LOCUS       NM_012300               4343 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 11 (FBXW11),
            transcript variant 3, mRNA.
ACCESSION   NM_012300
VERSION     NM_012300.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Tan,P., Cai,S., Huang,Z., Li,M., Liu,S., Chen,J., Fu,W. and Zhao,L.
  TITLE     E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is
            associated with immune infiltration and NF-kappaB pathway
            activation in pancreatitis and pancreatic cancer
  JOURNAL   Cell Signal 116, 111033 (2024)
   PUBMED   38182068
  REMARK    GeneRIF: E3 ubiquitin ligase FBXW11 as a novel inflammatory
            biomarker is associated with immune infiltration and NF-kappaB
            pathway activation in pancreatitis and pancreatic cancer.
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Dalle Carbonare,L., Gomez Lira,M., Minoia,A., Bertacco,J., Orsi,S.,
            Lauriola,A., Li Vigni,V., Gandini,A., Antoniazzi,F., Zipeto,D.,
            Mottes,M., Bhandary,L., Guardavaccaro,D. and Valenti,M.T.
  TITLE     Expression of FBXW11 in normal and disease-associated osteogenic
            cells
  JOURNAL   J Cell Mol Med 27 (11), 1580-1591 (2023)
   PUBMED   37199076
  REMARK    GeneRIF: Expression of FBXW11 in normal and disease-associated
            osteogenic cells.
REFERENCE   3  (bases 1 to 4343)
  AUTHORS   Nardone,C., Palanski,B.A., Scott,D.C., Timms,R.T., Barber,K.W.,
            Gu,X., Mao,A., Leng,Y., Watson,E.V., Schulman,B.A., Cole,P.A. and
            Elledge,S.J.
  TITLE     A central role for regulated protein stability in the control of
            TFE3 and MITF by nutrients
  JOURNAL   Mol Cell 83 (1), 57-73 (2023)
   PUBMED   36608670
REFERENCE   4  (bases 1 to 4343)
  AUTHORS   Liu,C., Chen,X., Zhang,L., Liu,J., Li,C., Zhao,J., Pu,J., Tang,P.,
            Liu,B. and Huang,X.
  TITLE     F-Box Protein 11 Suppresses Cell Proliferation and Aerobic
            Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation
            of Cdc25A
  JOURNAL   J Neuropathol Exp Neurol 81 (7), 511-521 (2022)
   PUBMED   35582896
  REMARK    GeneRIF: F-Box Protein 11 Suppresses Cell Proliferation and Aerobic
            Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation
            of Cdc25A.
REFERENCE   5  (bases 1 to 4343)
  AUTHORS   Chen,C., Zhou,H., Zhang,X., Liu,Z. and Ma,X.
  TITLE     Association of FBXW11 levels with tumor development and prognosis
            in chondrosarcoma
  JOURNAL   Cancer Biomark 35 (4), 429-437 (2022)
   PUBMED   36404534
  REMARK    GeneRIF: Association of FBXW11 levels with tumor development and
            prognosis in chondrosarcoma.
REFERENCE   6  (bases 1 to 4343)
  AUTHORS   Heissmeyer,V., Krappmann,D., Hatada,E.N. and Scheidereit,C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
REFERENCE   7  (bases 1 to 4343)
  AUTHORS   Koike,J., Sagara,N., Kirikoshi,H., Takagi,A., Miwa,T., Hirai,M. and
            Katoh,M.
  TITLE     Molecular cloning and genomic structure of the betaTRCP2 gene on
            chromosome 5q35.1
  JOURNAL   Biochem Biophys Res Commun 269 (1), 103-109 (2000)
   PUBMED   10694485
REFERENCE   8  (bases 1 to 4343)
  AUTHORS   Suzuki,H., Chiba,T., Suzuki,T., Fujita,T., Ikenoue,T., Omata,M.,
            Furuichi,K., Shikama,H. and Tanaka,K.
  TITLE     Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to
            IkappaBalpha for signal-dependent ubiquitination
  JOURNAL   J Biol Chem 275 (4), 2877-2884 (2000)
   PUBMED   10644755
REFERENCE   9  (bases 1 to 4343)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 4343)
  AUTHORS   Fuchs,S.Y., Chen,A., Xiong,Y., Pan,Z.Q. and Ronai,Z.
  TITLE     HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and
            Cullin1 and targets the phosphorylation-dependent degradation of
            IkappaB and beta-catenin
  JOURNAL   Oncogene 18 (12), 2039-2046 (1999)
   PUBMED   10321728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113342.2, AC011387.5 and
            AC011410.6.
            
            On Mar 17, 2020 this sequence version replaced NM_012300.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbws class and, in addition to an F-box, contains multiple WD40
            repeats. This gene contains at least 14 exons, and its alternative
            splicing generates 3 transcript variants diverging at the
            presence/absence of two alternate exons. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014596.1, SRR14038191.2623962.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC113342.2         25632-25812         c
            182-283             AC011387.5         134733-134834       c
            284-509             AC011387.5         87708-87933         c
            510-696             AC011387.5         77050-77236         c
            697-787             AC011387.5         76140-76230         c
            788-925             AC011387.5         68603-68740         c
            926-1044            AC011387.5         55147-55265         c
            1045-1294           AC011387.5         53421-53670         c
            1295-1413           AC011387.5         50008-50126         c
            1414-1524           AC011387.5         47884-47994         c
            1525-1603           AC011387.5         46865-46943         c
            1604-1790           AC011387.5         45746-45932         c
            1791-4343           AC011410.6         902-3454
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..4343
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="F-box and WD repeat domain containing 11"
                     /db_xref="GeneID:23291"
                     /db_xref="HGNC:HGNC:13607"
                     /db_xref="MIM:605651"
     exon            1..181
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1765
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="isoform C is encoded by transcript variant 3; F-box
                     and WD-40 domain protein 11; F-box and WD-40 domain
                     protein 1B; beta-transducin repeat-containing protein 2;
                     F-box protein Fbw1b; F-box/WD repeat-containing protein
                     11; homologous to Slimb protein; F-box/WD
                     repeat-containing protein 1B; F-box and WD repeats protein
                     beta-TrCP2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 11 isoform C"
                     /protein_id="NP_036432.2"
                     /db_xref="CCDS:CCDS34289.1"
                     /db_xref="GeneID:23291"
                     /db_xref="HGNC:HGNC:13607"
                     /db_xref="MIM:605651"
                     /translation="MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPS
                     VRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHY
                     QHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISE
                     GMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIET
                     IESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL
                     TGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMV
                     TCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTST
                     CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR
                     FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISS
                     SHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR"
     exon            182..283
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            284..509
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            510..696
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            697..787
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            788..925
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1044
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1294
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1413
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1524
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1603
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1790
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..4343
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4181..4186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="hexamer: AATAAA"
     polyA_site      4199
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="major polyA site"
     regulatory      4321..4326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="hexamer: AATAAA"
     polyA_site      4343
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
ORIGIN      
        1 gccggcggcc cgggcgggct ggcagctaga gtgggtgcga tagccgcctc cgcctctgcc
       61 gcctccgccg tcgcctcctc cgcccgggcc gttcgctgct gcgcggggag agcgaggcgg
      121 ggccgccggg gccgccatgg agcccgactc ggtgattgag gacaagacca tcgagctcat
      181 gtgttctgtg ccaaggtctt tgtggctagg ctgcgccaac ctggtagaga gcatgtgcgc
      241 actgagttgc ctgcagagca tgcccagtgt cagatgtctc cagataagta atggaacatc
      301 atctgtgatc gtctccagaa agaggccatc agaaggaaac tatcaaaaag aaaaagactt
      361 gtgtattaaa tattttgacc agtggtctga atcagatcaa gtggaatttg tggaacatct
      421 tatttcacga atgtgtcatt atcagcatgg acatattaac tcttacctga agcccatgtt
      481 gcagcgggac tttattaccg ctttaccaga gcaaggctta gatcacatag cagaaaacat
      541 tctttcgtac ctggatgcca ggtctctgtg tgcagcagag ctggtatgta aagaatggca
      601 gcgagtgatc tcagaaggaa tgctttggaa gaagctgatt gaacgaatgg tacgcactga
      661 tcccctatgg aaaggacttt cagaaagaag agggtgggat cagtacctgt ttaaaaacag
      721 acccacagat ggccctccaa attcatttta taggtcatta tacccaaaga ttatccagga
      781 tatagagact atagaatcta actggcggtg tggacgacac aacttgcaga ggattcagtg
      841 ccgctctgaa aatagtaaag gtgtctactg tttacagtac gatgatgaaa aaattatcag
      901 tggcctacga gataattcta ttaagatatg ggataaaacc agcctggaat gtttgaaagt
      961 gttaacagga cacacaggct ctgtcctctg tctgcagtat gatgagcgtg tcattgtaac
     1021 tggctcttca gattctacgg tgagagtgtg ggatgtgaac acgggtgaag ttcttaacac
     1081 attgatccac cacaatgagg ctgtattgca cttacgcttc agcaatggac tgatggtgac
     1141 ctgttccaag gaccgctcca ttgctgtgtg ggacatggct tctgcgaccg acatcacttt
     1201 acgccgtgtc ctggttggcc accgggctgc cgtcaatgta gtagactttg acgacaagta
     1261 catcgtgtct gcctctggtg acaggaccat caaagtctgg agcacgagca cctgtgaatt
     1321 tgttcgtact ctcaatgggc acaagcgggg cattgcctgt ctccagtaca gggatcgcct
     1381 ggttgttagt ggatcatcag ataataccat taggctctgg gatattgaat gtggtgcctg
     1441 tttaagagtc ctagagggac atgaagaatt ggtccgatgc atccggtttg ataacaagag
     1501 gattgtcagt ggggcctatg atgggaaaat taaagtttgg gacttgcaag ctgctcttga
     1561 ccctcgagcc ccagcaagca cattgtgttt gcgcacattg gtggaacatt ctggacgtgt
     1621 gtttcggctc cagtttgatg agtttcagat catcagcagc tcccatgatg acactatttt
     1681 gatttgggat ttcttaaatg tgcctcccag tgcccagaat gagacccgtt ctccctccag
     1741 aacatacact tacatctcta gataacagtc tgcactttca cccgtttcag ggttttctag
     1801 tcttgaacta ctggctacgt ggctaccaaa tgcctaaggg agttcgttca cagctgagtt
     1861 atgaagctgg aattggttct agacgctggg tagatgcaaa gcagcctaac tcttcaagta
     1921 ccgacatttc tcacctctga ttccggctct cctttgagaa ggagacctta gcttccccgg
     1981 cttcaagtag aacagaagcc cgtttccttc cctcatcagt gaaaaaatct aatgtttcaa
     2041 atgtaaattg ttcatagaaa aggaacatag aatctgtttt acagaagtaa atcgaccgtc
     2101 aagagaagac ttggcctcta atttatattg ctttgcactt tggtttgata ttaagaaaca
     2161 gcattcttct tcagtgaaat tttgggtgcc aaacacctac ccagaatgtc cagggctttc
     2221 attttcaaaa gttagcattc tccttttgac cgtccaagtc attatgaatt ctgacttgtt
     2281 gtattaggaa catgttggac agtggaaaat tttctctgga ttgttttagt aatatttttg
     2341 ggattatact tcctttctgt accaatttct tttaatttaa agaactataa gtcagttata
     2401 ttatctacca acaggtaata tagctctttc ttttattaac tgttctctgt cccccaacca
     2461 tctcctgata tttggtagag taacaccttt atacgtgtgc ttgcctccta atttaaaata
     2521 ctgtattcgc atgtagatat aatgtacata acagtttaac ctcaaagttg ctggagtcag
     2581 ggccccctgt gcttgagaca ctaatacaga gtgtgttcgc acttagccat gggctgggct
     2641 caagaacctg atacctgggt tgatgtggat tacctagaac ccttcctgca gtattcatac
     2701 agtgttttta ttttgttgtt gtcattgcgt gtgtgtggtt tgtgtgtgtt tttaatgaga
     2761 atcttgtttt aaaatgtaat ttctaaggtt taacaccaaa atgttttatt tgttgtggag
     2821 tatatattat acaatagaga ggtaccttaa acattttttg ttcttattct ttttctcata
     2881 agtactcctg agtacaagtg gtcacctccc atagtattca tttggcttcg ctgtcaaaaa
     2941 tcattattct gtgcagtcgt ggccctggga aggggaaata agaaggccct gttgacgggc
     3001 tgtcttggct ctggaattca tgcatcctgg ccttgccaag gttctggcag ggcctgctgg
     3061 tgtgttggag cctgcagggc aggtcaggct ggttcagagg cccatgctga ggggtgggtg
     3121 ctctgaagtg gagtgaagcc tcaagcccat gaatgccacc ccagtcatct ctggtgtcag
     3181 ctgctgctgt ggccccagca ggttctcaaa gctcccaagt cctccctacg acacagccca
     3241 aatgtgtaaa tggcactgtt gccctgacag tgcatggaaa ggacgttggc atccaattgg
     3301 cactccttct cccttattca atattaggtt tgatttgccc ttcgccattg tttccaaaga
     3361 tcaaggaatg tcaataacat tttaaaggac caataaacag cctcctataa agtaaacctc
     3421 ttcccgtgga agcacactct actactaaag ggaaggccct gggctctgat ttgtcctttg
     3481 cattgagaac ggtgtgggga tcagtgtgtg tgtatgtgat ttgtttattg agttggcttt
     3541 gcttttttag tttttctttt aaaaataaaa tccttccttc ccatgttact aaattaattt
     3601 atgtttttga gaggttgagt ctcaaagtgt aaacaataaa cctccattca taaggtggat
     3661 gttgtaagct tgatggtggt tgtgaaagtg atttagcttt gaccactttt catcctacag
     3721 cttcaatatc aaactggtta ggaaagccca gggggaaggg agggggcagg ggaggaggca
     3781 attctgaatg aatgaatgga ttttttgttg tttttgcatg tttaatatag aagttcccct
     3841 cgttccttgg gagatgatgg cctttgaata tgcagacaac ctttgaattg tgcctactaa
     3901 attatagcag gggactttgg cacccaagga gttctgactt tctgggatta taatagtaat
     3961 tcccagccat actctggact ttattttgct aaccataact gagcaaatgt aaattactgc
     4021 tatattaatg ttttaaagca ctgggatagt ctaattctaa cttgtaatta attatgtttg
     4081 ccaattatct gtttgaaata aatttgtgtc tgaacagcta ttgaaactgt taaattgtac
     4141 agatattatt catgacagct ttgtactgtg gaatgtgctt aataaaaaac aaaaaagttt
     4201 gacttttgtc cagtaaattg ctaagtaatg tcaataaatc gagtatgggt attatgcagt
     4261 gcacctaatc tggcttcatg caattgttac ttcagctact gattcaaagc caatactctt
     4321 aataaagtgt tgcaatactc tga
//
