LOCUS       NM_001267585            3401 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box and WD repeat domain containing 10 (FBXW10),
            transcript variant 1, mRNA.
ACCESSION   NM_001267585
VERSION     NM_001267585.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Sahay,O., Barik,G.K. and Islam,S.
  TITLE     FBXW10: a male-biased E3 ligase in liver cancer
  JOURNAL   Trends Cancer 9 (11), 876-878 (2023)
   PUBMED   37775405
  REMARK    GeneRIF: FBXW10: a male-biased E3 ligase in liver cancer.
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Zhang,Z.Y., Sun,J.H., Liang,M.J., Wang,X.P., Guan,J. and Zhou,Z.Q.
  TITLE     The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation
            regulates angiogenesis and liver metastasis in colorectal cancer
  JOURNAL   Int J Biochem Cell Biol 158, 106408 (2023)
   PUBMED   36990424
  REMARK    GeneRIF: The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2
            degradation regulates angiogenesis and liver metastasis in
            colorectal cancer.
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Luo,Y.D., Zhang,J., Fang,L., Zhu,Y.Y., You,Y.M., Zhang,C.C.,
            Zheng,P., Zhang,L.D., Yin,L.Y., Xia,F., Bie,P. and Xie,C.M.
  TITLE     FBXW10 promotes hepatocarcinogenesis in male patients and mice
  JOURNAL   Carcinogenesis 41 (5), 689-698 (2020)
   PUBMED   31400758
  REMARK    GeneRIF: FBXW10 promotes hepatocarcinogenesis in male patients and
            mice.
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Feng,Z., Hui,Y., Ling,L., Xiaoyan,L., Yuqiu,W., Peng,W. and
            Lianwen,Z.
  TITLE     FBXW10 is negatively regulated in transcription and expression
            level by protein O-GlcNAcylation
  JOURNAL   Biochem Biophys Res Commun 438 (2), 427-432 (2013)
   PUBMED   23899520
  REMARK    GeneRIF: O-GlcNAcylation is involved in the regulation of
            ubiquitination-related genes including FBXW10
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Chaturvedi,P. and Parnaik,V.K.
  TITLE     Lamin A rod domain mutants target heterochromatin protein 1alpha
            and beta for proteasomal degradation by activation of F-box
            protein, FBXW10
  JOURNAL   PLoS One 5 (5), e10620 (2010)
   PUBMED   20498703
  REMARK    GeneRIF: Mislocalized lamins can induce ubiquitin-mediated
            proteasomal degradation of certain HP1 isoforms by activation of
            FBXW10, a member of the F-box family of proteins that is involved
            in E3 ubiquitin ligase activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB055860.1, AY729024.1, AC107982.6 and AL136822.1.
            
            On May 17, 2019 this sequence version replaced NM_001267585.1.
            
            Summary: Members of the F-box protein family, such as FBXW10, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.113275.1, AY729024.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395665.9/ ENSP00000379025.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               DB055860.1         42-232
            192-1014            AY729024.1         1-823
            1015-1015           AC107982.6         123794-123794       c
            1016-2103           AY729024.1         825-1912
            2104-2104           AC107982.6         103677-103677       c
            2105-3350           AY729024.1         1914-3159
            3351-3401           AL136822.1         3171-3221
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3401
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="F-box and WD repeat domain containing 10"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:HGNC:1211"
                     /db_xref="MIM:611679"
     exon            1..696
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..3350
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and WD-40 domain protein 10; F-box/WD repeat-containing
                     protein 10; ubiquitin ligase specificity factor;
                     testicular tissue protein Li 69"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 10 isoform 1"
                     /protein_id="NP_001254514.1"
                     /db_xref="CCDS:CCDS11199.3"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:HGNC:1211"
                     /db_xref="MIM:611679"
                     /translation="MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEW
                     FCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVV
                     KSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLF
                     LREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLG
                     AASNPEEPWRNSLRCISEMNRLFSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRD
                     FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG
                     SYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVL
                     IEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFR
                     GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRL
                     VSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQL
                     VKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLL
                     FLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESNVLMFQ
                     FEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCNIQVHSPRESVSSKQTVIQEL
                     LPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDADDVEKAQKQGQLETPGKLP
                     SHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGPSISYPRKVL
                     NFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPMII
                     RSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRI
                     YTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGL
                     PIDNFTKQGKTAAPELGQNVFI"
     exon            697..861
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1062
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1190
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1313
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1423
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1624
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1746
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1895
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2038
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2197
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2469
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2526
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..3401
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="hexamer: AATAAA"
     polyA_site      3401
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="major polyA site"
ORIGIN      
        1 agacttctgc tggcagttac tgagagagat aggctttcca tccatggcag ccatttactt
       61 ttgctctggg agacgtttgt aatagaaaag gcacaactgg ggtatttatt cattcccccc
      121 gttcctctag tgtttggtgg cgttgccgtt gcaagtgcgc agggctaaaa tggactggtt
      181 atcttaggat catggaaaac ctggaatcaa ggctcaagaa tgccccctat tttcgttgtg
      241 agaagggaac cgattccatc cctctatgcc ggaagtgtga gacgtgtgtc ttagcctgga
      301 agatcttctc taccaaagag tggttctgca ggatcaatga catatcacag aggaggtttc
      361 tagttggcat tctgaagcag ttaaatagct tatatttgtt acactatttc caaaatatcc
      421 ttcagaccac acagggaaag gatttcatct ataacaggtc ccggatcaac ctcagcaaga
      481 aagaggggaa agttgtgaag tcctccttga accaaatgtt ggataaaaca gtagaacaga
      541 agatgaaaga gatcttgtac tggtttgcga acagcaccca gtggaccaag gcgaattata
      601 ctctcttact gctgcagatg tgcaacccca aattactgct cactgctgcc aatgtgatca
      661 gagtcctgtt tctgagagag gagaacaata tctcagggct caatcaagac atcacagatg
      721 tgtgtttttc ccctgagaaa gaccacagct ccaagtctgc gacctcacaa gtctattgga
      781 cagccaaaac tcagcacaca tcccttcctt tgtccaaagc cccagaaaat gaacacttgc
      841 ttggggcagc atctaaccct gaggaaccat ggaggaattc actccggtgt atatccgaaa
      901 tgaataggct gttttctgga aaaggagaca taaccaagcc agggtacgat ccctgcaatc
      961 tattggttga cctggatgac atcagagacc tgtcttctgg gttcagcaaa taccgagact
     1021 tcatccgtta cctgcccatc cacctctcca agtacattct aagaatgctg gatagacaca
     1081 ccctgaacaa gtgcgcctct gtgagccagc actgggccgc catggctcaa caggtcaaga
     1141 tggacttgtc agcgcacggc ttcattcaga accagattac cttcttgcag gggtcctaca
     1201 caagaggaat tgatcctaat tatgccaata aggtttctat cccagttcct aaaatggtag
     1261 atgacgggaa gagcatgcgt gtgaaacatc cgaagtggaa gctgagaacg aagaatgagt
     1321 acaacctgtg gactgcatac cagaacgagg aaacgcagca ggtcctgata gaggagagaa
     1381 atgttttctg tgggacctac aatgttcgca ttctctctga cacgtgggat caaaaccgag
     1441 tcatccacta ttccggggga gatctgatag ctgtgtcatc taatcgaaag atccatcttc
     1501 tggacatcat acaagtgaaa gcgatacccg ttgaattccg aggccatgct gggagtgtcc
     1561 gggccctctt cctgtgtgag gaggaaaact ttctcctaag cgggagctat gacctaagta
     1621 tcagatactg ggatctgaaa agtggggttt gcacacgaat cttcggtggt caccagggga
     1681 ctatcacttg catggacttg tgtaagaaca ggctcgtatc tggaggaaga gattgccagg
     1741 taaaagtatg ggatgtagac acagggaagt gcctgaagac gtttagacac aaagacccca
     1801 tcttggccac caggatcaat gatacctaca ttgtgagcag ctgtgagcga gggctggtga
     1861 aagtgtggca cattgccatg gcccagttgg taaagactct cagtggccat gagggagccg
     1921 tgaaatgcct gttctttgac cagtggcatc tcctctcagg aagtactgat ggcctggtca
     1981 tggcctggag catggtgggg aagtacgagc gctgcctgat ggccttcaag catcccaagg
     2041 aggtgctcga cgtgtccctt ctcttcctcc gggtcatcag cgcctgtgca gatggcaaga
     2101 tccgaattta caatttcctc aacgggaact gtatgaaggt gttaaaagcc aatggcagag
     2161 gtgatcctgt gctgtccttc tttattcagg gcaacaggat ggtggtcaac acagagagca
     2221 atgttctcat gttccagttt gagcacataa agtggcagta tgccgtggaa aaaacgaaac
     2281 aaaagaagaa taaggagaaa gaggaggaaa aagaagaaaa tagtctcatg gaaattctct
     2341 ctaagtgtaa tattcaggtt cacagcccaa gagagtctgt atccagtaaa caaactgtga
     2401 tccaagagct cctaccaggc aaacctccca agtcccgagt actcctgaag ccggccaagt
     2461 tctcttcagc agtgttaata gaggaacttc aaagtcaagg aaagtcaaaa tcaccccgaa
     2521 gagatgcaga tgatgtggag aaagcacaaa aacaaggaca attggaaact cctggaaaac
     2581 tgcccagtca cccaaagaaa aagtcttgga aaatccctat gtcacctgac caattcctcc
     2641 tgactgttag cgccctgcag cacgcccata attccgggga atttgcctat ccctgtaggc
     2701 cccaaacaga aattactgat gtctggggac cttcaatttc atacccaagg aaggtcttga
     2761 atttcaaagg aaaatcaatc caacgtgcag ttgatcggtt gagattgagc aatcctccta
     2821 tagatgtgaa acgaaccagt attccccttg aaatccagaa actgcagccc aacttgaaga
     2881 tctctttgca cagtcctaga gtccagtcca ccatacccca gcccatgatt atccgctcca
     2941 ggttctctgg cagcttaaag ggtggagacc aagtgaccag ttcaattgaa agggctgtgt
     3001 gcagtacggg tcccctgacc agtatgcagg tcattaaacc aaaccgcatg ctagctccac
     3061 aagtgggcac agccaccctg tctcttaaga aagaacggcc tcgcatctat acagcccttg
     3121 atccttttag agtgaacact gagttcgtgc tgttgaccgt gaaggaggag aaggagcacc
     3181 aggaagccaa gatgaaggaa tatcaggcca gggagtccac tggagtggtt gatccaggaa
     3241 aagtcagcaa agctgcatgg atcaggaaga tcaaaggcct gcctattgat aatttcacga
     3301 agcaagggaa aacagcggcc cctgaacttg gacaaaatgt atttatctaa accagccttg
     3361 ggaaattaca atgttttaca ataaacagaa agccaagcgg a
//
