LOCUS       NM_002000               2476 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Fc alpha receptor (FCAR), transcript variant 1, mRNA.
ACCESSION   NM_002000
VERSION     NM_002000.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Liu,Q. and Stadtmueller,B.M.
  TITLE     SIgA structures bound to Streptococcus pyogenes M4 and human CD89
            provide insights into host-pathogen interactions
  JOURNAL   Nat Commun 14 (1), 6726 (2023)
   PUBMED   37872175
  REMARK    GeneRIF: SIgA structures bound to Streptococcus pyogenes M4 and
            human CD89 provide insights into host-pathogen interactions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Wu,H., Wang,X., Yang,Z., Zhao,Q., Wen,Y., Li,X., Zhang,W. and
            Gao,R.
  TITLE     Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy
            without Immunosuppressant History
  JOURNAL   Dis Markers 2020, 8393075 (2020)
   PUBMED   32076466
  REMARK    GeneRIF: Serum Soluble CD89-IgA Complexes Are Elevated in IgA
            Nephropathy without Immunosuppressant History.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Hansen,I.S., Krabbendam,L., Bernink,J.H., Loayza-Puch,F.,
            Hoepel,W., van Burgsteden,J.A., Kuijper,E.C., Buskens,C.J.,
            Bemelman,W.A., Zaat,S.A.J., Agami,R., Vidarsson,G., van den
            Brink,G.R., de Jong,E.C., Wildenberg,M.E., Baeten,D.L.P., Everts,B.
            and den Dunnen,J.
  TITLE     FcalphaRI co-stimulation converts human intestinal CD103+ dendritic
            cells into pro-inflammatory cells through glycolytic reprogramming
  JOURNAL   Nat Commun 9 (1), 863 (2018)
   PUBMED   29491406
  REMARK    GeneRIF: FcalphaRI-induced cytokine production is orchestrated via
            upregulation of cytokine translation and caspase-1 activation,
            which is dependent on glycolytic reprogramming.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Pleass,R.J., Andrews,P.D., Kerr,M.A. and Woof,J.M.
  TITLE     Alternative splicing of the human IgA Fc receptor CD89 in
            neutrophils and eosinophils
  JOURNAL   Biochem J 318 (Pt 3) (Pt 3), 771-777 (1996)
   PUBMED   8836118
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Patry,C., Sibille,Y., Lehuen,A. and Monteiro,R.C.
  TITLE     Identification of Fc alpha receptor (CD89) isoforms generated by
            alternative splicing that are differentially expressed between
            blood monocytes and alveolar macrophages
  JOURNAL   J Immunol 156 (11), 4442-4448 (1996)
   PUBMED   8666819
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Morton,H.C., Schiel,A.E., Janssen,S.W. and van de Winkel,J.G.
  TITLE     Alternatively spliced forms of the human myeloid Fc alpha receptor
            (CD89) in neutrophils
  JOURNAL   Immunogenetics 43 (4), 246-247 (1996)
   PUBMED   8575829
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   de Wit,T.P., Morton,H.C., Capel,P.J. and van de Winkel,J.G.
  TITLE     Structure of the gene for the human myeloid IgA Fc receptor (CD89)
  JOURNAL   J Immunol 155 (3), 1203-1209 (1995)
   PUBMED   7636188
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Kremer,E.J., Kalatzis,V., Baker,E., Callen,D.F., Sutherland,G.R.
            and Maliszewski,C.R.
  TITLE     The gene for the human IgA Fc receptor maps to 19q13.4
  JOURNAL   Hum Genet 89 (1), 107-108 (1992)
   PUBMED   1577457
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Maliszewski,C.R., March,C.J., Schoenborn,M.A., Gimpel,S. and
            Shen,L.
  TITLE     Expression cloning of a human Fc receptor for IgA
  JOURNAL   J Exp Med 172 (6), 1665-1672 (1990)
   PUBMED   2258698
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Kimata,H. and Saxon,A.
  TITLE     Subset of natural killer cells is induced by immune complexes to
            display Fc receptors for IgE and IgA and demonstrates isotype
            regulatory function
  JOURNAL   J Clin Invest 82 (1), 160-167 (1988)
   PUBMED   2455732
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290922.1, BC027953.1 and
            AC245128.3.
            
            On Nov 22, 2018 this sequence version replaced NM_002000.3.
            
            Summary: This gene is a member of the immunoglobulin gene
            superfamily and encodes a receptor for the Fc region of IgA. The
            receptor is a transmembrane glycoprotein present on the surface of
            myeloid lineage cells such as neutrophils, monocytes, macrophages,
            and eosinophils, where it mediates immunologic responses to
            pathogens. It interacts with IgA-opsonized targets and triggers
            several immunologic defense processes, including phagocytosis,
            antibody-dependent cell-mediated cytotoxicity, and stimulation of
            the release of inflammatory mediators. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, also known as a.1) represents
            the longest transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290922.1, SRR1803617.280490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355524.8/ ENSP00000347714.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-685               AK290922.1         1-685
            686-1034            BC027953.1         655-1003
            1035-2476           AC245128.3         191603-193044
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2476
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /note="Fc alpha receptor"
                     /db_xref="GeneID:2204"
                     /db_xref="HGNC:HGNC:3608"
                     /db_xref="MIM:147045"
     exon            1..89
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..919
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; immunoglobulin alpha Fc receptor; Fc fragment
                     of IgA, receptor for; Fc fragment of IgA receptor"
                     /codon_start=1
                     /product="immunoglobulin alpha Fc receptor isoform a
                     precursor"
                     /protein_id="NP_001991.1"
                     /db_xref="CCDS:CCDS12907.1"
                     /db_xref="GeneID:2204"
                     /db_xref="HGNC:HGNC:3608"
                     /db_xref="MIM:147045"
                     /translation="MDPKQTTLLCLVLCLGQRIQAQEGDFPMPFISAKSSPVIPLDGS
                     VKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQY
                     RIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAK
                     EGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDS
                     IHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNKEASADVAEPSWSQQMCQPG
                     LTFARTPSVCK"
     exon            90..125
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /inference="alignment:Splign:2.1.0"
     exon            126..416
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /inference="alignment:Splign:2.1.0"
     exon            417..704
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /inference="alignment:Splign:2.1.0"
     exon            705..2476
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /note="hexamer: ATTAAA"
     polyA_site      2170
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /note="major polyA site"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
                     /note="hexamer: ATTAAA"
     polyA_site      2476
                     /gene="FCAR"
                     /gene_synonym="CD89; CTB-61M7.2; FcalphaR; FcalphaRI"
ORIGIN      
        1 atcctgctaa tgtgcattga aaggagagca acggggctga ggccgtgtca gcacgatgga
       61 ccccaaacag accaccctcc tgtgtcttgt gctctgtctg ggccagagga ttcaggcaca
      121 ggaaggggac tttcccatgc ctttcatatc tgccaaatcg agtcctgtga ttcccttgga
      181 tggatctgtg aaaatccagt gccaggccat tcgtgaagct tacctgaccc agctgatgat
      241 cataaaaaac tccacgtacc gagagatagg cagaagactg aagttttgga atgagactga
      301 tcctgagttc gtcattgacc acatggacgc aaacaaggca gggcgctatc agtgccaata
      361 taggataggg cactacaggt tccggtacag tgacaccctg gagctggtag tgacaggctt
      421 gtatggcaaa cccttcctct ctgcagatcg gggtctggtg ttgatgccag gagagaatat
      481 ttccctcacg tgcagctcag cacacatccc atttgataga ttttcactgg ccaaggaggg
      541 agaactttct ctgccacagc accaaagtgg ggaacacccg gccaacttct ctttgggtcc
      601 tgtggacctc aatgtctcag ggatctacag gtgctacggt tggtacaaca ggagccccta
      661 cctgtggtcc ttccccagta atgccttgga gcttgtggtc acagactcca tccaccaaga
      721 ttacacgacg cagaacttga tccgcatggc cgtggcagga ctggtcctcg tggctctctt
      781 ggccatactg gttgaaaatt ggcacagcca tacggcactg aacaaggaag cctcggcaga
      841 tgtggctgaa ccgagctgga gccaacagat gtgtcagcca ggattgacct ttgcacgaac
      901 accaagtgtc tgcaagtaaa cacctggagg tgaaggcaga gaggagccag gactgtggag
      961 tccgacaaag ctacttgaag gacacaagag agaaaagctc actaagaagc ttgaatctac
     1021 tttttttttt ttttgagaca gagtctggct ctgtcaccca ggctggagtg cagtggagca
     1081 atctcggctc attgaacctc ttgggttcaa gtgattcttg tgcctcagcc tcccaagtag
     1141 ctggaattac aggcacatac cactgcaccc agctaatttt tgtattttta gtagagatgg
     1201 ggtttcactg tgttggccag gctggtctcg aactcctgac ctcaggtgat ccacccacct
     1261 tggcctccca aagtgctgag attataggca tgagccacca cgcctggcca gatgcatgtt
     1321 caaaccaatc aaatggtgtt ttcttatgca ggactgatcg atttgcaccc acctttctgc
     1381 acataagtta tggttttcca tcttatctgt cttctgattt tttatatcct gtttaatttc
     1441 ttccttcatt gttcttctct ttttttattt attttattta tttttatttt tatttttatt
     1501 tgagacagag tctcactctg ttgcccaggc tggagtgcag tggcacgatc tcggctcact
     1561 gcaacctctg cctcctgggt tcaagtgatt ctcctgcctc ggcctcccaa gtagctggga
     1621 ttgcaggctc ccaccatcac gcccagctac ttttacagta tttttagtag agacggggtt
     1681 tcatcacatt ggccaagctg gtctcaaact tctgacctcg tgatctgccc gcctcggcct
     1741 cccaaagtgc tgggattaca gatgtgagcc actgcgccca gccttctttt tatattttta
     1801 aatgtgtctt ccccaaatat aaatggttgg taagcatgcc aaatatattc aataaccccc
     1861 ctcctttatt tttttttgtt gaagtgaggc tctccctatg ttgcctaagc tggtcttgaa
     1921 ctcctggtct caagcaatcc tcctacctca gcctcctgct gtgttcatct acaaattgat
     1981 aagagtgaaa gtcataatcc tacaggagga ttaccctatt tatttcacaa accctatttc
     2041 taccggattt tcatacaagg aatacaggca tgtgtttcac ctcattaatt tattttttca
     2101 cttagttttg atgatattca catatattat caagtgtgca aacattaaat tcttgtgtac
     2161 aaaactcaaa tggtcttcca aataattccc cattcttttt tcttataaac tttcacagct
     2221 ttacccttga cagactttac tcaaggaaat ctaagttggt catatgtggc tctttcactg
     2281 attgctattt acttcattgt ccagtagctt atgtatgaaa atataattat aaaatgtaag
     2341 ggtcctactt ccagtgaaac tgaagggact taggcccact tttatccttt actgagagct
     2401 tatctctact tgataaaatt tctactgtat tcttggctta actcaggtcc tgtgattaaa
     2461 aaaaaaatgc aaagta
//
