactgct cccaccagct tggagacaac atgtggttct
       61 tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca aaggcagtga
      121 tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc ttgcactgtg
      181 aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc acagccactc
      241 agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt ggtgaataca
      301 ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc cacagaggct
      361 ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg gccttgaggt
      421 gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat ggcaaagcct
      481 ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata agtcacaatg
      541 gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga atatctgtca
      601 ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc ccactcctgg
      661 aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg cctggtttgc
      721 agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac acatcctctg
      781 aataccaaat actaactgct agaagagaag actctgggtt atactggtgc gaggctgcca
      841 cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg cttggcctcc
      901 agttaccaac tcctgtctgg tttcatgtcc ttttctatct ggcagtggga ataatgtttt
      961 tagtgaacac tgttctctgg gtgacaatac gtaaagaact gaaaagaaag aaaaagtggg
     1021 atttagaaat ctctttggat tctggtcatg agaagaaggt aatttccagc cttcaagaag
     1081 acagacattt agaagaagag ctgaaatgtc aggaacaaaa agaagaacag ctgcaggaag
     1141 gggtgcaccg gaaggagccc cagggggcca cgtagcagcg gctcagtggg tggccatcga
     1201 tctggaccgt cccctgccca cttgctcccc gtgagcactg cgtacaaaca tccaaaagtt
     1261 caacaacacc agaactgtgt gtctcatggt atgtaactct taaagcaaat aaatgaactg
     1321 acttcaactg gga
//
