LOCUS       NM_001220500            1585 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc epsilon receptor II (FCER2), transcript variant 3,
            mRNA.
ACCESSION   NM_001220500
VERSION     NM_001220500.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Xu,M., Chen,Z., Jiang,Q., Gong,Y. and Tang,H.
  TITLE     Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of
            Eosinophilic Chronic Sinusitis with Nasal Polyps
  JOURNAL   Altern Ther Health Med 29 (8), 638-643 (2023)
   PUBMED   37678868
  REMARK    GeneRIF: Role of CD23 Activated ERK Signaling Pathway in the
            Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Aranda,C.J., Gonzalez-Kozlova,E., Saunders,S.P.,
            Fernandes-Braga,W., Ota,M., Narayanan,S., He,J.S., Del Duca,E.,
            Swaroop,B., Gnjatic,S., Shattner,G., Reibman,J., Soter,N.A.,
            Guttman-Yassky,E. and Curotto de Lafaille,M.A.
  TITLE     IgG memory B cells expressing IL4R and FCER2 are associated with
            atopic diseases
  JOURNAL   Allergy 78 (3), 752-766 (2023)
   PUBMED   36445014
  REMARK    GeneRIF: IgG memory B cells expressing IL4R and FCER2 are
            associated with atopic diseases.
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Zhang,N., Lyu,Y., Guo,J., Liu,J., Song,Y., Fan,Z., Li,X., Li,N.,
            Zhang,D. and Wang,H.
  TITLE     Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients
            with Meniere's Disease
  JOURNAL   J Immunol 208 (4), 827-838 (2022)
   PUBMED   35046106
  REMARK    GeneRIF: Bidirectional Transport of IgE by CD23 in the Inner Ear of
            Patients with Meniere's Disease.
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Montagnac,G., Molla-Herman,A., Bouchet,J., Yu,L.C., Conrad,D.H.,
            Perdue,M.H. and Benmerah,A.
  TITLE     Intracellular trafficking of CD23: differential regulation in
            humans and mice by both extracellular and intracellular exons
  JOURNAL   J Immunol 174 (9), 5562-5572 (2005)
   PUBMED   15843555
  REMARK    GeneRIF: In humans, in contrast to what was previously found in
            mice, intestinal cells coexpress CD23a and CD23b, and the two
            splice forms show different localizations in polarized cells.
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Visan,I., Goller,M., Berberich,I., Kneitz,C. and Tony,H.P.
  TITLE     Pax-5 is a key regulator of the B cell-restricted expression of the
            CD23a isoform
  JOURNAL   Eur J Immunol 33 (5), 1163-1173 (2003)
   PUBMED   12731041
  REMARK    GeneRIF: Pax-5 is a key regulator of the B-cell-restricted
            expression of the CD23a isoform.
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Kneitz,C., Goller,M., Tony,H., Simon,A., Stibbe,C., Konig,T.,
            Serfling,E. and Avots,A.
  TITLE     The CD23b promoter is a target for NF-AT transcription factors in
            B-CLL cells
  JOURNAL   Biochim Biophys Acta 1588 (1), 41-47 (2002)
   PUBMED   12379312
  REMARK    GeneRIF: promoter is a target for NF-AT transcription factors in
            B-CLL cells
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Ewart,M.A., Ozanne,B.W. and Cushley,W.
  TITLE     The CD23a and CD23b proximal promoters display different
            sensitivities to exogenous stimuli in B lymphocytes
  JOURNAL   Genes Immun 3 (3), 158-164 (2002)
   PUBMED   12070780
  REMARK    GeneRIF: upstream regions of the CD23a and CD23b isoform coding
            sequences show distinct sensitivities to agents which induce CD23
            protein expression at the plasma membrane
REFERENCE   8  (bases 1 to 1585)
  AUTHORS   Rose,K., Turcatti,G., Graber,P., Pochon,S., Regamey,P.O.,
            Jansen,K.U., Magnenat,E., Aubonney,N. and Bonnefoy,J.Y.
  TITLE     Partial characterization of natural and recombinant human soluble
            CD23
  JOURNAL   Biochem J 286 (Pt 3) (Pt 3), 819-824 (1992)
   PUBMED   1417742
REFERENCE   9  (bases 1 to 1585)
  AUTHORS   Maekawa,N., Kawabe,T., Sugie,K., Kawakami,T., Iwata,S., Uchida,A.
            and Yodoi,J.
  TITLE     Induction of Fc epsilon RII/CD23 on PHA-activated human peripheral
            blood T lymphocytes and the association of Fyn tyrosine kinase with
            Fc epsilon RII/CD23
  JOURNAL   Res Immunol 143 (4), 422-425 (1992)
   PUBMED   1387715
REFERENCE   10 (bases 1 to 1585)
  AUTHORS   Ludin,C., Hofstetter,H., Sarfati,M., Levy,C.A., Suter,U.,
            Alaimo,D., Kilchherr,E., Frost,H. and Delespesse,G.
  TITLE     Cloning and expression of the cDNA coding for a human lymphocyte
            IgE receptor
  JOURNAL   EMBO J 6 (1), 109-114 (1987)
   PUBMED   3034567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA957269.1 and BC062591.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001220500.1.
            
            Summary: The protein encoded by this gene is a B-cell specific
            antigen, and a low-affinity receptor for IgE. It has essential
            roles in B cell growth and differentiation, and the regulation of
            IgE production. This protein also exists as a soluble secreted
            form, then functioning as a potent mitogenic growth factor.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene.[provided by RefSeq, Jul
            2011].
            
            Transcript Variant: This variant (3) uses an alternate donor splice
            site in the 5' UTR, compared to variant 1. Both variants 1 and 3
            encode the same isoform (a, also known as CD23a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062591.1, AK223207.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000597921.6/ ENSP00000471974.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA957269.1         16-46
            32-1585             BC062591.1         1-1554
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1585
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /note="Fc epsilon receptor II"
                     /db_xref="GeneID:2208"
                     /db_xref="HGNC:HGNC:3612"
                     /db_xref="MIM:151445"
     exon            1..117
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            118..224
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1168
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /note="isoform a is encoded by transcript variant 3;
                     C-type lectin domain family 4, member J; Fc fragment of
                     IgE receptor II; FcepsilonRII; low affinity immunoglobulin
                     epsilon Fc receptor; CD23 antigen; fc-epsilon-RII;
                     lymphocyte IgE receptor; immunoglobulin E-binding factor;
                     immunoglobulin epsilon-chain; Fc fragment of IgE, low
                     affinity II, receptor for (CD23)"
                     /codon_start=1
                     /product="low affinity immunoglobulin epsilon Fc receptor
                     isoform a"
                     /protein_id="NP_001207429.1"
                     /db_xref="CCDS:CCDS12184.1"
                     /db_xref="GeneID:2208"
                     /db_xref="HGNC:HGNC:3612"
                     /db_xref="MIM:151445"
                     /translation="MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLL
                     WHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRL
                     KSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVC
                     NTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTG
                     SWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRK
                     LGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS"
     exon            225..338
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            339..392
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            393..455
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            456..518
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            519..581
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            582..671
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            672..823
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            824..930
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1585
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /note="hexamer: AATAAA"
     polyA_site      1585
                     /gene="FCER2"
                     /gene_synonym="BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCErII;
                     IGEBF"
                     /note="major polyA site"
ORIGIN      
        1 agaagaaagt gtctctcttc ctgcttaaac ctctgtctct gacggtccct gccaatcgct
       61 ctggtcgacc ccaacacact aggaggacag acacaggctc caaactccac taagtgacca
      121 gagctgtgat tgtgcccgct gagtggactg cgttgtcagg gagtgagtgc tccatcatcg
      181 ggagaatcca agcaggaccg ccatggagga aggtcaatat tcagagatcg aggagcttcc
      241 caggaggcgg tgttgcaggc gtgggactca gatcgtgctg ctggggctgg tgaccgccgc
      301 tctgtgggct gggctgctga ctctgcttct cctgtggcac tgggacacca cacagagtct
      361 aaaacagctg gaagagaggg ctgcccggaa cgtctctcaa gtttccaaga acttggaaag
      421 ccaccacggt gaccagatgg cgcagaaatc ccagtccacg cagatttcac aggaactgga
      481 ggaacttcga gctgaacagc agagattgaa atctcaggac ttggagctgt cctggaacct
      541 gaacgggctt caagcagatc tgagcagctt caagtcccag gaattgaacg agaggaacga
      601 agcttcagat ttgctggaaa gactccggga ggaggtgaca aagctaagga tggagttgca
      661 ggtgtccagc ggctttgtgt gcaacacgtg ccctgaaaag tggatcaatt tccaacggaa
      721 gtgctactac ttcggcaagg gcaccaagca gtgggtccac gcccggtatg cctgtgacga
      781 catggaaggg cagctggtca gcatccacag cccggaggag caggacttcc tgaccaagca
      841 tgccagccac accggctcct ggattggcct tcggaacttg gacctgaagg gggagtttat
      901 ctgggtggat gggagccacg tggactacag caactgggct ccaggggagc ccaccagccg
      961 gagccagggc gaggactgcg tgatgatgcg gggctccggt cgctggaacg acgccttctg
     1021 cgaccgtaag ctgggcgcct gggtgtgcga ccggctggcc acatgcacgc cgccagccag
     1081 cgaaggttcc gcggagtcca tgggacctga ttcaagacca gaccctgacg gccgcctgcc
     1141 caccccctct gcccctctcc actcttgagc atggatacag ccaggcccag agcaagaccc
     1201 tgaagacccc caaccacggc ctaaaagcct ctttgtggct gaaaggtccc tgtgacattt
     1261 tctgccaccc aaacggaggc agctgacaca tctcccgctc ctctatggcc cctgccttcc
     1321 caggagtaca ccccaacagc accctctcca gatgggagtg cccccaacag caccctctcc
     1381 agatgagagt acaccccaac agcaccctct ccagatgaga gtacacccca acagcaccct
     1441 ctccagatga gagtacaccc caacagcacc ctctccagat gcagccccat ctcctcagca
     1501 ccccaggacc tgagtatccc cagctcaggt ggtgagtcct cctgtccagc ctgcatcaat
     1561 aaaatggggc agtgatggcc tccca
//
