LOCUS       NM_153348               4861 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 8 (FBXW8),
            transcript variant 1, mRNA.
ACCESSION   NM_153348
VERSION     NM_153348.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4861)
  AUTHORS   Gautam,Y., Caldwell,J., Kottyan,L., Chehade,M., Dellon,E.S.,
            Rothenberg,M.E. and Mersha,T.B.
  CONSRTM   Consortium of Eosinophilic Gastrointestinal Disease Researchers
            (CEGIR) investigators
  TITLE     Genome-wide admixture and association analysis identifies African
            ancestry-specific risk loci of eosinophilic esophagitis in African
            Americans
  JOURNAL   J Allergy Clin Immunol 151 (5), 1337-1350 (2023)
   PUBMED   36400179
  REMARK    GeneRIF: Genome-wide admixture and association analysis identifies
            African ancestry-specific risk loci of eosinophilic esophagitis in
            African Americans.
REFERENCE   2  (bases 1 to 4861)
  AUTHORS   Islam,S., Dutta,P., Chopra,K., Rapole,S., Chauhan,R. and
            Santra,M.K.
  TITLE     FBXW8 regulates G1 and S phases of cell cycle progression by
            restricting beta-TrCP1 function
  JOURNAL   FEBS J 288 (18), 5474-5497 (2021)
   PUBMED   33742524
  REMARK    GeneRIF: FBXW8 regulates G1 and S phases of cell cycle progression
            by restricting beta-TrCP1 function.
REFERENCE   3  (bases 1 to 4861)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4861)
  AUTHORS   Wang,J., Bogdanova,N., Schurmann,P., Park-Simon,T.W., Geffers,R.
            and Dork,T.
  TITLE     Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in
            breast cancer patients and controls from Central Europe
  JOURNAL   Cancer Genet 220, 38-43 (2018)
   PUBMED   29310837
  REMARK    GeneRIF: Frameshift mutation FBXW8 c.1312_1313delGT was considered
            functionally relevant and was investigated for its potential
            association with breast cancer risk through subsequent genotyping
            in two hospital-based breast cancer case-control series from
            Belarus and Germany, respectively, comprising a total of 2740
            breast cancer cases and 2174 controls.
REFERENCE   5  (bases 1 to 4861)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 4861)
  AUTHORS   Okabe,H., Lee,S.H., Phuchareon,J., Albertson,D.G., McCormick,F. and
            Tetsu,O.
  TITLE     A critical role for FBXW8 and MAPK in cyclin D1 degradation and
            cancer cell proliferation
  JOURNAL   PLoS One 1 (1), e128 (2006)
   PUBMED   17205132
  REMARK    GeneRIF: FBXW8 plays an essential role in cancer cell proliferation
            through proteolysis of cyclin D1. It may present new opportunities
            to develop therapies targeting destruction of cyclin D1 or its
            regulator E3 ligase selectively.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4861)
  AUTHORS   Watanabe,N., Arai,H., Nishihara,Y., Taniguchi,M., Watanabe,N.,
            Hunter,T. and Osada,H.
  TITLE     M-phase kinases induce phospho-dependent ubiquitination of somatic
            Wee1 by SCFbeta-TrCP
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4419-4424 (2004)
   PUBMED   15070733
REFERENCE   8  (bases 1 to 4861)
  AUTHORS   Dias,D.C., Dolios,G., Wang,R. and Pan,Z.Q.
  TITLE     CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29
            to form an SCF-like complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16601-16606 (2002)
   PUBMED   12481031
REFERENCE   9  (bases 1 to 4861)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4861)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083806.16, AC127164.2 and
            AC026368.37.
            
            On Nov 26, 2018 this sequence version replaced NM_153348.2.
            
            Summary: This gene encodes a member of the F-box protein family,
            members of which are characterized by an approximately 40 amino
            acid motif, the F-box. The F-box proteins constitute one of the
            four subunits of ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into three classes:
            Fbws containing WD-40 domains, Fbls containing leucine-rich
            repeats, and Fbxs containing either different protein-protein
            interaction modules or no recognizable motifs. The protein encoded
            by this gene contains a WD-40 domain, in addition to an F-box
            motif, so it belongs to the Fbw class. Alternatively spliced
            transcript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037296.2, DRR138509.21041.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652555.1/ ENSP00000498999.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               AC083806.16        50758-51163         c
            407-511             AC083806.16        33986-34090         c
            512-676             AC083806.16        16585-16749         c
            677-765             AC083806.16        12407-12495         c
            766-923             AC127164.2         37359-37516         c
            924-1120            AC127164.2         16811-17007         c
            1121-1327           AC127164.2         13344-13550         c
            1328-1455           AC026368.37        166509-166636       c
            1456-1629           AC026368.37        152639-152812       c
            1630-1740           AC026368.37        149455-149565       c
            1741-4861           AC026368.37        145811-148931       c
FEATURES             Location/Qualifiers
     source          1..4861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.22"
     gene            1..4861
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="F-box and WD repeat domain containing 8"
                     /db_xref="GeneID:26259"
                     /db_xref="HGNC:HGNC:13597"
                     /db_xref="MIM:609073"
     exon            1..406
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1885
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and WD-40 domain protein 8; F-box only protein 29;
                     F-box/WD repeat-containing protein 8; F-box and WD-40
                     domain-containing protein 8"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 8 isoform 1"
                     /protein_id="NP_699179.2"
                     /db_xref="CCDS:CCDS9182.1"
                     /db_xref="GeneID:26259"
                     /db_xref="HGNC:HGNC:13597"
                     /db_xref="MIM:609073"
                     /translation="MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSG
                     RGEQASGDPALAQRLLEGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQL
                     IRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC
                     QQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHS
                     HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAY
                     EDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQ
                     IAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLD
                     VSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVS
                     GNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKL
                     WEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQL
                     AFQSPLPVCRSSCDAMATHYYDLALAFPYNHV"
     exon            407..511
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            512..676
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            677..765
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            766..923
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1120
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1327
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1455
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1629
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1740
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..4861
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="hexamer: AATAAA"
     polyA_site      3129
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="major polyA site"
     regulatory      4843..4848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="hexamer: ATTAAA"
     polyA_site      4861
                     /gene="FBXW8"
                     /gene_synonym="FBW6; FBW8; FBX29; FBXO29; FBXW6"
                     /note="major polyA site"
ORIGIN      
        1 ccggccgcgg cggacacttc cctgggcggg actgtctcgt ggcacccggt ggaaccgagg
       61 agaacgtgga gcgccgggag cggcgaatat ggacgactac agcctggatg agttccgtcg
      121 gcgctggcag gaggagctgg cgcaggccca ggcgccgaag aagcggcgac ggcccgaggc
      181 tgccgagagg cgggctcggc ggccggaggt gggctccggg cgcggcgaac aggcctcggg
      241 ggacccggcg ctggcccagc gtctcctgga gggcgcgggg aggcccccgg cggcgcgggc
      301 gactcgggcc gaggggcagg acgtagcgag ccgctcacgt tctcctctgg cccgcgaggg
      361 cgccgggggc ggggagcagc tggtggacca gctcatccgc gacctgaatg aaatgaatga
      421 tgtgcctttc tttgatatcc aactgcctta cgaattggca atcaatatat ttcagtatct
      481 ggacaggaaa gaactaggaa gatgtgcaca ggtgagcaag acgtggaagg tgattgcaga
      541 ggatgaggtg ctgtggtaca ggctgtgcca gcaggaaggg caccttccgg atagcagcat
      601 ctctgactat tcttgctgga agctcatctt ccaagagtgc cgagccaagg aacacatgtt
      661 acgaaccaac tggaagaatc gcaaaggtgc cgtgagcgag ctggagcatg ttcctgacac
      721 agttttgtgt gatgtgcatt ctcacgatgg tgtggtcatt gcgggatata catcagggga
      781 tgtgagagtg tgggacaccc gcacctggga ctacgtagcc cccttcctgg aatcagagga
      841 cgaggaggat gagcctggaa tgcagccaaa tgtctccttt gtgaggataa acagctcgtt
      901 ggcagtagca gcttatgagg atgggtttct taatatttgg gatttaagga ccggaaagta
      961 ccctgttcat cgttttgagc acgatgcaag aatacaggca ctagccctca gccaggacga
     1021 tgcaaccgtg gccacagctt ctgcttttga tgtcgtgatg ttatccccca atgaggaggg
     1081 gtactggcag atagctgcgg aatttgaagt tccgaaactg gttcagtacc ttgaaatagt
     1141 tccagaaacc agaaggtacc ctgtggcagt agccgctgct ggagatctga tgtacctgct
     1201 caaagccgaa gactccgcca gaaccctcct ttacgcccac ggcccgcctg tcacatgtct
     1261 agacgtctcg gccaaccaag ttgcttttgg tgtacagggt ctgggatggg tgtacgaagg
     1321 aagcaagatc ctggtgtata gcctggaagc aggacgccgc ctcttgaagc tgggtaacgt
     1381 tctccgtgac ttcacgtgtg tcaacctcag cgacagccct cccaacctca tggtcagtgg
     1441 caacatggac gggagggtga ggatccacga cctccgcagt ggtaacatcg ccctgtcgct
     1501 ctccgcccat cagctcaggg tctctgctgt gcagatggat gactggaaga tcgtcagtgg
     1561 aggcgaggaa ggcctggtgt ccgtgtggga ttatcggatg aaccagaagc tgtgggaggt
     1621 gtattccggg cacccggtgc agcacatctc attcagcagc cacagcctca tcacggccaa
     1681 cgtgccttac cagacggtaa tgcgaaacgc cgacctggac agcttcacta ctcacaggag
     1741 acaccggggg ctgatccgcg cctatgagtt tgcggtggac cagctggcct tccagagccc
     1801 tctccctgtc tgccgttcat cctgtgacgc catggccact cactactacg acctcgcact
     1861 ggcctttccc tataaccatg tttagggatg tgcctcagtt gggagcaagg agaaaaatgg
     1921 gaagaaccag ttttatccat cttaaaacgc caggcacctc ttcacaggtg gtaaacattt
     1981 aggggaagaa agcagcccag ggtgccatgc ctgacagcac gcatctccct gacccctgca
     2041 cttcccccag cgcctggggc aagctggcgt gtgccagggc tcgagtccca cgtgctgcca
     2101 actcaaacat agcctccttc cccacccagc tggccaccct ggcctcagct ccctcaggac
     2161 gcctcaggga tctcgctgcg cggtcctata cggtccctgc ttagccagct tctgtgtgtc
     2221 cgccctccca gctccagccc tgcaggccgt cttttccgtc tccagcccct tacctctttt
     2281 cctccgaggg cctttggatg tgcttgttcc tggcctccaa ggcaataacc tccatgtcct
     2341 tttccctgta tttacttggg gtgctcttct gtgacacttg ccaccaccac cttccagtag
     2401 caagctggta gagctgtact ttttcttcac agcttttacc atggtttata attatatact
     2461 tatacagttt agtcatcaat gactattttg cttactattg tgtctatgat atgtgataca
     2521 aagcaaatat tttctaaata ttcattgact aaacagccat caagatgaaa caggacagga
     2581 gagaactgtt cagtgtgata cagagctgcc atttccaaag tattctggaa gcaagccatt
     2641 gccttactct tgattttcaa cagttctaaa cagcaacagc atccacctaa tataccttca
     2701 gaatatcaaa gcgaaaactg atagaactac aaagagaaat aaaatccatt ctcacggcag
     2761 gcaaatcagt gagaaaaatg taaagatctg gaggatttac ttagtatcgc taacaagctg
     2821 gatccagtag atgcgtatgg aatttcaaat acacatagac gatgcacaaa aaaccaccct
     2881 gtacgaaggc cacaaagaac agctcagatg cacaaagatt cacaccatac aggccaaatt
     2941 atagaatccc ccaaccccaa gacactgcac cctatgggct ataccctcag gcagggccct
     3001 gcttttctag gaattgactc caatgcagaa tagtgagaaa tcaacaaaaa gcaaaataag
     3061 acaattccag acactcctga atttacttgg atttaaagag gttaataaaa acaaactata
     3121 aactctctag actgggctga cagtaaaagc acagaataca aaacccaggg gatggggctg
     3181 ggaggggctg tgaggggctg gcacctcagc tcagaaaagg tagcagcaat cccaaagcag
     3241 cagaaggcag gggttaaatc aggataaaaa cagacatcag tggaatcgaa aaccaatagt
     3301 tagttaatat aaagccagaa ggttttgttt tttttcaggt ggggtctcgc tctgtcacct
     3361 agactagact ggagtgcaat ggcctgatct cggctcactg caacctctgc ctcccgagtt
     3421 caagcaattc tcctgcctca gcctcctgag tagctgggat tacaggcgtc cgctaccaca
     3481 actggctaat ttttacattt ttagtagaga cgggggatat tgctatgttg gccaggctgg
     3541 tctcaaactt ctgacctcaa atgattgcct gcctcagcct cccaaagtgc tgggattaca
     3601 ggtgtaagtc actgtaccca gcccaaaagc agtttaaaaa aaaaaaagac aaaatataca
     3661 actcttgata aaacataaag gtacagtggt ctatgaggaa gagaaaaggt acctgaggat
     3721 gcagaagtac ctaccacatg ggaaccgttt gtccacactc attccagaga aaaccgagtc
     3781 ctctcagttg cacacgtgta cgtatcagtg ggaagtgctt gccattactc caaagcctag
     3841 aaccttcacg tcatgaaggt tctggaaggt ttttcagatt gcttaagata cgcagccatt
     3901 ccatattcat ctccaactac acaggggaac ggagcagata gagctgcgac tgggaagcgt
     3961 caccttcccg tccagagcgc tttctttcag accctgccta cctgcaggca gatggaccgg
     4021 agggttttct gcttcctttc aaccagataa cttcctaagt ggagatggcc tgtaggtagc
     4081 aaatgcagga ttttgtttac tttcatcatg tcatgtggtg gtcagactgc tcgctggtgg
     4141 cctcgcttta gaaggttttc atcaagcccc gccctttctc tctcatagtc ttaatgcgtc
     4201 tggaccactg gggaaaatat ttttcttttc aaaaagcagc cccttcagtc tgcgttccca
     4261 gttcattttg caggcgcatt cgcccttcct agtttgcagc aattaaagat aacggagtgt
     4321 aaagtcatta gacccagaat tagagcagcc agcagctggc ccagtgtaaa aatgtcccaa
     4381 gtgtagcccc tcccaccgca gagcctgttt ctaacgtacc tgccattcgt ggaagtcgcc
     4441 tgggttttgt aaaggagaat tttttggact caagctgtca tcttcaagca cgccaacttc
     4501 aggcagtgtt ttctactgca aacctccaca tcctggaatc aatcacactg acagggaaag
     4561 gataaatgct cctttataag ccaacatgta tccaaattaa gcccccttac ctttatccag
     4621 accctttcac aaacaagttc tgagttttta gccaattgat cctctacttt ccttctttag
     4681 tccctctcag ggacgcctcc atccccggct cccctaaagg tagaagatac tcgagcatgc
     4741 tgccagggga gctggatggt gaaacacctg aagatctcat atcgcctctc aaaacactgt
     4801 cggacttgct ttctgcttta tgatgtccgt agttgttcta atattaaatg ctttgaattt
     4861 c
//
