LOCUS       NM_018998               2362 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 5 (FBXW5), mRNA.
ACCESSION   NM_018998
VERSION     NM_018998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Schweiggert,J., Habeck,G., Hess,S., Mikus,F., Beloshistov,R.,
            Meese,K., Hata,S., Knobeloch,K.P. and Melchior,F.
  TITLE     SCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis
  JOURNAL   EMBO J 40 (18), e107735 (2021)
   PUBMED   34368969
  REMARK    GeneRIF: SCF(Fbxw5) targets kinesin-13 proteins to facilitate
            ciliogenesis.
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Jeong,Y.T., Simoneschi,D., Keegan,S., Melville,D., Adler,N.S.,
            Saraf,A., Florens,L., Washburn,M.P., Cavasotto,C.N., Fenyo,D.,
            Cuervo,A.M., Rossi,M. and Pagano,M.
  TITLE     The ULK1-FBXW5-SEC23B nexus controls autophagy
  JOURNAL   Elife 7, e42253 (2018)
   PUBMED   30596474
  REMARK    GeneRIF: Here, the authors show that the F-box protein FBXW5
            targets SEC23B, a component of COPII, for proteasomal degradation
            and that this event limits the autophagic flux in the presence of
            nutrients. In response to starvation, ULK1 phosphorylates SEC23B on
            Serine 186, preventing the interaction of SEC23B with FBXW5 and,
            therefore, inhibiting SEC23B degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Hu,J., Zacharek,S., He,Y.J., Lee,H., Shumway,S., Duronio,R.J. and
            Xiong,Y.
  TITLE     WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2
            by DDB1-CUL4-ROC1 ligase
  JOURNAL   Genes Dev 22 (7), 866-871 (2008)
   PUBMED   18381890
  REMARK    GeneRIF: Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3
            ubiquitin ligase regulating TSC2 protein stability and TSC complex
            turnover.
REFERENCE   8  (bases 1 to 2362)
  AUTHORS   Watanabe,N., Arai,H., Nishihara,Y., Taniguchi,M., Watanabe,N.,
            Hunter,T. and Osada,H.
  TITLE     M-phase kinases induce phospho-dependent ubiquitination of somatic
            Wee1 by SCFbeta-TrCP
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4419-4424 (2004)
   PUBMED   15070733
REFERENCE   9  (bases 1 to 2362)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 2362)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF132404.1, DB460097.1 and
            BC014130.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018998.3.
            
            Summary: This gene encodes a member of the F-box protein family,
            members of which are characterized by an approximately 40 amino
            acid motif, the F-box. The F-box proteins constitute one of the
            four subunits of ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into three classes:
            Fbws containing WD-40 domains, Fbls containing leucine-rich
            repeats, and Fbxs containing either different protein-protein
            interaction modules or no recognizable motifs. The protein encoded
            by this gene contains WD-40 domains, in addition to an F-box motif,
            so it belongs to the Fbw class. Alternatively spliced transcript
            variants encoding distinct isoforms have been identified for this
            gene, however, they were found to be nonsense-mediated mRNA decay
            (NMD) candidates, hence not represented. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.31293.1,
                                           SRR3476690.293664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325285.8/ ENSP00000313034.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CF132404.1         17-17
            2-88                DB460097.1         2-88
            89-2362             BC014130.1         1-2274
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2362
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /note="F-box and WD repeat domain containing 5"
                     /db_xref="GeneID:54461"
                     /db_xref="HGNC:HGNC:13613"
                     /db_xref="MIM:609072"
     exon            1..145
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            146..361
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1869
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /note="WD repeat-containing F-box protein FBW5; F-box and
                     WD-40 domain-containing protein 5"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 5"
                     /protein_id="NP_061871.1"
                     /db_xref="CCDS:CCDS7014.1"
                     /db_xref="GeneID:54461"
                     /db_xref="HGNC:HGNC:13613"
                     /db_xref="MIM:609072"
                     /translation="MDEGGTPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEF
                     LWREQFYRYYQVARDVPRHPAAMSWYEEFQRLYDTVPCVEVQTLREHTDQVLHLSFSH
                     SGYQFASCSKDCTVKIWSNDLTISLLHSADMRPYNWSYTQFSQFNKDDSLLLASGVFL
                     GPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVL
                     WLNNAFQDVESENVNVVKRLFKIQNLNASTVRTVMVADCSRFDSPDLLLEAGDPATSP
                     CRIFDLGSDNEEVVAGPAPAHAKEGLRHFLDRVLEGRAQPQLSERMLETKVAELLAQG
                     HTKPPERSATGAKSKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFF
                     DALDHVIDIHGHIIGMGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDL
                     KTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR
                     HEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR
                     "
     exon            362..519
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..694
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..843
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1264
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1412
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1625
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..2362
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /note="hexamer: AATAAA"
     polyA_site      2362
                     /gene="FBXW5"
                     /gene_synonym="Fbw5"
                     /note="major polyA site"
ORIGIN      
        1 ctcggccatc gatgcctcgg ggctcgtggc gtcgggcctg gcgggctccc cgttgggcgg
       61 gggcggcggt ccgagcggct gcggcagcgg aagcgggtcc gggtcgcgca gggcgggggc
      121 ggcgcagcgg gcggaggcgg ccgtgggccg cctgggcaga atgtcacgat ggacgagggc
      181 ggcacgcccc tgctccccga cagcctggtc taccagatct tcctgagcct gggcccggcc
      241 gacgtgctgg ccgccgggct ggtgtgccgc caatggcagg ccgtgtcgcg ggacgagttc
      301 ctgtggaggg agcagttcta ccgctactac caggtggccc gcgacgtgcc ccgacaccca
      361 gcggccatgt cctggtacga ggagttccag cggctgtatg acacggtgcc ctgcgtggag
      421 gtgcagacgc tgcgggaaca cacagaccag gtcctgcacc tcagcttctc ccattccggg
      481 taccagttcg cgtcctgctc caaggactgc actgtgaaga tctggagcaa cgacctgacc
      541 atctcgctgc tgcacagcgc ggacatgcgg ccctacaact ggagctacac ccagttctcc
      601 cagttcaaca aggacgactc gctactgctg gcctcggggg tgttcctggg gccgcacaac
      661 tcctcatccg gcgagattgc tgtcatcagc ctagactcct tcgcgctgct gtcccgcgtg
      721 cggaacaagc cctatgacgt gtttggctgt tggctcaccg agaccagcct catctcgggg
      781 aacctgcacc gcatcggaga tatcacctcc tgctcggtgc tgtggctcaa caatgccttc
      841 caggatgtgg agtcagagaa cgtcaacgtg gtgaagcggc tgttcaagat ccagaacctc
      901 aatgccagca ccgtccgcac ggtgatggtg gccgactgca gccgcttcga cagccctgac
      961 ctgctgctgg aagccggtga cccggccacg tccccctgcc gcatctttga cctgggcagc
     1021 gacaacgagg aggtggtggc tggcccggcc cccgcccacg ccaaggaggg cttgcggcac
     1081 tttctggacc gcgtgctgga ggggcgggcg cagccacagc tgtcggagcg catgctagag
     1141 accaaggtgg ccgagctgct ggcccagggc cacaccaagc cacccgagcg cagtgccaca
     1201 ggcgccaaga gcaagtacct catcttcacc actggctgcc tcacctactc cccacaccag
     1261 atcggcatca agcagatcct gccacaccag atgaccacgg cagggcccgt gctgggtgag
     1321 ggccggggct ccgatgcctt cttcgacgcg ctggaccacg tcatagacat acacggacac
     1381 atcatcggca tgggcctgtc gcccgacaac aggtacctgt acgtgaacag ccgcgcctgg
     1441 cccaacggtg cggtggtggc cgaccccatg cagccgccac caatcgcgga ggagattgac
     1501 ctgctggtgt tcgacctcaa gaccatgcgg gaggtgaggc gggctctgcg tgcgcaccgc
     1561 gcctacacgc ccaacgacga gtgcttcttc atcttcctgg acgtcagcag ggacttcgtg
     1621 gccagcgggg cggaggaccg gcacggctac atctgggacc gccactacaa catctgtctg
     1681 gccaggctgc ggcacgagga tgtggtcaac tcagtggtct tcagtcccca ggagcaggag
     1741 ctgctgctca cggccagcga cgacgccacc atcaaagcct ggcgctcccc acgcaccatg
     1801 cgcgtcctcc aggcacctcg cccacggcct cgcaccttct tctcctggct tgccagccag
     1861 aggcgctgag gtgtgctggg tgcactggag ccaccgggac cccttgagga catcgccagg
     1921 ctctgtggct ttttcccgag cgggagaggt ggagatgctt atagcagtta cgccttagga
     1981 aggggacaac caggccccgc cacacgctca cacacaaacc tgctcacgca gctgtgatgc
     2041 ttggcacggg gtggccagtg cagatggagc ccaaggcccc ctcggcctcc tgggcaactt
     2101 ggggtacaca ggatactggg ggtgccgctc ctcactcaac cccaggctag gggtacacct
     2161 gacccagctg gcctcggccc ggggcacctt cggctggtcc tgtggggccc tggacggtgg
     2221 cccagtggtg gcaggggctg ctcctggctg tggttgtgcg cccggggctt gggagcggcc
     2281 ggtcacgctg ctgtgggccc gagtgtgttg catgtccacg caccacccgt tcagggccct
     2341 gaataaacag ttggcaacag ca
//
