LOCUS       NM_012164               9142 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 2 (FBXW2),
            transcript variant 1, mRNA.
ACCESSION   NM_012164
VERSION     NM_012164.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9142)
  AUTHORS   Barik,G.K., Sahay,O., Mukhopadhyay,A., Manne,R.K., Islam,S.,
            Roy,A., Nath,S. and Santra,M.K.
  TITLE     FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2
            axis
  JOURNAL   Cell Death Dis 14 (9), 623 (2023)
   PUBMED   37736741
  REMARK    GeneRIF: FBXW2 suppresses breast tumorigenesis by targeting
            AKT-Moesin-SKP2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9142)
  AUTHORS   Zhou,T., Chen,T., Lai,B., Zhang,W., Luo,X., Xia,D., Fu,W. and Xu,J.
  TITLE     FBXW2 inhibits prostate cancer proliferation and metastasis via
            promoting EGFR ubiquitylation and degradation
  JOURNAL   Cell Mol Life Sci 79 (5), 268 (2022)
   PUBMED   35499593
  REMARK    GeneRIF: FBXW2 inhibits prostate cancer proliferation and
            metastasis via promoting EGFR ubiquitylation and degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9142)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 9142)
  AUTHORS   Xia,S., Ji,L., Tao,L., Pan,Y., Lin,Z., Wan,Z., Pan,H., Zhao,J.,
            Cai,L., Xu,J. and Cai,X.
  TITLE     TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes
            to Sorafenib Resistance
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (3), 1121-1143 (2021)
   PUBMED   33962073
  REMARK    GeneRIF: TAK1 Is a Novel Target in Hepatocellular Carcinoma and
            Contributes to Sorafenib Resistance.
REFERENCE   5  (bases 1 to 9142)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 9142)
  AUTHORS   Chiaur,D.S., Murthy,S., Cenciarelli,C., Parks,W., Loda,M.,
            Inghirami,G., Demetrick,D. and Pagano,M.
  TITLE     Five human genes encoding F-box proteins: chromosome mapping and
            analysis in human tumors
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 255-258 (2000)
   PUBMED   10828603
REFERENCE   7  (bases 1 to 9142)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   8  (bases 1 to 9142)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   9  (bases 1 to 9142)
  AUTHORS   Patton,E.E., Willems,A.R. and Tyers,M.
  TITLE     Combinatorial control in ubiquitin-dependent proteolysis: don't Skp
            the F-box hypothesis
  JOURNAL   Trends Genet 14 (6), 236-243 (1998)
   PUBMED   9635407
  REMARK    Review article
REFERENCE   10 (bases 1 to 9142)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA703966.1, BC110334.1,
            AL161911.17 and AL138836.15.
            
            On Nov 22, 2018 this sequence version replaced NM_012164.3.
            
            Summary: F-box proteins are an expanding family of eukaryotic
            proteins characterized by an approximately 40 amino acid motif, the
            F box. Some F-box proteins have been shown to be critical for the
            ubiquitin-mediated degradation of cellular regulatory proteins. In
            fact, F-box proteins are one of the four subunits of ubiquitin
            protein ligases, called SCFs. SCF ligases bring ubiquitin
            conjugating enzymes to substrates that are specifically recruited
            by the different F-box proteins. Mammalian F-box proteins are
            classified into three groups based on the presence of either WD-40
            repeats, leucine-rich repeats, or the presence or absence of other
            protein-protein interacting domains. This gene encodes the second
            identified member of the F-box gene family and contains multiple
            WD-40 repeats. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.68383.1,
                                           SRR1660809.50075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608872.6/ ENSP00000476369.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DA703966.1         47-100
            55-1682             BC110334.1         1-1628
            1683-8111           AL161911.17        101-6529            c
            8112-9140           AL138836.15        187453-188481       c
            9141-9142           AL138836.15        187451-187452       c
FEATURES             Location/Qualifiers
     source          1..9142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..9142
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="F-box and WD repeat domain containing 2"
                     /db_xref="GeneID:26190"
                     /db_xref="HGNC:HGNC:13608"
                     /db_xref="MIM:609071"
     exon            1..63
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            64..172
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            173..682
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1557
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and WD-40 domain protein 2; F-box/WD repeat-containing
                     protein 2; F-box and WD-40 domain-containing protein 2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 2 isoform 1"
                     /protein_id="NP_036296.2"
                     /db_xref="CCDS:CCDS43872.1"
                     /db_xref="GeneID:26190"
                     /db_xref="HGNC:HGNC:13608"
                     /db_xref="MIM:609071"
                     /translation="MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHL
                     SNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTAC
                     KNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGL
                     LCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGAR
                     TQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVL
                     QKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHF
                     DGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDL
                     RTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW
                     KEHG"
     exon            683..877
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1011
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1098
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1268
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..9142
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="hexamer: ATTAAA"
     polyA_site      1944
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="major polyA site"
     regulatory      6894..6899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="hexamer: AATAAA"
     polyA_site      6919
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="major polyA site"
     regulatory      8416..8421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="hexamer: AATAAA"
     polyA_site      8439
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
     regulatory      9088..9093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="hexamer: AATAAA"
     polyA_site      9108
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
     regulatory      9125..9130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
                     /note="hexamer: AATAAT"
     polyA_site      9142
                     /gene="FBXW2"
                     /gene_synonym="FBW2; Fwd2; Md6"
ORIGIN      
        1 aggcagcacc ggaagccgct cccctgtgag gctgcggacc gggagcagcg gccgcaggtc
       61 cgggcgccat ggctgcggag cggacccggc cgctgcaagg ctctggcggt ccgagcgtgc
      121 ctagtagctg tgaacccggc gcgaggtccc gggccccggg gcgctcgctc aggtaaattt
      181 ttccataacc ttatggagag aaaggacttt gagacatggc ttgataacat ttctgttaca
      241 tttctttctc tgacggactt gcagaaaaat gaaactctgg atcacctgat tagtctgagt
      301 ggggcagtcc agctcaggca tctctccaat aacctagaga ctctcctcaa gcgggacttc
      361 ctcaaactcc ttcccctgga gctcagtttt tatttgttaa aatggctcga tcctcagact
      421 ttactcacat gctgcctcgt ctctaaacag tggaataagg tgataagtgc ctgtacagag
      481 gtgtggcaga ctgcatgtaa aaatttgggc tggcagatag atgattctgt tcaggacgct
      541 ttgcactgga agaaggttta tttgaaggct attttgagaa tgaagcaact ggaggaccat
      601 gaagcctttg aaacctcgtc attaattgga cacagtgcca gagtgtatgc actttactac
      661 aaagatggac ttctctgtac agggtcagat gacttgtctg caaagctgtg ggatgtgagc
      721 acagggcagt gcgtttatgg catccagacc cacacttgtg cagcggtgaa gtttgatgaa
      781 cagaagcttg tgacaggctc ctttgacaac actgtggctt gctgggaatg gagttccgga
      841 gccaggaccc agcactttcg ggggcacacg ggggcggtat ttagcgtgga ctacaatgat
      901 gaactggata tcttggtgag cggctctgca gacttcactg tgaaagtatg ggctttatct
      961 gctgggacat gcctgaacac actcaccggg cacacggaat gggtcaccaa ggtagttttg
     1021 cagaagtgca aagtcaagtc tctcttgcac agtcctggag actacatcct cttaagtgca
     1081 gacaaatatg agattaagat ttggccaatt gggagagaaa tcaactgtaa gtgcttaaag
     1141 acattgtctg tctctgagga tagaagtatc tgcctgcagc caagacttca ttttgatggc
     1201 aaatacattg tctgtagttc agcacttggt ctctaccagt gggactttgc cagttatgat
     1261 attctcaggg tcatcaagac tcctgagata gcaaacttgg ccttgcttgg ctttggagat
     1321 atctttgccc tgctgtttga caaccgctac ctgtacatca tggacttgcg gacagagagc
     1381 ctgattagtc gctggcctct gccagagtac aggaaatcaa agagaggctc aagcttcctg
     1441 gcaggcgaag catcctggct gaatggactg gatgggcaca atgacacggg cttggtcttt
     1501 gccaccagca tgcctgacca cagtattcac ctggtgttgt ggaaggagca cggctgacac
     1561 catgagccac caccgctgac tgactttggg tgccggggct gcgggttttg ggtgcaacct
     1621 ctgcggcagc cgactgcatg aaccaaagtt ctcacctaat ggtatcatca cgcagtgcac
     1681 aatcatttat ctatgttttg ccaggggcca gggctcgggg tgggggaggg cttgttttat
     1741 tgacatacaa cgcagcatgc taatggggta caccattgac ttcatttgta cttagttatg
     1801 ttggtcagtg ttagaggatg cattttgggt tcatctttct tgagtggagt attggtttta
     1861 agtaaagaaa gttaaatgat ccattaatct gctaattggt tgcctatgaa atcacattgt
     1921 ctgttattaa agctttttac catagccttt ttttcttttg aagttgaagc aaaggtgcta
     1981 tgatgttgtt acagcaactt tcctcacacg gggtttagct cttataagag ccagtgttaa
     2041 aacttccacc aaataccagt ttataaactt ccaccaaata ccagtgctaa ggaaagtctg
     2101 tcttccagtt caaatccaat tctgtaaatt gaatgttagc aactcattct aaaccttata
     2161 tcttggcaga gtcaaggttg gccatgttta agatgtgagc gagttctgta gtttttgttg
     2221 ccatgtcggg gaagctagtc cccggcagcc tggatgactg cacagcggtg ccctggtata
     2281 gcagaaaaga gcagtgagct ggaaggttag agaccgggcc tcttaccctg gaactctgca
     2341 ccctctctgg gtcccagctt ccttgtctgt acagccaggt atgaagctca gtgatttcta
     2401 agattctttc tggtccttca cctactgaaa tgtgtaaaag ttgatcatgt atttttgtct
     2461 gatccctgat tcatggtttc tttcaggtcg gataatattt aaatgaaatg actgttacag
     2521 agttttctat aagaacatca attatatgaa aaggatgaat aaaagggaaa tgtagaaaat
     2581 atagctgatt ccacttagac agtttaagta attggttgaa gaaatgctga tagaagccat
     2641 ggtttaaata gggacacagt atgctatact agaaggatac ctgaacccaa cctaacttcc
     2701 tcctttgcct ctaacttaat ctgcagcctc aggcaagtta actttctctt ctaagaccat
     2761 cattttcttc atcttttaag tgagggaatt gtcctagatg agggctcaca aacccaaatg
     2821 cctaagggag ccgtgcaggt aacataaatg agtaaaacat tctggggagg attgtgctgt
     2881 cccctggaaa gttgatctaa tagggcagtt attcagctct gttttgtcat taggagaagc
     2941 aagcccaggg ttggcaggtc ttcacattgt ttcaggagga gctagaaatc cagattttta
     3001 tttgaaatcc tggattttta aaacgttaca actgattaaa gaaaatttga aataaggtga
     3061 gccaaacaaa acatgtccct gggttgccag attgtgtcct cctccctctc taaagttagg
     3121 taattttgtg attcagcagt ggaaatgtta gtggtcacaa tcagggagag agtagaggga
     3181 gcaagcagta gaaaaatctc agccgctctt cagctgtctc cccttgtatt acaagggtgg
     3241 tggggaggga tgtatttcat tcacagacca ataggaaggt agtttgaaga tgaacataag
     3301 aattggaacc tcagtgacag cttatgtctg ggaacatgag ttattccttc ttgctgactc
     3361 cagtataaag catatccatt ttacaggtga gaaaaagggt tgctggcaga gctgagaatg
     3421 atgtgaactc tagagtgggg acctatctct tgcagaatct gcattagcat agagccagac
     3481 tctggacctc tgagtgctgt gaagttgata gaaattaatg gtgaatttca aggacagata
     3541 tcattaatat ccatgttgaa actctgtggg gtttaagcaa aagaacaata tcttccccca
     3601 tcccacaaaa tctgggttta atctatctca cattgagttc tgtgcatcag ctctgcttag
     3661 tactctagaa atagaaccgg aatcacaact gaatctattt tgcagaagcc ccaggagact
     3721 ttgggcaatg atgatggtaa atgacttttt actttattat tatttttttt tttttgagac
     3781 agagtttcgc tcttactgcg caggctggag tgcaatggca cgatcttggc tcactgcaac
     3841 ctccgcctcc tgggttcaag tgattctcct gcctcagcct cctaagtagc tgggattaca
     3901 agcatctgcc atgacaccca actaattttt atatttttag tagagacagg gttccaccat
     3961 gttggccagg ctggtcttga actcctgacc tcaggtcatc cacctgcctt ggcctcccaa
     4021 agtgctggga ttacaggcgt gagccaccac gcctggccga gtttttactt tttatcgagc
     4081 ctgaacagat aactattact gatctaatga ccatccccac cctacctcac tttcagatct
     4141 atccaatagc ttcaaagggc aagtaattat aatcatttgt gggaaaagtt ttattaaaaa
     4201 gtgacaaact tgaagctgta tatagtatgt tctatttcag tttttagtgg tgaatacaga
     4261 agtcatcaag gtggtacttg gtgccgctgg aatttttttt ttttcctagg cagtcttgct
     4321 ctgtcataca ggctggagta cagtggcatc atcatgcagc tggattttga cagcagaact
     4381 tcaggcagta attggagtcc taatgtcagt tcttccttat ggaggccttt atttggcctg
     4441 agattttatt caactacttt atagatgctg ggtttattca tactatcgcc agtttttata
     4501 aaaatggaaa actagctcat cctttttgca aaagaaagca aagtggggag tcagaatgag
     4561 aagtggatag gggataacta aaactattct ttactctcct ttcattgcct ttgagagcta
     4621 gctcttgcac acactgactt tggcttcctt agcgcatagg taagggaatt gcctttccct
     4681 cttttgtgaa tattctcatt tctgaaaaat tctaagtcat gagaagataa gccctatcct
     4741 ttcttacaag gattggattt cttgggtgac actgtggtgt ggtggaagcc agcggcttct
     4801 ttcaggttca taaaggccat cataacaact tcaggcttca tggtgtggac agggatccag
     4861 gagagctgag tggatgtgtg aagtttctga tagattctgt catcattcca aaggaatgta
     4921 gtttcctcca gctcaatcat ttgaagtaat acacattgcc aaatctgact gtaacctgac
     4981 attttagacc tattggagaa ataggaagaa agcccctcca gtggaaggac tggacttgga
     5041 agaagttctg caggaaggtg catgcaattg gatagctgtt catgagtgaa acgtggggaa
     5101 cattgctatg aaattgtaag gtttgcactt catttttcgt agtttaaaaa ttgctctgtt
     5161 ctggctgttg aaaacacttg gtgtgaggtt tgaatgagga ttatataatc attctagtat
     5221 tcataggaaa atgattactg ctctctattt gtaaaacaaa agaaataact ttcggaaaca
     5281 gtattttaga catgaggaaa ttgtttgtat taggcatttt gatctaacag aatcagctaa
     5341 ggatagtgga tcctggcttt acacatttct ttgaccaaac ccagctggca acttgaagtt
     5401 gttactgtgt ggcttccaga ttgcctagag gtgaatccta ccaacatcac tgtttttttt
     5461 gttttgtttt gttttttttg tatgtttttg agacagagtc ttgctctatc cccaggctgg
     5521 agtgcagtgg cgtgatctcg gcttactgca acctcagcct cctgggttca agcgattctc
     5581 ctgcctcagc ctcctgagta gctgagacta caggcgcgtg ccaccacgcc cagctatttt
     5641 tgtattttta gtagagacga ggtttcacta tgttggccag gatggtcttg atttcttgac
     5701 ctcgtgttct gcccgcctct acctcccaaa gtgccgggat tacaggcgtg agctgctgtg
     5761 cccggcccca gcatcacttt tatagctttc tgtgcctctt cctctgggcc ttggtgtatg
     5821 aagccacttg cctttctctg ttgggaagcg agcagaatca gattgctact catgatgcag
     5881 tccgggcagg gcatactgtc acctttgcct gtggacacag ttgtcaggat aggggagaag
     5941 ccctttaggt ccgtcttctt gacacagccc tcctacctgg ttacgctggt gctttcgctt
     6001 ggtttagaca accaagacac ttgagaatta tgctgtcctc agaatgtctg atgaaaagaa
     6061 cagattcact tttttgacac aatgcccatt agccatcttt ggcagtgttt ctgatcaaag
     6121 gttccccatg cctgctctag gaaagtaaac ttttttcaga ataaatcctc aaatggatta
     6181 ctgagtagtc tttgcaccat tcccatcagc ctaatcagac tgaatggtca cgctcagtgc
     6241 aaaaagctgt tttgctgtta ggatgtttca gtgtttcttg tctttcctgg aacagttcag
     6301 ttgtttaaat ttagtaattc aatcctgacc agtgtaaacc cacttaatta ttgcagccta
     6361 aagaattcag ctacttctac tcttcataaa tgtgcccaag taaatatgtg tttttaatat
     6421 tcaaccctgg aaaattagta attcagatga taaaagctca tgttttggtg tctttgtact
     6481 cagattgtga acaggcatat ttcactgatt tagacttagt atacttgatg agaatgctca
     6541 ggttgaagag atagttctgt cagcaatcca acatctatag caatgtggaa aaagtaatca
     6601 actcatattt cacgaatttg atgtatgttg tgatttagag ggcatgagat aaagtttata
     6661 tttgaactgt gtggggtagg gggaagaaga ggttgcttaa gcaaatagtg gggtgattgt
     6721 ggaacaagat gtctctaaga tgagaagtta ttttcttgca tcatagaagc actcttttta
     6781 cccgtgagtg attgtgttaa ctataaatca tttatatctg tacattaaag cagattccct
     6841 caattaggca aatttggtta gccaagccca agttattgtt tgtacttgaa agtaataaag
     6901 ctgcatttcc ttaaaaatat attctgtagt taagactttg tcttgctttc cccccaacca
     6961 cttcagacat tttatccaac caatgcaggg acttttcaaa agtcagtgtg tttttgaaaa
     7021 tagaacaacc ccttgagtga tctgaggtgg ctctgttttt ttactgtttc tgcatcttct
     7081 agaaggtaaa ctcaacaata taaccatttc tgaaggtgat ccaaaaagca aaacaataaa
     7141 ggtaaaacac aaggaaataa ttttggtgaa tttcatgaat agttgcaaat gaagggatgg
     7201 ggtgggtaaa agtcccattt tgcttccaga ccttggaata gtcttcctct cttttgccca
     7261 aggatgtgtc tatccagcac atctttgcat gagttctttc ttactaactt aaacttacgg
     7321 ggcttcttgt catttgagta ccacggccct gcacctttga tcccctgaca gcatcattaa
     7381 gggcagattg tcattcctgt tttacagatg agaaagctgt ggcttggtaa agtgattcat
     7441 tgcctagagg agttatagta agtggtgagg ctgaagccct gattttcagc ccccacacac
     7501 ctggattttt tccatgtttt catgtttgtc tgttctttct gtatttcaag tctcttcaaa
     7561 tcccgactgc tgccttctgc cttcaccact tgtgtgcact gttcaacctg tcttatgctt
     7621 tgcttccagg gagtctcccc aaccacttct ttgagcactt acttgctctt gttcaatctt
     7681 ggtaactctc cgttaccatc agggcacatc tggattcctt aacatcatgg agccctagct
     7741 aatttcttcg agcaaacagt tcttgctcct ctatttattt ccacccttgc gctttgggtg
     7801 ttaatctccc atcctcgtgg aaagttcttg atgttccttt ccaccagtcc tagggccagg
     7861 ctttaatccc attgatctcc cactatcttt aaagcctctg ctgaccacca taccccactc
     7921 cagcctcact gagcattttt gtgtaaggtt agtggtgcag ttcatttagc aataaatact
     7981 gttgtacctt ttgcagtaga caactattaa ctttcatcct tgattctcag ttttttccaa
     8041 aatacaagtg aatacctggt ttccccagca acattgtaag attgagagta ggaattcatt
     8101 gagattttaa tgaattccat ggattgtctt aagagctatc taaacttgga agaaaaataa
     8161 cttccagagc atctaaaatt gaaaataaaa gatcagaagc aaatgaaaga tcaattccac
     8221 acagcttttc ctctcttaga cgtccctctt ctgccatatc ctgtaaacat ctgaagtgtt
     8281 ctgagtacat ttggagagaa tatttaatga tcacactgtg attagacatg agtagtccct
     8341 gccagtggga tgttcctgtc ctttgcattt taaccacatg ttctgtgctc tctgtggtaa
     8401 agataatcta acagtaataa aaacttatgg agaaaattac ccagagctcc tttatcatta
     8461 cgatttttaa tactctcttc taatccttat gcacatgtgt atggatttat gtactgcaaa
     8521 tcattgtttt gtaatacatt ctcaaaaatg tgctttaggt ttttacaact accataatat
     8581 tttgtaattt tccttcatta ctgtaatttg ctaaaccatt tctgttttgg tagataatta
     8641 ggtagtttcc agttctgctt tttagaagat actacagaga acttctttgt gcatatttcc
     8701 ttagaacaag ttccagtaga agacttactc gcaaaagcag tggaattttt tcttagtatt
     8761 ttctgttaca ggtacagaag agtgcataca acacacagtt ttgtcgaata gttatgaagt
     8821 gaacacttgt ctaaccactg cccgagtcaa gaaagaacat ttctaaacat gtttgccaat
     8881 ttaatagata taaaggaagt atctcaaggt tgctttaact gacatttctt taacacatga
     8941 caacattttt atgggggagg ggactagaga gaaaatgaca tatttttatg tgtgcttatt
     9001 tgtatctctt gaattctgtc tgcatctttt acccattaca ctttcaaata cttgtgaaat
     9061 cattggtcga gatgaattat ggctataaat aaaatttcac taatctaatt atcactgatt
     9121 tagaaataat agttcaaccc aa
//
