LOCUS       NM_004106                590 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc epsilon receptor Ig (FCER1G), mRNA.
ACCESSION   NM_004106
VERSION     NM_004106.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 590)
  AUTHORS   Qiu,X., Zhang,J.H., Xu,Y., Cao,Y.X., Zhang,R.T., Hu,L.N. and
            Zhou,J.H.
  TITLE     Identification of FCER1G as a key gene in multiple myeloma based on
            weighted gene co-expression network analysis
  JOURNAL   Hematology 28 (1), 2210904 (2023)
   PUBMED   37170758
  REMARK    GeneRIF: Identification of FCER1G as a key gene in multiple myeloma
            based on weighted gene co-expression network analysis.
REFERENCE   2  (bases 1 to 590)
  AUTHORS   Chang,R., Ji,Y., Xu,J., Lai,Y., Zhang,H., Zhong,Z., Su,G. and
            Yang,P.
  TITLE     Identification of FCER1G as a cyclosporin A plus corticosteroid
            sensitization gene in female patients with Vogt-Koyanagi-Harada
            disease
  JOURNAL   Clin Immunol 256, 109800 (2023)
   PUBMED   37821074
  REMARK    GeneRIF: Identification of FCER1G as a cyclosporin A plus
            corticosteroid sensitization gene in female patients with
            Vogt-Koyanagi-Harada disease.
REFERENCE   3  (bases 1 to 590)
  AUTHORS   Yang,R., Chen,Z., Liang,L., Ao,S., Zhang,J., Chang,Z., Wang,Z.,
            Zhou,Y., Duan,X. and Deng,T.
  TITLE     Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved
            in cancer immune infiltration and tumour microenvironment
  JOURNAL   Immunology 168 (2), 302-319 (2023)
   PUBMED   36054819
  REMARK    GeneRIF: Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene
            involved in cancer immune infiltration and tumour microenvironment.
REFERENCE   4  (bases 1 to 590)
  AUTHORS   Shemesh,A., Su,Y., Calabrese,D.R., Chen,D., Arakawa-Hoyt,J.,
            Roybal,K.T., Heath,J.R., Greenland,J.R. and Lanier,L.L.
  TITLE     Diminished cell proliferation promotes natural killer cell
            adaptive-like phenotype by limiting FcepsilonRIgamma expression
  JOURNAL   J Exp Med 219 (11) (2022)
   PUBMED   36066491
  REMARK    GeneRIF: Diminished cell proliferation promotes natural killer cell
            adaptive-like phenotype by limiting FcepsilonRIgamma expression.
REFERENCE   5  (bases 1 to 590)
  AUTHORS   Li,J., Shi,H., Yuan,Z., Wu,Z., Li,H., Liu,Y., Lu,M. and Lu,M.
  TITLE     The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis
            of osteosarcoma, and its association with immune infiltration
  JOURNAL   BMC Cancer 22 (1), 108 (2022)
   PUBMED   35078433
  REMARK    GeneRIF: The role of SPI1-TYROBP-FCER1G network in oncogenesis and
            prognosis of osteosarcoma, and its association with immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 590)
  AUTHORS   Maurer,D., Fiebiger,S., Ebner,C., Reininger,B., Fischer,G.F.,
            Wichlas,S., Jouvin,M.H., Schmitt-Egenolf,M., Kraft,D., Kinet,J.P.
            and Stingl,G.
  TITLE     Peripheral blood dendritic cells express Fc epsilon RI as a complex
            composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and
            can use this receptor for IgE-mediated allergen presentation
  JOURNAL   J Immunol 157 (2), 607-616 (1996)
   PUBMED   8752908
REFERENCE   7  (bases 1 to 590)
  AUTHORS   Kihara,H. and Siraganian,R.P.
  TITLE     Src homology 2 domains of Syk and Lyn bind to
            tyrosine-phosphorylated subunits of the high affinity IgE receptor
  JOURNAL   J Biol Chem 269 (35), 22427-22432 (1994)
   PUBMED   8071371
REFERENCE   8  (bases 1 to 590)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   9  (bases 1 to 590)
  AUTHORS   Kuster,H., Thompson,H. and Kinet,J.P.
  TITLE     Characterization and expression of the gene for the human Fc
            receptor gamma subunit. Definition of a new gene family
  JOURNAL   J Biol Chem 265 (11), 6448-6452 (1990)
   PUBMED   2138619
REFERENCE   10 (bases 1 to 590)
  AUTHORS   Le Coniat,M., Kinet,J.P. and Berger,R.
  TITLE     The human genes for the alpha and gamma subunits of the mast cell
            receptor for immunoglobulin E are located on human chromosome band
            1q23
  JOURNAL   Immunogenetics 32 (3), 183-186 (1990)
   PUBMED   2146219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590714.27 and M33195.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004106.1.
            
            Summary: The high affinity IgE receptor is a key molecule involved
            in allergic reactions. It is a tetramer composed of 1 alpha, 1
            beta, and 2 gamma chains. The gamma chains are also subunits of
            other Fc receptors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD364792.1, BU789936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289902.2/ ENSP00000289902.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL590714.27        70475-70476
            3-590               M33195.1           1-588
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..590
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /note="Fc epsilon receptor Ig"
                     /db_xref="GeneID:2207"
                     /db_xref="HGNC:HGNC:3611"
                     /db_xref="MIM:147139"
     exon            1..76
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..288
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /note="immunoglobulin E receptor, high affinity, gamma
                     chain; high affinity immunoglobulin epsilon receptor
                     subunit gamma; fceRI gamma; fc-epsilon RI-gamma; fcRgamma;
                     Fc receptor gamma-chain; Fc fragment of IgE, high affinity
                     I, receptor for; gamma polypeptide; Fc fragment of IgE
                     receptor Ig; FcepsilonRIgamma; FcepsilonRI gamma chain"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit gamma precursor"
                     /protein_id="NP_004097.1"
                     /db_xref="CCDS:CCDS1225.1"
                     /db_xref="GeneID:2207"
                     /db_xref="HGNC:HGNC:3611"
                     /db_xref="MIM:147139"
                     /translation="MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYC
                     RLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ"
     exon            77..168
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /inference="alignment:Splign:2.1.0"
     exon            169..204
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /inference="alignment:Splign:2.1.0"
     exon            205..225
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /inference="alignment:Splign:2.1.0"
     exon            226..590
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /note="hexamer: AATAAA"
     polyA_site      590
                     /gene="FCER1G"
                     /gene_synonym="FCRG"
                     /note="major polyA site"
ORIGIN      
        1 gtcagaacgg ccgatctcca gcccaagatg attccagcag tggtcttgct cttactcctt
       61 ttggttgaac aagcagcggc cctgggagag cctcagctct gctatatcct ggatgccatc
      121 ctgtttctgt atggaattgt cctcaccctc ctctactgtc gactgaagat ccaagtgcga
      181 aaggcagcta taaccagcta tgagaaatca gatggtgttt acacgggcct gagcaccagg
      241 aaccaggaga cttacgagac tctgaagcat gagaaaccac cacagtagct ttagaataga
      301 tgcggtcata ttcttctttg gcttctggtt cttccagccc tcatggttgg catcacatat
      361 gcctgcatgc cattaacacc agctggccct acccctataa tgatcctgtg tcctaaatta
      421 atatacacca gtggttcctc ctccctgtta aagactaatg ctcagatgct gtttacggat
      481 atttatattc tagtctcact ctcttgtccc acccttcttc tcttccccat tcccaactcc
      541 agctaaaata tgggaaggga gaacccccaa taaaactgcc atggactgga
//
