LOCUS       NM_207102               1647 bp    mRNA    linear   PRI 30-JUL-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 12 (FBXW12),
            transcript variant 1, mRNA.
ACCESSION   NM_207102 XM_376226
VERSION     NM_207102.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   De La Chesnaye,E., Mendez,J.P., Lopez-Romero,R., De Los Angeles
            Romero-Tlalolini,M., Vergara,M.D., Salcedo,M. and Ojeda,S.R.
  TITLE     FBXW12, a novel F box protein-encoding gene, is deleted or
            methylated in some cases of epithelial ovarian cancer
  JOURNAL   Int J Clin Exp Pathol 8 (9), 10192-10203 (2015)
   PUBMED   26617728
  REMARK    GeneRIF: FBXW12 gene is deleted in approximately ten percent of the
            epithelial ovarian cancer cases studied; such deletions comprised
            either the FBXW12 promoter or the mRNA-encoding region.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Franz,J., Jerome,J., Lear,T., Gong,Q. and Weathington,N.M.
  TITLE     The Human IL-22 Receptor Is Regulated through the Action of the
            Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial
            Growth Suppressor
  JOURNAL   J Immunol Res 2015, 912713 (2015)
   PUBMED   26171402
  REMARK    GeneRIF: FBXW12 functions as an E3 ligase constituent to
            ubiquitinate and degrade IL-22R and that therapeutic FBXW12
            inhibition may enhance IL-22 signaling and bolster mucosal host
            defense and infection containment.
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 1647)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   5  (bases 1 to 1647)
  AUTHORS   Zeng,L., Gu,S., Li,Y., Wang,W., Huang,Y., Ye,X., Xu,J., Zhao,E.,
            Ji,C., Ying,K., Xie,Y. and Mao,Y.
  TITLE     cDNA cloning and expression analysis of a novel human F-box domain
            containing gene
  JOURNAL   Mol Biol Rep 31 (1), 51-57 (2004)
   PUBMED   15040455
  REMARK    GeneRIF: FBXO35 gene had a ubiquitously low expression pattern in
            most human adult tissues. FBXO35 gene was found located in
            chromosome 3p21.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY247969.1 and AC104448.2.
            
            On May 7, 2009 this sequence version replaced NM_207102.1.
            
            Summary: Members of the F-box protein family, such as FBXW12, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603034), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY247969.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296438.9/ ENSP00000296438.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AY247969.1         1-125
            126-144             AC104448.2         32168-32186
            145-1003            AY247969.1         145-1003
            1004-1135           AC104448.2         40206-40337
            1136-1647           AY247969.1         1136-1647
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1647
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /note="F-box and WD repeat domain containing 12"
                     /db_xref="GeneID:285231"
                     /db_xref="HGNC:HGNC:20729"
                     /db_xref="MIM:609075"
     exon            1..102
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            103..276
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1581
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 35; F-box and WD-40 domain protein 12; F-box-
                     and WD40-repeat-containing protein; F-box/WD
                     repeat-containing protein 12; F-box and WD-40
                     domain-containing protein 12"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 12 isoform 1"
                     /protein_id="NP_996985.2"
                     /db_xref="CCDS:CCDS2764.1"
                     /db_xref="GeneID:285231"
                     /db_xref="HGNC:HGNC:20729"
                     /db_xref="MIM:609075"
                     /translation="MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRS
                     LSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELA
                     YLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHL
                     AITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTL
                     PGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
                     TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIAS
                     FQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCY
                     VLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRK
                     VSDSSILVMYSLNT"
     exon            277..314
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            315..472
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            473..591
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            592..801
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            802..960
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1171
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1350
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1481
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1647
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /note="hexamer: AAGAAA"
     polyA_site      1647
                     /gene="FBXW12"
                     /gene_synonym="FBW12; FBXO12; FBXO35"
                     /note="major polyA site"
ORIGIN      
        1 ttctttctcc tccactgcaa agttaaatgc gagaaggtag aaacccagag gccatgctgg
       61 cgctgagaga tgagccccac tcaccagatt caagatccca agtgctgcag actttggcaa
      121 agcctataaa ttcagagcag cccggagagg agaaaggaaa gtggatgtgg gttcaggccg
      181 catgaaatgg agatccgatt gcctgactta gctttgaagc gaatcttctc tttcctggac
      241 ctgttcggct tgctgcaggt ttcccaggtg aacaagcatt ggaataggat tgcagacagt
      301 gattacctgt ggaggtcact atctctgcag agatgggact gcagcaactt caccaatcaa
      361 cacctgggca cacacacatg gaagcaattt ttcctgcatc aaagaaggaa ggagcttcgg
      421 ttggcattgg cacagccgca taactttatc tacaaagtaa ctaagaacat cgcatttgag
      481 acggagttgg cttatctctc aggaaataga cttacagtgg atgaacagga gaaatcaatc
      541 atttgtagtg tatctccaaa gcaagagctt tgtgcctggg atgtgcaaga gggtaccatg
      601 atctggtcaa gcccagtcca ggagttccat ttctcaaatc tggtaaccct ccctcagatg
      661 catctcgcca tcactatgga tcggaaaaaa actatcaaag tgtggaactg tcaggacagg
      721 gacgctctgg ctgttctccc catgccacag ccctgttatt gcatggaagc ctatcttaca
      781 aaggatggcc cattcctgat ggttggcgat gctgcaggtg acatctacac atttacactg
      841 cctgggttaa gagatgtttc taaagttact gcatttcaat atggtattgt acttctacac
      901 tgctctcctg acaagaaatg ggtatttgca tgtgggacat acagtcgtac cttgccacag
      961 gtattcctca cagagtcctt actgagacca tcagaaggca gtgttcctct gtctaccttt
     1021 ctcccacata aattatgtgc cagcgcctgc tggaccccaa aggtgaaaaa caggataaca
     1081 ctgatgtccc aaagtagcac tggaaaaaag acagaattta tcacctttga tctaacaacc
     1141 aagaagactg gaggccaaac agtcatccaa gcatatgaga tcgcaagttt ccaggtggca
     1201 gctcatctga agtgccctat ctggatggga gccagtgatg gatatatgat tgtctttacc
     1261 agtggaccat acttgttact cttcagcatc actggcttcc tgctgcaacg atttgaggac
     1321 catcaggcag ccatcaacaa cttctgggtg gatccttgct atgtgctcac cacatccgag
     1381 aactctgtgc acgtgtacat gtgggaagaa ggaggccgcc atccatacct caggagctgc
     1441 tgtcacctgg aaaacacgtg gcatgatcac acaacagaca gctgcatctc cagtgtgatg
     1501 tgtgataatg caagcatagt acttagggtg aggaaagtaa gtgactccag cattctggtg
     1561 atgtattctt tgaatacgta atatggaaac taacaaaatt gaccttgcat catcttctgc
     1621 aatgtagtaa agaaattcta tttgcaa
//
