LOCUS       NM_022039               2394 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 4 (FBXW4),
            transcript variant 1, mRNA.
ACCESSION   NM_022039
VERSION     NM_022039.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2394)
  AUTHORS   Song,W., Fu,J., Wu,J., Ren,J., Xiang,R., Kong,C. and Fu,T.
  TITLE     CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating
            the MiR-338-5p/SLC5A7 Axis
  JOURNAL   Adv Sci (Weinh) 11 (18), e2300129 (2024)
   PUBMED   38461489
  REMARK    GeneRIF: CircFBXW4 Suppresses Colorectal Cancer Progression by
            Regulating the MiR-338-5p/SLC5A7 Axis.
REFERENCE   2  (bases 1 to 2394)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2394)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2394)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 2394)
  AUTHORS   Lockwood,W.W., Chandel,S.K., Stewart,G.L., Erdjument-Bromage,H. and
            Beverly,L.J.
  TITLE     The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the
            COP9 signalosome in an F-box dependent manner, is mutated, lost and
            under-expressed in human cancers
  JOURNAL   PLoS One 8 (5), e63610 (2013)
   PUBMED   23658844
  REMARK    GeneRIF: biochemical characterization of the novel F-box and WD40
            containing protein, FBXW4
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2394)
  AUTHORS   de Mollerat,X.J., Gurrieri,F., Morgan,C.T., Sangiorgi,E.,
            Everman,D.B., Gaspari,P., Amiel,J., Bamshad,M.J., Lyle,R.,
            Blouin,J.L., Allanson,J.E., Le Marec,B., Wilson,M., Braverman,N.E.,
            Radhakrishna,U., Delozier-Blanchet,C., Abbott,A., Elghouzzi,V.,
            Antonarakis,S., Stevenson,R.E., Munnich,A., Neri,G. and
            Schwartz,C.E.
  TITLE     A genomic rearrangement resulting in a tandem duplication is
            associated with split hand-split foot malformation 3 (SHFM3) at
            10q24
  JOURNAL   Hum Mol Genet 12 (16), 1959-1971 (2003)
   PUBMED   12913067
  REMARK    GeneRIF: a complex rearrangement associated with a approximately
            0.5 Mb tandem duplication ion containing a disrupted extra copy of
            the DACTYLIN gene and the entire LBX1 and beta-TRCP genes.
REFERENCE   7  (bases 1 to 2394)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   8  (bases 1 to 2394)
  AUTHORS   Ianakiev,P., Kilpatrick,M.W., Dealy,C., Kosher,R., Korenberg,J.R.,
            Chen,X.N. and Tsipouras,P.
  TITLE     A novel human gene encoding an F-box/WD40 containing protein maps
            in the SHFM3 critical region on 10q24
  JOURNAL   Biochem Biophys Res Commun 261 (1), 64-70 (1999)
   PUBMED   10405324
REFERENCE   9  (bases 1 to 2394)
  AUTHORS   Gurrieri,F., Prinos,P., Tackels,D., Kilpatrick,M.W., Allanson,J.,
            Genuardi,M., Vuckov,A., Nanni,L., Sangiorgi,E., Garofalo,G.,
            Nunes,M.E., Neri,G., Schwartz,C. and Tsipouras,P.
  TITLE     A split hand-split foot (SHFM3) gene is located at 10q24-->25
  JOURNAL   Am J Med Genet 62 (4), 427-436 (1996)
   PUBMED   8723077
REFERENCE   10 (bases 1 to 2394)
  AUTHORS   Palmer,S.E., Scherer,S.W., Kukolich,M., Wijsman,E.M., Tsui,L.C.,
            Stephens,K. and Evans,J.P.
  TITLE     Evidence for locus heterogeneity in human autosomal dominant split
            hand/split foot malformation
  JOURNAL   Am J Hum Genet 55 (1), 21-26 (1994)
   PUBMED   7912888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF281859.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 1, 2018 this sequence version replaced NM_022039.3.
            
            Summary: This gene is a member of the F-box/WD-40 gene family,
            which recruit specific target proteins through their WD-40
            protein-protein binding domains for ubiquitin mediated degradation.
            In mouse, a highly similar protein is thought to be responsible for
            maintaining the apical ectodermal ridge of developing limb buds;
            disruption of the mouse gene results in the absence of central
            digits, underdeveloped or absent metacarpal/metatarsal bones and
            syndactyly. This phenotype is remarkably similar to split
            hand-split foot malformation in humans, a clinically heterogeneous
            condition with a variety of modes of transmission. An autosomal
            recessive form has been mapped to the chromosomal region where this
            gene is located, and complex rearrangements involving duplications
            of this gene and others have been associated with the condition. A
            pseudogene of this locus has been mapped to one of the introns of
            the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF281859.1, SRR1163655.35849.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331272.9/ ENSP00000359149.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2394              AF281859.1         90-2483
FEATURES             Location/Qualifiers
     source          1..2394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2394
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="F-box and WD repeat domain containing 4"
                     /db_xref="GeneID:6468"
                     /db_xref="HGNC:HGNC:10847"
                     /db_xref="MIM:608071"
     exon            1..790
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1769
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and WD-40 domain protein 4; F-box/WD repeat protein 4;
                     dactylin; F-box/WD repeat-containing protein 4; F-box and
                     WD-40 domain-containing protein 4; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 4 isoform 1"
                     /protein_id="NP_071322.2"
                     /db_xref="CCDS:CCDS31271.2"
                     /db_xref="GeneID:6468"
                     /db_xref="HGNC:HGNC:10847"
                     /db_xref="MIM:608071"
                     /translation="MGSQGRSGPPGNGGPGEGEGGEARKLQEGRVARGKRRKGKGKGK
                     ARAGQGGRGSGAEGKPGPQTAKEAAGPGADAGARACPREEAEGGRSVEEGARGIVKGV
                     EGSAGAGKEAQGREYGKKEEWRVRARRREGARPGRAQGRGGQAWADIAGTGVAMAAAA
                     GEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTS
                     CDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQM
                     PWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSA
                     GGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQC
                     LHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAG
                     VLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT
                     GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQN
                     P"
     exon            791..886
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1072
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1205
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1300
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1366
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1507
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1649
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..2394
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="major polyA site"
ORIGIN      
        1 ctcccggggc ggcggcggtg gcggctcggg ctgggctccg cgtcgggccg gccccgcggc
       61 cgctcatggg cagccagggc cgctcggggc cccccgggaa cggcgggccc ggcgagggcg
      121 agggcggaga ggcgaggaag ctgcaggaag ggagggtggc gagggggaag cgaaggaagg
      181 ggaaggggaa gggaaaagcg agagcggggc aaggcggaag aggaagcggg gcggaaggga
      241 agcccgggcc gcagacggcg aaggaggcag ccgggccggg ggctgacgcg ggagcgaggg
      301 catgcccaag ggaggaagca gagggaggca gaagcgtgga ggaaggggcg agaggcatcg
      361 tcaagggagt cgaggggagc gcaggggccg ggaaggaggc acaaggaaga gagtatggga
      421 agaaggagga atggagggtc agggctaggc ggcgggaggg cgccaggccg ggaagagcac
      481 agggacgagg gggtcaggct tgggccgaca tcgcggggac aggggtggcc atggcggcgg
      541 cggccgggga ggaggaggag gaggaggagg cggctcggga gtcggctgcc cgcccggccg
      601 cggggcctgc gctctggcgc ctgccggagg agctgctgct gctcatctgc tcctacctgg
      661 acatgcgggc cctcggccgc ctggcccagg tgtgccgctg gctgcggcgc ttcaccagct
      721 gcgatctgct ctggcgccgg atagcccggg cctcgctcaa ctccggcttc acgcggctcg
      781 gcaccgacct gatgaccagt gtcccagtga aggaacgagt gaaggtgtct cagaactgga
      841 gactggggcg ctgccgagag gggattctgc tgaagtggag atgcagtcag atgccctgga
      901 tgcagctaga ggatgattct ctgtacatat cccaggctaa tttcatcctg gcctaccagt
      961 tccgtccaga tggtgccagc ttgaatcgtc ggcctctggg agtctttgct gggcatgatg
     1021 aggacgtttg ccactttgtg ctggccaact cgcatattgt tagtgcagga ggggatggga
     1081 agattggcat tcataagatt cacagcacct tcactgtcaa gtactcggct catgaacagg
     1141 aggtgaactg tgtggattgc aaagggggca tcattgtgag tggctccagg gacaggacgg
     1201 ccaaggtgtg gcctttggcc tcaggccggc tggggcagtg cttacacacc atccagactg
     1261 aagaccgagt ctggtccatt gctatcagcc cattactcag ctcttttgtg acagggacgg
     1321 cttgttgcgg gcacttctca cccctgagaa tctgggacct caacagtggg cagctgatga
     1381 cacacttggg cagtgacttt cccccagggg ctggggtgct ggatgtcatg tatgagtccc
     1441 ctttcacact gctgtcctgt ggctatgaca cctatgttcg ctactgggac ctccgcacca
     1501 gcgtccggaa atgtgtcatg gagtgggagg agccccacga cagcaccctg tactgcctgc
     1561 agacagatgg caaccacctg ctggccacag gttcctccta ctacggtgtt gtacggctgt
     1621 gggaccggcg tcaaagggcc tgcctgcacg ccttcccgct gacgtcgact cccctcagca
     1681 gccctgtgta ctgcctgcgt ctcaccacca agcatctcta tgctgccctg tcttacaacc
     1741 tccacgtcct ggattttcaa aacccatgac cgtcagggcc acccctgcct ctgggccagg
     1801 gaaaccagct actcagggac ttctcttgcc tggagggtgc agtgatagct cctcctcact
     1861 gccccactgt gctcctgggc ctgtgacccc agtgctcagg caccttgcac tagaggcttc
     1921 tgactcctgg gactttggag cttaccagag atgcagtccc tcccaggaac ctgttggaga
     1981 ggcaggacct gctgctttag agtgcggctg aacccgggcc ttgcgtccct gtttggccag
     2041 agcaaggatc tggcctggag aggcccatcc tatacccctt attagagcca tgacagccta
     2101 cagagtgagg tgaggtgctc ccaccttccc agatggttcc tttctgcccc ttcctggaag
     2161 gaaaggtgag gctgccaata gcctcctggc accagccaga cctcaccctt gaccaacctc
     2221 tcggggctgg gggttcattc ctggggcact gtggcctggt tttgctttga aaccaagaaa
     2281 gagcaaaggg aacccagcag ttctgagtga gttctgagcc agccctacct caggctggct
     2341 gttgagacat gctacaattt tcatttttgt aaaaataaag cttgattgtt caca
//
