LOCUS       NM_001378974            4406 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 11 (FBXW11),
            transcript variant 4, mRNA.
ACCESSION   NM_001378974 XM_005265855
VERSION     NM_001378974.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Tan,P., Cai,S., Huang,Z., Li,M., Liu,S., Chen,J., Fu,W. and Zhao,L.
  TITLE     E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is
            associated with immune infiltration and NF-kappaB pathway
            activation in pancreatitis and pancreatic cancer
  JOURNAL   Cell Signal 116, 111033 (2024)
   PUBMED   38182068
  REMARK    GeneRIF: E3 ubiquitin ligase FBXW11 as a novel inflammatory
            biomarker is associated with immune infiltration and NF-kappaB
            pathway activation in pancreatitis and pancreatic cancer.
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Dalle Carbonare,L., Gomez Lira,M., Minoia,A., Bertacco,J., Orsi,S.,
            Lauriola,A., Li Vigni,V., Gandini,A., Antoniazzi,F., Zipeto,D.,
            Mottes,M., Bhandary,L., Guardavaccaro,D. and Valenti,M.T.
  TITLE     Expression of FBXW11 in normal and disease-associated osteogenic
            cells
  JOURNAL   J Cell Mol Med 27 (11), 1580-1591 (2023)
   PUBMED   37199076
  REMARK    GeneRIF: Expression of FBXW11 in normal and disease-associated
            osteogenic cells.
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Nardone,C., Palanski,B.A., Scott,D.C., Timms,R.T., Barber,K.W.,
            Gu,X., Mao,A., Leng,Y., Watson,E.V., Schulman,B.A., Cole,P.A. and
            Elledge,S.J.
  TITLE     A central role for regulated protein stability in the control of
            TFE3 and MITF by nutrients
  JOURNAL   Mol Cell 83 (1), 57-73 (2023)
   PUBMED   36608670
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Liu,C., Chen,X., Zhang,L., Liu,J., Li,C., Zhao,J., Pu,J., Tang,P.,
            Liu,B. and Huang,X.
  TITLE     F-Box Protein 11 Suppresses Cell Proliferation and Aerobic
            Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation
            of Cdc25A
  JOURNAL   J Neuropathol Exp Neurol 81 (7), 511-521 (2022)
   PUBMED   35582896
  REMARK    GeneRIF: F-Box Protein 11 Suppresses Cell Proliferation and Aerobic
            Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation
            of Cdc25A.
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Chen,C., Zhou,H., Zhang,X., Liu,Z. and Ma,X.
  TITLE     Association of FBXW11 levels with tumor development and prognosis
            in chondrosarcoma
  JOURNAL   Cancer Biomark 35 (4), 429-437 (2022)
   PUBMED   36404534
  REMARK    GeneRIF: Association of FBXW11 levels with tumor development and
            prognosis in chondrosarcoma.
REFERENCE   6  (bases 1 to 4406)
  AUTHORS   Heissmeyer,V., Krappmann,D., Hatada,E.N. and Scheidereit,C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
REFERENCE   7  (bases 1 to 4406)
  AUTHORS   Koike,J., Sagara,N., Kirikoshi,H., Takagi,A., Miwa,T., Hirai,M. and
            Katoh,M.
  TITLE     Molecular cloning and genomic structure of the betaTRCP2 gene on
            chromosome 5q35.1
  JOURNAL   Biochem Biophys Res Commun 269 (1), 103-109 (2000)
   PUBMED   10694485
REFERENCE   8  (bases 1 to 4406)
  AUTHORS   Suzuki,H., Chiba,T., Suzuki,T., Fujita,T., Ikenoue,T., Omata,M.,
            Furuichi,K., Shikama,H. and Tanaka,K.
  TITLE     Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to
            IkappaBalpha for signal-dependent ubiquitination
  JOURNAL   J Biol Chem 275 (4), 2877-2884 (2000)
   PUBMED   10644755
REFERENCE   9  (bases 1 to 4406)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 4406)
  AUTHORS   Fuchs,S.Y., Chen,A., Xiong,Y., Pan,Z.Q. and Ronai,Z.
  TITLE     HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and
            Cullin1 and targets the phosphorylation-dependent degradation of
            IkappaB and beta-catenin
  JOURNAL   Oncogene 18 (12), 2039-2046 (1999)
   PUBMED   10321728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113342.2, AC011387.5 and
            AC011410.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 17, 2020 this sequence version replaced XM_005265855.5.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbws class and, in addition to an F-box, contains multiple WD40
            repeats. This gene contains at least 14 exons, and its alternative
            splicing generates 3 transcript variants diverging at the
            presence/absence of two alternate exons. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2878996.1,
                                           SRR11853558.20082.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517395.6/ ENSP00000428753.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC113342.2         25632-25812         c
            182-283             AC011387.5         134733-134834       c
            284-346             AC011387.5         91479-91541         c
            347-572             AC011387.5         87708-87933         c
            573-759             AC011387.5         77050-77236         c
            760-850             AC011387.5         76140-76230         c
            851-988             AC011387.5         68603-68740         c
            989-1107            AC011387.5         55147-55265         c
            1108-1357           AC011387.5         53421-53670         c
            1358-1476           AC011387.5         50008-50126         c
            1477-1587           AC011387.5         47884-47994         c
            1588-1666           AC011387.5         46865-46943         c
            1667-1853           AC011387.5         45746-45932         c
            1854-4406           AC011410.6         902-3454
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..4406
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="F-box and WD repeat domain containing 11"
                     /db_xref="GeneID:23291"
                     /db_xref="HGNC:HGNC:13607"
                     /db_xref="MIM:605651"
     exon            1..181
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1828
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="isoform D is encoded by transcript variant 4; F-box
                     and WD-40 domain protein 11; F-box and WD-40 domain
                     protein 1B; beta-transducin repeat-containing protein 2;
                     F-box protein Fbw1b; F-box/WD repeat-containing protein
                     11; homologous to Slimb protein; F-box/WD
                     repeat-containing protein 1B; F-box and WD repeats protein
                     beta-TrCP2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 11 isoform D"
                     /protein_id="NP_001365903.1"
                     /db_xref="CCDS:CCDS93825.1"
                     /db_xref="GeneID:23291"
                     /db_xref="HGNC:HGNC:13607"
                     /db_xref="MIM:605651"
                     /translation="MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPS
                     VRCLQNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFD
                     QWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYL
                     DARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPT
                     DGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIIS
                     GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL
                     NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF
                     DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWD
                     IECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRT
                     LVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR"
     exon            182..283
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            284..346
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            347..572
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            573..759
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            760..850
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            851..988
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1107
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1357
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1476
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1587
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1666
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1853
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..4406
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4244..4249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="hexamer: AATAAA"
     polyA_site      4262
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="major polyA site"
     regulatory      4384..4389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
                     /note="hexamer: AATAAA"
     polyA_site      4406
                     /gene="FBXW11"
                     /gene_synonym="BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
                     NEDJED"
ORIGIN      
        1 gccggcggcc cgggcgggct ggcagctaga gtgggtgcga tagccgcctc cgcctctgcc
       61 gcctccgccg tcgcctcctc cgcccgggcc gttcgctgct gcgcggggag agcgaggcgg
      121 ggccgccggg gccgccatgg agcccgactc ggtgattgag gacaagacca tcgagctcat
      181 gtgttctgtg ccaaggtctt tgtggctagg ctgcgccaac ctggtagaga gcatgtgcgc
      241 actgagttgc ctgcagagca tgcccagtgt cagatgtctc cagaacactt cagttatgga
      301 agatcaaaat gaagatgagt ccccaaagaa aaatactctt tggcagataa gtaatggaac
      361 atcatctgtg atcgtctcca gaaagaggcc atcagaagga aactatcaaa aagaaaaaga
      421 cttgtgtatt aaatattttg accagtggtc tgaatcagat caagtggaat ttgtggaaca
      481 tcttatttca cgaatgtgtc attatcagca tggacatatt aactcttacc tgaagcccat
      541 gttgcagcgg gactttatta ccgctttacc agagcaaggc ttagatcaca tagcagaaaa
      601 cattctttcg tacctggatg ccaggtctct gtgtgcagca gagctggtat gtaaagaatg
      661 gcagcgagtg atctcagaag gaatgctttg gaagaagctg attgaacgaa tggtacgcac
      721 tgatccccta tggaaaggac tttcagaaag aagagggtgg gatcagtacc tgtttaaaaa
      781 cagacccaca gatggccctc caaattcatt ttataggtca ttatacccaa agattatcca
      841 ggatatagag actatagaat ctaactggcg gtgtggacga cacaacttgc agaggattca
      901 gtgccgctct gaaaatagta aaggtgtcta ctgtttacag tacgatgatg aaaaaattat
      961 cagtggccta cgagataatt ctattaagat atgggataaa accagcctgg aatgtttgaa
     1021 agtgttaaca ggacacacag gctctgtcct ctgtctgcag tatgatgagc gtgtcattgt
     1081 aactggctct tcagattcta cggtgagagt gtgggatgtg aacacgggtg aagttcttaa
     1141 cacattgatc caccacaatg aggctgtatt gcacttacgc ttcagcaatg gactgatggt
     1201 gacctgttcc aaggaccgct ccattgctgt gtgggacatg gcttctgcga ccgacatcac
     1261 tttacgccgt gtcctggttg gccaccgggc tgccgtcaat gtagtagact ttgacgacaa
     1321 gtacatcgtg tctgcctctg gtgacaggac catcaaagtc tggagcacga gcacctgtga
     1381 atttgttcgt actctcaatg ggcacaagcg gggcattgcc tgtctccagt acagggatcg
     1441 cctggttgtt agtggatcat cagataatac cattaggctc tgggatattg aatgtggtgc
     1501 ctgtttaaga gtcctagagg gacatgaaga attggtccga tgcatccggt ttgataacaa
     1561 gaggattgtc agtggggcct atgatgggaa aattaaagtt tgggacttgc aagctgctct
     1621 tgaccctcga gccccagcaa gcacattgtg tttgcgcaca ttggtggaac attctggacg
     1681 tgtgtttcgg ctccagtttg atgagtttca gatcatcagc agctcccatg atgacactat
     1741 tttgatttgg gatttcttaa atgtgcctcc cagtgcccag aatgagaccc gttctccctc
     1801 cagaacatac acttacatct ctagataaca gtctgcactt tcacccgttt cagggttttc
     1861 tagtcttgaa ctactggcta cgtggctacc aaatgcctaa gggagttcgt tcacagctga
     1921 gttatgaagc tggaattggt tctagacgct gggtagatgc aaagcagcct aactcttcaa
     1981 gtaccgacat ttctcacctc tgattccggc tctcctttga gaaggagacc ttagcttccc
     2041 cggcttcaag tagaacagaa gcccgtttcc ttccctcatc agtgaaaaaa tctaatgttt
     2101 caaatgtaaa ttgttcatag aaaaggaaca tagaatctgt tttacagaag taaatcgacc
     2161 gtcaagagaa gacttggcct ctaatttata ttgctttgca ctttggtttg atattaagaa
     2221 acagcattct tcttcagtga aattttgggt gccaaacacc tacccagaat gtccagggct
     2281 ttcattttca aaagttagca ttctcctttt gaccgtccaa gtcattatga attctgactt
     2341 gttgtattag gaacatgttg gacagtggaa aattttctct ggattgtttt agtaatattt
     2401 ttgggattat acttcctttc tgtaccaatt tcttttaatt taaagaacta taagtcagtt
     2461 atattatcta ccaacaggta atatagctct ttcttttatt aactgttctc tgtcccccaa
     2521 ccatctcctg atatttggta gagtaacacc tttatacgtg tgcttgcctc ctaatttaaa
     2581 atactgtatt cgcatgtaga tataatgtac ataacagttt aacctcaaag ttgctggagt
     2641 cagggccccc tgtgcttgag acactaatac agagtgtgtt cgcacttagc catgggctgg
     2701 gctcaagaac ctgatacctg ggttgatgtg gattacctag aacccttcct gcagtattca
     2761 tacagtgttt ttattttgtt gttgtcattg cgtgtgtgtg gtttgtgtgt gtttttaatg
     2821 agaatcttgt tttaaaatgt aatttctaag gtttaacacc aaaatgtttt atttgttgtg
     2881 gagtatatat tatacaatag agaggtacct taaacatttt ttgttcttat tctttttctc
     2941 ataagtactc ctgagtacaa gtggtcacct cccatagtat tcatttggct tcgctgtcaa
     3001 aaatcattat tctgtgcagt cgtggccctg ggaaggggaa ataagaaggc cctgttgacg
     3061 ggctgtcttg gctctggaat tcatgcatcc tggccttgcc aaggttctgg cagggcctgc
     3121 tggtgtgttg gagcctgcag ggcaggtcag gctggttcag aggcccatgc tgaggggtgg
     3181 gtgctctgaa gtggagtgaa gcctcaagcc catgaatgcc accccagtca tctctggtgt
     3241 cagctgctgc tgtggcccca gcaggttctc aaagctccca agtcctccct acgacacagc
     3301 ccaaatgtgt aaatggcact gttgccctga cagtgcatgg aaaggacgtt ggcatccaat
     3361 tggcactcct tctcccttat tcaatattag gtttgatttg cccttcgcca ttgtttccaa
     3421 agatcaagga atgtcaataa cattttaaag gaccaataaa cagcctccta taaagtaaac
     3481 ctcttcccgt ggaagcacac tctactacta aagggaaggc cctgggctct gatttgtcct
     3541 ttgcattgag aacggtgtgg ggatcagtgt gtgtgtatgt gatttgttta ttgagttggc
     3601 tttgcttttt tagtttttct tttaaaaata aaatccttcc ttcccatgtt actaaattaa
     3661 tttatgtttt tgagaggttg agtctcaaag tgtaaacaat aaacctccat tcataaggtg
     3721 gatgttgtaa gcttgatggt ggttgtgaaa gtgatttagc tttgaccact tttcatccta
     3781 cagcttcaat atcaaactgg ttaggaaagc ccagggggaa gggagggggc aggggaggag
     3841 gcaattctga atgaatgaat ggattttttg ttgtttttgc atgtttaata tagaagttcc
     3901 cctcgttcct tgggagatga tggcctttga atatgcagac aacctttgaa ttgtgcctac
     3961 taaattatag caggggactt tggcacccaa ggagttctga ctttctggga ttataatagt
     4021 aattcccagc catactctgg actttatttt gctaaccata actgagcaaa tgtaaattac
     4081 tgctatatta atgttttaaa gcactgggat agtctaattc taacttgtaa ttaattatgt
     4141 ttgccaatta tctgtttgaa ataaatttgt gtctgaacag ctattgaaac tgttaaattg
     4201 tacagatatt attcatgaca gctttgtact gtggaatgtg cttaataaaa aacaaaaaag
     4261 tttgactttt gtccagtaaa ttgctaagta atgtcaataa atcgagtatg ggtattatgc
     4321 agtgcaccta atctggcttc atgcaattgt tacttcagct actgattcaa agccaatact
     4381 cttaataaag tgttgcaata ctctga
//
