LOCUS       NM_032301               1727 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 9 (FBXW9), mRNA.
ACCESSION   NM_032301
VERSION     NM_032301.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1727)
  AUTHORS   Yu,S., Liang,Z., Fan,Z., Cao,B., Wang,N., Wu,R. and Sun,H.
  TITLE     A Comprehensive Analysis Revealing FBXW9 as a Potential Prognostic
            and Immunological Biomarker in Breast Cancer
  JOURNAL   Int J Mol Sci 24 (6), 5262 (2023)
   PUBMED   36982338
  REMARK    GeneRIF: A Comprehensive Analysis Revealing FBXW9 as a Potential
            Prognostic and Immunological Biomarker in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1727)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1727)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   4  (bases 1 to 1727)
  AUTHORS   Sun,Y., Hu,Z., Goeb,Y. and Dreier,L.
  TITLE     The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in
            GABAergic motor neurons in C. elegans
  JOURNAL   PLoS One 8 (3), e59132 (2013)
   PUBMED   23527112
REFERENCE   5  (bases 1 to 1727)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   6  (bases 1 to 1727)
  AUTHORS   Lievens,S., Vanderroost,N., Van der Heyden,J., Gesellchen,V.,
            Vidal,M. and Tavernier,J.
  TITLE     Array MAPPIT: high-throughput interactome analysis in mammalian
            cells
  JOURNAL   J Proteome Res 8 (2), 877-886 (2009)
   PUBMED   19159283
REFERENCE   7  (bases 1 to 1727)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA079240.1, AK123037.1 and AW083348.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032301.2.
            
            Summary: Members of the F-box protein family, such as FBXW9, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603034), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004290.1, AK123037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393261.8/ ENSP00000376945.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               DA079240.1         11-570
            561-1720            AK123037.1         570-1729
            1721-1727           AW083348.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..1727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1727
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /note="F-box and WD repeat domain containing 9"
                     /db_xref="GeneID:84261"
                     /db_xref="HGNC:HGNC:28136"
                     /db_xref="MIM:609074"
     exon            1..459
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1427
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /note="F-box and WD-40 domain protein 9; specificity
                     factor for SCF ubiquitin ligase; F-box and WD-40 repeat
                     containing protein 9; F-box and WD-40 domain-containing
                     protein 9"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 9"
                     /protein_id="NP_115677.2"
                     /db_xref="CCDS:CCDS12278.2"
                     /db_xref="GeneID:84261"
                     /db_xref="HGNC:HGNC:28136"
                     /db_xref="MIM:609074"
                     /translation="MELPLGRCDDSRTWDDDSDPESETDPDAQAKAYVARVLSPPKSG
                     LAFSRPSQLSTPAASPSASEPRAASRVSAVSEPGLLSLPPELLLEICSYLDARLVLHV
                     LSRVCHALRDLVSDHVTWRLRALRRVRAPYPVVEEKNFDWPAACIALEQHLSRWAEDG
                     RWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLG
                     TKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLP
                     DILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDR
                     RANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPI
                     TGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVCAEGNLVVAGSGDLS
                     LEVWRLQA"
     exon            460..599
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            600..728
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            729..841
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            842..933
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1082
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1196
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1286
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1352
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1727
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /note="hexamer: AATAAA"
     polyA_site      1727
                     /gene="FBXW9"
                     /gene_synonym="Fbw9; MEC-15"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgccta ggagacaaga cgcgaggccg gcagcgccca cccggtcgca atggagcttc
       61 ccctagggcg gtgcgatgat tcccgcacct gggacgatga ctcggaccca gagtcagaga
      121 cagacccaga cgcgcaggcc aaggcctacg tggcccgcgt tctcagtccg ccaaaatccg
      181 ggctggcgtt ctcgcgcccc tcgcagctat ccacacccgc cgcgtccccg agcgcttcgg
      241 agcctcgggc cgcgtccagg gtttcggccg taagtgagcc gggccttctg agccttcccc
      301 cggagctgct gctcgagatc tgctcctacc tggacgcccg cctcgtgctc cacgtcctgt
      361 cgcgggtgtg ccacgcgctc cgcgacctcg tgtctgacca tgtcacctgg aggctacgcg
      421 cgctacgccg cgtacgcgcg ccctacccag tggtggaaga gaagaacttt gactggccgg
      481 cagcctgcat tgcgctggag cagcacctgt cccgctgggc agaggatggg cgctgggtcg
      541 aatacttctg cctggccgaa ggccacgtgg cttccgttga ctcagtgctg ctgctccagg
      601 gtgggtcact ctgtctgtcg ggctcccgag atcgcaacgt caacttgtgg gacctgcggc
      661 agctggggac ggagtccaac caggttctga tcaagacctt aggcactaag cgaaatagta
      721 cccatgaggg ctgggtgtgg tcactggcag cgcaggacca ccgcgtgtgc tccggctcct
      781 gggacagcac agtgaagctc tgggacatgg cagcggatgg gcagcagttc ggcgagataa
      841 aggccagctc agccgtgctg tgcctctcct acctgcctga catcctggtg actggcacct
      901 atgacaagaa ggtgaccatc tacgacccca gagccggccc agccctgttg aagcaccagc
      961 aactacactc cagacccgtg ctgaccctgc tggcggatga ccggcacatc atctcaggca
     1021 gcgaggacca caccctggtg gtggtggacc gccgagccaa cagcgtcctg cagcgtctgc
     1081 agctggactc ctacctgctc tgcatgtcct accaggaacc ccagctctgg gctggtgaca
     1141 accagggcct gctgcacgtc ttcgccaacc gcaacggctg cttccagctt atccggtcct
     1201 ttgatgtggg ccacagcttt cccatcactg ggatccagta ctccgtggga gccttgtaca
     1261 ccacatccac tgacaagacc atccgggtgc acgtgcccac agacccacca aggaccattt
     1321 gcacccgaag gcatgacaat gggctcaata gggtctgtgc tgagggcaac ctggtggtgg
     1381 ccggctctgg agacctgtcg ctagaggtct ggaggctgca ggcctgagca ggtgggcgtg
     1441 gatgtggata ctgcctgccg gaggctgggc ttcctcctct gttcttgggg gaccatcccc
     1501 aatgttggtg ctgcctccgc cccgtgggcc tagggcacaa ggagtcccag ccacattcgg
     1561 gtgagcgtcc tggcctgggc cctatgcccg ggggaagggt gaaattgggg ttcaggccca
     1621 cccagggggc cgcttcccac tcttgggccc tggttttgtt atgatttgga tgccccgctc
     1681 tcagttgaga gcgaaggaga aataaacctg acatgttggt gcttggg
//
