LOCUS       NM_001323541            1660 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 4 (FBXW4),
            transcript variant 2, mRNA.
ACCESSION   NM_001323541
VERSION     NM_001323541.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Song,W., Fu,J., Wu,J., Ren,J., Xiang,R., Kong,C. and Fu,T.
  TITLE     CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating
            the MiR-338-5p/SLC5A7 Axis
  JOURNAL   Adv Sci (Weinh) 11 (18), e2300129 (2024)
   PUBMED   38461489
  REMARK    GeneRIF: CircFBXW4 Suppresses Colorectal Cancer Progression by
            Regulating the MiR-338-5p/SLC5A7 Axis.
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Lockwood,W.W., Chandel,S.K., Stewart,G.L., Erdjument-Bromage,H. and
            Beverly,L.J.
  TITLE     The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the
            COP9 signalosome in an F-box dependent manner, is mutated, lost and
            under-expressed in human cancers
  JOURNAL   PLoS One 8 (5), e63610 (2013)
   PUBMED   23658844
  REMARK    GeneRIF: biochemical characterization of the novel F-box and WD40
            containing protein, FBXW4
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   de Mollerat,X.J., Gurrieri,F., Morgan,C.T., Sangiorgi,E.,
            Everman,D.B., Gaspari,P., Amiel,J., Bamshad,M.J., Lyle,R.,
            Blouin,J.L., Allanson,J.E., Le Marec,B., Wilson,M., Braverman,N.E.,
            Radhakrishna,U., Delozier-Blanchet,C., Abbott,A., Elghouzzi,V.,
            Antonarakis,S., Stevenson,R.E., Munnich,A., Neri,G. and
            Schwartz,C.E.
  TITLE     A genomic rearrangement resulting in a tandem duplication is
            associated with split hand-split foot malformation 3 (SHFM3) at
            10q24
  JOURNAL   Hum Mol Genet 12 (16), 1959-1971 (2003)
   PUBMED   12913067
  REMARK    GeneRIF: a complex rearrangement associated with a approximately
            0.5 Mb tandem duplication ion containing a disrupted extra copy of
            the DACTYLIN gene and the entire LBX1 and beta-TRCP genes.
REFERENCE   7  (bases 1 to 1660)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   8  (bases 1 to 1660)
  AUTHORS   Ianakiev,P., Kilpatrick,M.W., Dealy,C., Kosher,R., Korenberg,J.R.,
            Chen,X.N. and Tsipouras,P.
  TITLE     A novel human gene encoding an F-box/WD40 containing protein maps
            in the SHFM3 critical region on 10q24
  JOURNAL   Biochem Biophys Res Commun 261 (1), 64-70 (1999)
   PUBMED   10405324
REFERENCE   9  (bases 1 to 1660)
  AUTHORS   Gurrieri,F., Prinos,P., Tackels,D., Kilpatrick,M.W., Allanson,J.,
            Genuardi,M., Vuckov,A., Nanni,L., Sangiorgi,E., Garofalo,G.,
            Nunes,M.E., Neri,G., Schwartz,C. and Tsipouras,P.
  TITLE     A split hand-split foot (SHFM3) gene is located at 10q24-->25
  JOURNAL   Am J Med Genet 62 (4), 427-436 (1996)
   PUBMED   8723077
REFERENCE   10 (bases 1 to 1660)
  AUTHORS   Palmer,S.E., Scherer,S.W., Kukolich,M., Wijsman,E.M., Tsui,L.C.,
            Stephens,K. and Evans,J.P.
  TITLE     Evidence for locus heterogeneity in human autosomal dominant split
            hand/split foot malformation
  JOURNAL   Am J Hum Genet 55 (1), 21-26 (1994)
   PUBMED   7912888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010789.9, AL627144.7 and
            AL627424.8.
            
            On Aug 13, 2020 this sequence version replaced NM_001323541.1.
            
            Summary: This gene is a member of the F-box/WD-40 gene family,
            which recruit specific target proteins through their WD-40
            protein-protein binding domains for ubiquitin mediated degradation.
            In mouse, a highly similar protein is thought to be responsible for
            maintaining the apical ectodermal ridge of developing limb buds;
            disruption of the mouse gene results in the absence of central
            digits, underdeveloped or absent metacarpal/metatarsal bones and
            syndactyly. This phenotype is remarkably similar to split
            hand-split foot malformation in humans, a clinically heterogeneous
            condition with a variety of modes of transmission. An autosomal
            recessive form has been mapped to the chromosomal region where this
            gene is located, and complex rearrangements involving duplications
            of this gene and others have been associated with the condition. A
            pseudogene of this locus has been mapped to one of the introns of
            the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BQ943924.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC010789.9         23937-23992         c
            57-152              AC010789.9         5038-5133           c
            153-338             AC010789.9         2185-2370           c
            339-471             AL627144.7         36066-36198         c
            472-566             AL627144.7         31037-31131         c
            567-632             AL627424.8         94402-94467         c
            633-773             AL627424.8         81994-82134         c
            774-915             AL627424.8         81285-81426         c
            916-1660            AL627424.8         80323-81067         c
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..1660
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="F-box and WD repeat domain containing 4"
                     /db_xref="GeneID:6468"
                     /db_xref="HGNC:HGNC:10847"
                     /db_xref="MIM:608071"
     exon            1..56
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            57..152
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1035
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     and WD-40 domain protein 4; F-box/WD repeat protein 4;
                     dactylin; F-box/WD repeat-containing protein 4; F-box and
                     WD-40 domain-containing protein 4; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 4 isoform 2"
                     /protein_id="NP_001310470.1"
                     /db_xref="GeneID:6468"
                     /db_xref="HGNC:HGNC:10847"
                     /db_xref="MIM:608071"
                     /translation="MTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSL
                     YISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHK
                     IHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRV
                     WSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPF
                     TLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRL
                     WDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP"
     exon            153..338
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            339..471
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..566
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..632
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            633..773
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..915
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1660
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="FBXW4"
                     /gene_synonym="DAC; FBW4; FBWD4; SHFM3; SHSF3"
                     /note="major polyA site"
ORIGIN      
        1 ggtggtgtca gcgccccggc cccagcccgc accccgaagt ggctccaagg ctgcaggatg
       61 accagtgtcc cagtgaagga acgagtgaag gtgtctcaga actggagact ggggcgctgc
      121 cgagagggga ttctgctgaa gtggagatgc agtcagatgc cctggatgca gctagaggat
      181 gattctctgt acatatccca ggctaatttc atcctggcct accagttccg tccagatggt
      241 gccagcttga atcgtcggcc tctgggagtc tttgctgggc atgatgagga cgtttgccac
      301 tttgtgctgg ccaactcgca tattgttagt gcaggagggg atgggaagat tggcattcat
      361 aagattcaca gcaccttcac tgtcaagtac tcggctcatg aacaggaggt gaactgtgtg
      421 gattgcaaag ggggcatcat tgtgagtggc tccagggaca ggacggccaa ggtgtggcct
      481 ttggcctcag gccggctggg gcagtgctta cacaccatcc agactgaaga ccgagtctgg
      541 tccattgcta tcagcccatt actcagctct tttgtgacag ggacggcttg ttgcgggcac
      601 ttctcacccc tgagaatctg ggacctcaac agtgggcagc tgatgacaca cttgggcagt
      661 gactttcccc caggggctgg ggtgctggat gtcatgtatg agtccccttt cacactgctg
      721 tcctgtggct atgacaccta tgttcgctac tgggacctcc gcaccagcgt ccggaaatgt
      781 gtcatggagt gggaggagcc ccacgacagc accctgtact gcctgcagac agatggcaac
      841 cacctgctgg ccacaggttc ctcctactac ggtgttgtac ggctgtggga ccggcgtcaa
      901 agggcctgcc tgcacgcctt cccgctgacg tcgactcccc tcagcagccc tgtgtactgc
      961 ctgcgtctca ccaccaagca tctctatgct gccctgtctt acaacctcca cgtcctggat
     1021 tttcaaaacc catgaccgtc agggccaccc ctgcctctgg gccagggaaa ccagctactc
     1081 agggacttct cttgcctgga gggtgcagtg atagctcctc ctcactgccc cactgtgctc
     1141 ctgggcctgt gaccccagtg ctcaggcacc ttgcactaga ggcttctgac tcctgggact
     1201 ttggagctta ccagagatgc agtccctccc aggaacctgt tggagaggca ggacctgctg
     1261 ctttagagtg cggctgaacc cgggccttgc gtccctgttt ggccagagca aggatctggc
     1321 ctggagaggc ccatcctata ccccttatta gagccatgac agcctacaga gtgaggtgag
     1381 gtgctcccac cttcccagat ggttcctttc tgccccttcc tggaaggaaa ggtgaggctg
     1441 ccaatagcct cctggcacca gccagacctc acccttgacc aacctctcgg ggctgggggt
     1501 tcattcctgg ggcactgtgg cctggttttg ctttgaaacc aagaaagagc aaagggaacc
     1561 cagcagttct gagtgagttc tgagccagcc ctacctcagg ctggctgttg agacatgcta
     1621 caattttcat ttttgtaaaa ataaagcttg attgttcaca
//
