LOCUS       NM_001170631            2618 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Fc alpha and mu receptor (FCAMR), transcript variant
            3, mRNA.
ACCESSION   NM_001170631
VERSION     NM_001170631.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Ward-Caviness,C.K., Neas,L.M., Blach,C., Haynes,C.S.,
            LaRocque-Abramson,K., Grass,E., Dowdy,Z.E., Devlin,R.B.,
            Diaz-Sanchez,D., Cascio,W.E., Miranda,M.L., Gregory,S.G.,
            Shah,S.H., Kraus,W.E. and Hauser,E.R.
  TITLE     A genome-wide trans-ethnic interaction study links the PIGR-FCAMR
            locus to coronary atherosclerosis via interactions between genetic
            variants and residential exposure to traffic
  JOURNAL   PLoS One 12 (3), e0173880 (2017)
   PUBMED   28355232
  REMARK    GeneRIF: A genome-wide trans-ethnic interaction study links the
            PIGR-FCAMR locus to coronary atherosclerosis via interactions
            between genetic variants and residential exposure to traffic
            pollution.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Schneider,B.P., Li,L., Radovich,M., Shen,F., Miller,K.D.,
            Flockhart,D.A., Jiang,G., Vance,G., Gardner,L., Vatta,M., Bai,S.,
            Lai,D., Koller,D., Zhao,F., O'Neill,A., Smith,M.L., Railey,E.,
            White,C., Partridge,A., Sparano,J., Davidson,N.E., Foroud,T. and
            Sledge,G.W. Jr.
  TITLE     Genome-Wide Association Studies for Taxane-Induced Peripheral
            Neuropathy in ECOG-5103 and ECOG-1199
  JOURNAL   Clin Cancer Res 21 (22), 5082-5091 (2015)
   PUBMED   26138065
  REMARK    GeneRIF: rs3125923 FCAMR gene represents a validated SNP to predict
            grade 3-4 Taxane-induced peripheral neuropathy . Genetically
            determined AA race represents the most significant predictor of
            TIPN.
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Ten Klooster,L., van Moorsel,C.H., Kwakkel-van Erp,J.M., van
            Velzen-Blad,H. and Grutters,J.C.
  TITLE     Immunoglobulin A in serum: an old acquaintance as a new prognostic
            biomarker in idiopathic pulmonary fibrosis
  JOURNAL   Clin Exp Immunol 181 (2), 357-361 (2015)
   PUBMED   25845491
  REMARK    GeneRIF: A significantly worse survival was found in patients with
            IgA serum levels>2.85 g/l compared to patients with lower IgA serum
            levels.
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Peng,M., Guo,S., Yin,N., Xue,J., Shen,L., Zhao,Q. and Zhang,W.
  TITLE     Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and
            ADAM17
  JOURNAL   Immunology 130 (1), 83-91 (2010)
   PUBMED   20059578
  REMARK    GeneRIF: ADAM10 and ADAM17 are involved in the shedding of FcalphaR
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Cho,Y., Honda,S., Yoshizawa,Y., Takagaki,K., Usui,K. and Shibuya,A.
  TITLE     Requirement of the cytoplasmic portion for dimer formation of
            Fcalpha/micro receptor expressed on cell surface
  JOURNAL   Mol Immunol 47 (4), 878-882 (2010)
   PUBMED   19945166
  REMARK    GeneRIF: These results suggest that the cytoplasmic portion is
            required for the dimer formation and thus for efficient cell
            surface expression of Fcalpha/microR.
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   Wang,R., Fu,Y., Zhao,Q., Pan,L. and Zhang,W.
  TITLE     Human Fcalpha/muR and pIgR distribute differently in intestinal
            tissues
  JOURNAL   Biochem Biophys Res Commun 381 (2), 148-152 (2009)
   PUBMED   19338768
  REMARK    GeneRIF: These results indicate for the first time that Fcalpha/muR
            protein is expressed by human intestinal tissues
REFERENCE   7  (bases 1 to 2618)
  AUTHORS   Yang,L., Shen,L., Shao,Y., Zhao,Q. and Zhang,W.
  TITLE     Cytoplasmic domain of human Fcalpha/mu receptor is required for
            ligand internalization
  JOURNAL   Cell Immunol 258 (1), 78-82 (2009)
   PUBMED   19393604
  REMARK    GeneRIF: the cytoplasmic portion of human Fcalpha/microR is
            required in the internalization.
REFERENCE   8  (bases 1 to 2618)
  AUTHORS   Vallender,E.J., Priddy,C.M., Chen,G.L. and Miller,G.M.
  TITLE     Human expression variation in the mu-opioid receptor is paralleled
            in rhesus macaque
  JOURNAL   Behav Genet 38 (4), 390-395 (2008)
   PUBMED   18379868
  REMARK    GeneRIF: Comprehensive survey of naturally occurring polymorphisms
            in rhesus macaques and in humans.
REFERENCE   9  (bases 1 to 2618)
  AUTHORS   McDonald,K.J., Cameron,A.J., Allen,J.M. and Jardine,A.G.
  TITLE     Expression of Fc alpha/mu receptor by human mesangial cells: a
            candidate receptor for immune complex deposition in IgA nephropathy
  JOURNAL   Biochem Biophys Res Commun 290 (1), 438-442 (2002)
   PUBMED   11779189
REFERENCE   10 (bases 1 to 2618)
  AUTHORS   Shibuya,A., Sakamoto,N., Shimizu,Y., Shibuya,K., Osawa,M.,
            Hiroyama,T., Eyre,H.J., Sutherland,G.R., Endo,Y., Fujita,T.,
            Miyabayashi,T., Sakano,S., Tsuji,T., Nakayama,E., Phillips,J.H.,
            Lanier,L.L. and Nakauchi,H.
  TITLE     Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes
  JOURNAL   Nat Immunol 1 (5), 441-446 (2000)
   PUBMED   11062505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298394.1 and AI269147.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001170631.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298394.1, ERR279862.2835.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324852.9/ ENSP00000316491.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2354              AK298394.1         142-2495
            2355-2618           AI269147.1         1-264               c
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2618
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /note="Fc alpha and mu receptor"
                     /db_xref="GeneID:83953"
                     /db_xref="HGNC:HGNC:24692"
                     /db_xref="MIM:605484"
     exon            1..374
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2069
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /note="isoform b is encoded by transcript variant 3;
                     receptor for Fc fragment of IgA and IgM; immunity related
                     factor; high affinity immunoglobulin alpha and
                     immunoglobulin mu Fc receptor; Fc alpha/mu receptor; Fc
                     receptor, IgA, IgM, high affinity; Fc fragment of IgA and
                     IgM receptor"
                     /codon_start=1
                     /product="high affinity immunoglobulin alpha and
                     immunoglobulin mu Fc receptor isoform b"
                     /protein_id="NP_001164102.1"
                     /db_xref="CCDS:CCDS53468.1"
                     /db_xref="GeneID:83953"
                     /db_xref="HGNC:HGNC:24692"
                     /db_xref="MIM:605484"
                     /translation="MDGEATVKPGEQKEVVRRGREVDYSRLIAGTLPQSHVTSRRAGW
                     KMPLFLILCLLQGSSFALPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESS
                     FAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQ
                     YTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTISAG
                     PASTLPTATPAAGELTMRSYGTASPVANRWTPGTTQTLGQGTAWDTVASTPGTSKTTA
                     SAEGRRTPGATRPAAPGTGSWAEGSVKAPAPIPESPPSKSRSMSNTTEGVWEGTRSSV
                     TNRARASKDRREMTTTKADRPREDIEGVRIALDAAKKVLGTIGPPALVSETLAWEILP
                     QATPVSKQQSQGSIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAASGEGSAAG
                     DLDAATGDRGPQATLSQTPAVGPWGPPGKESSVKRTFPEDESSSRTLAPVSTMLALFM
                     LMALVLLQRKLWRRRTSQEAERVTLIQMTHFLEVNPQADQLPHVERKMLQDDSLPAGA
                     SLTAPERNPGP"
     exon            375..443
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            444..504
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            505..648
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            649..987
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1789
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1908
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2618
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2596..2601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /note="hexamer: AATAAA"
     polyA_site      2618
                     /gene="FCAMR"
                     /gene_synonym="CD351; FCA/MR; Fcalpha/muR; FKSG87"
                     /note="major polyA site"
ORIGIN      
        1 acaagaggag gaaggatatg gatcagtgtt ttcttttttg aagctactgt taccactcct
       61 ggaaaagttc ttcaggaata agtgacagta agaatgacaa gggattagga ctggcttcct
      121 cttataaata ataaaatcca aagagaagtg acttgaggtg agtggcagag ctacgccttg
      181 caccccgacc ttccgttgct agctccagct gctttccaaa ataccacctt gacttctcag
      241 tctccaggtt taaaggagag caactagaag tcgtccaaac acctgcatct cataaggaga
      301 agaaaagtcc acctggatct tgtttctgga ctgagatgga tggagaggcc acagtgaagc
      361 ctggagaaca aaaggaagtg gtgaggagag gaagagaagt ggactactcc aggctcattg
      421 ctggcacttt accacaatct cacgtcacca gcaggagggc gggatggaaa atgcccctct
      481 tcctcatact gtgcctgcta caaggttctt ctttcgccct tccacaaaaa agaccccatc
      541 cgagatggct gtgggagggc tctctcccct ccaggaccca tctccgggcc atgggaacac
      601 tcaggccttc ctcgcccctc tgctggcggg aggagagctc ctttgcagct ccaaattcat
      661 tgaagggctc aaggctggtg tcaggggagc ctggaggagc tgtcaccatc cagtgccatt
      721 atgccccctc atctgtcaac aggcaccaga ggaagtactg gtgccgtctg gggcccccaa
      781 gatggatctg ccagaccatt gtgtccacca accagtatac tcaccatcgc tatcgtgacc
      841 gtgtggccct cacagacttt ccacagagag gcttgtttgt ggtgaggctg tcccaactgt
      901 ccccggatga catcggatgc tacctctgcg gcattggaag tgaaaacaac atgctgttct
      961 taagcatgaa tctgaccatc tctgcaggtc ccgccagcac cctccccaca gccactccag
     1021 ctgctgggga gctcaccatg agatcctatg gaacagcgtc tccagtggcc aacagatgga
     1081 ccccaggaac cacccagacc ttaggacagg ggacagcatg ggacacagtt gcttccactc
     1141 caggaaccag caagactaca gcttcagctg agggaagacg aaccccagga gcaaccaggc
     1201 cagcagctcc agggacaggc agctgggcag agggttctgt caaagcacct gctccgattc
     1261 cagagagtcc accttcaaag agcagaagca tgtccaatac aacagaaggt gtttgggagg
     1321 gcaccagaag ctcggtgaca aacagggcta gagccagcaa ggacaggagg gagatgacaa
     1381 ctaccaaggc tgataggcca agggaggaca tagagggggt caggatagct cttgatgcag
     1441 ccaaaaaggt cctaggaacc attgggccac cagctctggt ctcagaaact ttggcctggg
     1501 aaatcctccc acaagcaacg ccagtttcta agcaacaatc tcagggttcc attggagaaa
     1561 caactccagc tgcaggcatg tggaccttgg gaactccagc tgcagatgtg tggatcttgg
     1621 gaactccagc tgcagatgtg tggaccagca tggaggcagc atctggggaa ggaagcgctg
     1681 caggggacct agatgctgcc actggagaca gaggtcccca agcaacactg agccagaccc
     1741 cggcagtagg accctgggga ccccctggca aggagtcctc cgtgaagcgt acttttccag
     1801 aagatgaaag cagctctcgg accctggctc ctgtctctac catgctggcc ctgtttatgc
     1861 ttatggctct ggttctattg caaaggaagc tctggagaag gaggacctct caggaggcag
     1921 aaagggtcac cttaattcag atgacacatt ttctggaagt gaacccccaa gcagaccagc
     1981 tgccccatgt ggaaagaaag atgctccagg atgactctct tcctgctggg gccagcctga
     2041 ctgccccaga gagaaatcca ggaccctgag ggacagagag atgaactgct cagttaccat
     2101 gggagaagga ccaagatcaa aggccttcag gaccccagcc tctttccatc atccttcctc
     2161 cacctgtggg aagagaagct gatgcagccg gtgctccacc catggaagaa aggctggctg
     2221 tccttgggcc caagaaagtc aagcattatc cacgtccaaa ggtgacaaga tgactcaaag
     2281 gagacttcaa gaacagtgta tgaaacactg gaagaggtca cctaggaaaa gcatgaaatt
     2341 tccattcctg aatgtttgaa aatagaagag gcttccaatc agtgtggaaa gtgacaaatc
     2401 ccctatcaac actcccagcc cttgctgggg gctccttttc tgactactgt tagcactcag
     2461 cctcccattc acatgtatta tatttaagtg taccagcctt gccttctcaa gtagattcta
     2521 agctccttta aggcagtaat tgcattttat ctgtctcatg atgcccccag agaacttcca
     2581 actcagtagg accccaataa atacctgtgt ctgattga
//
