LOCUS       NM_001387280            1073 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc epsilon receptor Ia (FCER1A), transcript variant 1,
            mRNA.
ACCESSION   NM_001387280
VERSION     NM_001387280.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Zhou,C., Li,M., Liu,Y., Wang,X., Zhang,S., Guan,L., Hong,J.,
            Zhou,W., Wu,G., Diao,W., Huang,Q. and Yang,P.
  TITLE     Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by
            modulating the expression of FcepsilonRI in mast cells
  JOURNAL   Clin Exp Immunol 211 (1), 15-22 (2023)
   PUBMED   36368013
  REMARK    GeneRIF: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal
            allergy by modulating the expression of FcepsilonRI in mast cells.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Jo,H., Shim,K. and Jeoung,D.
  TITLE     The Crosstalk between FcepsilonRI and Sphingosine Signaling in
            Allergic Inflammation
  JOURNAL   Int J Mol Sci 23 (22), 13892 (2022)
   PUBMED   36430378
  REMARK    GeneRIF: The Crosstalk between FcepsilonRI and Sphingosine
            Signaling in Allergic Inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Sur,S., Nguyen,M., Boada,P., Sigdel,T.K., Sollinger,H. and
            Sarwal,M.M.
  TITLE     FcER1: A Novel Molecule Implicated in the Progression of Human
            Diabetic Kidney Disease
  JOURNAL   Front Immunol 12, 769972 (2021)
   PUBMED   34925339
  REMARK    GeneRIF: FcER1: A Novel Molecule Implicated in the Progression of
            Human Diabetic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Andiappan,A.K., Puan,K.J., Lee,B., Yeow,P.T., Yusof,N., Merid,S.K.,
            Kumar,D., Lum,J., Foo,S., Koh,G., Poidinger,M., Zolezzi,F.,
            Wang,Y., Melen,E. and Rotzschke,O.
  CONSRTM   eQTLGen Consortium; BIOS Consortium
  TITLE     Inverse association of FCER1A allergy variant in monocytes and
            plasmacytoid dendritic cells
  JOURNAL   J Allergy Clin Immunol 147 (4), 1510-1513 (2021)
   PUBMED   33160967
  REMARK    GeneRIF: Inverse association of FCER1A allergy variant in monocytes
            and plasmacytoid dendritic cells.
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Roshanizadeh,Z., Ghandil,P., Khodadadi,A., Tavakol,H., Kambiz,A.A.
            and Ghadiri,A.
  TITLE     Genetic association study of CTLA4 and FCepsilonRIalpha
            polymorphisms in asthmatic patients in the southwestern region of
            Iran
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 40 (9), 914-925 (2021)
   PUBMED   34420484
  REMARK    GeneRIF: Genetic association study of CTLA4 and FCepsilonRIalpha
            polymorphisms in asthmatic patients in the southwestern region of
            Iran.
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Potaczek,D.P., Nastalek,M., Wojas-Pelc,A., Okumura,K., Undas,A. and
            Nishiyama,C.
  TITLE     Naturally occurring FCER1A N222K mutation - its ethnicity-dependent
            distribution and a role in atopic dermatitis
  JOURNAL   Mol Immunol 48 (8), 979-980 (2011)
   PUBMED   21216468
  REMARK    GeneRIF: Data indicate that although results rather show the lack
            of an association between FCER1A rs41264475 mutation and atopic
            dermatitis, they suggest that its minor allele can predispose to
            the concomitant asthma in AD patients.
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Padlan,E.A. and Helm,B.A.
  TITLE     A modeling study of the alpha-subunit of human high-affinity
            receptor for immunoglobulin-E
  JOURNAL   Receptor 2 (2), 129-144 (1992)
   PUBMED   1472946
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Wang,B., Rieger,A., Kilgus,O., Ochiai,K., Maurer,D., Fodinger,D.,
            Kinet,J.P. and Stingl,G.
  TITLE     Epidermal Langerhans cells from normal human skin bind monomeric
            IgE via Fc epsilon RI
  JOURNAL   J Exp Med 175 (5), 1353-1365 (1992)
   PUBMED   1533243
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Le Coniat,M., Kinet,J.P. and Berger,R.
  TITLE     The human genes for the alpha and gamma subunits of the mast cell
            receptor for immunoglobulin E are located on human chromosome band
            1q23
  JOURNAL   Immunogenetics 32 (3), 183-186 (1990)
   PUBMED   2146219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513323.14.
            
            Summary: The immunoglobulin epsilon receptor (IgE receptor) is the
            initiator of the allergic response. When two or more high-affinity
            IgE receptors are brought together by allergen-bound IgE molecules,
            mediators such as histamine that are responsible for allergy
            symptoms are released. This receptor is comprised of an alpha
            subunit, a beta subunit, and two gamma subunits. The protein
            encoded by this gene represents the alpha subunit. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005912.1, BG542554.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000693622.1/
                                                ENSP00000509626.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL513323.14        112095-112178       c
            85-105              AL513323.14        111640-111660       c
            106-360             AL513323.14        110332-110586       c
            361-618             AL513323.14        108269-108526       c
            619-1073            AL513323.14        106312-106766       c
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1073
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /note="Fc epsilon receptor Ia"
                     /db_xref="GeneID:2205"
                     /db_xref="HGNC:HGNC:3609"
                     /db_xref="MIM:147140"
     exon            1..84
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..803
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Fc IgE receptor, alpha polypeptide;
                     immunoglobulin E receptor, high-affinity, of mast cells,
                     alpha polypeptide; Fc-epsilon RI-alpha; Fc fragment of
                     IgE, high affinity I, receptor for; alpha polypeptide;
                     high affinity immunoglobulin epsilon receptor
                     alpha-subunit; Fc fragment of IgE receptor Ia;
                     FcepsilonRIalpha; FcepsilonRI alpha chain; high affinity
                     immunoglobulin epsilon receptor subunit alpha; Fc epsilon
                     RI alpha-chain; igE Fc receptor subunit alpha"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit alpha isoform 1 precursor"
                     /protein_id="NP_001374209.1"
                     /db_xref="CCDS:CCDS1184.1"
                     /db_xref="GeneID:2205"
                     /db_xref="HGNC:HGNC:3609"
                     /db_xref="MIM:147140"
                     /translation="MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKG
                     ENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESE
                     PVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHN
                     ISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAV
                     DTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN"
     exon            85..105
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /inference="alignment:Splign:2.1.0"
     exon            106..360
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /inference="alignment:Splign:2.1.0"
     exon            361..618
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1073
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /note="hexamer: AATAAA"
     polyA_site      1059
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /note="major polyA site"
     polyA_site      1073
                     /gene="FCER1A"
                     /gene_synonym="FCE1A; FcERI; FCERIA"
                     /note="major polyA site"
ORIGIN      
        1 acagtaagca ccaggagtcc atgaagaaga tggctcctgc catggaatcc cctactctac
       61 tgtgtgtagc cttactgttc ttcgctccag atggcgtgtt agcagtccct cagaaaccta
      121 aggtctcctt gaaccctcca tggaatagaa tatttaaagg agagaatgtg actcttacat
      181 gtaatgggaa caatttcttt gaagtcagtt ccaccaaatg gttccacaat ggcagccttt
      241 cagaagagac aaattcaagt ttgaatattg tgaatgccaa atttgaagac agtggagaat
      301 acaaatgtca gcaccaacaa gttaatgaga gtgaacctgt gtacctggaa gtcttcagtg
      361 actggctgct ccttcaggcc tctgctgagg tggtgatgga gggccagccc ctcttcctca
      421 ggtgccatgg ttggaggaac tgggatgtgt acaaggtgat ctattataag gatggtgaag
      481 ctctcaagta ctggtatgag aaccacaaca tctccattac aaatgccaca gttgaagaca
      541 gtggaaccta ctactgtacg ggcaaagtgt ggcagctgga ctatgagtct gagcccctca
      601 acattactgt aataaaagct ccgcgtgaga agtactggct acaatttttt atcccattgt
      661 tggtggtgat tctgtttgct gtggacacag gattatttat ctcaactcag cagcaggtca
      721 catttctctt gaagattaag agaaccagga aaggcttcag acttctgaac ccacatccta
      781 agccaaaccc caaaaacaac tgatataatt actcaagaaa tatttgcaac attagttttt
      841 ttccagcatc agcaattgct actcaattgt caaacacagc ttgcaatata catagaaacg
      901 tctgtgctca aggatttata gaaatgcttc attaaactga gtgaaactgg ttaagtggca
      961 tgtaatagta agtgctcaat taacattggt tgaataaatg agagaatgaa tagattcatt
     1021 tattagcatt tgtaaaagag atgttcaatt tcaataaaat aaatataaaa cca
//
